Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer
13 p.
- Autores:
-
Cárdenas, Denny Miley
Sánchez, Angie Carolina
Rosas, Daris Angélica
Rivero López, Esmeralda
Paparoni, Massiel Dayana
Cruz, Mildred Andreína
Suárez, Yeicy Paola
Galvis Serrano, Nestor Fabián
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3121
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3121
- Palabra clave:
- Genetic Polymorphism
Cytokines
Neoplasia
- Rights
- openAccess
- License
- Derechos Reservados - BioMed Central Ltd unless otherwise stated. Part of Springer Nature, 2018
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Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer |
| title |
Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer |
| spellingShingle |
Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer Genetic Polymorphism Cytokines Neoplasia |
| title_short |
Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer |
| title_full |
Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer |
| title_fullStr |
Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer |
| title_full_unstemmed |
Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer |
| title_sort |
Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer |
| dc.creator.fl_str_mv |
Cárdenas, Denny Miley Sánchez, Angie Carolina Rosas, Daris Angélica Rivero López, Esmeralda Paparoni, Massiel Dayana Cruz, Mildred Andreína Suárez, Yeicy Paola Galvis Serrano, Nestor Fabián |
| dc.contributor.author.spa.fl_str_mv |
Cárdenas, Denny Miley Sánchez, Angie Carolina Rosas, Daris Angélica Rivero López, Esmeralda Paparoni, Massiel Dayana Cruz, Mildred Andreína Suárez, Yeicy Paola Galvis Serrano, Nestor Fabián |
| dc.subject.proposal.eng.fl_str_mv |
Genetic Polymorphism Cytokines Neoplasia |
| topic |
Genetic Polymorphism Cytokines Neoplasia |
| description |
13 p. |
| publishDate |
2018 |
| dc.date.issued.spa.fl_str_mv |
2018-12-10 |
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2019-06-18T22:17:04Z |
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2019-06-18T22:17:04Z |
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10.1186/s12876-018-0913-9 |
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1471-230X |
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https://repositorio.udes.edu.co/handle/001/3121 |
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10.1186/s12876-018-0913-9 1471-230X |
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eng |
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eng |
| dc.relation.ispartof.eng.fl_str_mv |
BMC Gastroenterology |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - BioMed Central Ltd unless otherwise stated. Part of Springer Nature, 2018 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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Derechos Reservados - BioMed Central Ltd unless otherwise stated. Part of Springer Nature, 2018 Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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Cárdenas, Denny Mileyff4a4030-94ec-44fc-9f1e-19bf9a8d2add-1Sánchez, Angie Carolina0de08e80-412f-4440-8cc6-35aa056fec04-1Rosas, Daris Angélicad78bcd66-440c-42fb-ba26-c3fb2aab4c21-1Rivero López, Esmeralda4cf9af31-e15c-4ec1-8443-634c90759540-1Paparoni, Massiel Dayana053037a1-1941-46b7-90db-a723bebdeab3-1Cruz, Mildred Andreína39532609-d12b-420d-a924-79f1a8843aaf-1Suárez, Yeicy Paola2f24f596-9762-4a6a-bde7-080c02a58424-1Galvis Serrano, Nestor Fabián214941d4-65ed-4726-86f0-cf28ab7b7511-12019-06-18T22:17:04Z2019-06-18T22:17:04Z2018-12-1013 p.Background: Gastric Cancer is highly prevalent and deadly worldwide. In Colombia, it is the most lethal form of cancer. Some single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes have been associated with an anti-inflammatory environment and a Th2 profile in detriment of the antitumor Th1 response. This research sought to detect single-nucleotide polymorphisms in promoter sequences, like − 1082 (G/A), − 592 (C/A), and − 819 (C/T), as well as − 590 (C/T) of the IL-10 and IL-4 genes, respectively; in addition to the IL-4Rα mutation variants, Ile50Val and Q576R, together with circulating levels of IL-4, TNF-α, IL-10, and IFN-γ in patients with gastric carcinoma in Cúcuta, Colombia. Methods: In a cross-sectional study, 17 patients and 30 healthy individuals were genotyped for the six polymorphisms mentioned through PCR-RFLP of DNA obtained from peripheral blood cells and serum samples were analyzed by sandwich ELISA to quantify cytokines. Statistical difference between groups was determined along with the association between the presence of polymorphisms and the risk of gastric cancer, as well as the mortality in patients, using Mann-Whitney U test and logistic regression analysis, respectively. Results: An association between the − 1082 (G/A) and the risk of gastric cancer was found (OR = 7.58, range 0.77– 74.06, P = 0.08). Furthermore, patients had a significant increase in IL-4 serum levels (P < 0.01) compared to healthy individuals, both variables showed a higher estimated risk of mortality in patients, although without statistical association (P > 0.05). Conclusion: We infer that two possible biomarkers (one immunological and one genetic) could be considered in association with gastric cancer in our population, which should be confirmed by subsequent studies involving a greater number of individuals.application/pdf10.1186/s12876-018-0913-91471-230Xhttps://repositorio.udes.edu.co/handle/001/3121engBMC GastroenterologyDerechos Reservados - BioMed Central Ltd unless otherwise stated. Part of Springer Nature, 2018info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-018-0913-9#Bib1Genetic PolymorphismCytokinesNeoplasiaPreliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric CancerArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILPreliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.pdf.jpgPreliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.pdf.jpgGenerated Thumbnailimage/jpeg1715https://repositorio.udes.edu.co/bitstreams/d1a034ee-59cf-4150-a2f9-68ac8ebde88f/download954e99df896bbe8ebd8afc6203c064c9MD54TEXTPreliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.pdf.txtPreliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.pdf.txtExtracted texttext/plain63313https://repositorio.udes.edu.co/bitstreams/cbba6c66-83a0-4cea-b206-84adc66b7a84/download722f51f40451d374594b83452e436706MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/84624785-c452-41d7-abf0-2224256d739f/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALPreliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.pdfPreliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.pdfapplication/pdf303062https://repositorio.udes.edu.co/bitstreams/f18b4f8d-83bd-46bb-a977-c50022d373a0/download6c93333b5988d5dbf94aded70399bea9MD55001/3121oai:repositorio.udes.edu.co:001/31212023-10-09 10:28:11.022https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - BioMed Central Ltd unless otherwise stated. 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