Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea

13 p.

Autores:: García, Ronald G.
Kim, Jieun
Sheehan, James D.
Beissner, Florian
Bianchi, Anna M.
Cerutti, Sergio
Kuo, Braden
Barbieri, Riccardo
Napadow, Vitaly
Sclocco, Roberta

Tipo de recurso:: Article of journal

Fecha de publicación:: 2016

Institución:: Universidad de Santander

Repositorio:: Repositorio Universidad de Santander

Idioma:: eng

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dc.title.eng.fl_str_mv	Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
title	Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
spellingShingle	Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea Brain–gut interactions Motion sickness Neuroimaging Parasympathetic Sympathetic
title_short	Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
title_full	Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
title_fullStr	Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
title_full_unstemmed	Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
title_sort	Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
dc.creator.fl_str_mv	García, Ronald G. Kim, Jieun Sheehan, James D. Beissner, Florian Bianchi, Anna M. Cerutti, Sergio Kuo, Braden Barbieri, Riccardo Napadow, Vitaly Sclocco, Roberta
dc.contributor.author.spa.fl_str_mv	García, Ronald G. Kim, Jieun Sheehan, James D. Beissner, Florian Bianchi, Anna M. Cerutti, Sergio Kuo, Braden Barbieri, Riccardo Napadow, Vitaly Sclocco, Roberta
dc.subject.proposal.eng.fl_str_mv	Brain–gut interactions Motion sickness Neuroimaging Parasympathetic Sympathetic
topic	Brain–gut interactions Motion sickness Neuroimaging Parasympathetic Sympathetic
description	13 p.
publishDate	2016
dc.date.issued.spa.fl_str_mv	2016-02
dc.date.accessioned.spa.fl_str_mv	2019-07-02T13:08:39Z
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dc.relation.ispartof.eng.fl_str_mv	Cerebral Cortex
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spelling	García, Ronald G.41c4b822-ac96-4ffc-ac48-9d3227b75257-1Kim, Jieun50116560-db3f-4ad0-9f98-e80b6e3116e9-1Sheehan, James D.9bf878b1-f437-4ea0-9874-96e47f8ffb85-1Beissner, Floriane2897172-ba53-40cb-8ed4-19f70db97762-1Bianchi, Anna M.7a04c0da-18e8-4a65-8a56-8f7d3b762f02-1Cerutti, Sergio8de653fe-779f-4f81-94e4-8d5eabdb6428-1Kuo, Braden9338e467-9679-45fc-823b-4c054264d191-1Barbieri, Riccardo55ed48ad-21cc-4907-831a-b87ac479a69c-1Napadow, Vitalye2796f75-2336-48e3-94e5-3cab2fe51420-1Sclocco, Robertafe9d7fb4-a15a-4c07-8822-e36b0a28d4fc-12019-07-02T13:08:39Z2019-07-02T13:08:39Z2016-0213 p.While autonomic outflow is an important co-factor of nausea physiology, central control of this outflow is poorly understood. We evaluated sympathetic (skin conductance level) and cardiovagal (high-frequency heart rate variability) modulation, collected synchronously with functional MRI (fMRI) data during nauseogenic visual stimulation aimed to induce vection in susceptible individuals. Autonomic data guided analysis of neuroimaging data, using a stimulus-based (analysis windows set by visual stimulation protocol) and percept-based (windows set by subjects’ ratings) approach. Increased sympathetic and decreased parasympathetic modulation was associated with robust and anti-correlated brain activity in response to nausea. Specifically, greater autonomic response was associated with reduced fMRI signal in brain regions such as the insula, suggesting an inhibitory relationship with premotor brainstem nuclei. Interestingly, some sympathetic/parasympathetic specificity was noted. Activity in default mode network and visual motion areas was anti-correlated with parasympathetic outflow at peak nausea. In contrast, lateral prefrontal cortical activity was anticorrelated with sympathetic outflow during recovery, soon after cessation of nauseogenic stimulation. These results suggest divergent central autonomic control for sympathetic and parasympathetic response to nausea. Autonomic outflow and the central autonomic network underlying ANS response to nausea may be an important determinant of overall nausea intensity and, ultimately, a potential therapeutic target.application/pdf10.1093/cercor/bhu1721460-21991047-3211https://repositorio.udes.edu.co/handle/001/3241engCerebral CortexDerechos Reservados - Universidad de Santander, 2016info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://watermark.silverchair.com/bhu172.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAkEwggI9BgkqhkiG9w0BBwagggIuMIICKgIBADCCAiMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMy-2qEYYrFUUV3eATAgEQgIIB9In72CfRT54L5wtynd9F_Mm06XrM4lOgIqeuSUuPL10CbjZ9QSQ_T5s76ZhVL6mu6e_33jAgyc9XE7vGBLCjT0ikeDklrP6RLdLkoSbV0jftJFC7ZVak9f_iksNZ-rCBBfXsRLWKIxchSHkO-b-w23Wy1yuL1w21rr-kfNxfG_JIxYWmcDM9Jt9lccJ_VGJbkpSlwrOszCegQBvGLMT29TQ3Xep8ynijxd2Rmgjn8EcbFdY9b6wx-KTi6o5RaAim8JDzVe1Ox2ccq3O8x1ETcM12Wfnv3xlxQa5LbjZD1OVC-ZwHUwiBaB-6Rtk6KPEmitcFmtkGwJ8SLZzjw4TFCFC073RJsd2utozvZiR4j52ZC34gQHymg4VjDWos_I7CbLosJjpXtHVId6E6bhUrWz9x7xhBhvpns02zdNlunQlJ2F4K37Rm0K2gzMsvkwDkgzGcgt1ndHo2cvKnMVqEcRE7WUHelG_6Kqr-J0vJFOJv5erXza_W7o_6IqD1pE-sjYJ6yDMF5U2SaJkRq_dpuEpCTw5pKV7YLeXRStDyfn7gUcvf9q-5xeuOu8B4pkXrHeMLrT0xDpe_jI47OhMnm8nLeANIdQHtKF9Ki0e2-m83XdIQPKLsJ-U_sSErOggRP4fbUgYcuLylTPuuFgmxR0gEUXR-Brain–gut interactionsMotion sicknessNeuroimagingParasympatheticSympatheticBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to NauseaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdf.jpgBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdf.jpgGenerated Thumbnailimage/jpeg1939https://repositorio.udes.edu.co/bitstreams/570f3e30-a5a4-4bcf-a96c-06bb7af665f4/download0c7a2d3ff1198271a8deab67418672a2MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/c07e2387-ff04-44a4-89cc-75a26809768a/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdfBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdfapplication/pdf361534https://repositorio.udes.edu.co/bitstreams/e7b6011b-5597-47ea-ae5e-0c7094dbdc80/downloadd1c6f4f477fabf3c841557577ecd4badMD55TEXTBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdf.txtBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdf.txtExtracted texttext/plain63776https://repositorio.udes.edu.co/bitstreams/3b31fe7f-13f4-442d-960f-95fc1cc5e058/download9d0bb556549821fccca333c6f4fd7f4aMD53001/3241oai:repositorio.udes.edu.co:001/32412023-10-10 13:15:15.918https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Santander, 2016https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo=

Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea

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