Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
Digital
- Autores:
-
Gonzalez, Maria Carolina
Radiske, Andressa
Rossato, Janine I.
Conde‑Ocazionez, Sergio A.
Bevilaqua, Lia R. M.
Cammarota, Martín
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/7395
- Acceso en línea:
- https://doi.org/10.1186/s13041-022-00938-3
https://repositorio.udes.edu.co/handle/001/7395
- Palabra clave:
- Theta rhythm
Amnesia
Hippocampus
Brain oscillations
Long-term memory
- Rights
- openAccess
- License
- © The Author(s) 2022.
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Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation |
| title |
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation |
| spellingShingle |
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation Theta rhythm Amnesia Hippocampus Brain oscillations Long-term memory |
| title_short |
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation |
| title_full |
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation |
| title_fullStr |
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation |
| title_full_unstemmed |
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation |
| title_sort |
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation |
| dc.creator.fl_str_mv |
Gonzalez, Maria Carolina Radiske, Andressa Rossato, Janine I. Conde‑Ocazionez, Sergio A. Bevilaqua, Lia R. M. Cammarota, Martín |
| dc.contributor.author.none.fl_str_mv |
Gonzalez, Maria Carolina Radiske, Andressa Rossato, Janine I. Conde‑Ocazionez, Sergio A. Bevilaqua, Lia R. M. Cammarota, Martín |
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Neurociencias |
| dc.subject.proposal.eng.fl_str_mv |
Theta rhythm Amnesia Hippocampus Brain oscillations Long-term memory |
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Theta rhythm Amnesia Hippocampus Brain oscillations Long-term memory |
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Digital |
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2022 |
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2022-08-12T22:36:14Z |
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2022-08-12T22:36:14Z |
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2022-06-07 |
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https://repositorio.udes.edu.co/handle/001/7395 |
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eng |
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Gonzalez, M.C., Radiske, A., Rossato, J.I. et al. Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation. Mol Brain 15, 50 (2022). https://doi.org/10.1186/s13041-022-00938-3 |
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Scopus |
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Molecular Brain |
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© The Author(s) 2022. |
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info:eu-repo/semantics/openAccess |
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Atribución 4.0 Internacional (CC BY 4.0) |
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https://creativecommons.org/licenses/by/4.0/ |
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© The Author(s) 2022. Atribución 4.0 Internacional (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2 |
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5 p |
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Reino Unido |
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https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-022-00938-3 |
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Gonzalez, Maria Carolina687b5ea5-d3d1-4bb1-aae8-8d8ac5be3599-1Radiske, Andressad2239c4d-fabd-4032-af75-e674a1557b40-1Rossato, Janine I.e4218bae-7421-4f5b-9910-339a026c40f9-1Conde‑Ocazionez, Sergio A.c7b305a0-788b-453d-aaa4-a86ddeb17146-1Bevilaqua, Lia R. M.54635670-c376-49ac-9419-4cfc994964af-1Cammarota, Martín7eae5cf3-78b5-408c-8f61-6674b1f9f3a6-1Neurociencias2022-08-12T22:36:14Z2022-08-12T22:36:14Z2022-06-07DigitalTheta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of some learning paradigms, suggesting that it may be implicated in hippocampus-dependent long-term memory process‑ing. Object recognition memory (ORM) allows animals to identify familiar items and is essential for remembering facts and events. In rodents, long-term ORM formation requires a functional hippocampus but the involvement of the MS in this process remains controversial. We found that training adult male Wistar rats in a long-term ORM-inducing learn‑ing task involving exposure to two diferent, but behaviorally equivalent novel stimuli objects increased hippocampal theta power, and that suppressing theta via optogenetic MS inactivation caused amnesia. Importantly, the amne‑sia was specifc to the object the animals were exploring when the MS was inactivated. Taken together, our results indicate that the MS is necessary for long-term ORM formation and suggest that hippocampal theta activity is causally linked to this process.Ciencias Médicas y de la Salud5 papplication/pdfhttps://doi.org/10.1186/s13041-022-00938-31756-66061756-6606https://repositorio.udes.edu.co/handle/001/7395engReino Unido5015Gonzalez, M.C., Radiske, A., Rossato, J.I. et al. Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation. Mol Brain 15, 50 (2022). https://doi.org/10.1186/s13041-022-00938-3ScopusMolecular Brain© The Author(s) 2022.info:eu-repo/semantics/openAccessAtribución 4.0 Internacional (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-022-00938-3Theta rhythmAmnesiaHippocampusBrain oscillationsLong-term memoryOptogenetic inactivation of the medial septum impairs long-term object recognition memory formationArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationORIGINALOptogenetic inactivation of the medial septum impairs long-term object recognition memory formation.pdfOptogenetic inactivation of the medial septum impairs long-term object recognition memory formation.pdfapplication/pdf244458https://repositorio.udes.edu.co/bitstreams/24464f34-6531-4abc-833f-c5f34208ce82/download9df048322be7235cb032e4cf449e2b78MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/ee74a2d6-a242-4c5d-ab15-42cc7a539878/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTOptogenetic inactivation of the medial septum impairs long-term object recognition memory formation.pdf.txtOptogenetic inactivation of the medial septum impairs long-term object recognition memory formation.pdf.txtExtracted texttext/plain8https://repositorio.udes.edu.co/bitstreams/518d63f0-ef2b-4907-9f2a-2d0d58e49439/download34a9d760095bb0c290f35e73faa3ef88MD53THUMBNAILOptogenetic inactivation of the medial septum impairs long-term object recognition memory formation.pdf.jpgOptogenetic inactivation of the medial septum impairs long-term object recognition memory formation.pdf.jpgGenerated Thumbnailimage/jpeg12971https://repositorio.udes.edu.co/bitstreams/6febfb03-1eb0-40da-922a-d2de106e58fd/download548fb2588f74e9f63dff1a807ee429b9MD54001/7395oai:repositorio.udes.edu.co:001/73952023-10-10 13:02:09.135https://creativecommons.org/licenses/by/4.0/© The Author(s) 2022.https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |