Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE)
8 p.
- Autores:
-
Punthakee, Zubin
Gerstein, Hertzel C.
Bosch Pagans, Jordi
Tyrwhitt, Jessica
Jung, Hyejung
Lee, Shun Fu
Lonn, Eva
Marsden, Tamara
McKelvie, Robert
McQueen, Matthew J.
Morillo, Carlos
Yusuf, Shazzid
Dagenais, Gilles
Diaz, Rafael
Maggioni, Aldo P.
Probstfield, Jeffrey
Ramachandran, Ambady
Riddle, Matthew C.
Rydén, Lars
Badings, Erik
Birkeland, Kare
Cardona Munoz, Ernesto G.
Commerford, Patrick
Davies, Melanie
Fodor, George J.
Gomis, Ramon
Hanefeld, Markolf
Hildebrandt, Per
Kacerovsky Bielesz, Gertrud
Keltai, Matyas
Lanas, Fernando
Lewis, Basil S.
Lopez-Jaramillo, Patricio
Marin Neto, Jose Antonio
Marre, Michel
Mendoza, Ivan
Pan, Chun yue
Pirags, Valdis
Rosenstock, Julio
Spinas, Giatgen A.
Sreenan, Seamus
Syvänne, Mikko
Yale, Jean Francois
ORIGIN Trial Investigators
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3487
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3487
- Palabra clave:
- Cardiovascular
Postintervention
Insulin Glargine
Omega-3
Fatty Acids
- Rights
- openAccess
- License
- Derechos Reservados - Diabetes Care, 2016
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| dc.title.eng.fl_str_mv |
Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) |
| title |
Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) |
| spellingShingle |
Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) Cardiovascular Postintervention Insulin Glargine Omega-3 Fatty Acids |
| title_short |
Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) |
| title_full |
Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) |
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Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) |
| title_full_unstemmed |
Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) |
| title_sort |
Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) |
| dc.creator.fl_str_mv |
Punthakee, Zubin Gerstein, Hertzel C. Bosch Pagans, Jordi Tyrwhitt, Jessica Jung, Hyejung Lee, Shun Fu Lonn, Eva Marsden, Tamara McKelvie, Robert McQueen, Matthew J. Morillo, Carlos Yusuf, Shazzid Dagenais, Gilles Diaz, Rafael Maggioni, Aldo P. Probstfield, Jeffrey Ramachandran, Ambady Riddle, Matthew C. Rydén, Lars Badings, Erik Birkeland, Kare Cardona Munoz, Ernesto G. Commerford, Patrick Davies, Melanie Fodor, George J. Gomis, Ramon Hanefeld, Markolf Hildebrandt, Per Kacerovsky Bielesz, Gertrud Keltai, Matyas Lanas, Fernando Lewis, Basil S. Lopez-Jaramillo, Patricio Marin Neto, Jose Antonio Marre, Michel Mendoza, Ivan Pan, Chun yue Pirags, Valdis Rosenstock, Julio Spinas, Giatgen A. Sreenan, Seamus Syvänne, Mikko Yale, Jean Francois ORIGIN Trial Investigators |
| dc.contributor.author.spa.fl_str_mv |
Punthakee, Zubin Gerstein, Hertzel C. Bosch Pagans, Jordi Tyrwhitt, Jessica Jung, Hyejung Lee, Shun Fu Lonn, Eva Marsden, Tamara McKelvie, Robert McQueen, Matthew J. Morillo, Carlos Yusuf, Shazzid Dagenais, Gilles Diaz, Rafael Maggioni, Aldo P. Probstfield, Jeffrey Ramachandran, Ambady Riddle, Matthew C. Rydén, Lars Badings, Erik Birkeland, Kare Cardona Munoz, Ernesto G. Commerford, Patrick Davies, Melanie Fodor, George J. Gomis, Ramon Hanefeld, Markolf Hildebrandt, Per Kacerovsky Bielesz, Gertrud Keltai, Matyas Lanas, Fernando Lewis, Basil S. Lopez-Jaramillo, Patricio Marin Neto, Jose Antonio Marre, Michel Mendoza, Ivan Pan, Chun yue Pirags, Valdis Rosenstock, Julio Spinas, Giatgen A. Sreenan, Seamus Syvänne, Mikko Yale, Jean Francois ORIGIN Trial Investigators |
| dc.subject.proposal.eng.fl_str_mv |
Cardiovascular Postintervention Insulin Glargine Omega-3 Fatty Acids |
| topic |
Cardiovascular Postintervention Insulin Glargine Omega-3 Fatty Acids |
| description |
8 p. |
| publishDate |
2016 |
| dc.date.issued.spa.fl_str_mv |
2016-05 |
| dc.date.accessioned.spa.fl_str_mv |
2019-07-30T13:29:39Z |
| dc.date.available.spa.fl_str_mv |
2019-07-30T13:29:39Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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10.2337/dc15-1676/-/DC1. |
| dc.identifier.isbn.spa.fl_str_mv |
0149-5992 |
| dc.identifier.issn.spa.fl_str_mv |
1935-5548 |
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https://repositorio.udes.edu.co/handle/001/3487 |
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10.2337/dc15-1676/-/DC1. 0149-5992 1935-5548 |
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https://repositorio.udes.edu.co/handle/001/3487 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
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Diabetes Care |
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Derechos Reservados - Diabetes Care, 2016 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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https://care.diabetesjournals.org/content/diacare/39/5/709.full.pdf |
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Punthakee, Zubin957d684a-ab5f-414d-aa8d-a12f3d37bc26-1Gerstein, Hertzel C.8dbb4c88-f0dd-45f2-8bc4-590f0a1e3c3c-1Bosch Pagans, Jordi5b22748d-fe43-4715-bae5-3c56327798c4-1Tyrwhitt, Jessica14c17e69-9ac3-4ebb-b512-5da039244643-1Jung, Hyejung50f4ceae-59e5-4f12-9788-b713f56de3be-1Lee, Shun Fu4581e29f-0fc3-4c3c-a05a-0d0c2133eb61-1Lonn, Eva7a977a4b-14e3-44cc-8057-933d424aaa9b-1Marsden, Tamarab3769f5c-3b75-4827-9adb-f321b65211f6-1McKelvie, Robertb7cfc72e-3a56-4797-8848-d0db71a3ef50-1McQueen, Matthew J.be481328-a518-4786-a3d6-1e8bb68f1f3c-1Morillo, Carlose30cc216-ee70-4368-bf91-5029ab76f944-1Yusuf, Shazziddd288a7d-55b6-4ec2-b404-e92a485bb078-1Dagenais, Gillesc865f015-4dc7-483d-9dae-132288d901f8-1Diaz, Rafaelf2be4a74-501a-4e63-8bbd-965cbcf8c57b-1Maggioni, Aldo P.cffeb2b7-a22b-437a-9feb-8971ddf92836-1Probstfield, Jeffreycce7af47-ba6b-4280-bbb5-4c0a46da5d7d-1Ramachandran, Ambadybd1081ee-c7d7-4f1c-8612-4992d47691fd-1Riddle, Matthew C.d5c956b6-8f40-43ca-83bc-4b130c672a99-1Rydén, Larsfbe7a352-5488-4e8a-866d-b966ed6789b4-1Badings, Erik186d6bc4-66e1-43d8-8c02-5ff2d866f22a-1Birkeland, Kare89b281d3-5c22-4dcc-8671-a5ca2e05c758-1Cardona Munoz, Ernesto G.594c0ff9-eb7f-4a00-a127-97169b1f7317-1Commerford, Patrickba2d7957-8631-40da-b896-637147eaa6e0-1Davies, Melanieaf6caeb6-a747-46bd-9097-993c73c8bcde-1Fodor, George J.4e2c9e54-7090-4288-8ae6-eec3df4c7d30-1Gomis, Ramon63101e36-40fd-4c6e-b2a4-c5632d47803a-1Hanefeld, Markolf411c9d9d-d3a2-4a87-b8e7-dbd8bc7c968e-1Hildebrandt, Perd6637f0e-707c-4c00-9be8-7ea59d565837-1Kacerovsky Bielesz, Gertrudc84bdf98-d6a5-4bdf-afef-30e25b27421d-1Keltai, Matyas65c5da4f-dca6-4e4f-aa9e-6c2ff81f2df9-1Lanas, Fernandod22b7fe4-9f1f-4028-a22b-be782ef03d3c-1Lewis, Basil S.a8106b8e-2b4b-412e-90c7-4012b1272405-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Marin Neto, Jose Antonio644f731e-2ee3-46f6-b0f3-07ba35add8cf-1Marre, Michelcde2fc77-4887-46eb-98ba-75c8c7a08986-1Mendoza, Ivanaeb3d421-e5af-42af-87c2-a9eebdc98dc9-1Pan, Chun yue99620023-4372-4275-8c18-790240945b2a-1Pirags, Valdisc43a25fe-51ee-4b71-863e-54b03868e125-1Rosenstock, Julio264f101a-31d5-4fab-8233-48aea34d021c-1Spinas, Giatgen A.7be9db73-7a11-439a-b483-3bb6cb579fbd-1Sreenan, Seamus38470fad-68ae-47ad-9f38-bbad2563892c-1Syvänne, Mikkoba4f2117-a342-4be3-bf26-68559243d12b-1Yale, Jean Francois0a4ba036-1a50-48b2-9de8-fdd4a86a06df-1ORIGIN Trial