Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia
Digital
- Autores:
-
Sánchez-Villamil, Juana P.
Pino-Vélez, Carolina
Trejos Suárez, Juanita
Cardona, Nestor
España, Ana Lucía
Alfonso, Pedro A.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/5667
- Acceso en línea:
- https://doi.org/10.7705/biomedica.5149
https://repositorio.udes.edu.co/handle/001/5667
- Palabra clave:
- Periodontitis
Oxidative stress
Saliva
Virus
Aggregatibacter actinomycetemcomitans
Porphyromonas gingivalis
- Rights
- openAccess
- License
- The Editor(s) and the Author(s), 2020
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Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia |
| title |
Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia |
| spellingShingle |
Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia Periodontitis Oxidative stress Saliva Virus Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis |
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Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia |
| title_full |
Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia |
| title_fullStr |
Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia |
| title_full_unstemmed |
Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia |
| title_sort |
Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia |
| dc.creator.fl_str_mv |
Sánchez-Villamil, Juana P. Pino-Vélez, Carolina Trejos Suárez, Juanita Cardona, Nestor España, Ana Lucía Alfonso, Pedro A. |
| dc.contributor.author.none.fl_str_mv |
Sánchez-Villamil, Juana P. Pino-Vélez, Carolina Trejos Suárez, Juanita Cardona, Nestor España, Ana Lucía Alfonso, Pedro A. |
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CLINIUDES |
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Periodontitis Oxidative stress Saliva Virus Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis |
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Periodontitis Oxidative stress Saliva Virus Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis |
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Digital |
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2020 |
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2020-02-12 |
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2021-10-06T16:25:06Z |
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2021-10-06T16:25:06Z |
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https://doi.org/10.7705/biomedica.5149 |
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https://repositorio.udes.edu.co/handle/001/5667 |
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https://doi.org/10.7705/biomedica.5149 https://repositorio.udes.edu.co/handle/001/5667 |
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eng |
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eng |
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124 |
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Suplemento 1, 1 de mayo de 2020 |
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113 |
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40 |
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Sánchez-Villamil JP, Pino-Vélez C, Trejos-Suárez J, Cardona N, España AL, Alfonso PA. Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia. Biomedica. 2020 May 1;40(Supl. 1):113-124. doi: 10.7705/biomedica.5149. PMID: 32463613; PMCID: PMC7449106. |
| dc.relation.indexed.spa.fl_str_mv |
Biomédica 2020;40(Supl.1):113-24 Oxidative stress and pathogens in periodontitis doi: https://doi.org/10.7705/biomedica.5149 |
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Biomédica, Revista del Instituto Nacional de Salud |
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The Editor(s) and the Author(s), 2020 |
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http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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1 p. |
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Biomédica |
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Santa Fe de Bogotá, Colombia |
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https://pubmed.ncbi.nlm.nih.gov/32463613/ |
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Universidad de Santander |
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Sánchez-Villamil, Juana P.88d3aaa1-2bab-458a-95de-f9ce249545fe-1Pino-Vélez, Carolinaef58fe09-1389-4377-a0e9-4becea3a8e33-1Trejos Suárez, Juanitad1ff80c8-4661-4ad3-8cc1-ac4b0fe1abe3-1Cardona, Nestor37119b9c-d8a2-48ec-9d44-2156cbf381c7-1España, Ana Lucía38b3fcc0-b7a3-4106-ab4b-7a599bedd75d-1Alfonso, Pedro A.d797e845-b2b3-4b8a-8723-0c5178a2362f-1CLINIUDES2021-10-06T16:25:06Z2021-10-06T16:25:06Z2020-02-12DigitalIntroduction: Periodontitis affects more than 20% of the Latin American population. Oxidative markers are associated with greater progression of periodontitis; therefore, its role in pathogenesis should be studied. Objective: To determine the prevalence of the main oral bacteria and viruses associated with periodontitis and estimate the total antioxidant capacity and lipid peroxidation in saliva from patients with periodontitis. Materials and methods: We conducted systemically a cross-sectional study in 101 healthy subjects, 87 of whom had been diagnosed with periodontitis (P), according to the criteria of the Centers of Disease Control and Prevention and the American Academy of Periodontology, and 14 without periodontal pockets as controls (C). In subgingival samples, major viruses and dental pathogenic bacteria were identified using PCR techniques. The levels of total antioxidant capacity and malon-di-aldehyde (MDA) were determined by spectrophotometry in samples of unstimulated saliva. Results: The mean of periodontal depth pocket and clinical attachment loss in patients with periodontitis was 5.6 ± 1.7 and 6.1 ± 3.1 mm, respectively. The most prevalent microorganisms were Aggregatibacter actinomycetemcomitans (32.5%) and Porphyromonas gingivalis (18.6%). The patients from rural areas showed a higher percentage of A. actinomycetemcomitans (urban: 17.9% vs. rural: 48.9%, p=0.0018). In patients with periodontitis, the frequency of EBV, HSV1 and 2, and HCMV genes was 2.3%. Periodontitis patients had higher levels of MDA (P: 2.1 ± 1.5; C: 0.46 ± 0.3 μmol/g protein; p=0.0001) and total antioxidant capacity (P: 0.32 ± 0.2; C: 0.15 ± 0.1 mM; p< 0.0036). Oxidative markers showed no modifications due to the presence of periodontopathic bacteria. Conclusions: Aggregatibacter actinomycetemcomitans was the most prevalent bacteria; its presence did not modify the levels of oxidative markers in the saliva of patients with periodontitis.Introducción. La periodontitis afecta a más del 20 % de la población latinoamericana. La presencia de marcadores de estrés oxidativo se asocia con una mayor progresión de periodontitis, por lo que su rol en la patogenia debe estudiarse. Objetivo. Determinar la prevalencia de las principales bacterias y virus asociados con la periodontitis y estimar la capacidad antioxidante total y la peroxidación de lípidos en la saliva de los pacientes con periodontitis. Materiales y métodos. Se hizo un estudio transversal en 87 sujetos sanos diagnosticados con periodontitis (P) según los criterios de los Centers of Disease Control and Prevention y la American Academy of Periodontology y 14 sujetos sin enfermedad periodontal como grupo control (C). En las muestras subgingivales se identificaron los principales virus y bacterias mediante técnicas de PCR. Los niveles de capacidad antioxidante total y malon-di-aldehído (MDA) se establecieron mediante espectrofotometría en muestras de saliva no estimulada. Resultados. Las medias de profundidad del sondaje y del nivel de inserción clínico periodontal en pacientes con periodontitis fueron 5,6 ± 1,7 y 6,1 ± 3,1 mm, respectivamente. Los microorganismos más prevalentes fueron Aggregatibacter actinomycetemcomitans (32,5 %) y Porphyromonas gingivalis (18,6 %). Los pacientes de áreas rurales registraron un mayor porcentaje de A. actinomycetemcomitans (urbano: 17,9 % Vs. rural: 48,9 %; p=0,0018). La frecuencia de los genes EBV, HSV1 y 2, y HCMV fue de 2,3 %. En pacientes con periodontitis se evidenciaron mayores niveles de MDA (P: 2,1 ± 1,5; C: 0,46 ± 0,3 μmol/g proteína; p=0,0001) y capacidad antioxidante total (P: 0,32 ± 0,2; C: 0,15 ± 0,1 mM; p<0,0036). La presencia de bacterias periodontales patógenas no modificó los marcadores oxidativos. Conclusiones. Aggregatibacter actinomycetemcomitans fue el agente patógeno mas prevalente. Su presencia no modificó los niveles de marcadores oxidativos en la saliva de los pacientes con periodontitis.Ciencias básicas biomédicas, epidemiología, salud pública enfermedades infecciosas, enfermedades no transmisibles epidemiología, salud y desarrollo, discapacidad1 p.application/pdfhttps://doi.org/10.7705/biomedica.5149https://repositorio.udes.edu.co/handle/001/5667engBiomédicaSanta Fe de Bogotá, Colombia124Suplemento 1, 1 de mayo de 202011340Sánchez-Villamil JP, Pino-Vélez C, Trejos-Suárez J, Cardona N, España AL, Alfonso PA. Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia. Biomedica. 2020 May 1;40(Supl. 1):113-124. doi: 10.7705/biomedica.5149. PMID: 32463613; PMCID: PMC7449106.Biomédica 2020;40(Supl.1):113-24 Oxidative stress and pathogens in periodontitis doi: https://doi.org/10.7705/biomedica.5149Biomédica, Revista del Instituto Nacional de SaludThe Editor(s) and the Author(s), 2020info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://pubmed.ncbi.nlm.nih.gov/32463613/PeriodontitisOxidative stressSalivaVirusAggregatibacter actinomycetemcomitansPorphyromonas gingivalisSalivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, ColombiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALSalivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia.pdfSalivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia.pdfapplication/pdf235414https://repositorio.udes.edu.co/bitstreams/8a5b33d9-cd2a-4023-acc2-158a0e63036d/download64faaddc3a71dbe89c726fe8a99b63b0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/c84c8d1b-6ffb-4eea-b737-18e84a9e811a/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTSalivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia.pdf.txtSalivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/f92e5224-dcf6-4131-9a89-495830a04342/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILSalivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia.pdf.jpgSalivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia.pdf.jpgGenerated Thumbnailimage/jpeg11996https://repositorio.udes.edu.co/bitstreams/819c43d2-22d2-49b6-8755-d41c3fe0332b/downloadff32fd9db151b791ebbe2e9d7dde2f29MD54001/5667oai:repositorio.udes.edu.co:001/56672023-10-10 09:50:42.597https://creativecommons.org/licenses/by-nc/4.0/The Editor(s) and the Author(s), 2020https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |