Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation
Digital
- Autores:
-
Sclocco, Roberta
Garcia, Ronald G.
Kettner, Norman W.
Fisher, Harrison P.
Isenburg, Kylie
Makarovsky, Maya
Stowell, Jessica A.
Goldstein, Jill
Barbieri, Riccardo
Napadow, Vitaly
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/6779
- Acceso en línea:
- https://doi.org/10.1016/j.brs.2020.03.011
https://repositorio.udes.edu.co/handle/001/6779
- Palabra clave:
- tVNS
Medulla
Locus Coeruleus
Raphe
fMRI
- Rights
- openAccess
- License
- © 2020 The Author(s). Published by Elsevier Inc.
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Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation |
| title |
Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation |
| spellingShingle |
Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation tVNS Medulla Locus Coeruleus Raphe fMRI |
| title_short |
Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation |
| title_full |
Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation |
| title_fullStr |
Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation |
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Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation |
| title_sort |
Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation |
| dc.creator.fl_str_mv |
Sclocco, Roberta Garcia, Ronald G. Kettner, Norman W. Fisher, Harrison P. Isenburg, Kylie Makarovsky, Maya Stowell, Jessica A. Goldstein, Jill Barbieri, Riccardo Napadow, Vitaly |
| dc.contributor.author.none.fl_str_mv |
Sclocco, Roberta Garcia, Ronald G. Kettner, Norman W. Fisher, Harrison P. Isenburg, Kylie Makarovsky, Maya Stowell, Jessica A. Goldstein, Jill Barbieri, Riccardo Napadow, Vitaly |
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Neurociencias |
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tVNS Medulla Locus Coeruleus Raphe fMRI |
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tVNS Medulla Locus Coeruleus Raphe fMRI |
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Digital |
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2020 |
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2020-03-27 |
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2022-05-11T17:53:12Z |
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2022-05-11T17:53:12Z |
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https://doi.org/10.1016/j.brs.2020.03.011 |
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1935-861X |
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https://repositorio.udes.edu.co/handle/001/6779 |
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https://doi.org/10.1016/j.brs.2020.03.011 https://repositorio.udes.edu.co/handle/001/6779 |
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1935-861X |
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eng |
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eng |
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Roberta Sclocco, Ronald G. Garcia, Norman W. Kettner, Harrison P. Fisher, Kylie Isenburg, Maya Makarovsky, Jessica A. Stowell, Jill Goldstein, Riccardo Barbieri, Vitaly Napadow, Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation, Brain Stimulation, Volume 13, Issue 4, 2020, Pages 970-978, ISSN 1935-861X, https://doi.org/10.1016/j.brs.2020.03.011. |
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Scopus |
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Brain Stimulation |
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© 2020 The Author(s). Published by Elsevier Inc. |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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9 p |
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Holanda |
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https://www.brainstimjrnl.com/article/S1935-861X(20)30064-4/pdf |
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Sclocco, Robertafe9d7fb4-a15a-4c07-8822-e36b0a28d4fc-1Garcia, Ronald G.d93fb222-20db-4a1c-bebb-2c309d2fa41a-1Kettner, Norman W.f86d9313-571e-44fe-b141-b1888b02aa80-1Fisher, Harrison P.a7337c0b-a193-4903-b7e2-9d475176ef59-1Isenburg, Kyliec642f90a-809c-454e-b8be-74638c6bc222-1Makarovsky, Maya3c3907fd-6c02-462e-96e0-e7f9dddb683e-1Stowell, Jessica A.1cac1fc7-c401-4a60-a4eb-2b131c66e3ed-1Goldstein, Jill9691ef7d-1d11-420a-8528-145ee9e99925-1Barbieri, Riccardo55ed48ad-21cc-4907-831a-b87ac479a69c-1Napadow, Vitalye2796f75-2336-48e3-94e5-3cab2fe51420-1Neurociencias2022-05-11T17:53:12Z2022-05-11T17:53:12Z2020-03-27DigitalBackground: The therapeutic potential of transcutaneous auricular VNS (taVNS) is currently being explored for numerous clinical applications. However, optimized response for different clinical indications may depend on specific neuromodulation parameters, and systematic assessments of their influence are still needed to optimize this promising approach. Hypothesis: We proposed that stimulation frequency would have a significant effect on nucleus tractus solitarii (NTS) functional MRI (fMRI) response to respiratory-gated taVNS (RAVANS). Methods: Brainstem fMRI response to auricular RAVANS (cymba conchae) was assessed for four different stimulation frequencies (2, 10, 25, 100 Hz). Sham (no current) stimulation was used to control for respiration effects on fMRI signal. Results: Our findings demonstrated that RAVANS delivered at 100 Hz evoked the strongest brainstem response, localized to a cluster in the left (ipsilateral) medulla and consistent with purported NTS. A colocalized, although weaker, response was found for 2 Hz RAVANS. Furthermore, RAVANS delivered at 100 Hz also evoked stronger fMRI responses for important monoamine neurotransmitter source nuclei (LC, noradrenergic; MR, DR, serotonergic) and pain/homeostatic regulation nuclei (i.e. PAG). Conclusion: Our fMRI results support previous localization of taVNS afference to pontomedullary aspect of NTS in the human brainstem, and demonstrate the significant influence of the stimulation frequency on brainstem fMRI response.Ciencias Médicas y de la Salud9 papplication/pdfhttps://doi.org/10.1016/j.brs.2020.03.0111935-861Xhttps://repositorio.udes.edu.co/handle/001/6779engHolanda97897013Roberta Sclocco, Ronald G. Garcia, Norman W. Kettner, Harrison P. Fisher, Kylie Isenburg, Maya Makarovsky, Jessica A. Stowell, Jill Goldstein, Riccardo Barbieri, Vitaly Napadow, Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation, Brain Stimulation, Volume 13, Issue 4, 2020, Pages 970-978, ISSN 1935-861X, https://doi.org/10.1016/j.brs.2020.03.011.ScopusBrain Stimulation© 2020 The Author(s). Published by Elsevier Inc.info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.brainstimjrnl.com/article/S1935-861X(20)30064-4/pdftVNSMedullaLocus CoeruleusRaphefMRIStimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulationArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALStimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation.pdfStimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation.pdfapplication/pdf230438https://repositorio.udes.edu.co/bitstreams/9fe1fe3f-8baf-4f8b-a1a2-6c1fcf34d6e7/download2723194afd358215a188cd392e1abee1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/e9304a18-a079-48fd-8670-4130c54ad314/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTStimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation.pdf.txtStimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/693f85db-27ab-4c5b-ac66-ff7f289a2ab1/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILStimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation.pdf.jpgStimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation.pdf.jpgGenerated Thumbnailimage/jpeg10916https://repositorio.udes.edu.co/bitstreams/3b126742-79ab-4679-b89a-e3ad8391f7ae/downloade371f07c6faed6ccdf83e771dfea792eMD54001/6779oai:repositorio.udes.edu.co:001/67792023-10-10 13:18:51.961https://creativecommons.org/licenses/by-nc/4.0/© 2020 The Author(s). 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