Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial
7 p.
- Autores:
-
Joseph, Philip
Lonn, Eva
Bosch, Jackie
Lopez-Jaramillo, Patricio
Zhu, Jun
Keltai, Matyas
Dans, Antonio
Reid, Christopher M.
Khunti, Kamlesh
Toff, William D.
Piegas, Leopoldo S.
Kim, Jae Hyung
Swaminathan, Balakumar
Bohm, Michael
Yusuf, Salim
HOPE-3 Investigators
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3404
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3404
- Palabra clave:
- Blood Pressure-Lowering
Erectile Function
Risk for Cardiovascular Diseas
HOPE-3
- Rights
- openAccess
- License
- Derechos Reservados - Canadian Journal of Cardiology, 2018
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Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial |
| title |
Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial |
| spellingShingle |
Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial Blood Pressure-Lowering Erectile Function Risk for Cardiovascular Diseas HOPE-3 |
| title_short |
Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial |
| title_full |
Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial |
| title_fullStr |
Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial |
| title_full_unstemmed |
Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial |
| title_sort |
Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial |
| dc.creator.fl_str_mv |
Joseph, Philip Lonn, Eva Bosch, Jackie Lopez-Jaramillo, Patricio Zhu, Jun Keltai, Matyas Dans, Antonio Reid, Christopher M. Khunti, Kamlesh Toff, William D. Piegas, Leopoldo S. Kim, Jae Hyung Swaminathan, Balakumar Bohm, Michael Yusuf, Salim HOPE-3 Investigators |
| dc.contributor.author.spa.fl_str_mv |
Joseph, Philip Lonn, Eva Bosch, Jackie Lopez-Jaramillo, Patricio Zhu, Jun Keltai, Matyas Dans, Antonio Reid, Christopher M. Khunti, Kamlesh Toff, William D. Piegas, Leopoldo S. Kim, Jae Hyung Swaminathan, Balakumar Bohm, Michael Yusuf, Salim HOPE-3 Investigators |
| dc.subject.proposal.eng.fl_str_mv |
Blood Pressure-Lowering Erectile Function Risk for Cardiovascular Diseas HOPE-3 |
| topic |
Blood Pressure-Lowering Erectile Function Risk for Cardiovascular Diseas HOPE-3 |
| description |
7 p. |
| publishDate |
2018 |
| dc.date.issued.spa.fl_str_mv |
2018-01 |
| dc.date.accessioned.spa.fl_str_mv |
2019-07-16T16:10:50Z |
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2019-07-16T16:10:50Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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10.1016/j.cjca.2017.09.026 |
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0828-282X |
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https://repositorio.udes.edu.co/handle/001/3404 |
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10.1016/j.cjca.2017.09.026 0828-282X |
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https://repositorio.udes.edu.co/handle/001/3404 |
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eng |
| language |
eng |
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Canadian Journal of Cardiology |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - Canadian Journal of Cardiology, 2018 |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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application/pdf |
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https://www.sciencedirect.com/science/article/abs/pii/S0828282X17310917?via%3Dihub |
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Joseph, Philip35ddb523-bb0e-4c55-9a59-b24968824fbf-1Lonn, Eva7a977a4b-14e3-44cc-8057-933d424aaa9b-1Bosch, Jackie503f2202-0dda-463c-acc9-f5888e895278-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Zhu, Jund97cdbd2-6a82-430c-abfe-c978f085997e-1Keltai, Matyas65c5da4f-dca6-4e4f-aa9e-6c2ff81f2df9-1Dans, Antoniof365ef5a-7610-4022-8485-31d6d3879cd6-1Reid, Christopher M.7d8a8211-12ad-464c-948d-16952b66144d-1Khunti, Kamleshe9aff03a-6f97-433d-a56e-8d7f703caa03-1Toff, William D.97acb6df-c33b-45ad-b772-c52ac4aa7281-1Piegas, Leopoldo S.0f1da4dd-76bd-4381-87fa-1e01066eee6f-1Kim, Jae Hyung02f6ce1a-0939-4a0d-9f08-bb2d131dcf4e-1Swaminathan, Balakumar9a123b7e-ad88-4396-95f1-41abbda4cb89-1Bohm, Michael34b4dfc7-61d4-4d02-b80c-68493ef743e9-1Yusuf, Salim06a836b5-f5e3-41d9-a516-9cc46e5d7948-1HOPE-3 Investigatorsad5cd98d-86e0-4739-a226-91ef50ed152c-12019-07-16T16:10:50Z2019-07-16T16:10:50Z2018-017 p.Background: It is unclear whether modifying cholesterol, blood pressure, or both affect erectile dysfunction. Also, there are concerns that erectile dysfunction is worsened by common medications used to treat these risk factors. In this study, we evaluated the effect of: (1) cholesterol-lowering with a statin; (2) pharmacologic blood pressure reduction; and (3) their combination, on erectile function. Methods: A priori, this was a secondary analysis of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) randomized controlled trial. Men were 55 years of age or older with at least 1 cardiovascular risk factor. Erectile function was measured using the erectile function domain of the International Index of Erectile Function (IIEF-EF) score. Men with incomplete scores, or who did not engage in sexual activity, were excluded. Using a 2 × 2 factorial design, participants were randomized to rosuvastatin (10 mg/d) or placebo, and to candesartan with hydrochlorothiazide (HCTZ; 16 mg/12.5 mg/d; Cand+HCTZ) or placebo. Primary outcome was change in IIEF-EF from baseline to end of study follow-up. Results: Two thousand one hundred fifty-three men were included; mean age was 61.5 years, and mean follow-up was 5.8 years. Mean IIEF-EF score at baseline was 23.0 (SD 5.6). Least square mean change in the IIEF-EF score did not differ with rosuvastatin compared with placebo (−1.4; standard error [SE], 0.3 vs −1.5; SE, 0.3; P = 0.74), Cand+HCTZ compared with placebo (−1.6; SE, 0.3 vs −1.3; SE, 0.3; P = 0.10), or combination therapy compared with double placebo (P = 0.35). Conclusions: Cholesterol-lowering using a statin, and blood pressure-lowering using Cand+HCTZ, either alone or in combination, do not improve or adversely affect erectile function.application/pdf10.1016/j.cjca.2017.09.0260828-282Xhttps://repositorio.udes.edu.co/handle/001/3404engCanadian Journal of CardiologyDerechos Reservados - Canadian Journal of Cardiology, 2018info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.sciencedirect.com/science/article/abs/pii/S0828282X17310917?via%3DihubBlood Pressure-LoweringErectile FunctionRisk for Cardiovascular DiseasHOPE-3Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease : A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled TrialArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTEXTLong-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease.pdf.txtLong-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease.pdf.txtExtracted texttext/plain2https://repositorio.udes.edu.co/bitstreams/7e992880-4511-478f-9c34-033edca36c96/downloadd784fa8b6d98d27699781bd9a7cf19f0MD56BRANDED_PREVIEWLONG-T~1.PNG.preview.jpgLONG-T~1.PNG.preview.jpgGenerated Branded Previewimage/jpeg5785https://repositorio.udes.edu.co/bitstreams/1edac0f2-1e64-42de-a332-27e0dc1ac81b/downloadbfbf86f3247c16594408ef4ee8704a55MD54THUMBNAILLONG-T~1.PNG.jpgLONG-T~1.PNG.jpgUDESimage/jpeg1502https://repositorio.udes.edu.co/bitstreams/84a5d9dd-7df4-44b1-9038-09310c7655d8/download26624db148d8fc25ef648ffe0e2bcf2aMD53Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease.pdf.jpgLong-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease.pdf.jpgGenerated Thumbnailimage/jpeg1444https://repositorio.udes.edu.co/bitstreams/8fb78b15-5def-4703-904a-539e0e0d76c3/download0171834d94f66edfa62590a2f0014a5aMD57LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/b94b33be-ec72-478b-bb0a-e081e06492a0/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALLong-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease.pdfLong-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease.pdfapplication/pdf253035https://repositorio.udes.edu.co/bitstreams/3cf6f5f8-9b6f-4059-b626-431928c0ecff/download55a2db8f00334ff895d1bf11d6d9e68dMD55001/3404oai:repositorio.udes.edu.co:001/34042023-10-10 08:42:33.771https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Canadian Journal of Cardiology, 2018https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |