Nanosensors in clinical development of CAR-T cell immunotherapy
Digital
- Autores:
-
Nguyen-Le, Trang Anh
Bartsch, Tabea
Wodtke, Robert
Brandt, Florian
Arndt, Claudia
Feldman, Anja
Sandoval-Bojorquez, Diana Isabel
Roig, Arnau Perez
Ibarlucea, Bergoi
Lee, Seungho
Chan-Ki, Baek
Cuniberti, Gianaurelio
Bergmann, Ralf
Puentes-Cala, Edinson
Soto, Javier Andres
Kurien, Biji T.
Bachmann, Michael
Larysa, Baraban
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/7324
- Acceso en línea:
- https://doi.org/10.1016/j.bios.2022.114124
https://repositorio.udes.edu.co/handle/001/7324
- Palabra clave:
- CAR-T cells
Immunotherapy
Silicon nanowires
Field-effect transistor
Cancer
Nanosensor
- Rights
- closedAccess
- License
- © 2022 Elsevier B.V. All rights reserved
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Nanosensors in clinical development of CAR-T cell immunotherapy |
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Nanosensors in clinical development of CAR-T cell immunotherapy |
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Nanosensors in clinical development of CAR-T cell immunotherapy CAR-T cells Immunotherapy Silicon nanowires Field-effect transistor Cancer Nanosensor |
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Nanosensors in clinical development of CAR-T cell immunotherapy |
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Nanosensors in clinical development of CAR-T cell immunotherapy |
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Nanosensors in clinical development of CAR-T cell immunotherapy |
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Nanosensors in clinical development of CAR-T cell immunotherapy |
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Nanosensors in clinical development of CAR-T cell immunotherapy |
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Nguyen-Le, Trang Anh Bartsch, Tabea Wodtke, Robert Brandt, Florian Arndt, Claudia Feldman, Anja Sandoval-Bojorquez, Diana Isabel Roig, Arnau Perez Ibarlucea, Bergoi Lee, Seungho Chan-Ki, Baek Cuniberti, Gianaurelio Bergmann, Ralf Puentes-Cala, Edinson Soto, Javier Andres Kurien, Biji T. Bachmann, Michael Larysa, Baraban |
| dc.contributor.author.none.fl_str_mv |
Nguyen-Le, Trang Anh Bartsch, Tabea Wodtke, Robert Brandt, Florian Arndt, Claudia Feldman, Anja Sandoval-Bojorquez, Diana Isabel Roig, Arnau Perez Ibarlucea, Bergoi Lee, Seungho Chan-Ki, Baek Cuniberti, Gianaurelio Bergmann, Ralf Puentes-Cala, Edinson Soto, Javier Andres Kurien, Biji T. Bachmann, Michael Larysa, Baraban |
| dc.contributor.researchgroup.spa.fl_str_mv |
BIOGEN |
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CAR-T cells Immunotherapy Silicon nanowires Field-effect transistor Cancer Nanosensor |
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CAR-T cells Immunotherapy Silicon nanowires Field-effect transistor Cancer Nanosensor |
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Digital |
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2022 |
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2022-08-01T23:44:19Z |
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2022-08-01T23:44:19Z |
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2022-06-15 |
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26 |
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Trang Anh Nguyen-Le, Tabea Bartsch, Robert Wodtke, Florian Brandt, Claudia Arndt, Anja Feldmann, Diana Isabel Sandoval Bojorquez, Arnau Perez Roig, Bergoi Ibarlucea, Seungho Lee, Chan-Ki Baek, Gianaurelio Cuniberti, Ralf Bergmann, Edinson Puentes-Cala, Javier Andrés Soto, Biji T. Kurien, Michael Bachmann, Larysa Baraban, Nanosensors in clinical development of CAR-T cell immunotherapy, Biosensors and Bioelectronics, Volume 206, 2022, 114124, ISSN 0956-5663, https://doi.org/10.1016/j.bios.2022.114124. |
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Scopus |
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Biosensors and Bioelectronics |
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© 2022 Elsevier B.V. All rights reserved |
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Nguyen-Le, Trang Anhb5baf202-699c-4bdc-b109-4069a3100f3c-1Bartsch, Tabea7fc8ddaf-3289-43dc-9785-15b1abac091d-1Wodtke, Robert796cfca2-7419-4156-bdb9-7ae1d3c96d19-1Brandt, Florian73cd2ba5-76a6-4f6f-a01b-0b8d2fc3156e-1Arndt, Claudia15aa7eca-d54a-4daa-b28c-a56412622780-1Feldman, Anja9c733861-ec20-41c5-9b02-c8950fff9300-1Sandoval-Bojorquez, Diana Isabeld74bdfd8-abf5-4eab-8bf6-00e8f085a49a-1Roig, Arnau Pereza62ce812-5e77-445d-b551-20925dc09640-1Ibarlucea, Bergoi12c673c9-738a-4b29-92c3-c3817672f889-1Lee, Seunghoc9ff3565-0a5c-424e-8415-66e9e65bb6e6-1Chan-Ki, Baekd1eb1d07-9baf-47d6-970c-1f5b5d4115be-1Cuniberti, Gianaurelioc73ab790-fb4b-4473-a9aa-2243d05cad48-1Bergmann, Ralf42ee2bae-2c97-4474-89fe-e2149df4bd4f-1Puentes-Cala, Edinson9649c845-5bef-4bab-ab46-8124f11616c0-1Soto, Javier Andres1967ffcd-13c8-4b5f-86df-70712da6fc1a-1Kurien, Biji T.e65ae9da-2a1b-4b25-bf77-33e67fb31607-1Bachmann, Michael08a94c5e-ed5b-4e74-96a8-2fcd547a5a78-1Larysa, Baraban4db7a173-aeee-477b-9271-167c318c47e5-1BIOGEN2022-08-01T23:44:19Z2022-08-01T23:44:19Z2022-06-15DigitalImmunotherapy using CAR-T cells is a new technological paradigm for cancer treatment. To avoid severe side effects and tumor escape variants observed for conventional CAR-T cells approach, adaptor CAR technologies are under development, where intermediate target modules redirect immune cells against cancer. In this work, silicon nanowire field-effect transistors are used to develop target modules for an optimized CAR-T cell operation. Focusing on a library of seven variants of E5B9 peptide that is used as CAR targeting epitope, we performed multiplexed binding tests using nanosensor chips. These peptides had been immobilized onto the sensor to compare the transistor signals upon titration with anti-La 5B9 antibodies. The correlation of binding affinities and sensor sensitivities enabled a selection of candidates for the interaction between CAR and target modules. An extremely low detection limit was observed for the sensor, down to femtomolar concentration, outperforming the current assay of the same purpose. Finally, the CAR T-cells redirection capability of selected peptides in target modules was proven successful in an in-vitro cytotoxicity assay. Our results open the perspective for the nanosensors to go beyond the early diagnostics in clinical cancer research towards developing and monitoring immunotherapeutic treatment, where the quantitative analysis with the standard techniques is limited.Ciencias Médicas y de la Saludapplication/pdfhttps://doi.org/10.1016/j.bios.2022.1141241873423509565663https://repositorio.udes.edu.co/handle/001/7324engReino Unido26Trang Anh Nguyen-Le, Tabea Bartsch, Robert Wodtke, Florian Brandt, Claudia Arndt, Anja Feldmann, Diana Isabel Sandoval Bojorquez, Arnau Perez Roig, Bergoi Ibarlucea, Seungho Lee, Chan-Ki Baek, Gianaurelio Cuniberti, Ralf Bergmann, Edinson Puentes-Cala, Javier Andrés Soto, Biji T. Kurien, Michael Bachmann, Larysa Baraban, Nanosensors in clinical development of CAR-T cell immunotherapy, Biosensors and Bioelectronics, Volume 206, 2022, 114124, ISSN 0956-5663, https://doi.org/10.1016/j.bios.2022.114124.ScopusBiosensors and Bioelectronics© 2022 Elsevier B.V. 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