Investigators44c35632-b7e3-4e26-978f-e2c2ef588291-12019-07-30T13:29:39Z2019-07-30T13:29:39Z2016-058 p.OBJECTIVE The Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial reported neutral effects of insulin glargine on cardiovascular outcomes and cancers and reduced incident diabetes in high–cardiovascular risk adults with dysglycemia after 6.2 years of active treatment. Omega-3 fatty acids had neutral effects on cardiovascular outcomes. The ORIGIN and Legacy Effects (ORIGINALE) study measured posttrial effects of these interventions during an additional 2.7 years. RESEARCH DESIGN AND METHODS Surviving ORIGIN participants attended up to two additional visits. The hazard of clinical outcomes during the entire follow-up period from randomization was calculated. RESULTS Of 12,537 participants randomized, posttrial data were analyzed for 4,718 originally allocated to insulin glargine (2,351) versus standard care (2,367), and 4,771 originally allocated to omega-3 fatty acid supplements (2,368) versus placebo (2,403). Posttrial, small differences in median HbA1c persisted (glargine 6.6% [49 mmol/mol], standard care 6.7% [50 mmol/mol], P = 0.025). From randomization to the end of posttrial follow-up, no differences were found between the glargine and standard care groups in myocardial infarction, stroke, or cardiovascular death (1,185 vs. 1,165 events; hazard ratio 1.01 [95% CI 0.94–1.10]; P = 0.72); myocardial infarction, stroke, cardiovascular death, revascularization, or hospitalization for heart failure (1,958 vs. 1,910 events; 1.03 [0.97–1.10]; P = 0.38); or any cancer (524 vs. 529 events; 0.99 [0.88–1.12]; P = 0.91) or between omega-3 and placebo groups in cardiovascular death (688 vs. 700; 0.98 [0.88–1.09]; P = 0.68) or other outcomes. CONCLUSIONS During >6 years of treatment followed by >2.5 years of observation, insulin glargine had neutral effects on health outcomes and salutary effects on metabolic control, whereas omega-3 fatty acid supplementation had no effect.application/pdf10.2337/dc15-1676/-/DC1.0149-59921935-5548https://repositorio.udes.edu.co/handle/001/3487engDiabetes CareDerechos Reservados - Diabetes Care, 2016info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://care.diabetesjournals.org/content/diacare/39/5/709.full.pdfCardiovascularPostinterventionInsulin GlargineOmega-3Fatty AcidsCardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE)Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILCardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE).pdf.jpgCardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE).pdf.jpgGenerated Thumbnailimage/jpeg1733https://repositorio.udes.edu.co/bitstreams/430e565a-77a9-4d88-a61e-54840083f98a/download5bda9a0a9941ff62720ebb4ff89e1cc2MD54TEXTCardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE).pdf.txtCardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE).pdf.txtExtracted texttext/plain43697https://repositorio.udes.edu.co/bitstreams/7458c902-65da-48e8-b77f-a546686a0de4/download2f44a8b119d51a0aad540352069bba25MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/9e216da5-bf9c-4f21-801f-90f5290a6a03/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALCardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE).pdfCardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE).pdfapplication/pdf265996https://repositorio.udes.edu.co/bitstreams/563a9758-8f57-4aa6-b081-2a2be5b50719/downloadf534853675942cd1039afdba49d594f2MD55001/3487oai:repositorio.udes.edu.co:001/34872023-10-10 08:50:37.071https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Diabetes Care, 2016https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |