Scorpion Venom: New Promise in the Treatment of Cancer
Digital
- Autores:
-
Gómez Rave, Lyz Jenny
Muñoz Bravo, Adriana Ximena
Sierra-Castrillo, Jhoalmis
Román Marín, Laura-Melisa
Corredor Pereira, Carlos
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/5615
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/5615
- Palabra clave:
- Anti-infective agents
Antineoplastic agents
Arachnida
Molecular biology
Peptides
Anti-infecciosos
Agentes antineoplásicos
Arachnida
Biología molecular
Péptidos
- Rights
- openAccess
- License
- The Authors
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Scorpion Venom: New Promise in the Treatment of Cancer |
| dc.title.alternative.spa.fl_str_mv |
Veneno de Escorpión: Una Nueva Promesa en el Tratamiento del Cancer |
| title |
Scorpion Venom: New Promise in the Treatment of Cancer |
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Scorpion Venom: New Promise in the Treatment of Cancer Anti-infective agents Antineoplastic agents Arachnida Molecular biology Peptides Anti-infecciosos Agentes antineoplásicos Arachnida Biología molecular Péptidos |
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Scorpion Venom: New Promise in the Treatment of Cancer |
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Scorpion Venom: New Promise in the Treatment of Cancer |
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Scorpion Venom: New Promise in the Treatment of Cancer |
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Scorpion Venom: New Promise in the Treatment of Cancer |
| title_sort |
Scorpion Venom: New Promise in the Treatment of Cancer |
| dc.creator.fl_str_mv |
Gómez Rave, Lyz Jenny Muñoz Bravo, Adriana Ximena Sierra-Castrillo, Jhoalmis Román Marín, Laura-Melisa Corredor Pereira, Carlos |
| dc.contributor.author.none.fl_str_mv |
Gómez Rave, Lyz Jenny Muñoz Bravo, Adriana Ximena Sierra-Castrillo, Jhoalmis Román Marín, Laura-Melisa Corredor Pereira, Carlos |
| dc.contributor.editor.none.fl_str_mv |
Matta, Edna |
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Anti-infective agents Antineoplastic agents Arachnida Molecular biology Peptides |
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Anti-infective agents Antineoplastic agents Arachnida Molecular biology Peptides Anti-infecciosos Agentes antineoplásicos Arachnida Biología molecular Péptidos |
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Anti-infecciosos Agentes antineoplásicos Arachnida Biología molecular Péptidos |
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eng |
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Gómez LJ, Muñoz AX, Sierra J, Román LM, Corredor C. Scorpion Venom: New Promise in the Treatment of Cancer. Acta biol. Colomb. 2019;24(2):213-223. DOI: http://dx.doi.org/10.15446/abc.v24n2.71512 |
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Acta Biológica Colombiana, Mayo - Agosto 2019 |
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The Authors |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Facultad de Ciencias Departamento de Biología Sede Bogotá, Universidad nacional de Colombia |
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Bogotá, Colombia |
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Gómez Rave, Lyz Jenny65b72736-42e3-4a34-8092-027d28ade314-1Muñoz Bravo, Adriana Ximenaa2f2d086-76d1-4789-a323-75745bbdc49e-1Sierra-Castrillo, Jhoalmisebe89d7f-74cf-4e15-9037-694c1e61b2e8-1Román Marín, Laura-Melisad0aa187f-38c7-4ede-98d1-5d65f11136a7-1Corredor Pereira, Carloseee3a3a9-77b7-421f-b30d-3af22255d95b-1Matta, Edna2021-09-14T20:58:55Z2021-09-14T20:58:55Z2019-05-01DigitalCancer is a public health problem due to its high worldwide morbimortality. Current treatment protocols do not guarantee complete remission, which has prompted to search for new and more effective antitumoral compounds. Several substances exhibiting cytostatic and cytotoxic effects over cancer cells might contribute to the treatment of this pathology. Some studies indicate the presence of such substances in scorpion venom. In this review, we report characteristics of the principal scorpion venom components found in recent literature and their potential activity against tumor cells. There are different toxin groups present in the venom, and it seems that their mode of actions involves ionic channel blocking, disruption of the cell membrane integrity and damage to internal cell organelles. These properties make good prospects for studies on drugs and adjuvants in cancer treatment.El cáncer es un problema de salud pública debido a su alta morbimortalidad mundial. Los protocolos de tratamiento actuales no garantizan la remisión completa lo que ha llevado a buscar compuestos antitumorales más efectivos. Varias sustancias que exhiben efectos citostáticos y citotóxicos sobre células tumorales pueden contribuir al diagnóstico y tratamiento de esta patología. Algunos estudios indican la presencia de tales sustancias en el veneno de escorpión. En esta revisión, se dan a conocer las características de los principales componentes del veneno de escorpión encontrados en la literatura reciente y su actividad potencial contra las células tumorales. Existen diferentes grupos de toxinas presentes en el veneno y parece que su modo de acción implica el bloqueo del canal iónico, la alteración de la integridad de la membrana celular y el daño a los orgánulos celulares internos. Estas propiedades ofrecen buenas perspectivas para estudios sobre medicamentos y adyuvantes en el tratamiento del cáncer.1 ed.1 papplication/pdfDOI: http://dx.doi.org/10.15446/abc.v24n2.71512https://repositorio.udes.edu.co/handle/001/5615engFacultad de Ciencias Departamento de Biología Sede Bogotá, Universidad nacional de ColombiaBogotá, Colombia223221324Gómez LJ, Muñoz AX, Sierra J, Román LM, Corredor C. Scorpion Venom: New Promise in the Treatment of Cancer. Acta biol. Colomb. 2019;24(2):213-223. DOI: http://dx.doi.org/10.15446/abc.v24n2.71512Acta Biológica Colombiana, Mayo - Agosto 2019The Authorsinfo:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0120-548X2019000200213Anti-infective agentsAntineoplastic agentsArachnidaMolecular biologyPeptidesAnti-infecciososAgentes antineoplásicosArachnidaBiología molecularPéptidosScorpion Venom: New Promise in the Treatment of CancerVeneno de Escorpión: Una Nueva Promesa en el Tratamiento del CancerArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALScorpion_Venom_New_Promise_in_the_Treatment_of_Cancer.pdfScorpion_Venom_New_Promise_in_the_Treatment_of_Cancer.pdfapplication/pdf165090https://repositorio.udes.edu.co/bitstreams/4a752f6c-61e7-424e-a16d-b2da0dba81d8/download63f162e09f9c8584fc732e76d1485008MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/1b3b5416-734a-422f-bb31-9745c9162fc9/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTScorpion_Venom_New_Promise_in_the_Treatment_of_Cancer.pdf.txtScorpion_Venom_New_Promise_in_the_Treatment_of_Cancer.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/ac544502-b7d9-49c3-b8a0-2b02cff88937/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILScorpion_Venom_New_Promise_in_the_Treatment_of_Cancer.pdf.jpgScorpion_Venom_New_Promise_in_the_Treatment_of_Cancer.pdf.jpgGenerated Thumbnailimage/jpeg10867https://repositorio.udes.edu.co/bitstreams/1af924bc-d6ff-4805-9827-8ba4e3d5f60b/download06d702247b264623400fd8e012bf3ac0MD54001/5615oai:repositorio.udes.edu.co:001/56152023-10-09 10:16:26.872https://creativecommons.org/licenses/by-nc/4.0/The Authorshttps://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |