Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity
Digital
- Autores:
-
Fonseca, Daniela
Leal-Pinto, Sandra Milena
Roa-Cordero, Martha Viviana
Vargas, Jose D.
Moreno-Moreno, Erika Marcela
Macias, Mario A.
Suescun, Leopoldo
Muñoz-Castro, Alvaro
Hurtado, John J.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/6728
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/6728
- Palabra clave:
- Pyrazole and dinitrobenzoate ligands
Cobalt(II) complexes
Crystal structure
Trypanosoma cruzi
Antifungal activity
Cytotoxicity
Dimorphic switch
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
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| dc.title.spa.fl_str_mv |
Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity |
| title |
Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity |
| spellingShingle |
Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity Pyrazole and dinitrobenzoate ligands Cobalt(II) complexes Crystal structure Trypanosoma cruzi Antifungal activity Cytotoxicity Dimorphic switch |
| title_short |
Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity |
| title_full |
Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity |
| title_fullStr |
Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity |
| title_full_unstemmed |
Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity |
| title_sort |
Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity |
| dc.creator.fl_str_mv |
Fonseca, Daniela Leal-Pinto, Sandra Milena Roa-Cordero, Martha Viviana Vargas, Jose D. Moreno-Moreno, Erika Marcela Macias, Mario A. Suescun, Leopoldo Muñoz-Castro, Alvaro Hurtado, John J. |
| dc.contributor.author.none.fl_str_mv |
Fonseca, Daniela Leal-Pinto, Sandra Milena Roa-Cordero, Martha Viviana Vargas, Jose D. Moreno-Moreno, Erika Marcela Macias, Mario A. Suescun, Leopoldo Muñoz-Castro, Alvaro Hurtado, John J. |
| dc.contributor.researchgroup.spa.fl_str_mv |
Microbiota |
| dc.subject.proposal.eng.fl_str_mv |
Pyrazole and dinitrobenzoate ligands Cobalt(II) complexes Crystal structure Trypanosoma cruzi Antifungal activity Cytotoxicity Dimorphic switch |
| topic |
Pyrazole and dinitrobenzoate ligands Cobalt(II) complexes Crystal structure Trypanosoma cruzi Antifungal activity Cytotoxicity Dimorphic switch |
| description |
Digital |
| publishDate |
2019 |
| dc.date.issued.none.fl_str_mv |
2019-07-01 |
| dc.date.accessioned.none.fl_str_mv |
2022-05-09T14:36:24Z |
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2022-05-09T14:36:24Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_6501 |
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Text |
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10.3390/ijms20133237 |
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1422-0067 |
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https://repositorio.udes.edu.co/handle/001/6728 |
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10.3390/ijms20133237 1422-0067 |
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eng |
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eng |
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20 |
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Fonseca, D.; Leal-Pinto, S.M.; Roa-Cordero, M.V.; Vargas, J.D.; Moreno-Moreno, E.M.; Macías, M.A.; Suescun, L.; Muñoz-Castro, Á.; Hurtado, J.J. Inhibition of C. albicans Dimorphic Switch by Cobalt(II) Complexes with Ligands Derived from Pyrazoles and Dinitrobenzoate: Synthesis, Characterization and Biological Activity. Int. J. Mol. Sci. 2019, 20, 3237. https://doi.org/10.3390/ijms20133237 |
| dc.relation.indexed.spa.fl_str_mv |
Scopus |
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International Journal of Molecular Sciences |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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20 p |
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application/pdf |
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Suiza |
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https://www.mdpi.com/1422-0067/20/13/3237 |
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Universidad de Santander |
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Fonseca, Daniela2e0e4a4e-97b9-4d80-a240-05e86384705b-1Leal-Pinto, Sandra Milena7a951a90-7d60-410c-b90b-8f1763525a99-1Roa-Cordero, Martha Viviana290bf92f-fb46-426b-bed1-359915a56e41-1Vargas, Jose D.c90606ed-73a4-4674-a1cf-db6126eaca65-1Moreno-Moreno, Erika Marcela43351170-bbb9-4abc-adc1-0e9ffa35532c-1Macias, Mario A.d001eb61-6fe7-408f-adae-7b9fa11390f5-1Suescun, Leopoldo57a18685-2a55-4f5e-bd77-475bf28dfaad-1Muñoz-Castro, Alvaro9d44a366-4049-4e05-b718-5adcbf70ac24-1Hurtado, John J.4eaad30c-8862-4ab3-bad0-3aa3d14b5b8b-1Microbiota2022-05-09T14:36:24Z2022-05-09T14:36:24Z2019-07-01DigitalSeven cobalt(II) complexes of pyrazole derivatives and dinitrobenzoate ligands were synthesized and characterized. The single-crystal X-ray diffraction structure was determined for one of the ligands and one of the complexes. The analysis and spectral data showed that all the cobalt complexes had octahedral geometries, which was supported by DFT calculations. The complexes and their free ligands were evaluated against fungal strains of Candida albicans and emerging non-albicans species and epimastigotes of Trypanosoma cruzi. We obtained antifungal activity with a minimum inhibitory concentration (MIC) ranging from 31.3 to 250 µg mL−1. The complexes were more active against C. krusei, showing MIC values between 31.25 and 62.5 µg mL−1 . In addition, some ligands (L1–L6) and complexes (5 and Co(OAc)2 · 4H2O) significantly reduced the yeast to hypha transition of C. albicans at 500 µg mL−1 (inhibition ranging from 30 to 54%). Finally, the complexes and ligands did not present trypanocidal activity and were not toxic to Vero cells. Our results suggest that complexes of cobalt(II) with ligands derived from pyrazoles and dinitrobenzoate may be an attractive alternative for the treatment of diseases caused by fungi, especially because they target one of the most important virulence factors of C. albicans.Biotecnología, Agroambiente y Salud20 papplication/pdf10.3390/ijms201332371422-0067https://repositorio.udes.edu.co/handle/001/6728engSuiza20Fonseca, D.; Leal-Pinto, S.M.; Roa-Cordero, M.V.; Vargas, J.D.; Moreno-Moreno, E.M.; Macías, M.A.; Suescun, L.; Muñoz-Castro, Á.; Hurtado, J.J. Inhibition of C. albicans Dimorphic Switch by Cobalt(II) Complexes with Ligands Derived from Pyrazoles and Dinitrobenzoate: Synthesis, Characterization and Biological Activity. Int. J. Mol. Sci. 2019, 20, 3237. https://doi.org/10.3390/ijms20133237ScopusInternational Journal of Molecular Sciencesinfo:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.mdpi.com/1422-0067/20/13/3237Pyrazole and dinitrobenzoate ligandsCobalt(II) complexesCrystal structureTrypanosoma cruziAntifungal activityCytotoxicityDimorphic switchInhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activityArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/11190f22-82d6-4aa6-b832-78985db40d6a/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALInhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate.pdfInhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate.pdfapplication/pdf247328https://repositorio.udes.edu.co/bitstreams/9c12a9de-b853-41a3-933d-c4fb7fb5804a/downloadf8a2fcb322f5c0ce871f3c1d297314a8MD51TEXTInhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate.pdf.txtInhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/c986e2a0-5d51-4d29-b3aa-252396d3bb2a/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILInhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate.pdf.jpgInhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate.pdf.jpgGenerated Thumbnailimage/jpeg12789https://repositorio.udes.edu.co/bitstreams/813d9f62-964e-4479-8579-f344994df88b/download228f0d0c3bea1ce57e11592e652858d1MD54001/6728oai:repositorio.udes.edu.co:001/67282023-10-11 10:53:38.731https://creativecommons.org/licenses/by-nc/4.0/https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |