Polypill with or without aspirin in persons without cardiovascular disease
Digital
- Autores:
-
Yusuf, Salim
Joseph, Philip
Dans, Antonio
Gao, Peggy
Teo, Koon
Xavier, Denis
Lopez-Jaramillo, Patricio
Yusoff, Khalid
Santoso, Anwar
Gamra, Habib
Talukder, Shamim
Christou, Courtney
Girish, Preeti
Yeates, Karen
Xavier, Freeda
Dagenais, Gilles
Rocha, Catalina
McCready, Tara
Tyrwhitt, Jessica
Bosch, Jackie
Pais, Prem
The International Polycap Study 3 Investigators
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/6139
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/6139
- Palabra clave:
- Rights
- openAccess
- License
- Copyright © 2020 The Authors, Massachusetts Medical Society.
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Polypill with or without aspirin in persons without cardiovascular disease |
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Polypill with or without aspirin in persons without cardiovascular disease |
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Polypill with or without aspirin in persons without cardiovascular disease |
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Polypill with or without aspirin in persons without cardiovascular disease |
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Polypill with or without aspirin in persons without cardiovascular disease |
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Polypill with or without aspirin in persons without cardiovascular disease |
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Polypill with or without aspirin in persons without cardiovascular disease |
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Polypill with or without aspirin in persons without cardiovascular disease |
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Yusuf, Salim Joseph, Philip Dans, Antonio Gao, Peggy Teo, Koon Xavier, Denis Lopez-Jaramillo, Patricio Yusoff, Khalid Santoso, Anwar Gamra, Habib Talukder, Shamim Christou, Courtney Girish, Preeti Yeates, Karen Xavier, Freeda Dagenais, Gilles Rocha, Catalina McCready, Tara Tyrwhitt, Jessica Bosch, Jackie Pais, Prem The International Polycap Study 3 Investigators |
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Yusuf, Salim Joseph, Philip Dans, Antonio Gao, Peggy Teo, Koon Xavier, Denis Lopez-Jaramillo, Patricio Yusoff, Khalid Santoso, Anwar Gamra, Habib Talukder, Shamim Christou, Courtney Girish, Preeti Yeates, Karen Xavier, Freeda Dagenais, Gilles Rocha, Catalina McCready, Tara Tyrwhitt, Jessica Bosch, Jackie Pais, Prem The International Polycap Study 3 Investigators |
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Masira |
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Digital |
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2021 |
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2021-01-21 |
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2022-02-23T22:25:36Z |
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2022-02-23T22:25:36Z |
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10.1056/NEJMoa2028220 |
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https://repositorio.udes.edu.co/handle/001/6139 |
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10.1056/NEJMoa2028220 |
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eng |
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eng |
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384 |
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Scopus |
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The New England Journal of Medicine |
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Copyright © 2020 The Authors, Massachusetts Medical Society. |
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Copyright © 2020 The Authors, Massachusetts Medical Society. Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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13 p |
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application/pdf |
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The New England Journal of Medicine |
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USA |
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https://www.nejm.org/doi/10.1056/NEJMoa2028220 |
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Yusuf, Salim06a836b5-f5e3-41d9-a516-9cc46e5d7948-1Joseph, Philip35ddb523-bb0e-4c55-9a59-b24968824fbf-1Dans, Antoniof365ef5a-7610-4022-8485-31d6d3879cd6-1Gao, Peggy46954da1-6290-4040-9c8c-33dcfaf225dd-1Teo, Koon60475883-56ab-4acc-833d-b027ad828534-1Xavier, Denis88c9cf48-fa3b-45c6-be03-2cc79e59289d-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Yusoff, Khalid933db13d-f5bb-4ea6-91a5-68eea1ca9ffc-1Santoso, Anwar81602b58-844e-47fc-90c0-f5131cf6fa7d-1Gamra, Habib1b3172ed-091a-41ca-bfb4-fb5570f87f4e-1Talukder, Shamimb8ece34e-a3bf-49b4-b8d6-f1bccfa5ad07-1Christou, Courtney44a43e74-0ff8-49d5-9805-2473c4f51be1-1Girish, Preeti0696d8f7-f20d-4ab5-bc9d-19afda02da10-1Yeates, Karen79418492-ec06-4cc6-831a-4bf5b245b584-1Xavier, Freedadbb85690-3453-47d8-abdf-240ebb4bf9a5-1Dagenais, Gillesc865f015-4dc7-483d-9dae-132288d901f8-1Rocha, Catalinaf4655f35-4905-4403-ab00-f8022153a1cf-1McCready, Tara2e01aadd-bde9-4281-96ec-00e0c64a8a5d-1Tyrwhitt, Jessica14c17e69-9ac3-4ebb-b512-5da039244643-1Bosch, Jackie503f2202-0dda-463c-acc9-f5888e895278-1Pais, Prem5abdbf77-3c3f-4396-8634-83723aa215b9-1The International Polycap Study 3 Investigators132ef9b1-dfc4-4fae-a678-6b89fdaa405b-1Masira2022-02-23T22:25:36Z2022-02-23T22:25:36Z2021-01-21DigitalBACKGROUND A polypill comprising statins, multiple blood-pressure–lowering drugs, and aspirin has been proposed to reduce the risk of cardiovascular disease. METHODS Using a 2-by-2-by-2 factorial design, we randomly assigned participants without cardiovascular disease who had an elevated INTERHEART Risk Score to receive a polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or placebo daily, aspirin (75 mg) or placebo daily, and vitamin D or placebo monthly. We report here the outcomes for the polypill alone as compared with matching placebo, for aspirin alone as compared with matching placebo, and for the polypill plus aspirin as compared with double placebo. For the polypill-alone and polypill-plus-aspirin comparisons, the primary outcome was death from cardiovascular causes, myocardial infarction, stroke, resuscitated cardiac arrest, heart failure, or revascularization. For the aspirin comparison, the primary outcome was death from cardiovascular causes, myocardial infarction, or stroke. Safety was also assessed. RESULTS A total of 5713 participants underwent randomization, and the mean follow-up was 4.6 years. The low-density lipoprotein cholesterol level was lower by approximately 19 mg per deciliter and systolic blood pressure was lower by approximately 5.8 mm Hg with the polypill and with combination therapy than with placebo. The primary outcome for the polypill comparison occurred in 126 participants (4.4%) in the polypill group and in 157 (5.5%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.63 to 1.00). The primary outcome for the aspirin comparison occurred in 116 participants (4.1%) in the aspirin group and in 134 (4.7%) in the placebo group (hazard ratio, 0.86; 95% CI, 0.67 to 1.10). The primary outcome for the polypill-plus-aspirin comparison occurred in 59 participants (4.1%) in the combined-treatment group and in 83 (5.8%) in the double-placebo group (hazard ratio, 0.69; 95% CI, 0.50 to 0.97). The incidence of hypotension or dizziness was higher in groups that received the polypill than in their respective placebo groups. CONCLUSIONS Combined treatment with a polypill plus aspirin led to a lower incidence of cardiovascular events than did placebo among participants without cardiovascular disease who were at intermediate cardiovascular risk. (Funded by the Wellcome Trust and others; TIPS-3 ClinicalTrials.gov number, NCT01646437. opens in new tab.)Ciencias Médicas y de la Salud13 papplication/pdf10.1056/NEJMoa2028220https://repositorio.udes.edu.co/handle/001/6139engThe New England Journal of MedicineUSA2283216384ScopusThe New England Journal of MedicineCopyright © 2020 The Authors, Massachusetts Medical Society.info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.nejm.org/doi/10.1056/NEJMoa2028220Polypill with or without aspirin in persons without cardiovascular diseaseArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALPolypill with or without aspirin in persons without cardiovascular disease.pdfPolypill with or without aspirin in persons without cardiovascular disease.pdfapplication/pdf228980https://repositorio.udes.edu.co/bitstreams/2b7e13df-cdf5-44b9-b5da-370c752b40a5/downloade2eedb09b05cf58c1fb1c0df14984173MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/2ce507ff-6725-4ab9-9811-bfd14709f5a8/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTPolypill with or without aspirin in persons without cardiovascular disease.pdf.txtPolypill with or without aspirin in persons without cardiovascular disease.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/88b1417b-4716-40fe-81ef-8c3717a6c7bf/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILPolypill with or without aspirin in persons without cardiovascular disease.pdf.jpgPolypill with or without aspirin in persons without cardiovascular disease.pdf.jpgGenerated Thumbnailimage/jpeg10618https://repositorio.udes.edu.co/bitstreams/64b13d73-e462-4e65-aba7-88f4a6b5b289/downloadac5ca10240f96f3292cde9df394a9760MD54001/6139oai:repositorio.udes.edu.co:001/61392023-10-09 18:04:57.954https://creativecommons.org/licenses/by-nc/4.0/Copyright © 2020 The Authors, Massachusetts Medical Society.https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |