Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols
17 p.
- Autores:
-
Martínez Vega, Ruth Aralí
Reveiz, Ludovic
Haby, Michelle M.
Pinzón Flores, Carlos E.
Elias, Vanessa
Smith, Emma
Pinart, Mariona
Broutet, Nathalie
Becerra Posada, Francisco
Aldighieri, Sylvain
Van Kerkhove, Maria D.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3202
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3202
- Palabra clave:
- Zika
Virus
Infection
Risk
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Santander, 2017
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Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols |
| title |
Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols |
| spellingShingle |
Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols Zika Virus Infection Risk |
| title_short |
Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols |
| title_full |
Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols |
| title_fullStr |
Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols |
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Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols |
| title_sort |
Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols |
| dc.creator.fl_str_mv |
Martínez Vega, Ruth Aralí Reveiz, Ludovic Haby, Michelle M. Pinzón Flores, Carlos E. Elias, Vanessa Smith, Emma Pinart, Mariona Broutet, Nathalie Becerra Posada, Francisco Aldighieri, Sylvain Van Kerkhove, Maria D. |
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Martínez Vega, Ruth Aralí Reveiz, Ludovic Haby, Michelle M. Pinzón Flores, Carlos E. Elias, Vanessa Smith, Emma Pinart, Mariona Broutet, Nathalie Becerra Posada, Francisco Aldighieri, Sylvain Van Kerkhove, Maria D. |
| dc.subject.proposal.eng.fl_str_mv |
Zika Virus Infection Risk |
| topic |
Zika Virus Infection Risk |
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17 p. |
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2017 |
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2017-07-07 |
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2019-06-25T16:32:20Z |
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10.1371/journal.pone.0180220 |
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1932-6203 |
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https://repositorio.udes.edu.co/handle/001/3202 |
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10.1371/journal.pone.0180220 1932-6203 |
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eng |
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eng |
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Plos One |
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Derechos Reservados - Universidad de Santander, 2017 |
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Martínez Vega, Ruth Aralíaa92e0da-392f-46fd-886f-d56d43b46865-1Reveiz, Ludovicb24f1b18-106f-44cb-9c82-93c36b8a91c0-1Haby, Michelle M.f9dcb866-39d8-47d5-9ca5-9516cf5567ce-1Pinzón Flores, Carlos E.7d2d0a1c-7ef9-47e8-9a98-28fed0be84a3-1Elias, Vanessa58f8ba57-9007-49b9-89e8-9b696ff5f13c-1Smith, Emmada4410ad-e97d-4acb-bc2c-b2c7dc777633-1Pinart, Marionaf19c3b8c-6300-4ee2-8277-c0bb92178672-1Broutet, Nathalie0eda9149-c71d-423f-a4ff-455a87366fac-1Becerra Posada, Francisco474a7e3f-2cfd-4537-837e-7f3d7f10bb98-1Aldighieri, Sylvaina148ba23-cd33-4406-a8e9-1d17143c63cb-1Van Kerkhove, Maria D.9c6cc044-e0f0-4a79-b9a8-fe5f7fe34227-12019-06-25T16:32:20Z2019-06-25T16:32:20Z2017-07-0717 p.Given the severity and impact of the current Zika virus (ZIKV) outbreak in the Americas, numerous countries have rushed to develop research studies to assess ZIKV and its potential health consequences. In an effort to ensure that studies are comprehensive, both internally and externally valid, and with reliable results, the World Health Organization, the Pan American Health Organization, Institut Pasteur, the networks of Fiocruz, the Consortia for the Standardization of Influenza Seroepidemiology (CONSISE) and the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) have generated six standardized clinical and epidemiological research protocols and questionnaires to address key public health questions on ZIKV. Methods We conducted a systematic search of ongoing study protocols related to ZIKV research. We analyzed the content of protocols of 32 cohort studies and 13 case control studies for systematic bias that could produce erroneous results. Additionally we aimed to characterize the risks of bias and confounding in observational studies related to ZIKV and to propose ways to minimize them, including the use of six newly standardized research protocols. Results Observational studies of ZIKV face an array of challenges, including measurement of exposure and outcomes (microcephaly and Guillain-Barre´ Syndrome). Potential confounders need to be measured where known and controlled for in the analysis. Selection bias due tonon-random selection is a significant issue, particularly in the case-control design, and losses to follow-up is equally important for the cohort design. Conclusion Observational research seeking to answer key questions on the ZIKV should consider these restrictions and take precautions to minimize bias in an effort to provide reliable and valid results. Utilization of the standardized research protocols developed by the WHO, PAHO, Institut Pasteur, and CONSISE will harmonize the key methodological aspects of each study design to minimize bias at different stages of the study. Biases need to be considered by researchers implementing the standardized protocols as well as by users of observational epidemiological studies of ZIKV.application/pdf10.1371/journal.pone.01802201932-6203https://repositorio.udes.edu.co/handle/001/3202engPlos OneDerechos Reservados - Universidad de Santander, 2017info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180220&type=printableZikaVirusInfectionRiskRisk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocolsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILRisk of bias and confounding of observational studies of Zika virus infection. 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