Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy

Digital

Autores:
Ortega, Angel
Salazar, Juan
Galban, Néstor
Rojas, Milagros
Ariza, Daniela
Chavez-Castillo, Mervin
Nava, Manuel
Riano-Garzon, Manuel E.
Diaz-Camargo, Edgar Alexis
Medina-Ortiz, Oscar
Bermudez, Valmore
Tipo de recurso:
Review article
Fecha de publicación:
2022
Institución:
Universidad de Santander
Repositorio:
Repositorio Universidad de Santander
Idioma:
eng
OAI Identifier:
oai:repositorio.udes.edu.co:001/7337
Acceso en línea:
https://doi.org/10.3390/ijms23084196
https://repositorio.udes.edu.co/handle/001/7337
Palabra clave:
Placebo Effect
Psychoneuroimmunology;
Conditioning
Cannabinoids
Opioid
Hormones
Analgesia
Pain
Depression
Parkinson’s Disease
Rights
openAccess
License
Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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dc.title.spa.fl_str_mv Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
title Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
spellingShingle Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
Placebo Effect
Psychoneuroimmunology;
Conditioning
Cannabinoids
Opioid
Hormones
Analgesia
Pain
Depression
Parkinson’s Disease
title_short Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
title_full Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
title_fullStr Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
title_full_unstemmed Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
title_sort Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
dc.creator.fl_str_mv Ortega, Angel
Salazar, Juan
Galban, Néstor
Rojas, Milagros
Ariza, Daniela
Chavez-Castillo, Mervin
Nava, Manuel
Riano-Garzon, Manuel E.
Diaz-Camargo, Edgar Alexis
Medina-Ortiz, Oscar
Bermudez, Valmore
dc.contributor.author.none.fl_str_mv Ortega, Angel
Salazar, Juan
Galban, Néstor
Rojas, Milagros
Ariza, Daniela
Chavez-Castillo, Mervin
Nava, Manuel
Riano-Garzon, Manuel E.
Diaz-Camargo, Edgar Alexis
Medina-Ortiz, Oscar
Bermudez, Valmore
dc.contributor.researchgroup.spa.fl_str_mv Entropia
dc.subject.proposal.eng.fl_str_mv Placebo Effect
Psychoneuroimmunology;
Conditioning
Cannabinoids
Opioid
Hormones
Analgesia
Pain
Depression
Parkinson’s Disease
topic Placebo Effect
Psychoneuroimmunology;
Conditioning
Cannabinoids
Opioid
Hormones
Analgesia
Pain
Depression
Parkinson’s Disease
description Digital
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-08-03T21:40:33Z
dc.date.available.none.fl_str_mv 2022-08-03T21:40:33Z
dc.date.issued.none.fl_str_mv 2022-04-11
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.doi.none.fl_str_mv https://doi.org/10.3390/ijms23084196
dc.identifier.issn.spa.fl_str_mv 1422-0067
dc.identifier.uri.none.fl_str_mv https://repositorio.udes.edu.co/handle/001/7337
url https://doi.org/10.3390/ijms23084196
https://repositorio.udes.edu.co/handle/001/7337
identifier_str_mv 1422-0067
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationendpage.spa.fl_str_mv 22
dc.relation.citationissue.spa.fl_str_mv 8
dc.relation.citationstartpage.spa.fl_str_mv 1
dc.relation.citationvolume.spa.fl_str_mv 23
dc.relation.cites.none.fl_str_mv Ortega, Á.; Salazar, J.; Galban, N.; Rojas, M.; Ariza, D.; Chávez-Castillo, M.; Nava, M.; Riaño-Garzón, M.E.; Díaz-Camargo, E.A.; Medina-Ortiz, O.; Bermúdez, V. Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy. Int. J. Mol. Sci. 2022, 23, 4196. https://doi.org/10.3390/ijms23084196
dc.relation.indexed.spa.fl_str_mv Scopus
dc.relation.ispartofjournal.spa.fl_str_mv International Journal of Molecular Sciences
dc.rights.spa.fl_str_mv Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.creativecommons.spa.fl_str_mv Atribución 4.0 Internacional (CC BY 4.0)
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Atribución 4.0 Internacional (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.spa.fl_str_mv 22 p
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dc.publisher.place.spa.fl_str_mv Suiza
dc.source.spa.fl_str_mv https://www.mdpi.com/1422-0067/23/8/4196
institution Universidad de Santander
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spelling Ortega, Angel1ab36631-a9d0-4944-887a-f35d8f7a9860-1Salazar, Juanac044d2a-78fa-4bb8-9d8c-2ef9ccfe275f-1Galban, Néstor04e53785-fead-43a1-abfe-c69a7773c0fd-1Rojas, Milagrosea9e3f51-9796-4f19-a3c8-8e9dd889c4ec-1Ariza, Daniela80425a51-dfdd-4da7-a3f3-984f08bec0de-1Chavez-Castillo, Mervin0c55fb94-d695-4061-9965-5c45c96ada9e-1Nava, Manuel6fe6f9ab-7cec-4a74-80e2-e1e2149c0e21-1Riano-Garzon, Manuel E.825e35e3-2769-40f0-8b0c-b04ae1fe980b-1Diaz-Camargo, Edgar Alexis93bedbbd-c0bd-41db-9652-4f1af6aafc39-1Medina-Ortiz, Oscardd64d41b-e13a-4ce9-b1d6-62245e46857a-1Bermudez, Valmore1290aa1d-6b03-4912-aff2-b6c85a9f2378-1Entropia2022-08-03T21:40:33Z2022-08-03T21:40:33Z2022-04-11DigitalThe placebo effect can be defined as the improvement of symptoms in a patient after the administration of an innocuous substance in a context that induces expectations regarding its effects. During recent years, it has been discovered that the placebo response not only has neurobiological functions on analgesia, but that it is also capable of generating effects on the immune and endocrine systems. The possible integration of changes in different systems of the organism could favor the well-being of the individuals and go hand in hand with conventional treatment for multiple diseases. In this sense, classic conditioning and setting expectations stand out as psychological mechanisms implicated in the placebo effect. Recent advances in neuroimaging studies suggest a relationship between the placebo response and the opioid, cannabinoid, and monoaminergic systems. Likewise, a possible immune response conditioned by the placebo effect has been reported. There is evidence of immune suppression conditioned through the insular cortex and the amygdala, with noradrenalin as the responsible neurotransmitter. Finally, a conditioned response in the secretion of different hormones has been determined in different studies; however, the molecular mechanisms involved are not entirely known. Beyond studies about its mechanism of action, the placebo effect has proved to be useful in the clinical setting with promising results in the management of neurological, psychiatric, and immunologic disorders. However, more research is needed to better characterize its potential use. This review integrates current knowledge about the psycho-neuro-endocrine-immune basis of the placebo effect and its possible clinical applications.Ciencias Médicas y de la Salud22 papplication/pdfhttps://doi.org/10.3390/ijms230841961422-0067https://repositorio.udes.edu.co/handle/001/7337engSuiza228123Ortega, Á.; Salazar, J.; Galban, N.; Rojas, M.; Ariza, D.; Chávez-Castillo, M.; Nava, M.; Riaño-Garzón, M.E.; Díaz-Camargo, E.A.; Medina-Ortiz, O.; Bermúdez, V. Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy. Int. J. Mol. Sci. 2022, 23, 4196. https://doi.org/10.3390/ijms23084196ScopusInternational Journal of Molecular SciencesCopyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.info:eu-repo/semantics/openAccessAtribución 4.0 Internacional (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2https://www.mdpi.com/1422-0067/23/8/4196Placebo EffectPsychoneuroimmunology;ConditioningCannabinoidsOpioidHormonesAnalgesiaPainDepressionParkinson’s DiseasePsycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain TherapyArtículo de revistahttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_efa0http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTREVTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALPsycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect. Potential Applications beyond Pain Therapy.pdfPsycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect. 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