Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance
14 p.
- Autores:
-
Bautista Amorocho, Henry
Castellanos Domínguez, Yeny Zulay
Rodríguez Villamizar, Laura Andrea
Velandia Cruz, Sindi Alejandra
Becerra Peña, Jeysson Andrey
Farfán García, Ana Elvira
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3264
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3264
- Palabra clave:
- Epidemiology
Risk Factors
Genotypes of HBV
HIV-Infected Patients
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Santander, 2014
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Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance |
| title |
Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance |
| spellingShingle |
Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance Epidemiology Risk Factors Genotypes of HBV HIV-Infected Patients |
| title_short |
Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance |
| title_full |
Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance |
| title_fullStr |
Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance |
| title_full_unstemmed |
Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance |
| title_sort |
Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance |
| dc.creator.fl_str_mv |
Bautista Amorocho, Henry Castellanos Domínguez, Yeny Zulay Rodríguez Villamizar, Laura Andrea Velandia Cruz, Sindi Alejandra Becerra Peña, Jeysson Andrey Farfán García, Ana Elvira |
| dc.contributor.author.spa.fl_str_mv |
Bautista Amorocho, Henry Castellanos Domínguez, Yeny Zulay Rodríguez Villamizar, Laura Andrea Velandia Cruz, Sindi Alejandra Becerra Peña, Jeysson Andrey Farfán García, Ana Elvira |
| dc.subject.proposal.eng.fl_str_mv |
Epidemiology Risk Factors Genotypes of HBV HIV-Infected Patients |
| topic |
Epidemiology Risk Factors Genotypes of HBV HIV-Infected Patients |
| description |
14 p. |
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2014 |
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2014-12-02 |
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2019-07-05T14:44:15Z |
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2019-07-05T14:44:15Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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10.1371/journal.pone.0114272 |
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1932-6203 |
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https://repositorio.udes.edu.co/handle/001/3264 |
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10.1371/journal.pone.0114272 1932-6203 |
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eng |
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eng |
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Plos One |
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Derechos Reservados - Universidad de Santander, 2014 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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Bautista Amorocho, Henryd9a4964c-5a30-4208-8e21-c05d2e03f8ab-1Castellanos Domínguez, Yeny Zulay168c14f9-c918-41cb-acc1-1258f1e56290-1Rodríguez Villamizar, Laura Andrea4a9d9ff5-3943-48ee-9f19-f1357abb3dc5-1Velandia Cruz, Sindi Alejandra6d16acd0-93ff-45ae-bdc0-e058d9e04cfc-1Becerra Peña, Jeysson Andrey3e9c746f-fcc4-469b-bcde-7b4bd12381e1-1Farfán García, Ana Elvira74472815-bd1a-4bf4-932b-0264dd209268-12019-07-05T14:44:15Z2019-07-05T14:44:15Z2014-12-0214 p.Abstract Introduction: Chronic hepatitis B virus (HBV) infection is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected individuals. HIV-positive patients are commonly co-infected with HBV due to shared routes of transmission. Objectives: Our aim was to determine the risk factors, prevalence, genotypes, and mutations of the Surface S gene of HBV, and occult hepatitis B infection (OBI) among patients infected with HIV in a northeastern Colombian city. Methods: A cross-sectional study was conducted with 275 HIV-positive patients attending an outpatient clinic in Bucaramanga, Colombia during 2009–2010. Blood samples were collected and screened for serological markers of HBV (anti-HBs, anti-HBc and HBsAg) through ELISA assay. Regardless of their serological profile, all samples were tested for the HBV S gene by nested-PCR and HBV genotypes were determined by phylogenetic inference. Clinical records were used to examine demographic, clinical, virological, immunological and antiretroviral therapy (ART) variables of HIV infection. Results: Participants were on average 37¡11 years old and 65.1% male. The prevalence of HIV-HBV coinfection was 12% (95%CI 8.4–16.4) of which 3.3% had active HBV infection and 8.7% OBI. The prevalence of HIV-HBV coinfection was associated with AIDS stage and ART treatment. Sequence analysis identifiedgenotype F, subgenotype F3 in 93.8% of patients and genotype A in 6.2% of patients. A C149R mutation, which may have resulted from failure in HBsAg detection, was found in one patient with OBI. Conclusions: The present study found a high prevalence of HIV-HBV coinfection with an incidence of OBI 2.6-fold higher compared to active HBV infection. These findings suggest including HBV DNA testing to detect OBI in addition to screening for HBV serological markers in HIV patients.application/pdf10.1371/journal.pone.01142721932-6203https://repositorio.udes.edu.co/handle/001/3264engPlos OneDerechos Reservados - Universidad de Santander, 2014info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114272&type=printableEpidemiologyRisk FactorsGenotypes of HBVHIV-Infected PatientsEpidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominanceArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILEpidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia. High prevalence of occult hepatitis B and F3 subgenotype dominance.pdf.jpgEpidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia. High prevalence of occult hepatitis B and F3 subgenotype dominance.pdf.jpgGenerated Thumbnailimage/jpeg1923https://repositorio.udes.edu.co/bitstreams/c39f5310-6e2a-4562-9a53-f5209d1c5570/downloaddef23b412d32c7a4ce6dfc90e6719a2bMD54Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia. High prevalence of occult hepatitis B and F3 subgenotype dominance.pdf.jpgEpidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia. 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