Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity
Digital
- Autores:
-
Suarez-Barrera, Miguel Orlando
Visser, Lydia
Rondon-Villarreal, Paola
Herrera-Pineda, Diego Fernando
Alarcon-Aldana, Juan S.
Van den Berg, Anke
Orozco, Jahir
Pinzon- Reyes, Efrain-Hernando
Moreno, Ernesto
Rueda Forero, Nohora Juliana
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/6160
- Acceso en línea:
- https://doi.org/10.3390/molecules26247476
https://repositorio.udes.edu.co/handle/001/6160
- Palabra clave:
- Parasporins
Cry toxins
Cancer cells
Genetic improvement
- Rights
- openAccess
- License
- Copyright: © 2021 by the authors
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Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity |
| title |
Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity |
| spellingShingle |
Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity Parasporins Cry toxins Cancer cells Genetic improvement |
| title_short |
Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity |
| title_full |
Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity |
| title_fullStr |
Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity |
| title_full_unstemmed |
Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity |
| title_sort |
Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity |
| dc.creator.fl_str_mv |
Suarez-Barrera, Miguel Orlando Visser, Lydia Rondon-Villarreal, Paola Herrera-Pineda, Diego Fernando Alarcon-Aldana, Juan S. Van den Berg, Anke Orozco, Jahir Pinzon- Reyes, Efrain-Hernando Moreno, Ernesto Rueda Forero, Nohora Juliana |
| dc.contributor.author.none.fl_str_mv |
Suarez-Barrera, Miguel Orlando Visser, Lydia Rondon-Villarreal, Paola Herrera-Pineda, Diego Fernando Alarcon-Aldana, Juan S. Van den Berg, Anke Orozco, Jahir Pinzon- Reyes, Efrain-Hernando Moreno, Ernesto Rueda Forero, Nohora Juliana |
| dc.contributor.researchgroup.spa.fl_str_mv |
Masira |
| dc.subject.proposal.eng.fl_str_mv |
Parasporins Cry toxins Cancer cells Genetic improvement |
| topic |
Parasporins Cry toxins Cancer cells Genetic improvement |
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Digital |
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2021 |
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2021-12-10 |
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2022-02-25T14:09:50Z |
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eng |
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Suárez-Barrera, M.O.; Visser, L.; Rondón-Villarreal, P.; Herrera-Pineda, D.F.; Alarcón-Aldana, J.S.; Van den Berg, A.; Orozco, J.; Pinzón-Reyes, E.H.; Moreno, E.; Rueda-Forero, N.J. Genetic Modification Approaches for Parasporins Bacillus thuringiensis Proteins with Anticancer Activity. Molecules 2021, 26, 7476. https:// doi.org/10.3390/molecules26247476 |
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Molecules |
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Copyright: © 2021 by the authors |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Suarez-Barrera, Miguel Orlandof29bdf0a-38a9-4ff0-a936-6eca5b5e1e8a-1Visser, Lydiae51c095e-278c-427a-87e1-2005da5a6b4c-1Rondon-Villarreal, Paola11c8f1f2-3d60-445c-926a-bdc78cf4e626-1Herrera-Pineda, Diego Fernandoc1dcf7ba-d62e-41b1-a1d1-f922f8b55044-1Alarcon-Aldana, Juan S.31889b9a-ffe6-4f71-9c73-ed7a55a233ce-1Van den Berg, Anke4bbda755-d5dc-493e-98dd-d351045e7659-1Orozco, Jahir9817d14c-fb9c-48e5-9e05-50ac1c5e6448-1Pinzon- Reyes, Efrain-Hernandod14c9e27-9c95-4376-9273-13f29c2e0016-1Moreno, Ernesto2841066f-78c7-42a0-850e-725c776d18c3-1Rueda Forero, Nohora Juliana8a2dca8e-5326-487a-924d-96760e98b2bd-1Masira2022-02-25T14:09:50Z2022-02-25T14:09:50Z2021-12-10DigitalBacillus thuringiensis (Bt) is a bacterium capable of producing Cry toxins, which are recognized for their bio-controlling actions against insects. However, a few Bt strains encode proteins lacking insecticidal activity but showing cytotoxic activity against different cancer cell lines and low or no cytotoxicity toward normal human cells. A subset of Cry anticancer proteins, termed parasporins (PSs), has recently arisen as a potential alternative for cancer treatment. However, the molecular receptors that allow the binding of PSs to cells and their cytotoxic mechanisms of action have not been well established. Nonetheless, their selective cytotoxic activity against different types of cancer cell lines places PSs as a promising alternative treatment modality. In this review, we provide an overview of the classification, structures, mechanisms of action, and insights obtained from genetic modification approaches for PS proteins.Ciencias Médicas y de la Salud13 papplication/pdfhttps://doi.org/10.3390/molecules26247476https://repositorio.udes.edu.co/handle/001/6160engMDPIUSA1324126Suárez-Barrera, M.O.; Visser, L.; Rondón-Villarreal, P.; Herrera-Pineda, D.F.; Alarcón-Aldana, J.S.; Van den Berg, A.; Orozco, J.; Pinzón-Reyes, E.H.; Moreno, E.; Rueda-Forero, N.J. Genetic Modification Approaches for Parasporins Bacillus thuringiensis Proteins with Anticancer Activity. Molecules 2021, 26, 7476. https:// doi.org/10.3390/molecules26247476ScopusMoleculesCopyright: © 2021 by the authorsinfo:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.mdpi.com/1420-3049/26/24/7476ParasporinsCry toxinsCancer cellsGenetic improvementGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activityArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity.pdfGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity.pdfapplication/pdf232322https://repositorio.udes.edu.co/bitstreams/613a5042-ba7a-4517-b196-1a7fed68693e/downloadbad3e6ed5e2fb8fa18811cacc5f80623MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/43576205-37b5-4f73-b1bf-86aae2e23b3e/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity.pdf.txtGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/90503694-8e99-47dc-84cc-e7576d8e94d9/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity.pdf.jpgGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity.pdf.jpgGenerated Thumbnailimage/jpeg12989https://repositorio.udes.edu.co/bitstreams/0475b357-435b-4cab-8b36-bda8cacc518f/download584a6dcc63ed09d35862542fc58fcbc9MD54001/6160oai:repositorio.udes.edu.co:001/61602023-10-09 16:42:16.418https://creativecommons.org/licenses/by-nc/4.0/Copyright: © 2021 by the authorshttps://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |