Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking
Digital
- Autores:
-
Flórez Castillo, Johanna-Marcela
Rondón Villarreal, Paola
Ropero Vega, José Luis
Mendoza Espinel, Stephany Y.
Moreno Amézquita, July A.
Méndez Jaimes, Karen D.
Farfán García, Ana Elvira
Gómez Rangel, Sergio-Yebrail
Gómez Duarte, Oscar Gilberto
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/5665
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/5665
- Palabra clave:
- Antimicrobial peptides
Escherichia coli
Molecular docking
- Rights
- openAccess
- License
- The Editor(s) and the Author(s), 2020
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Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking |
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Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking |
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Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking Antimicrobial peptides Escherichia coli Molecular docking |
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Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking |
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Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking |
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Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking |
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Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking |
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Ib-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular docking |
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Flórez Castillo, Johanna-Marcela Rondón Villarreal, Paola Ropero Vega, José Luis Mendoza Espinel, Stephany Y. Moreno Amézquita, July A. Méndez Jaimes, Karen D. Farfán García, Ana Elvira Gómez Rangel, Sergio-Yebrail Gómez Duarte, Oscar Gilberto |
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Flórez Castillo, Johanna-Marcela Rondón Villarreal, Paola Ropero Vega, José Luis Mendoza Espinel, Stephany Y. Moreno Amézquita, July A. Méndez Jaimes, Karen D. Farfán García, Ana Elvira Gómez Rangel, Sergio-Yebrail Gómez Duarte, Oscar Gilberto |
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CLINIUDES CIBAS |
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Antimicrobial peptides Escherichia coli Molecular docking |
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Antimicrobial peptides Escherichia coli Molecular docking |
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Digital |
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2020 |
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2020-03-12 |
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2021-10-06T15:11:38Z |
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10.3390/antibiotics9020079 |
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eng |
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2, febrero de 2020 |
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9 |
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Flórez-Castillo, J.M.; Rondón-Villareal, P.; Ropero-Vega, J.L.; Mendoza-Espinel, S.Y.; Moreno-Amézquita, J.A.; Méndez-Jaimes, K.D.; Farfán-García, A.E.; Gómez-Rangel, S.Y.; Gómez-Duarte, O.G. Ib-M6 Antimicrobial Peptide: Antibacterial Activity against Clinical Isolates of Escherichia coli and Molecular Docking. Antibiotics 2020, 9, 79. https://doi.org/10.3390/antibiotics9020079 |
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Antibiotics 2020, 9, 79; doi:10.3390/antibiotics9020079 |
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Antibiotics |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Flórez Castillo, Johanna-Marcela7205eb3a-fbf2-4482-a4b0-79151dcda061-1Rondón Villarreal, Paola8c5e399b-8f10-43d4-9834-7a43f426c16c-1Ropero Vega, José Luis59baaeed-2919-48eb-8b0e-06a9f627863d-1Mendoza Espinel, Stephany Y.21317a74-3f72-41b2-b525-10cc63c1f349-1Moreno Amézquita, July A.81b7f9bd-dac0-4470-961d-b3c09718cfad-1Méndez Jaimes, Karen D.bad229d1-a756-44ef-b303-2e3275817e90-1Farfán García, Ana Elvira74472815-bd1a-4bf4-932b-0264dd209268-1Gómez Rangel, Sergio-Yebrail0347d3d7-298c-4b8a-a82b-e34275e1ea44-1Gómez Duarte, Oscar Gilberto9db9afe6-fc68-48aa-9961-f7fdf933be56-1CLINIUDESCIBAS2021-10-06T15:11:38Z2021-10-06T15:11:38Z2020-03-12DigitalThe Ib-M6 peptide has antibacterial activity against non-pathogenic Escherichia coli K-12 strain. The first part of this study determines the antibacterial activity of Ib-M6 against fourteen pathogenic strains of E. coli O157:H7. Susceptibility assay showed that Ib-M6 had values of Minimum Inhibitory Concentration (MIC) lower than streptomycin, used as a reference antibiotic. Moreover, to predict the possible interaction between Ib-M6 and outer membrane components of E. coli, we used molecular docking simulations where FhuA protein and its complex with Lipopolysaccharide (LPS–FhuA) were used as targets of the peptide. FhuA/Ib-M6 complexes had energy values between −39.5 and −40.5 Rosetta Energy Units (REU) and only one hydrogen bond. In contrast, complexes between LPS–FhuA and Ib-M6 displayed energy values between −25.6 and −40.6 REU, and the presence of five possible hydrogen bonds. Hence, the antimicrobial activity of Ib-M6 peptide shown in the experimental assays could be caused by its interaction with the outer membrane of E. coli. View Full-TextCiencias básicas biomédicas, epidemiología, salud pública enfermedades infecciosas, enfermedades no transmisibles epidemiología, salud y desarrollo, discapacidadCiencias Básicas y Aplicadas para la Sostenibilidad1 p.application/pdf10.3390/antibiotics9020079https://repositorio.udes.edu.co/handle/001/5665engSuiza2, febrero de 20209Flórez-Castillo, J.M.; Rondón-Villareal, P.; Ropero-Vega, J.L.; Mendoza-Espinel, S.Y.; Moreno-Amézquita, J.A.; Méndez-Jaimes, K.D.; Farfán-García, A.E.; Gómez-Rangel, S.Y.; Gómez-Duarte, O.G. Ib-M6 Antimicrobial Peptide: Antibacterial Activity against Clinical Isolates of Escherichia coli and Molecular Docking. Antibiotics 2020, 9, 79. https://doi.org/10.3390/antibiotics9020079Antibiotics 2020, 9, 79; doi:10.3390/antibiotics9020079AntibioticsThe Editor(s) and the Author(s), 2020info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.mdpi.com/2079-6382/9/2/79#framed_div_cited_countAntimicrobial peptidesEscherichia coliMolecular dockingIb-M6 antimicrobial peptide: Antibacterial activity against clinical isolates of Escherichia coli and molecular dockingArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALIb-M6 antimicrobial peptide. Antibacterial activity against clinical isolates of Escherichia coli and molecular docking.pdfIb-M6 antimicrobial peptide. Antibacterial activity against clinical isolates of Escherichia coli and molecular docking.pdfapplication/pdf259717https://repositorio.udes.edu.co/bitstreams/0fdb4594-6512-43b2-9754-ad4bb0199e2c/download7fc85f03057990f3bff5a2cdf835282aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/0b63c888-ae6c-49d9-941b-acbaab5c5e6a/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTIb-M6 antimicrobial peptide. Antibacterial activity against clinical isolates of Escherichia coli and molecular docking.pdf.txtIb-M6 antimicrobial peptide. Antibacterial activity against clinical isolates of Escherichia coli and molecular docking.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/bbd26b89-16d4-4abc-ad8f-ed3b8145f17a/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILIb-M6 antimicrobial peptide. Antibacterial activity against clinical isolates of Escherichia coli and molecular docking.pdf.jpgIb-M6 antimicrobial peptide. Antibacterial activity against clinical isolates of Escherichia coli and molecular docking.pdf.jpgGenerated Thumbnailimage/jpeg11975https://repositorio.udes.edu.co/bitstreams/f7296e44-720a-443b-b505-d1a346b95f1b/downloadf5a4ee5aeb29c45039e089f1c3440c87MD54001/5665oai:repositorio.udes.edu.co:001/56652023-10-10 09:51:17.203https://creativecommons.org/licenses/by-nc/4.0/The Editor(s) and the Author(s), 2020https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |