And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling
Digital
- Autores:
-
Berndt, Nicole
Bippes, Claudia C.
Michalk, Irene
Bartsch, Tabea
Arndt, Claudia
Puentes-Cala, Edinson
Soto, Javier-Andres
Loureiro, Liliana R.
Kegler, Alexandra
Bachmann, Dominik
Gross, Joanne K.
Gross, Tim
Kurien, Biji T.
Hal Scofield, R.
Darise Farris, A.
James, Judith A.
Bergmann, Ralf
Schmitz, Marc
Feldmann, Anja
Bachmann, Michael P.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/6154
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/6154
- Palabra clave:
- anti-La/SS-B antibodies
Autoimmunity
La/SS-B autoantigen
Systemic lupus erythematosus
Primary Sjögren’s Syndrome
Redox sensor
Shuttling of La protein
- Rights
- openAccess
- License
- Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
| id |
RUDES2_57a86dee72e09fbd438b1f6190134e4a |
|---|---|
| oai_identifier_str |
oai:repositorio.udes.edu.co:001/6154 |
| network_acronym_str |
RUDES2 |
| network_name_str |
Repositorio Universidad de Santander |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling |
| title |
And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling |
| spellingShingle |
And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling anti-La/SS-B antibodies Autoimmunity La/SS-B autoantigen Systemic lupus erythematosus Primary Sjögren’s Syndrome Redox sensor Shuttling of La protein |
| title_short |
And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling |
| title_full |
And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling |
| title_fullStr |
And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling |
| title_full_unstemmed |
And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling |
| title_sort |
And yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttling |
| dc.creator.fl_str_mv |
Berndt, Nicole Bippes, Claudia C. Michalk, Irene Bartsch, Tabea Arndt, Claudia Puentes-Cala, Edinson Soto, Javier-Andres Loureiro, Liliana R. Kegler, Alexandra Bachmann, Dominik Gross, Joanne K. Gross, Tim Kurien, Biji T. Hal Scofield, R. Darise Farris, A. James, Judith A. Bergmann, Ralf Schmitz, Marc Feldmann, Anja Bachmann, Michael P. |
| dc.contributor.author.none.fl_str_mv |
Berndt, Nicole Bippes, Claudia C. Michalk, Irene Bartsch, Tabea Arndt, Claudia Puentes-Cala, Edinson Soto, Javier-Andres Loureiro, Liliana R. Kegler, Alexandra Bachmann, Dominik Gross, Joanne K. Gross, Tim Kurien, Biji T. Hal Scofield, R. Darise Farris, A. James, Judith A. Bergmann, Ralf Schmitz, Marc Feldmann, Anja Bachmann, Michael P. |
| dc.contributor.researchgroup.spa.fl_str_mv |
Masira |
| dc.subject.proposal.eng.fl_str_mv |
anti-La/SS-B antibodies Autoimmunity La/SS-B autoantigen Systemic lupus erythematosus Primary Sjögren’s Syndrome Redox sensor |
| topic |
anti-La/SS-B antibodies Autoimmunity La/SS-B autoantigen Systemic lupus erythematosus Primary Sjögren’s Syndrome Redox sensor Shuttling of La protein |
| dc.subject.proposal.spa.fl_str_mv |
Shuttling of La protein |
| description |
Digital |
| publishDate |
2021 |
| dc.date.issued.none.fl_str_mv |
2021-09-08 |
| dc.date.accessioned.none.fl_str_mv |
2022-02-24T22:36:13Z |
| dc.date.available.none.fl_str_mv |
2022-02-24T22:36:13Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
http://purl.org/coar/resource_type/c_6501 |
| status_str |
publishedVersion |
| dc.identifier.doi.none.fl_str_mv |
10.3390/ijms22189699 |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.udes.edu.co/handle/001/6154 |
| identifier_str_mv |
10.3390/ijms22189699 |
| url |
https://repositorio.udes.edu.co/handle/001/6154 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationendpage.spa.fl_str_mv |
20 |
| dc.relation.citationissue.spa.fl_str_mv |
18 |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationvolume.spa.fl_str_mv |
22 |
| dc.relation.cites.none.fl_str_mv |
Berndt, N.; Bippes, C.C.; Michalk, I.; Bartsch, T.; Arndt, C.; Puentes-Cala, E.; Soto, J.A.; Loureiro, L.R.; Kegler, A.; Bachmann, D.; et al. And Yet It Moves: Oxidation of the Nuclear Autoantigen La/SS-B Is the Driving Force for Nucleo-Cytoplasmic Shuttling. Int. J. Mol. Sci. 2021, 22, 9699. https://doi.org/10.3390/ ijms22189699 |
| dc.relation.indexed.spa.fl_str_mv |
Scopus |
| dc.relation.ispartofjournal.spa.fl_str_mv |
International Journal of Molecular Sciences |
| dc.rights.spa.fl_str_mv |
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.creativecommons.spa.fl_str_mv |
Atribución 4.0 Internacional (CC BY 4.0) |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0/ |
| rights_invalid_str_mv |
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Atribución 4.0 Internacional (CC BY 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
20 p |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
International Journal of Molecular Sciences |
| dc.publisher.place.spa.fl_str_mv |
Suiza |
| dc.source.spa.fl_str_mv |
https://www.mdpi.com/1422-0067/22/18/9699 |
| institution |
Universidad de Santander |
| bitstream.url.fl_str_mv |
https://repositorio.udes.edu.co/bitstreams/f18324a5-1560-4f65-bb54-1f9ba972411f/download https://repositorio.udes.edu.co/bitstreams/f2c1b151-20f2-4bdc-b786-be51e1242d10/download https://repositorio.udes.edu.co/bitstreams/b702518d-2874-4a2b-81f3-c3b085bec221/download https://repositorio.udes.edu.co/bitstreams/a2dec216-52fd-432a-97e1-6c8e4245de6a/download |
| bitstream.checksum.fl_str_mv |
20800567f95f0361d09bace21f20bd15 38d94cf55aa1bf2dac1a736ac45c881c 5dbe86c1111d64f45ba435df98fdc825 78af74783cebab622c09be5d4ad5b989 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Universidad de Santander |
| repository.mail.fl_str_mv |
soporte@metabiblioteca.com |
| _version_ |
1814158634593026048 |
| spelling |
Berndt, Nicole71097c9d-2605-4e5e-b873-ed1513f6c7f6-1Bippes, Claudia C.97702ce5-3ef1-48a7-9fcd-a3217837238d-1Michalk, Irene28d91fbc-0553-46b4-9a70-7915571ded92-1Bartsch, Tabea7fc8ddaf-3289-43dc-9785-15b1abac091d-1Arndt, Claudia15aa7eca-d54a-4daa-b28c-a56412622780-1Puentes-Cala, Edinson9649c845-5bef-4bab-ab46-8124f11616c0-1Soto, Javier-Andres440906b9-866d-4bbd-945e-cf05c4ecec94-1Loureiro, Liliana R.ff7b95a3-8482-42e1-a1bb-7905e67653c6-1Kegler, Alexandrad66f48e1-cb93-45f8-a232-0b1bae45efb6-1Bachmann, Dominik581e05ee-8607-4e55-a7db-73d8a3b97ee0-1Gross, Joanne K.922e8828-8924-4c34-ac5d-b388a42e0fb3-1Gross, Tim42bf6c50-271b-48fc-bed2-e41d4747833a-1Kurien, Biji T.e65ae9da-2a1b-4b25-bf77-33e67fb31607-1Hal Scofield, R.f258cee1-7bbb-4d18-8728-c5a4c9f47169-1Darise Farris, A.3276c29c-f13e-471e-820f-24c7f13a1b42-1James, Judith A.5c355ca5-2fc6-447c-a515-6fac17174511-1Bergmann, Ralf42ee2bae-2c97-4474-89fe-e2149df4bd4f-1Schmitz, Marc1b83a0dc-e9f8-465b-81fa-d991b787d12c-1Feldmann, Anjaff85e74e-e8e8-4ad1-9f31-a7048c48b0f5-1Bachmann, Michael P.39be5227-2b61-4fc4-b94a-4065d691f227-1Masira2022-02-24T22:36:13Z2022-02-24T22:36:13Z2021-09-08DigitalDecades ago, we and many other groups showed a nucleo-cytoplasmic translocation of La protein in cultured cells. This shuttling of La protein was seen after UV irradiation, virus infections, hydrogen peroxide exposure and the Fenton reaction based on iron or copper ions. All of these conditions are somehow related to oxidative stress. Unfortunately, these harsh conditions could also cause an artificial release of La protein. Even until today, the shuttling and the cytoplasmic function of La/SS-B is controversially discussed. Moreover, the driving mechanism for the shuttling of La protein remains unclear. Recently, we showed that La protein undergoes redox-dependent conformational changes. Moreover, we developed anti-La monoclonal antibodies (anti-La mAbs), which are specific for either the reduced form of La protein or the oxidized form. Using these tools, here we show that redox-dependent conformational changes are the driving force for the shuttling of La protein. Moreover, we show that translocation of La protein to the cytoplasm can be triggered in a ligand/receptor-dependent manner under physiological conditions. We show that ligands of toll-like receptors lead to a redox-dependent shuttling of La protein. The shuttling of La protein depends on the redox status of the respective cell type. Endothelial cells are usually resistant to the shuttling of La protein, while dendritic cells are highly sensitive. However, the deprivation of intracellular reducing agents in endothelial cells makes endothelial cells sensitive to a redox-dependent shuttling of La protein.Ciencias Médicas y de la Salud20 papplication/pdf10.3390/ijms22189699https://repositorio.udes.edu.co/handle/001/6154engInternational Journal of Molecular SciencesSuiza2018122Berndt, N.; Bippes, C.C.; Michalk, I.; Bartsch, T.; Arndt, C.; Puentes-Cala, E.; Soto, J.A.; Loureiro, L.R.; Kegler, A.; Bachmann, D.; et al. And Yet It Moves: Oxidation of the Nuclear Autoantigen La/SS-B Is the Driving Force for Nucleo-Cytoplasmic Shuttling. Int. J. Mol. Sci. 2021, 22, 9699. https://doi.org/10.3390/ ijms22189699ScopusInternational Journal of Molecular SciencesCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.info:eu-repo/semantics/openAccessAtribución 4.0 Internacional (CC BY 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.mdpi.com/1422-0067/22/18/9699anti-La/SS-B antibodiesAutoimmunityLa/SS-B autoantigenSystemic lupus erythematosusPrimary Sjögren’s SyndromeRedox sensorShuttling of La proteinAnd yet it moves: Oxidation of the nuclear autoantigen La/SS-B is the driving force for nucleo-cytoplasmic shuttlingArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALAnd yet it moves. Oxidation of the nuclear autoantigen La-SS-B is the driving force for nucleo-cytoplasmic shuttling.pdfAnd yet it moves. Oxidation of the nuclear autoantigen La-SS-B is the driving force for nucleo-cytoplasmic shuttling.pdfapplication/pdf220743https://repositorio.udes.edu.co/bitstreams/f18324a5-1560-4f65-bb54-1f9ba972411f/download20800567f95f0361d09bace21f20bd15MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/f2c1b151-20f2-4bdc-b786-be51e1242d10/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTAnd yet it moves. Oxidation of the nuclear autoantigen La-SS-B is the driving force for nucleo-cytoplasmic shuttling.pdf.txtAnd yet it moves. Oxidation of the nuclear autoantigen La-SS-B is the driving force for nucleo-cytoplasmic shuttling.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/b702518d-2874-4a2b-81f3-c3b085bec221/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILAnd yet it moves. Oxidation of the nuclear autoantigen La-SS-B is the driving force for nucleo-cytoplasmic shuttling.pdf.jpgAnd yet it moves. Oxidation of the nuclear autoantigen La-SS-B is the driving force for nucleo-cytoplasmic shuttling.pdf.jpgGenerated Thumbnailimage/jpeg11918https://repositorio.udes.edu.co/bitstreams/a2dec216-52fd-432a-97e1-6c8e4245de6a/download78af74783cebab622c09be5d4ad5b989MD54001/6154oai:repositorio.udes.edu.co:001/61542023-10-09 16:43:03.588https://creativecommons.org/licenses/by-nc/4.0/Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |