Primary gliosarcoma of the brain : Radiologic and histopathologic features
11 p.
- Autores:
-
Romero Rojas, Alfredo E.
Diaz Perez, Julio A.
Ariza Serrano, Lina María
Amaro, Deirdre E.
Lozano Castillo, Alfonso
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2013
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3607
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3607
- Palabra clave:
- Glioblastoma multiforme
Gliosarcoma
Histopathology
Radiology
Immunohistochemistry
Neurosurgery
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Santander, 2013
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Primary gliosarcoma of the brain : Radiologic and histopathologic features |
| title |
Primary gliosarcoma of the brain : Radiologic and histopathologic features |
| spellingShingle |
Primary gliosarcoma of the brain : Radiologic and histopathologic features Glioblastoma multiforme Gliosarcoma Histopathology Radiology Immunohistochemistry Neurosurgery |
| title_short |
Primary gliosarcoma of the brain : Radiologic and histopathologic features |
| title_full |
Primary gliosarcoma of the brain : Radiologic and histopathologic features |
| title_fullStr |
Primary gliosarcoma of the brain : Radiologic and histopathologic features |
| title_full_unstemmed |
Primary gliosarcoma of the brain : Radiologic and histopathologic features |
| title_sort |
Primary gliosarcoma of the brain : Radiologic and histopathologic features |
| dc.creator.fl_str_mv |
Romero Rojas, Alfredo E. Diaz Perez, Julio A. Ariza Serrano, Lina María Amaro, Deirdre E. Lozano Castillo, Alfonso |
| dc.contributor.author.spa.fl_str_mv |
Romero Rojas, Alfredo E. Diaz Perez, Julio A. Ariza Serrano, Lina María Amaro, Deirdre E. Lozano Castillo, Alfonso |
| dc.subject.proposal.eng.fl_str_mv |
Glioblastoma multiforme Gliosarcoma Histopathology Radiology Immunohistochemistry Neurosurgery |
| topic |
Glioblastoma multiforme Gliosarcoma Histopathology Radiology Immunohistochemistry Neurosurgery |
| description |
11 p. |
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2013 |
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2013 |
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2019-08-21T16:34:11Z |
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2385-1996 1971-4009 |
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https://repositorio.udes.edu.co/handle/001/3607 |
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eng |
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eng |
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Neuroradiology Journal |
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Neuroradiology Journal;Vol. 26 (6), pp. 639-648. 2013 |
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Derechos Reservados - Universidad de Santander, 2013 |
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https://www.researchgate.net/publication/259393373_Primary_Gliosarcoma_of_the_Brain_Radiologic_and_Histopathologic_Features/link/56b7b4c408ae5ad3605dd64f/download |
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Romero Rojas, Alfredo E.3e465c15-1707-4dfe-ae44-dc7225c73f4e-1Diaz Perez, Julio A.c3667314-adc6-4295-bb6b-f33572645af0-1Ariza Serrano, Lina María67ac122c-945c-4edb-aec6-27dc88950451-1Amaro, Deirdre E.071480f0-ed97-43c7-ad11-2ad9e42eb1e6-1Lozano Castillo, Alfonso4a1c9a4a-9717-40df-9848-18c3b5e8574e-12019-08-21T16:34:11Z2019-08-21T16:34:11Z201311 p.Gliosarcoma is a rare central nervous system (CNS) neoplasm with biphasic glial and non-glial malignant components. Here we describe the radiologic and histopathologic features observed in five cases of primary gliosarcoma. The mean age at diagnosis in the studied patients was 54.2 years; these patients were predominantly males (male: female ratio = 4:1). At diagnosis all patients had several clinical deterioration. The most common symptoms of presentation were: headache (5/5 cases), seizures (4/5 cases) and hemiparesis (1/5 cases). All the tumors were large (mean major diameter= 4.12±1.64 cm) at diagnosis as evidenced in computer tomography (CT) scans and magnetic resonance images (MRIs), with preferential involvement of the temporal lobe and frequent associated deviation of the midline structures. Other common characteristics identified on CT scans and MRIs were partial contrast medium uptake with annular pattern (5/5 cases), peripheral edema (5/5 cases), and central calcification (3/5 cases). In additional a peak of dye uptake was observed (4/5 cases) on MRI spectrometry. In the histopathology, the glial component showed malignant astrocytes, with high Ki67 (>60%) and p53 positivity; the sarcomatous components displayed pleomorphic spindle cells similarly with p53 positivity and high Ki67 (75-90%) in all cases. Dedifferentiation to pleomorphic sarcoma (two cases), fibrosarcoma (one case), leiomyosarcoma (one case) and MPNST (one case) were documented. All patients received radiotherapy/chemotherapy and had a median overall survival of ten months. The study of radiologic and histopathologic features in primary gliosarcomas of the brain is a priority to achieve early diagnosis that can be translated to better outcomes. Here we describe the radiologic and histopathologic features observed in a group of gliosarcoma patients with variable histopathologic dedifferentiation.application/pdf10.1177/1971400913026006062385-19961971-4009https://repositorio.udes.edu.co/handle/001/3607engNeuroradiology JournalNeuroradiology Journal;Vol. 26 (6), pp. 639-648. 2013Derechos Reservados - Universidad de Santander, 2013info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.researchgate.net/publication/259393373_Primary_Gliosarcoma_of_the_Brain_Radiologic_and_Histopathologic_Features/link/56b7b4c408ae5ad3605dd64f/downloadGlioblastoma multiformeGliosarcomaHistopathologyRadiologyImmunohistochemistryNeurosurgeryPrimary gliosarcoma of the brain : Radiologic and histopathologic featuresArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTEXTPrimary Gliosarcoma of the Brain - Radiologic and Histopathologic Features..pdf.txtPrimary Gliosarcoma of the Brain - Radiologic and Histopathologic Features..pdf.txtExtracted texttext/plain33171https://repositorio.udes.edu.co/bitstreams/860b3988-d867-4d59-aa22-a14e768ed0a8/download80d0d186b671e3416bce6aa7d010e5f2MD53Primary gliosarcoma of the brain. 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