Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris

Digital

Autores:
Dudiuk, Catiana
Berrio, Indira
Leonardelli, Florencia
Morales López, Soraya
Theill, Laura
Macedo, Daiana
Rodríguez, José-Yesid
Salcedo, Soraya
Marín, Adriana
Gamarra, Soledad
Garcia Effron, Guillermo
Tipo de recurso:
Article of journal
Fecha de publicación:
2019
Institución:
Universidad de Santander
Repositorio:
Repositorio Universidad de Santander
Idioma:
eng
OAI Identifier:
oai:repositorio.udes.edu.co:001/5647
Acceso en línea:
https://doi.org/10.1093/jac/dkz178
https://repositorio.udes.edu.co/handle/001/5647
Palabra clave:
Amphotericin B
Antifungal agents
Ear
Polyenes
Kinetics
Pathogenic
Organism
Caspofungin
Echinocandins
Anidulafungin
Killing
Malnutrition
Inflammation
Cachexia syndrome
Candida auris
Rights
closedAccess
License
The Editor(s) and the Author(s), 2019
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repository_id_str
dc.title.spa.fl_str_mv Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
title Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
spellingShingle Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
Amphotericin B
Antifungal agents
Ear
Polyenes
Kinetics
Pathogenic
Organism
Caspofungin
Echinocandins
Anidulafungin
Killing
Malnutrition
Inflammation
Cachexia syndrome
Candida auris
title_short Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
title_full Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
title_fullStr Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
title_full_unstemmed Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
title_sort Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
dc.creator.fl_str_mv Dudiuk, Catiana
Berrio, Indira
Leonardelli, Florencia
Morales López, Soraya
Theill, Laura
Macedo, Daiana
Rodríguez, José-Yesid
Salcedo, Soraya
Marín, Adriana
Gamarra, Soledad
Garcia Effron, Guillermo
dc.contributor.author.none.fl_str_mv Dudiuk, Catiana
Berrio, Indira
Leonardelli, Florencia
Morales López, Soraya
Theill, Laura
Macedo, Daiana
Rodríguez, José-Yesid
Salcedo, Soraya
Marín, Adriana
Gamarra, Soledad
Garcia Effron, Guillermo
dc.contributor.researchgroup.spa.fl_str_mv Ciencia UDES
dc.subject.proposal.eng.fl_str_mv Amphotericin B
Antifungal agents
Ear
Polyenes
Kinetics
Pathogenic
Organism
Caspofungin
Echinocandins
Anidulafungin
Killing
Malnutrition
Inflammation
Cachexia syndrome
Candida auris
topic Amphotericin B
Antifungal agents
Ear
Polyenes
Kinetics
Pathogenic
Organism
Caspofungin
Echinocandins
Anidulafungin
Killing
Malnutrition
Inflammation
Cachexia syndrome
Candida auris
description Digital
publishDate 2019
dc.date.issued.none.fl_str_mv 2019-05-12
dc.date.accessioned.none.fl_str_mv 2021-09-30T13:29:31Z
dc.date.available.none.fl_str_mv 2021-09-30T13:29:31Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.type.content.spa.fl_str_mv Text
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dc.identifier.doi.none.fl_str_mv https://doi.org/10.1093/jac/dkz178
dc.identifier.uri.none.fl_str_mv https://repositorio.udes.edu.co/handle/001/5647
url https://doi.org/10.1093/jac/dkz178
https://repositorio.udes.edu.co/handle/001/5647
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationendpage.spa.fl_str_mv 2302
dc.relation.citationissue.spa.fl_str_mv 8, August 2019
dc.relation.citationstartpage.spa.fl_str_mv 2295
dc.relation.citationvolume.spa.fl_str_mv Vol. 74
dc.relation.cites.none.fl_str_mv Dudiuk C, Berrio I, Leonardelli F, Morales-Lopez S, Theill L, Macedo D, Yesid-Rodriguez J, Salcedo S, Marin A, Gamarra S, Garcia-Effron G. Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris. J Antimicrob Chemother. 2019 Aug 1;74(8):2295-2302. doi: 10.1093/jac/dkz178. PMID: 31081031.
dc.relation.indexed.spa.fl_str_mv Journal of Antimicrobial Chemotherapy, Volume 74, Issue 8, August 2019, Pages 2295–2302, https://doi.org/10.1093/jac/dkz178
dc.rights.spa.fl_str_mv The Editor(s) and the Author(s), 2019
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_14cb
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.creativecommons.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
rights_invalid_str_mv The Editor(s) and the Author(s), 2019
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
https://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
dc.format.extent.spa.fl_str_mv 1 p.
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Journal of Antimicrobial Chemotherapy
dc.publisher.place.spa.fl_str_mv Reino Unido
dc.source.spa.fl_str_mv https://pubmed.ncbi.nlm.nih.gov/31081031/
institution Universidad de Santander
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spelling Dudiuk, Catiana1e2e3bb8-fabb-4733-984d-b902f7c60be4-1Berrio, Indirada67c8d8-2cf7-4cdc-b75b-26cd0ed84831-1Leonardelli, Florenciabdf9f3bf-3388-413d-8b60-37dc74ed7b7d-1Morales López, Sorayab353daa0-fb44-42d1-b5ce-512ab2b15552-1Theill, Laura4faf73be-308f-4f25-ae90-bf799e2ce58e-1Macedo, Daiana2117fa3c-4174-4b87-8868-cf333bac1dff-1Rodríguez, José-Yesidec62b615-5cfc-47bf-981d-1d5a53d1c998-1Salcedo, Sorayafa630cab-496c-4989-9b73-26d60e7f966e-1Marín, Adriana9e6cf4bf-ac60-4dd8-be64-6788c2c4e3bf-1Gamarra, Soledadce95367a-9268-4530-92bc-f00fa58858dc-1Garcia Effron, Guillermo80ca0d4d-fa99-4c6c-8d4c-4c9cd620509c-1Ciencia UDES2021-09-30T13:29:31Z2021-09-30T13:29:31Z2019-05-12DigitalBackground: Candida auris is an emerging MDR pathogen. It shows reduced susceptibility to azole drugs and, in some strains, high amphotericin B MICs have been described. For these reasons, echinocandins were proposed as first-line treatment for C. auris infections. However, information on how echinocandins and amphotericin B act against this species is lacking. Objectives: Our aim was to establish the killing kinetics of anidulafungin, caspofungin and amphotericin B against C. auris by time-kill methodology and to determine if these antifungals behave as fungicidal or fungistatic agents against this species. Methods: The susceptibility of 50 C. auris strains was studied. Nine strains were selected (based on echinocandin MICs) to be further studied. Minimal fungicidal concentrations, in vitro dose-response and time-kill patterns were determined. Results: Echinocandins showed lower MIC values than amphotericin B (geometric mean of 0.12 and 0.94 mg/L, respectively). Anidulafungin and caspofungin showed no fungicidal activity at any concentration (maximum log decreases in cfu/mL between 1.34 and 2.22). On the other hand, amphotericin B showed fungicidal activity, but at high concentrations (≥2.00 mg/L). In addition, the tested polyene was faster than echinocandins at killing 50% of the initial inoculum (0.92 versus >8.00 h, respectively). Conclusions: Amphotericin B was the only agent regarded as fungicidal against C. auris. Moreover, C. auris should be considered tolerant to caspofungin and anidulafungin considering that their MFC:MIC ratios were mostly ≥32 and that after 6 h of incubation the starting inoculum was not reduced in >90%.1 ed.Ciencias Médicas y de la Salud1 p.application/pdfhttps://doi.org/10.1093/jac/dkz178https://repositorio.udes.edu.co/handle/001/5647engJournal of Antimicrobial ChemotherapyReino Unido23028, August 20192295Vol. 74Dudiuk C, Berrio I, Leonardelli F, Morales-Lopez S, Theill L, Macedo D, Yesid-Rodriguez J, Salcedo S, Marin A, Gamarra S, Garcia-Effron G. Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris. J Antimicrob Chemother. 2019 Aug 1;74(8):2295-2302. doi: 10.1093/jac/dkz178. PMID: 31081031.Journal of Antimicrobial Chemotherapy, Volume 74, Issue 8, August 2019, Pages 2295–2302, https://doi.org/10.1093/jac/dkz178The Editor(s) and the Author(s), 2019info:eu-repo/semantics/closedAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_14cbhttps://pubmed.ncbi.nlm.nih.gov/31081031/Amphotericin BAntifungal agentsEarPolyenesKineticsPathogenicOrganismCaspofunginEchinocandinsAnidulafunginKillingMalnutritionInflammationCachexia syndromeCandida aurisAntifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida aurisArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALAntifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris.pdfAntifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris.pdfapplication/pdf252839https://repositorio.udes.edu.co/bitstreams/07df843e-7a64-4a4d-b93a-f87c69076088/downloadf18670bad7e1bb70e6ce8acd05ea8e58MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/9bbcdd1d-b156-4ff0-8112-216cabb97ca0/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTAntifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris.pdf.txtAntifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/67798ac0-5788-4158-9e69-1da2e18e1c2a/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILAntifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris.pdf.jpgAntifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris.pdf.jpgGenerated Thumbnailimage/jpeg6381https://repositorio.udes.edu.co/bitstreams/a96ab599-1e27-4e6c-9fda-04d25b6daea2/downloadeffa1778b6f36248721716c035b2536dMD54001/5647oai:repositorio.udes.edu.co:001/56472023-10-10 17:11:46.101https://creativecommons.org/licenses/by-nc/4.0/The Editor(s) and the Author(s), 2019https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo=

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