The effect of dulaglutide on stroke
Digital
- Autores:
-
Gerstein, Hertzel C.
Hart, Robert
Colhoun, Helen M.
Diaz, Rafael
Lakshmanan, Mark
Botros, Fady T.
Probstfield, Jeffrey
Riddle, Matthew C.
Rydén, Lars
Messan Atisso, Charles
Dyal, Leanne
Hall, Stephanie
Avezum, Alvaro
Basile, Jan
Conget, Ignacio
Cushman, William C.
Hancu, Nicolae
Hanefeld, Markolf
Jansky, Petr
Keltai, Matyas
Lanas, Fernando
Leiter, Lawrence A.
Lopez-Jaramillo, Patricio
Cardona Muñoz, Ernesto Germán
Pogosova, Nana
Raubenheimer, Peter J.
Shaw, Jonathan E.
Sheu, Wayne H-H.
Temelkova-Kurktschiev, Theodora
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/5715
- Acceso en línea:
- https://doi.org/10.1016/S2213-8587(19)30423-1
https://repositorio.udes.edu.co/handle/001/5715
- Palabra clave:
- Rights
- closedAccess
- License
- © 2020 Elsevier Ltd. All rights reserved.
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Gerstein, Hertzel C. Hart, Robert Colhoun, Helen M. Diaz, Rafael Lakshmanan, Mark Botros, Fady T. Probstfield, Jeffrey Riddle, Matthew C. Rydén, Lars Messan Atisso, Charles Dyal, Leanne Hall, Stephanie Avezum, Alvaro Basile, Jan Conget, Ignacio Cushman, William C. Hancu, Nicolae Hanefeld, Markolf Jansky, Petr Keltai, Matyas Lanas, Fernando Leiter, Lawrence A. Lopez-Jaramillo, Patricio Cardona Muñoz, Ernesto Germán Pogosova, Nana Raubenheimer, Peter J. Shaw, Jonathan E. Sheu, Wayne H-H. Temelkova-Kurktschiev, Theodora |
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Hertzel C Gerstein, Robert Hart, Helen M Colhoun, Rafael Diaz, Mark Lakshmanan, Fady T Botros, Jeffrey Probstfield, Matthew C Riddle, Lars Rydén, Charles Messan Atisso, Leanne Dyal, Stephanie Hall, Alvaro Avezum, Jan Basile, Ignacio Conget, William C Cushman, Nicolae Hancu, Markolf Hanefeld, Petr Jansky, Matyas Keltai, Fernando Lanas, Lawrence A Leiter, Patricio Lopez-Jaramillo, Ernesto Germán Cardona Muñoz, Nana Pogosova, Peter J Raubenheimer, Jonathan E Shaw, Wayne H-H Sheu, Theodora Temelkova-Kurktschiev, The effect of dulaglutide on stroke: an exploratory analysis of the REWIND trial, The Lancet Diabetes & Endocrinology, Volume 8, Issue 2, 2020, Pages 106-114, ISSN 2213-8587, https://doi.org/10.1016/S2213-8587(19)30423-1. (https://www.sciencedirect.com/science/article/pii/S2213858719304231) |
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Scopus |
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The Lancet Diabetes and Endocrinology |
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Gerstein, Hertzel C.8dbb4c88-f0dd-45f2-8bc4-590f0a1e3c3c-1Hart, Robert1d24a62f-5d51-4282-b2e7-dcd184a24eeb-1Colhoun, Helen M.41617f18-e528-4e15-819a-0a30d7feb185-1Diaz, Rafaelf2be4a74-501a-4e63-8bbd-965cbcf8c57b-1Lakshmanan, Marke4d26b36-1c41-49d9-9c19-d57fb2109f53-1Botros, Fady T.a89c0a33-d2f3-4592-aca9-5201f7d73c72-1Probstfield, Jeffreycce7af47-ba6b-4280-bbb5-4c0a46da5d7d-1Riddle, Matthew C.d5c956b6-8f40-43ca-83bc-4b130c672a99-1Rydén, Larsfbe7a352-5488-4e8a-866d-b966ed6789b4-1Messan Atisso, Charles42893105-5995-4c81-b612-a885c11a8170-1Dyal, Leanne2c1519ed-7131-4c64-ae64-60293a636b7c-1Hall, Stephanie76425501-41fc-4b68-bd22-1a38e1e3d160-1Avezum, Alvaro8b920360-abb2-4ec8-b5ee-4e3f4e0b11eb-1Basile, Jan31df2eea-b661-4757-98a0-111336270810-1Conget, Ignacioc0327a53-3097-438b-9a40-d441f3c20758-1Cushman, William C.6e873915-69b2-4696-afa0-6d21bbeb3531-1Hancu, Nicolae65f98f93-ff67-40b8-bfc7-c1fed7923dd1-1Hanefeld, Markolf411c9d9d-d3a2-4a87-b8e7-dbd8bc7c968e-1Jansky, Petrbf8ec62a-6edc-439c-a698-2e4fa4172f04-1Keltai, Matyas65c5da4f-dca6-4e4f-aa9e-6c2ff81f2df9-1Lanas, Fernandod22b7fe4-9f1f-4028-a22b-be782ef03d3c-1Leiter, Lawrence A.bcdd3211-40b7-474d-9f6c-8a1051ceb9bf-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Cardona Muñoz, Ernesto Germán77f8be1b-1039-4eea-aa10-f5919f48fdf2-1Pogosova, Nana0f2fb5e5-6659-4562-96e6-74c03e0c46bf-1Raubenheimer, Peter J.260f749c-e594-4273-a34d-e926010f883c-1Shaw, Jonathan E.bee14056-7326-4051-b756-4d809e9c79f8-1Sheu, Wayne H-H.d377b549-9728-486e-820f-f5e9d3ba834b-1Temelkova-Kurktschiev, Theodoraa08e998d-95f2-4139-ae16-bd8009965b60-1Everest2021-11-18T15:28:14Z2021-11-18T15:28:14Z2020-02-02DigitalBackground Cardiovascular outcome trials have suggested that glucagon-like peptide 1 (GLP-1) receptor agonists might reduce strokes. We analysed the effect of dulaglutide on stroke within the researching cardiovascular events with a weekly incretin in diabetes (REWIND) trial. Methods REWIND was a multicentre, randomised, double-blind, placebo-controlled trial done at 371 sites in 24 countries. Men and women (aged ≥50 years) with established or newly detected type 2 diabetes whose HbA1c was 9·5% or less (with no lower limit) on stable doses of up to two oral glucose-lowering drugs with or without basal insulin therapy were eligible if their body-mass index was at least 23 kg/m2. Participants were randomly assigned (1:1) to weekly subcutaneous injections of either masked dulaglutide 1·5 mg or the same volume of masked placebo (containing the same excipients but without dulaglutide). Randomisation was done by a computer-generated random code with an interactive web response system with stratification by site. Participants, investigators, the trial leadership, and all other personnel were masked to treatment allocation until the trial was completed and the database was locked. During the treatment period, participants in both groups were instructed to inject study drug on the same day at around the same time, each week. Strokes were categorised as fatal or non-fatal, and as either ischaemic, haemorrhagic, or undetermined. Stroke severity was assessed using the modified Rankin scale. Participants were seen at 2 weeks, 3 months, 6 months, and then every 3 months for drug dispensing and every 6 months for detailed assessments, until 1200 confirmed primary outcomes accrued. The primary endpoint was the first occurrence of any component of the composite outcome, which comprised non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular or unknown causes. All analyses were done according to an intention-to-treat strategy that included all randomly assigned participants, irrespective of adherence. The trial is registered with ClinicalTrials.gov, number NCT01394952. Findings Between Aug 18, 2011, and Aug 14, 2013, we screened 12 133 patients, of whom 9901 with type 2 diabetes and additional cardiovascular risk factors were randomly assigned to either dulaglutide (n=4949) or an equal volume of placebo (n=4952). During a median follow-up of 5·4 years, cerebrovascular and other cardiovascular outcomes were ascertained and adjudicated. 158 (3·2%) of 4949 participants assigned to dulaglutide and 205 (4·1%) of 4952 participants assigned to placebo had a stroke during follow-up (hazard ratio [HR] 0·76, 95% CI 0·62–0·94; p=0·010). Dulaglutide reduced ischaemic stroke (0·75, 0·59–0·94, p=0·012) but had no effect on haemorrhagic stroke (1·05, 0·55–1·99; p=0·89). Dulaglutide also reduced the composite of non-fatal stroke or all-cause death (0·88, 0·79–0·98; p=0·017) and disabling stroke (0·74, 0·56–0·99; p=0·042). The degree of disability after stroke did not differ by treatment group. Interpretation Long-term dulaglutide use might reduce clinically relevant ischaemic stroke in people with type 2 diabetes but does not affect stroke severity.Ciencias Médicas y de la Salud9 papplication/pdfhttps://doi.org/10.1016/S2213-8587(19)30423-1https://repositorio.udes.edu.co/handle/001/5715engElsevierHolanda11421068Hertzel C Gerstein, Robert Hart, Helen M Colhoun, Rafael Diaz, Mark Lakshmanan, Fady T Botros, Jeffrey Probstfield, Matthew C Riddle, Lars Rydén, Charles Messan Atisso, Leanne Dyal, Stephanie Hall, Alvaro Avezum, Jan Basile, Ignacio Conget, William C Cushman, Nicolae Hancu, Markolf Hanefeld, Petr Jansky, Matyas Keltai, Fernando Lanas, Lawrence A Leiter, Patricio Lopez-Jaramillo, Ernesto Germán Cardona Muñoz, Nana Pogosova, Peter J Raubenheimer, Jonathan E Shaw, Wayne H-H Sheu, Theodora Temelkova-Kurktschiev, The effect of dulaglutide on stroke: an exploratory analysis of the REWIND trial, The Lancet Diabetes & Endocrinology, Volume 8, Issue 2, 2020, Pages 106-114, ISSN 2213-8587, https://doi.org/10.1016/S2213-8587(19)30423-1. (https://www.sciencedirect.com/science/article/pii/S2213858719304231)ScopusThe Lancet Diabetes and Endocrinology© 2020 Elsevier Ltd. All rights reserved.info:eu-repo/semantics/closedAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_14cbhttps://www.sciencedirect.com/science/article/abs/pii/S2213858719304231?via%3DihubThe effect of dulaglutide on strokeAn exploratory analysis of the REWIND trialArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALThe effect of dulaglutide on stroke. An exploratory analysis of the REWIND trial.pdfThe effect of dulaglutide on stroke. 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