Histopathological and immunohistochemical profile in anaplastic gangliogliomas
7 p.
- Autores:
-
Romero Rojas, Alfredo E.
Diaz Perez, Julio A.
Chinchilla Olaya, Sandra I.
Amaro, Deirdre E.
Lozano Castillo, Alfonso
Restrepo Escobar, Ligia I.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2013
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3609
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3609
- Palabra clave:
- Ganglioglioma
Anaplastic ganglioglioma
Histopathology
Immunohistochemistry
Neuroradiology
Neurosurgery
Observational study
Ganglioglioma anaplásico
Histopatología
Inmunohistoquímica
Neurorradiología
Neurocirugía
Estudio observacional
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Santander, 2013
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| dc.title.eng.fl_str_mv |
Histopathological and immunohistochemical profile in anaplastic gangliogliomas |
| title |
Histopathological and immunohistochemical profile in anaplastic gangliogliomas |
| spellingShingle |
Histopathological and immunohistochemical profile in anaplastic gangliogliomas Ganglioglioma Anaplastic ganglioglioma Histopathology Immunohistochemistry Neuroradiology Neurosurgery Observational study Ganglioglioma anaplásico Histopatología Inmunohistoquímica Neurorradiología Neurocirugía Estudio observacional |
| title_short |
Histopathological and immunohistochemical profile in anaplastic gangliogliomas |
| title_full |
Histopathological and immunohistochemical profile in anaplastic gangliogliomas |
| title_fullStr |
Histopathological and immunohistochemical profile in anaplastic gangliogliomas |
| title_full_unstemmed |
Histopathological and immunohistochemical profile in anaplastic gangliogliomas |
| title_sort |
Histopathological and immunohistochemical profile in anaplastic gangliogliomas |
| dc.creator.fl_str_mv |
Romero Rojas, Alfredo E. Diaz Perez, Julio A. Chinchilla Olaya, Sandra I. Amaro, Deirdre E. Lozano Castillo, Alfonso Restrepo Escobar, Ligia I. |
| dc.contributor.author.spa.fl_str_mv |
Romero Rojas, Alfredo E. Diaz Perez, Julio A. Chinchilla Olaya, Sandra I. Amaro, Deirdre E. Lozano Castillo, Alfonso Restrepo Escobar, Ligia I. |
| dc.subject.proposal.eng.fl_str_mv |
Ganglioglioma Anaplastic ganglioglioma Histopathology Immunohistochemistry Neuroradiology Neurosurgery Observational study |
| topic |
Ganglioglioma Anaplastic ganglioglioma Histopathology Immunohistochemistry Neuroradiology Neurosurgery Observational study Ganglioglioma anaplásico Histopatología Inmunohistoquímica Neurorradiología Neurocirugía Estudio observacional |
| dc.subject.proposal.spa.fl_str_mv |
Ganglioglioma anaplásico Histopatología Inmunohistoquímica Neurorradiología Neurocirugía Estudio observacional |
| description |
7 p. |
| publishDate |
2013 |
| dc.date.issued.spa.fl_str_mv |
2013-11 |
| dc.date.accessioned.spa.fl_str_mv |
2019-08-21T17:33:14Z |
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2019-08-21T17:33:14Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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10.1016/j.neucir.2013.07.001 |
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1130-1473 |
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https://repositorio.udes.edu.co/handle/001/3609 |
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10.1016/j.neucir.2013.07.001 1130-1473 |
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https://repositorio.udes.edu.co/handle/001/3609 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.spa.fl_str_mv |
Neurocirugía |
| dc.relation.ispartofseries.spa.fl_str_mv |
Neurocirugía;Vol. 24 (6), pp. 237-243. 2013 |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - Universidad de Santander, 2013 |
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http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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Derechos Reservados - Universidad de Santander, 2013 Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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https://www.sciencedirect.com/science/article/pii/S1130147313001085?via%3Dihub |
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Romero Rojas, Alfredo E.3e465c15-1707-4dfe-ae44-dc7225c73f4e-1Diaz Perez, Julio A.c3667314-adc6-4295-bb6b-f33572645af0-1Chinchilla Olaya, Sandra I.9f39315b-4a80-473e-8a33-6cb8efdd76dd-1Amaro, Deirdre E.071480f0-ed97-43c7-ad11-2ad9e42eb1e6-1Lozano Castillo, Alfonso4a1c9a4a-9717-40df-9848-18c3b5e8574e-1Restrepo Escobar, Ligia I.78520162-bbf3-46f7-8084-2510ec577fb5-12019-08-21T17:33:14Z2019-08-21T17:33:14Z2013-117 p.The anaplastic ganglioglioma (AG) is the high-grade counterpart of ganglioglioma, a rare mixed tumor composed of neuronal/ganglion and glial cells. Materials and methods We describe the histopathology and immunohistochemistry in 7 cases of AG and correlate them with the clinical and radiological features. Results Our AG patients correspond to 2.5% of the central nervous system tumor patients evaluated in our institution. The mean age at presentation was 25.7 years, with a male predominance. The most common clinical presentation was generalized tonic–clonic seizures (3/7 cases), in correlation with frequent cortical/subcortical location (6/7 cases). Histopathologically, all our cases showed high-grade features in glial (glial fibrillary acid protein-positive) and neuron-ganglion cells (synaptophysin, PGP-9.5, neurofilament, NSE and CD56-positive), as well as moderate cellularity, frequent mitotic figures and a Ki-67 labeling index >5%. All our patients had poor survival. Conclusion We found that a typical histopathological and immunohistochemical profile is constant and can be useful in early diagnosis of these aggressive neoplasms.Antecedentes El ganglioglioma anaplásico (GA) es la contraparte de alto grado del ganglioglioma, un raro tumor compuesto por una mezcla de células neuronales/ganglionares y gliales. Materiales y métodos Se describe la histopatología y la inmunohistoquímica en 7 casos de GA. Resultados Los casos de GA correspondieron al 2,5% de los tumores del SNC evaluados en nuestra institución. La edad media de presentación fue 25,7 años, con predominio del género masculino. La presentación más frecuente fue como convulsiones generalizadas tónico-clónicas (3/7 casos), en correlación con una frecuente localización cortical/subcortical (6/7 casos). Histopatológicamente todos los casos mostraron características de alto grado en las células gliales (GFAP positivas) y ganglio/neuronales (sinaptofisina, PG-9.5, neurofilamentos, NSE y CD56-positivo), además de celularidad moderada, figuras mitóticas frecuentes y Ki-67 > 5%. Todos los pacientes mostraron baja supervivencia. Conclusión Se describe el perfil histopatológico e inmunohistoquímico en GA, el cual es constante y posee utilidad para el diagnóstico precoz de estos tumoresapplication/pdf10.1016/j.neucir.2013.07.0011130-1473https://repositorio.udes.edu.co/handle/001/3609engNeurocirugíaNeurocirugía;Vol. 24 (6), pp. 237-243. 2013Derechos Reservados - Universidad de Santander, 2013info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.sciencedirect.com/science/article/pii/S1130147313001085?via%3DihubGangliogliomaAnaplastic gangliogliomaHistopathologyImmunohistochemistryNeuroradiologyNeurosurgeryObservational studyGanglioglioma anaplásicoHistopatologíaInmunohistoquímicaNeurorradiologíaNeurocirugíaEstudio observacionalHistopathological and immunohistochemical profile in anaplastic gangliogliomasArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILHistopathological and immunohistochemical profile in anaplastic gangliogliomas.PNG.jpgHistopathological and immunohistochemical profile in anaplastic gangliogliomas.PNG.jpgGenerated Thumbnailimage/jpeg1733https://repositorio.udes.edu.co/bitstreams/7689eea4-cd28-4f4a-aa71-ebd2eefc49d2/download1a3d06ac1ba74be67c75733930ec879dMD53Histopathological and immunohistochemical profile in anaplastic gangliogliomas.pdf.jpgHistopathological and immunohistochemical profile in anaplastic gangliogliomas.pdf.jpgGenerated Thumbnailimage/jpeg6872https://repositorio.udes.edu.co/bitstreams/6d41c7eb-2b94-4d98-aa7b-f90b1b9eadc6/download31ea297c0ac3c4ef77d00a396bd9003aMD56ORIGINALHistopathological and immunohistochemical profile in anaplastic gangliogliomas.pdfHistopathological and immunohistochemical profile in anaplastic gangliogliomas.pdfapplication/pdf227780https://repositorio.udes.edu.co/bitstreams/bac932d5-303b-47e7-9955-459cdcfbad78/download441f4f54a67d6a5dae1f79a21f63d06dMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/e2362c00-28a4-45c0-9046-ac74af034e0f/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTHistopathological and immunohistochemical profile in anaplastic gangliogliomas.pdf.txtHistopathological and immunohistochemical profile in anaplastic gangliogliomas.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/40fb4e53-d547-447a-958a-43273b5b12bc/download5dbe86c1111d64f45ba435df98fdc825MD55001/3609oai:repositorio.udes.edu.co:001/36092023-10-10 13:11:30.331https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Santander, 2013https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |