Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks
11 p.
- Autores:
-
Kim, Hyungjun
Kim, Jieun
Loggia, Marco L.
Cahalan, Christine M.
García, Ronald G.
Vangel, Mark G.
Wasan, Ajay D.
Edwards, Robert R.
Napadow, Vitaly
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3257
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3257
- Palabra clave:
- Fibromyalgia
Pain
Network
Tractography
Cerebellum
- Rights
- embargoedAccess
- License
- Derechos Reservados - Universidad de Santander, 2015
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Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks |
| title |
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks |
| spellingShingle |
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks Fibromyalgia Pain Network Tractography Cerebellum |
| title_short |
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks |
| title_full |
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks |
| title_fullStr |
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks |
| title_full_unstemmed |
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks |
| title_sort |
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks |
| dc.creator.fl_str_mv |
Kim, Hyungjun Kim, Jieun Loggia, Marco L. Cahalan, Christine M. García, Ronald G. Vangel, Mark G. Wasan, Ajay D. Edwards, Robert R. Napadow, Vitaly |
| dc.contributor.author.spa.fl_str_mv |
Kim, Hyungjun Kim, Jieun Loggia, Marco L. Cahalan, Christine M. García, Ronald G. Vangel, Mark G. Wasan, Ajay D. Edwards, Robert R. Napadow, Vitaly |
| dc.subject.proposal.eng.fl_str_mv |
Fibromyalgia Pain Network Tractography Cerebellum |
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Fibromyalgia Pain Network Tractography Cerebellum |
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11 p. |
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2015 |
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2015-03-04 |
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2019-07-02T22:46:51Z |
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10.1016/j.nicl.2015.02.022 |
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2213-1582 |
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https://repositorio.udes.edu.co/handle/001/3257 |
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eng |
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eng |
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NeuroImage: Clinical |
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Kim, Hyungjunb615cc24-de21-4b67-8873-7f23a43d32a7-1Kim, Jieun50116560-db3f-4ad0-9f98-e80b6e3116e9-1Loggia, Marco L.0dd849d1-5f7a-4e23-ae5d-898bc433e171-1Cahalan, Christine M.f66b748c-97ba-4ae2-9063-f345782a6e84-1García, Ronald G.41c4b822-ac96-4ffc-ac48-9d3227b75257-1Vangel, Mark G.3aa5799d-d20a-44e1-91df-e5699455b61d-1Wasan, Ajay D.121e368d-55c1-4776-beb2-5fc38235c935-1Edwards, Robert R.eb0345ff-5b93-4141-b41c-f75309362659-1Napadow, Vitalye2796f75-2336-48e3-94e5-3cab2fe51420-12019-07-02T22:46:51Z2019-07-02T22:46:51Z2015-03-0411 p.Altered brain morphometry has been widely acknowledged in chronic pain, and recent studies have implicated altered network dynamics, as opposed to properties of individual brain regions, in supporting persistent pain. Structural covariance analysis determines the inter-regional association in morphological metrics, such as gray matter volume, and such structural associations may be altered in chronic pain. In this study, voxel-based morphometry structural covariance networks were compared between fibromyalgia patients (N=42) and age- and sex-matched pain-free adults (N=63).We investigated network topology using spectral partitioning,which can delineate local network submodules with consistent structural covariance. We also explored white matter connectivity between regions comprising these submodules and evaluated the association between probabilistic white matter tractography and pain-relevant clinical metrics. Our structural covariance network analysis noted more connections within the cerebellum for fibromyalgia patients, and more connections in the frontal lobe for healthy controls. For fibromyalgia patients, spectral partitioning identified a distinct submodule with cerebellar connections to medial prefrontal and temporal and right inferior parietal lobes, whose gray matter volume was associated with the severity of depression in these patients. Volume for a submodule encompassing lateral orbitofrontal, inferior frontal, postcentral, lateral temporal, and insular cortices was correlated with evoked pain sensitivity. Additionally, the number ofwhitematter fibers between specific submodule regionswas also associated with measures of evoked pain sensitivity and clinical pain interference. Hence, altered gray and white matter morphometry in cerebellar and frontal cortical regions may contribute to, or result from, pain-relevant dysfunction in chronic pain patients.application/pdf10.1016/j.nicl.2015.02.0222213-1582https://repositorio.udes.edu.co/handle/001/3257engNeuroImage: ClinicalDerechos Reservados - Universidad de Santander, 2015info:eu-repo/semantics/embargoedAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_f1cfhttps://reader.elsevier.com/reader/sd/pii/S2213158215000406?token=80C321E73AC619FC74CD7EABFCC1D48C0D58A4505FBA52AFC7F6185EB89AC8E7450A12EF7E28A4995A179393F03CBFA3FibromyalgiaPainNetworkTractographyCerebellumFibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networksArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILFibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks.pdf.jpgFibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks.pdf.jpgGenerated Thumbnailimage/jpeg1625https://repositorio.udes.edu.co/bitstreams/986a7b6a-bb8a-4c51-bfff-186a3931d460/downloada3205d95498d48d068ec3420227f1c63MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/cf3ebad5-a3b0-4bb3-9421-6772e07e4421/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALFibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks.pdfFibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks.pdfapplication/pdf299214https://repositorio.udes.edu.co/bitstreams/2ecf6178-1217-418c-9a91-57ee30390010/download2dab9b960ec333bc2f444f8485e77bfeMD55TEXTFibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks.pdf.txtFibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks.pdf.txtExtracted texttext/plain74639https://repositorio.udes.edu.co/bitstreams/b3f32064-7a7f-4789-937f-0f0cc27dd615/downloadf2e5d5bc9bff1fd47dc03d5d9116cd0eMD53001/3257oai:repositorio.udes.edu.co:001/32572023-10-10 13:14:54.847https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Santander, 2015https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |