Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies
12 p.
- Autores:
-
Mente, Andrew
O’Donnell, Martin J.
Rangarajan, Sumathy
Dagenais, Gilles
Lear, Scott A.
McQueen, Matthew J.
Diaz, Rafael
Avezum, Alvaro
Lopez-Jaramillo, Patricio
Lanas, Fernando
Li, Wei
Lu, Yin
Yi, Sun
Rensheng, Lei
Iqbal, Romaina
Mony, Prem
Yusuf, Rita
Yusoff, Khalid
Szuba, Andrzej
Oguz, Aytekin
Rosengren, Annika
Bahonar, Ahmad
Yusufali, Afzalhussein
Schutte, Aletta Elisabeth
Chifamba, Jephat
Mann, Johannes F. E.
Anand, Sonia S.
Teo, Koon
Yusuf, Salim
The PURE, EPIDREAM, and ONTARGET/TRANSCEND Investigators
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3453
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3453
- Palabra clave:
- Urinary sodium excretion
Cardiovascular events
Hypertension
- Rights
- openAccess
- License
- Derechos Reservados - The Lancet, 2016
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| dc.title.eng.fl_str_mv |
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies |
| title |
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies |
| spellingShingle |
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies Urinary sodium excretion Cardiovascular events Hypertension |
| title_short |
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies |
| title_full |
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies |
| title_fullStr |
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies |
| title_full_unstemmed |
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies |
| title_sort |
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studies |
| dc.creator.fl_str_mv |
Mente, Andrew O’Donnell, Martin J. Rangarajan, Sumathy Dagenais, Gilles Lear, Scott A. McQueen, Matthew J. Diaz, Rafael Avezum, Alvaro Lopez-Jaramillo, Patricio Lanas, Fernando Li, Wei Lu, Yin Yi, Sun Rensheng, Lei Iqbal, Romaina Mony, Prem Yusuf, Rita Yusoff, Khalid Szuba, Andrzej Oguz, Aytekin Rosengren, Annika Bahonar, Ahmad Yusufali, Afzalhussein Schutte, Aletta Elisabeth Chifamba, Jephat Mann, Johannes F. E. Anand, Sonia S. Teo, Koon Yusuf, Salim The PURE, EPIDREAM, and ONTARGET/TRANSCEND Investigators |
| dc.contributor.author.spa.fl_str_mv |
Mente, Andrew O’Donnell, Martin J. Rangarajan, Sumathy Dagenais, Gilles Lear, Scott A. McQueen, Matthew J. Diaz, Rafael Avezum, Alvaro Lopez-Jaramillo, Patricio Lanas, Fernando Li, Wei Lu, Yin Yi, Sun Rensheng, Lei Iqbal, Romaina Mony, Prem Yusuf, Rita Yusoff, Khalid Szuba, Andrzej Oguz, Aytekin Rosengren, Annika Bahonar, Ahmad Yusufali, Afzalhussein Schutte, Aletta Elisabeth Chifamba, Jephat Mann, Johannes F. E. Anand, Sonia S. Teo, Koon Yusuf, Salim The PURE, EPIDREAM, and ONTARGET/TRANSCEND Investigators |
| dc.subject.proposal.eng.fl_str_mv |
Urinary sodium excretion Cardiovascular events Hypertension |
| topic |
Urinary sodium excretion Cardiovascular events Hypertension |
| description |
12 p. |
| publishDate |
2016 |
| dc.date.issued.spa.fl_str_mv |
2016-07-30 |
| dc.date.accessioned.spa.fl_str_mv |
2019-07-24T13:00:40Z |
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2019-07-24T13:00:40Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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10.1016/S0140-6736(16)30467-6 |
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0140-6736 |
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eng |
| language |
eng |
| dc.relation.ispartof.eng.fl_str_mv |
The Lancet |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - The Lancet, 2016 |
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http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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application/pdf |
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https://www.researchgate.net/publication/303462194_Associations_of_urinary_sodium_excretion_with_cardiovascular_events_in_individuals_with_and_without_hypertension_A_pooled_analysis_of_data_from_four_studies/link/575e7dac08ae414b8e53a7f7/download |
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Mente, Andrew9a80b664-b49e-4fce-961e-b7dd6e07a3ab-1O’Donnell, Martin J.6fe522ea-5a33-4480-8561-96b0975c3172-1Rangarajan, Sumathy5466c363-e515-4bd2-8537-eb839320f385-1Dagenais, Gillesc865f015-4dc7-483d-9dae-132288d901f8-1Lear, Scott A.dc924e5a-246b-40a8-b08f-59610fa89be1-1McQueen, Matthew J.be481328-a518-4786-a3d6-1e8bb68f1f3c-1Diaz, Rafaelf2be4a74-501a-4e63-8bbd-965cbcf8c57b-1Avezum, Alvaro8b920360-abb2-4ec8-b5ee-4e3f4e0b11eb-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Lanas, Fernandod22b7fe4-9f1f-4028-a22b-be782ef03d3c-1Li, Wei16f14ef2-1a33-4354-93fe-e8d6d1ae09b7-1Lu, Yin2c39c0eb-b0c4-41d3-b577-2f35813edc0f-1Yi, Sunc485f141-971c-4fc0-8ce0-d673b0ea7f64-1Rensheng, Lei29380d02-4abd-4708-9e03-543642d0756d-1Iqbal, Romaina015cbc16-dd01-4e26-adff-257bb8827f50-1Mony, Premab6dbf82-20a0-4744-abfd-8a723db46c4d-1Yusuf, Rita73629390-dae0-4d21-aca0-90da88bd2808-1Yusoff, Khalid933db13d-f5bb-4ea6-91a5-68eea1ca9ffc-1Szuba, Andrzej66d9d177-80f1-4191-9e5f-ef493dc7c253-1Oguz, Aytekince3e3101-01ec-4709-ad5f-2ba54357481e-1Rosengren, Annika923779f9-3a92-4086-b3d9-9d78974926d9-1Bahonar, Ahmad0f7df84f-12df-494e-9416-c33d4b5fedbe-1Yusufali, Afzalhussein2c177fd9-b761-4f07-b754-1e05fe659a48-1Schutte, Aletta Elisabeth8f34eb49-659f-4e91-9eba-4afaf95b71dc-1Chifamba, Jephatf2496279-e934-40b8-8f61-0039a09f03f8-1Mann, Johannes F. E.41917d82-2b58-48d8-85cf-ecf56ed98df8-1Anand, Sonia S.76cdf575-775c-4053-960b-9820a2f9db2d-1Teo, Koon60475883-56ab-4acc-833d-b027ad828534-1Yusuf, Salim06a836b5-f5e3-41d9-a516-9cc46e5d7948-1The PURE, EPIDREAM, and ONTARGET/TRANSCEND Investigators1fa4d839-cfd2-4523-8325-fd4db49384bd-12019-07-24T13:00:40Z2019-07-24T13:00:40Z2016-07-3012 p.Background: Several studies reported a U-shaped association between urinary sodium excretion and cardiovascular disease events and mortality. Whether these associations vary between those individuals with and without hypertension is uncertain. We aimed to explore whether the association between sodium intake and cardiovascular disease events and all-cause mortality is modified by hypertension status. Methods: In this pooled analysis, we studied 133118 individuals (63559 with hypertension and 69559 without hypertension), median age of 55 years (IQR 45–63), from 49 countries in four large prospective studies and estimated 24-h urinary sodium excretion (as group-level measure of intake). We related this to the composite outcome of death and major cardiovascular disease events over a median of 4·2 years (IQR 3·0–5·0) and blood pressure. Findings: Increased sodium intake was associated with greater increases in systolic blood pressure in individuals with hypertension (2·08 mm Hg change per g sodium increase) compared with individuals without hypertension (1·22 mm Hg change per g; pinteraction<0·0001). In those individuals with hypertension (6835 events), sodium excretion of 7 g/day or more (7060 [11%] of population with hypertension: hazard ratio [HR] 1·23 [95% CI 1·11–1·37]; p<0·0001) and less than 3 g/day (7006 [11%] of population with hypertension: 1·34 [1·23–1·47]; p<0·0001) were both associated with increased risk compared with sodium excretion of 4–5 g/day (reference 25% of the population with hypertension). In those individuals without hypertension (3021 events), compared with 4–5 g/day (18508 [27%] of the population without hypertension), higher sodium excretion was not associated with risk of the primary composite outcome (≥7 g/day in 6271 [9%] of the population without hypertension; HR 0·90 [95% CI 0·76–1·08]; p=0·2547), whereas an excretion of less than 3 g/day was associated with a significantly increased risk (7547 [11%] of the population without hypertension; HR 1·26 [95% CI 1·10–1·45]; p=0·0009). Interpretation: Compared with moderate sodium intake, high sodium intake is associated with an increased risk of cardiovascular events and death in hypertensive populations (no association in normotensive population), while the association of low sodium intake with increased risk of cardiovascular events and death is observed in those with or without hypertension. These data suggest that lowering sodium intake is best targeted at populations with hypertension who consume high sodium diets. Funding: Full funding sources listed at end of paper (see Acknowledgments).application/pdf10.1016/S0140-6736(16)30467-60140-6736https://repositorio.udes.edu.co/handle/001/3453engThe LancetDerechos Reservados - The Lancet, 2016info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.researchgate.net/publication/303462194_Associations_of_urinary_sodium_excretion_with_cardiovascular_events_in_individuals_with_and_without_hypertension_A_pooled_analysis_of_data_from_four_studies/link/575e7dac08ae414b8e53a7f7/downloadUrinary sodium excretionCardiovascular eventsHypertensionAssociations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension : A pooled analysis of data from four studiesArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILAssociations of urinary sodium excretion with cardiovascular events.pdf.jpgAssociations of urinary sodium excretion with cardiovascular events.pdf.jpgGenerated Thumbnailimage/jpeg1199https://repositorio.udes.edu.co/bitstreams/bfbdc58b-ad64-4b3c-a042-f4c62488668c/download824adab643214d845ac9a5511d3293c7MD54Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension. 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