Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
13 p.
- Autores:
-
García, Ronald G.
Kim, Jieun
Sheehan, James D.
Beissner, Florian
Bianchi, Anna M.
Cerutti, Sergio
Kuo, Braden
Barbieri, Riccardo
Napadow, Vitaly
Sclocco, Roberta
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3241
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3241
- Palabra clave:
- Brain–gut interactions
Motion sickness
Neuroimaging
Parasympathetic
Sympathetic
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Santander, 2016
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Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea |
| title |
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea |
| spellingShingle |
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea Brain–gut interactions Motion sickness Neuroimaging Parasympathetic Sympathetic |
| title_short |
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea |
| title_full |
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea |
| title_fullStr |
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea |
| title_full_unstemmed |
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea |
| title_sort |
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea |
| dc.creator.fl_str_mv |
García, Ronald G. Kim, Jieun Sheehan, James D. Beissner, Florian Bianchi, Anna M. Cerutti, Sergio Kuo, Braden Barbieri, Riccardo Napadow, Vitaly Sclocco, Roberta |
| dc.contributor.author.spa.fl_str_mv |
García, Ronald G. Kim, Jieun Sheehan, James D. Beissner, Florian Bianchi, Anna M. Cerutti, Sergio Kuo, Braden Barbieri, Riccardo Napadow, Vitaly Sclocco, Roberta |
| dc.subject.proposal.eng.fl_str_mv |
Brain–gut interactions Motion sickness Neuroimaging Parasympathetic Sympathetic |
| topic |
Brain–gut interactions Motion sickness Neuroimaging Parasympathetic Sympathetic |
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13 p. |
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2016 |
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2016-02 |
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2019-07-02T13:08:39Z |
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10.1093/cercor/bhu172 |
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1460-2199 |
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1047-3211 |
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https://repositorio.udes.edu.co/handle/001/3241 |
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eng |
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eng |
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Cerebral Cortex |
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Derechos Reservados - Universidad de Santander, 2016 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Derechos Reservados - Universidad de Santander, 2016 Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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García, Ronald G.41c4b822-ac96-4ffc-ac48-9d3227b75257-1Kim, Jieun50116560-db3f-4ad0-9f98-e80b6e3116e9-1Sheehan, James D.9bf878b1-f437-4ea0-9874-96e47f8ffb85-1Beissner, Floriane2897172-ba53-40cb-8ed4-19f70db97762-1Bianchi, Anna M.7a04c0da-18e8-4a65-8a56-8f7d3b762f02-1Cerutti, Sergio8de653fe-779f-4f81-94e4-8d5eabdb6428-1Kuo, Braden9338e467-9679-45fc-823b-4c054264d191-1Barbieri, Riccardo55ed48ad-21cc-4907-831a-b87ac479a69c-1Napadow, Vitalye2796f75-2336-48e3-94e5-3cab2fe51420-1Sclocco, Robertafe9d7fb4-a15a-4c07-8822-e36b0a28d4fc-12019-07-02T13:08:39Z2019-07-02T13:08:39Z2016-0213 p.While autonomic outflow is an important co-factor of nausea physiology, central control of this outflow is poorly understood. We evaluated sympathetic (skin conductance level) and cardiovagal (high-frequency heart rate variability) modulation, collected synchronously with functional MRI (fMRI) data during nauseogenic visual stimulation aimed to induce vection in susceptible individuals. Autonomic data guided analysis of neuroimaging data, using a stimulus-based (analysis windows set by visual stimulation protocol) and percept-based (windows set by subjects’ ratings) approach. Increased sympathetic and decreased parasympathetic modulation was associated with robust and anti-correlated brain activity in response to nausea. Specifically, greater autonomic response was associated with reduced fMRI signal in brain regions such as the insula, suggesting an inhibitory relationship with premotor brainstem nuclei. Interestingly, some sympathetic/parasympathetic specificity was noted. Activity in default mode network and visual motion areas was anti-correlated with parasympathetic outflow at peak nausea. In contrast, lateral prefrontal cortical activity was anticorrelated with sympathetic outflow during recovery, soon after cessation of nauseogenic stimulation. These results suggest divergent central autonomic control for sympathetic and parasympathetic response to nausea. Autonomic outflow and the central autonomic network underlying ANS response to nausea may be an important determinant of overall nausea intensity and, ultimately, a potential therapeutic target.application/pdf10.1093/cercor/bhu1721460-21991047-3211https://repositorio.udes.edu.co/handle/001/3241engCerebral CortexDerechos Reservados - Universidad de Santander, 2016info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://watermark.silverchair.com/bhu172.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAkEwggI9BgkqhkiG9w0BBwagggIuMIICKgIBADCCAiMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMy-2qEYYrFUUV3eATAgEQgIIB9In72CfRT54L5wtynd9F_Mm06XrM4lOgIqeuSUuPL10CbjZ9QSQ_T5s76ZhVL6mu6e_33jAgyc9XE7vGBLCjT0ikeDklrP6RLdLkoSbV0jftJFC7ZVak9f_iksNZ-rCBBfXsRLWKIxchSHkO-b-w23Wy1yuL1w21rr-kfNxfG_JIxYWmcDM9Jt9lccJ_VGJbkpSlwrOszCegQBvGLMT29TQ3Xep8ynijxd2Rmgjn8EcbFdY9b6wx-KTi6o5RaAim8JDzVe1Ox2ccq3O8x1ETcM12Wfnv3xlxQa5LbjZD1OVC-ZwHUwiBaB-6Rtk6KPEmitcFmtkGwJ8SLZzjw4TFCFC073RJsd2utozvZiR4j52ZC34gQHymg4VjDWos_I7CbLosJjpXtHVId6E6bhUrWz9x7xhBhvpns02zdNlunQlJ2F4K37Rm0K2gzMsvkwDkgzGcgt1ndHo2cvKnMVqEcRE7WUHelG_6Kqr-J0vJFOJv5erXza_W7o_6IqD1pE-sjYJ6yDMF5U2SaJkRq_dpuEpCTw5pKV7YLeXRStDyfn7gUcvf9q-5xeuOu8B4pkXrHeMLrT0xDpe_jI47OhMnm8nLeANIdQHtKF9Ki0e2-m83XdIQPKLsJ-U_sSErOggRP4fbUgYcuLylTPuuFgmxR0gEUXR-Brain–gut interactionsMotion sicknessNeuroimagingParasympatheticSympatheticBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to NauseaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdf.jpgBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdf.jpgGenerated Thumbnailimage/jpeg1939https://repositorio.udes.edu.co/bitstreams/570f3e30-a5a4-4bcf-a96c-06bb7af665f4/download0c7a2d3ff1198271a8deab67418672a2MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/c07e2387-ff04-44a4-89cc-75a26809768a/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdfBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdfapplication/pdf361534https://repositorio.udes.edu.co/bitstreams/e7b6011b-5597-47ea-ae5e-0c7094dbdc80/downloadd1c6f4f477fabf3c841557577ecd4badMD55TEXTBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdf.txtBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.pdf.txtExtracted texttext/plain63776https://repositorio.udes.edu.co/bitstreams/3b31fe7f-13f4-442d-960f-95fc1cc5e058/download9d0bb556549821fccca333c6f4fd7f4aMD53001/3241oai:repositorio.udes.edu.co:001/32412023-10-10 13:15:15.918https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Santander, 2016https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |