Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants
Digital
- Autores:
-
Bosch, Jackie
Lonn, Eva M.
Jung, Hyejung
Zhu, Jun
Liu, Lisheng
Lopez-Jaramillo, Patricio
Pais, Prem
Xavier, Denis
Diaz, Rafael
Dagenais, Gilles
Dans, Antonio
Avezum, Alvaro
Piegas, Leopoldo S.
Parkhomenko, Alexander
Keltai, Kati
Keltai, Matya
Sliwa, Karen
Held, Claus
Peters, Ronald J.G.
Lewis, Basil S.
Jansky, Petr
Yusoff, Khalid
Khunti, Kamlesh
Toff, William D.
Reid, Christopher M.
Varigos, John
Joseph, Philip
Leiter, Lawrence A.
Yusuf, Salim
The Heart Outcomes Prevention Evaluation (HOPE)-3 Investigators
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/6117
- Acceso en línea:
- https://doi.org/10.1093/eurheartj/ehab225
https://repositorio.udes.edu.co/handle/001/6117
- Palabra clave:
- Primary prevention
Cardiovascular disease
Statins
- Rights
- openAccess
- License
- Copyright © 2021, The Authors, Oxford University Press
| id |
RUDES2_67a5741e4416657bb873c40be0711c25 |
|---|---|
| oai_identifier_str |
oai:repositorio.udes.edu.co:001/6117 |
| network_acronym_str |
RUDES2 |
| network_name_str |
Repositorio Universidad de Santander |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants |
| title |
Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants |
| spellingShingle |
Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants Primary prevention Cardiovascular disease Statins |
| title_short |
Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants |
| title_full |
Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants |
| title_fullStr |
Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants |
| title_full_unstemmed |
Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants |
| title_sort |
Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants |
| dc.creator.fl_str_mv |
Bosch, Jackie Lonn, Eva M. Jung, Hyejung Zhu, Jun Liu, Lisheng Lopez-Jaramillo, Patricio Pais, Prem Xavier, Denis Diaz, Rafael Dagenais, Gilles Dans, Antonio Avezum, Alvaro Piegas, Leopoldo S. Parkhomenko, Alexander Keltai, Kati Keltai, Matya Sliwa, Karen Held, Claus Peters, Ronald J.G. Lewis, Basil S. Jansky, Petr Yusoff, Khalid Khunti, Kamlesh Toff, William D. Reid, Christopher M. Varigos, John Joseph, Philip Leiter, Lawrence A. Yusuf, Salim The Heart Outcomes Prevention Evaluation (HOPE)-3 Investigators |
| dc.contributor.author.none.fl_str_mv |
Bosch, Jackie Lonn, Eva M. Jung, Hyejung Zhu, Jun Liu, Lisheng Lopez-Jaramillo, Patricio Pais, Prem Xavier, Denis Diaz, Rafael Dagenais, Gilles Dans, Antonio Avezum, Alvaro Piegas, Leopoldo S. Parkhomenko, Alexander Keltai, Kati Keltai, Matya Sliwa, Karen Held, Claus Peters, Ronald J.G. Lewis, Basil S. Jansky, Petr Yusoff, Khalid Khunti, Kamlesh Toff, William D. Reid, Christopher M. Varigos, John Joseph, Philip Leiter, Lawrence A. Yusuf, Salim The Heart Outcomes Prevention Evaluation (HOPE)-3 Investigators |
| dc.contributor.researchgroup.spa.fl_str_mv |
Masira |
| dc.subject.proposal.eng.fl_str_mv |
Primary prevention Cardiovascular disease Statins |
| topic |
Primary prevention Cardiovascular disease Statins |
| description |
Digital |
| publishDate |
2021 |
| dc.date.issued.none.fl_str_mv |
2021-08-14 |
| dc.date.accessioned.none.fl_str_mv |
2022-02-23T13:35:46Z |
| dc.date.available.none.fl_str_mv |
2022-02-23T13:35:46Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
http://purl.org/coar/resource_type/c_6501 |
| status_str |
publishedVersion |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1093/eurheartj/ehab225 |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.udes.edu.co/handle/001/6117 |
| url |
https://doi.org/10.1093/eurheartj/ehab225 https://repositorio.udes.edu.co/handle/001/6117 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationendpage.spa.fl_str_mv |
3007 |
| dc.relation.citationissue.spa.fl_str_mv |
31 |
| dc.relation.citationstartpage.spa.fl_str_mv |
2995 |
| dc.relation.citationvolume.spa.fl_str_mv |
42 |
| dc.relation.cites.none.fl_str_mv |
Jackie Bosch, Eva M Lonn, Hyejung Jung, Jun Zhu, Lisheng Liu, Patricio Lopez-Jaramillo, Prem Pais, Denis Xavier, Rafael Diaz, Gilles Dagenais, Antonio Dans, Alvaro Avezum, Leopoldo S Piegas, Alexander Parkhomenko, Kati Keltai, Matyas Keltai, Karen Sliwa, Claus Held, Ronald J G Peters, Basil S Lewis, Petr Jansky, Khalid Yusoff, Kamlesh Khunti, William D Toff, Christopher M Reid, John Varigos, Philip Joseph, Lawrence A Leiter, Salim Yusuf, the Heart Outcomes Prevention Evaluation (HOPE)-3 Investigators, Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants, European Heart Journal, Volume 42, Issue 31, 14 August 2021, Pages 2995–3007, https://doi.org/10.1093/eurheartj/ehab225 |
| dc.relation.indexed.spa.fl_str_mv |
Scopus |
| dc.relation.ispartofjournal.spa.fl_str_mv |
European Heart Journal |
| dc.rights.spa.fl_str_mv |
Copyright © 2021, The Authors, Oxford University Press |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.creativecommons.spa.fl_str_mv |
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0/ |
| rights_invalid_str_mv |
Copyright © 2021, The Authors, Oxford University Press Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
14 p |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Oxford Academic |
| dc.publisher.place.spa.fl_str_mv |
Reino Unido |
| dc.source.spa.fl_str_mv |
https://academic.oup.com/eurheartj/article/42/31/2995/6272124?login=true |
| institution |
Universidad de Santander |
| bitstream.url.fl_str_mv |
https://repositorio.udes.edu.co/bitstreams/0bd21291-386b-4b1f-90bb-6983e9655adb/download https://repositorio.udes.edu.co/bitstreams/06dc2595-2543-4f4d-8775-e5fb5d11c4c9/download https://repositorio.udes.edu.co/bitstreams/4bea7e47-bef6-43a2-a278-3f3d73d7cee2/download https://repositorio.udes.edu.co/bitstreams/630f918d-6aef-4b06-ab07-facf376aa488/download |
| bitstream.checksum.fl_str_mv |
20f46775ecb6480fde7a43788e4b71ee 38d94cf55aa1bf2dac1a736ac45c881c 5dbe86c1111d64f45ba435df98fdc825 c207c531b4ed5478aa92a4e2d59adfd5 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Universidad de Santander |
| repository.mail.fl_str_mv |
soporte@metabiblioteca.com |
| _version_ |
1818101393254252544 |
| spelling |
Bosch, Jackie503f2202-0dda-463c-acc9-f5888e895278-1Lonn, Eva M.3556c9df-ffc4-46be-a381-8a85392cfeec-1Jung, Hyejung50f4ceae-59e5-4f12-9788-b713f56de3be-1Zhu, Jund97cdbd2-6a82-430c-abfe-c978f085997e-1Liu, Lishenga14adafe-ef37-42b0-8f5b-0de4ea71b0fc-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Pais, Prem5abdbf77-3c3f-4396-8634-83723aa215b9-1Xavier, Denis88c9cf48-fa3b-45c6-be03-2cc79e59289d-1Diaz, Rafaelf2be4a74-501a-4e63-8bbd-965cbcf8c57b-1Dagenais, Gillesc865f015-4dc7-483d-9dae-132288d901f8-1Dans, Antoniof365ef5a-7610-4022-8485-31d6d3879cd6-1Avezum, Alvaro8b920360-abb2-4ec8-b5ee-4e3f4e0b11eb-1Piegas, Leopoldo S.0f1da4dd-76bd-4381-87fa-1e01066eee6f-1Parkhomenko, Alexander11fab1ea-f0f6-47e0-97e9-36e372b7e2f9-1Keltai, Katia010286e-4eb6-4124-9605-a81ab11cf9d6-1Keltai, Matyac0cce8ce-d307-42ab-82f2-4ca7988d6936-1Sliwa, Karen7ff2b80f-9412-4d65-99cd-7d01d5578687-1Held, Clausa7c8ac51-7a26-49e5-b15b-e36f8020b503-1Peters, Ronald J.G.f0a1184b-8f28-478f-bf4f-130dea532e33-1Lewis, Basil S.a8106b8e-2b4b-412e-90c7-4012b1272405-1Jansky, Petrbf8ec62a-6edc-439c-a698-2e4fa4172f04-1Yusoff, Khalid933db13d-f5bb-4ea6-91a5-68eea1ca9ffc-1Khunti, Kamleshe9aff03a-6f97-433d-a56e-8d7f703caa03-1Toff, William D.97acb6df-c33b-45ad-b772-c52ac4aa7281-1Reid, Christopher M.7d8a8211-12ad-464c-948d-16952b66144d-1Varigos, Johnedec3b03-87c5-454c-aec5-b2c04c91a9d9-1Joseph, Philip35ddb523-bb0e-4c55-9a59-b24968824fbf-1Leiter, Lawrence A.bcdd3211-40b7-474d-9f6c-8a1051ceb9bf-1Yusuf, Salim06a836b5-f5e3-41d9-a516-9cc46e5d7948-1The Heart Outcomes Prevention Evaluation (HOPE)-3 Investigators17c19761-c6a6-4d56-9fcf-f312996c8b4e-1Masira2022-02-23T13:35:46Z2022-02-23T13:35:46Z2021-08-14DigitalAims. Rosuvastatin (10 mg per day) compared with placebo reduced major adverse cardiovascular (CV) events by 24% in 12 705 participants at intermediate CV risk after 5.6 years. There was no benefit of blood pressure (BP) lowering treatment in the overall group, but a reduction in events in the third of participants with elevated systolic BP. After cessation of all the trial medications, we examined whether the benefits observed during the active treatment phase were sustained, enhanced, or attenuated. Methods and results. After the randomized treatment period (5.6 years), participants were invited to participate in 3.1 further years of observation (total 8.7 years). The first co-primary outcome for the entire length of follow-up was the composite of myocardial infarction, stroke, or CV death [major adverse cardiovascular event (MACE)-1], and the second was MACE-1 plus resuscitated cardiac arrest, heart failure, or coronary revascularization (MACE-2). In total, 9326 (78%) of 11 994 surviving Heart Outcomes Prevention Evaluation (HOPE)-3 subjects consented to participate in extended follow-up. During 3.1 years of post-trial observation (total follow-up of 8.7 years), participants originally randomized to rosuvastatin compared with placebo had a 20% additional reduction in MACE-1 [95% confidence interval (CI), 0.64–0.99] and a 17% additional reduction in MACE-2 (95% CI 0.68–1.01). Therefore, over the 8.7 years of follow-up, there was a 21% reduction in MACE-1 (95% CI 0.69–0.90, P = 0.005) and 21% reduction in MACE-2 (95% CI 0.69–0.89, P = 0.002). There was no benefit of BP lowering in the overall study either during the active or post-trial observation period, however, a 24% reduction in MACE-1 was observed over 8.7 years. Conclusion. The CV benefits of rosuvastatin, and BP lowering in those with elevated systolic BP, compared with placebo continue to accrue for at least 3 years after cessation of randomized treatment in individuals without cardiovascular disease indicating a legacy effectCiencias Médicas y de la Educación14 papplication/pdfhttps://doi.org/10.1093/eurheartj/ehab225https://repositorio.udes.edu.co/handle/001/6117engOxford AcademicReino Unido300731299542Jackie Bosch, Eva M Lonn, Hyejung Jung, Jun Zhu, Lisheng Liu, Patricio Lopez-Jaramillo, Prem Pais, Denis Xavier, Rafael Diaz, Gilles Dagenais, Antonio Dans, Alvaro Avezum, Leopoldo S Piegas, Alexander Parkhomenko, Kati Keltai, Matyas Keltai, Karen Sliwa, Claus Held, Ronald J G Peters, Basil S Lewis, Petr Jansky, Khalid Yusoff, Kamlesh Khunti, William D Toff, Christopher M Reid, John Varigos, Philip Joseph, Lawrence A Leiter, Salim Yusuf, the Heart Outcomes Prevention Evaluation (HOPE)-3 Investigators, Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants, European Heart Journal, Volume 42, Issue 31, 14 August 2021, Pages 2995–3007, https://doi.org/10.1093/eurheartj/ehab225ScopusEuropean Heart JournalCopyright © 2021, The Authors, Oxford University Pressinfo:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://academic.oup.com/eurheartj/article/42/31/2995/6272124?login=truePrimary preventionCardiovascular diseaseStatinsLowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participantsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALLowering cholesterol, blood pressure, or both to prevent cardiovascular events. Results of 8.pdfLowering cholesterol, blood pressure, or both to prevent cardiovascular events. Results of 8.pdfapplication/pdf250111https://repositorio.udes.edu.co/bitstreams/0bd21291-386b-4b1f-90bb-6983e9655adb/download20f46775ecb6480fde7a43788e4b71eeMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/06dc2595-2543-4f4d-8775-e5fb5d11c4c9/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTLowering cholesterol, blood pressure, or both to prevent cardiovascular events. Results of 8.pdf.txtLowering cholesterol, blood pressure, or both to prevent cardiovascular events. Results of 8.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/4bea7e47-bef6-43a2-a278-3f3d73d7cee2/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILLowering cholesterol, blood pressure, or both to prevent cardiovascular events. Results of 8.pdf.jpgLowering cholesterol, blood pressure, or both to prevent cardiovascular events. Results of 8.pdf.jpgGenerated Thumbnailimage/jpeg12849https://repositorio.udes.edu.co/bitstreams/630f918d-6aef-4b06-ab07-facf376aa488/downloadc207c531b4ed5478aa92a4e2d59adfd5MD54001/6117oai:repositorio.udes.edu.co:001/61172023-10-09 18:23:59.756https://creativecommons.org/licenses/by-nc/4.0/Copyright © 2021, The Authors, Oxford University Presshttps://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |