Plasma nitrate levels and flow-mediated vasodilation in untreated
6 p.
- Autores:
-
García, Ronald G.
Zarruk, Juan G.
Barrera, Carlos
Pinzón, Alexander
Trillos, Elizabeth
Arenas, William D.
Luengas, Carlos
Tomaz, Carlos A.
Lopez-Jaramillo, Patricio
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3719
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3719
- Palabra clave:
- Major depression
Endothelium
Blood flow
Nitric oxide
Nervous system
- Rights
- openAccess
- License
- Derechos Reservados - Psychosomatic Medicine, 2011
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Plasma nitrate levels and flow-mediated vasodilation in untreated |
| title |
Plasma nitrate levels and flow-mediated vasodilation in untreated |
| spellingShingle |
Plasma nitrate levels and flow-mediated vasodilation in untreated Major depression Endothelium Blood flow Nitric oxide Nervous system |
| title_short |
Plasma nitrate levels and flow-mediated vasodilation in untreated |
| title_full |
Plasma nitrate levels and flow-mediated vasodilation in untreated |
| title_fullStr |
Plasma nitrate levels and flow-mediated vasodilation in untreated |
| title_full_unstemmed |
Plasma nitrate levels and flow-mediated vasodilation in untreated |
| title_sort |
Plasma nitrate levels and flow-mediated vasodilation in untreated |
| dc.creator.fl_str_mv |
García, Ronald G. Zarruk, Juan G. Barrera, Carlos Pinzón, Alexander Trillos, Elizabeth Arenas, William D. Luengas, Carlos Tomaz, Carlos A. Lopez-Jaramillo, Patricio |
| dc.contributor.author.spa.fl_str_mv |
García, Ronald G. Zarruk, Juan G. Barrera, Carlos Pinzón, Alexander Trillos, Elizabeth Arenas, William D. Luengas, Carlos Tomaz, Carlos A. Lopez-Jaramillo, Patricio |
| dc.subject.proposal.eng.fl_str_mv |
Major depression Endothelium Blood flow Nitric oxide Nervous system |
| topic |
Major depression Endothelium Blood flow Nitric oxide Nervous system |
| description |
6 p. |
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2011 |
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2011-05 |
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2019-09-02T13:39:13Z |
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10.1097/PSY.0b013e31821566cf |
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1534-7796 0033-3174 |
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https://repositorio.udes.edu.co/handle/001/3719 |
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https://repositorio.udes.edu.co/handle/001/3719 |
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eng |
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eng |
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Psychosomatic Medicine |
| dc.relation.ispartofseries.eng.fl_str_mv |
Psychosomatic Medicine;Volume 73 - Issue 4 - p 344-349, May 2011 |
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Derechos Reservados - Psychosomatic Medicine, 2011 |
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https://journals.lww.com/psychosomaticmedicine/fulltext/2011/05000/Plasma_Nitrate_Levels_and_Flow_Mediated.9.aspx#pdf-link |
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Universidad de Santander |
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García, Ronald G.41c4b822-ac96-4ffc-ac48-9d3227b75257-1Zarruk, Juan G.d274699c-e1ac-43b5-a287-26ee11182046-1Barrera, Carlos30c4eeb8-b01f-41d7-823f-c71d9de35e10-1Pinzón, Alexander78203816-dc1b-400b-91e1-0214d5d3016d-1Trillos, Elizabeth62d10c81-3d5d-43e4-a33b-4d6697e2a763-1Arenas, William D.a776bc8f-583d-45a0-b958-c4982c17557b-1Luengas, Carlosee445833-8270-473a-a213-cd325da1dad6-1Tomaz, Carlos A.76752efe-2bbe-48dd-9e78-7ed83f845630-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-12019-09-02T13:39:13Z2019-09-02T13:39:13Z2011-056 p.Objective: Findings from several studies have revealed that major depression is associated with an increased cardiovascular risk. The physiopathologic mechanisms of this association remain unclear, although recently, it has been hypothesized that a decreased production of nitric oxide could be a potential contributor to vascular dysfunction in depressive patients. The objective of this study was to evaluate nitric oxide production and vascular endothelial function in treatment-naive young healthy adults with a first episode of major depression. Methods: A case-control study in 50 treatment-naive young adults with a first episode of major depression and 50 healthy control subjects was conducted. Plasma levels of nitric oxide metabolites (nitrates/nitrites) were determined using a colorimetric assay based on Griess reaction. Endothelial function was assessed by flow-mediated vasodilation measurements after reactive hyperemia. Results: The mean age of the depressed patients was 22.6 (standard deviation [SD], 4.6) years, whereas the controls were 23.4 (SD, 4.8) years. Sixteen men (32%) and 34 women (68%) were included in each group. The plasma nitrite/nitrate concentrations were significantly lower in depressive subjects compared with healthy controls (17.5 [SD, 4.9] Kmol/L versus 21.6 [SD, 7.0] Kmol/L, p G .001); however, flow-mediated vasodilation values were similar in both groups (13.1% [SD, 4.3%] versus 12.1% [SD, 5.0%], p = .10). Conclusions: Decreased plasma concentrations of nitric oxide metabolites are not associated with vascular endothelial dysfunction in young subjects with a first episode of major depression. Reduced nitrate/nitrite levels could reflect a decreased nitric oxide production in the central nervous system of depressed subjects. Further studies are needed to confirm this hypothesis.application/pdf10.1097/PSY.0b013e31821566cf1534-77960033-3174https://repositorio.udes.edu.co/handle/001/3719engPsychosomatic MedicinePsychosomatic Medicine;Volume 73 - Issue 4 - p 344-349, May 2011Derechos Reservados - Psychosomatic Medicine, 2011info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://journals.lww.com/psychosomaticmedicine/fulltext/2011/05000/Plasma_Nitrate_Levels_and_Flow_Mediated.9.aspx#pdf-linkMajor depressionEndotheliumBlood flowNitric oxideNervous systemPlasma nitrate levels and flow-mediated vasodilation in untreatedArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationORIGINALPlasma nitrate levels and flow-mediated vasodilation in untreated.pdfPlasma nitrate levels and flow-mediated vasodilation in untreated.pdfapplication/pdf322567https://repositorio.udes.edu.co/bitstreams/a42a8fc2-1af8-4501-809e-49b034625d17/downloadb3d90e5925bb043e7573db5bd83f7f2eMD55LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/c99298a2-b135-44c0-8f9e-c7fb6e9c21ed/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTPlasma nitrate levels and flow-mediated vasodilation in untreated.pdf.txtPlasma nitrate levels and flow-mediated vasodilation in untreated.pdf.txtExtracted texttext/plain40492https://repositorio.udes.edu.co/bitstreams/142158c2-cbfb-4c7e-bd0e-b7db3c596d53/download4c5acff94cff01857c183886ddd0f357MD53THUMBNAILPlasma nitrate levels and flow-mediated vasodilation in untreated.pdf.jpgPlasma nitrate levels and flow-mediated vasodilation in untreated.pdf.jpgGenerated Thumbnailimage/jpeg1736https://repositorio.udes.edu.co/bitstreams/e8b34249-e413-43b0-8526-32a7d770ca3a/download5104c4dc24df2ccc86d51e4bbf50cc3dMD54001/3719oai:repositorio.udes.edu.co:001/37192023-10-09 18:15:25.368https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Psychosomatic Medicine, 2011https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |