Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)
Digital
- Autores:
-
Quintero, Wendy Lorena
Moreno, Erika Marcela
Leal Pinto, Sandra Milena
Sanabria, Sandra Milena
Stashenko, Elena
García, Liliana Torcoroma
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/6209
- Acceso en línea:
- https://doi.org/10.1186/s12906-021-03347-6
https://repositorio.udes.edu.co/handle/001/6209
- Palabra clave:
- Chagas disease
Trypanosoma cruzi
Immunomodulation
Antioxidant
Lippia alba, Essential oil fractions
- Rights
- openAccess
- License
- © The Author(s). 2021
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Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae) |
| title |
Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae) |
| spellingShingle |
Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae) Chagas disease Trypanosoma cruzi Immunomodulation Antioxidant Lippia alba, Essential oil fractions |
| title_short |
Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae) |
| title_full |
Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae) |
| title_fullStr |
Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae) |
| title_full_unstemmed |
Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae) |
| title_sort |
Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae) |
| dc.creator.fl_str_mv |
Quintero, Wendy Lorena Moreno, Erika Marcela Leal Pinto, Sandra Milena Sanabria, Sandra Milena Stashenko, Elena García, Liliana Torcoroma |
| dc.contributor.author.none.fl_str_mv |
Quintero, Wendy Lorena Moreno, Erika Marcela Leal Pinto, Sandra Milena Sanabria, Sandra Milena Stashenko, Elena García, Liliana Torcoroma |
| dc.contributor.researchgroup.spa.fl_str_mv |
CliniUDES |
| dc.subject.proposal.eng.fl_str_mv |
Chagas disease Trypanosoma cruzi Immunomodulation Antioxidant Lippia alba, Essential oil fractions |
| topic |
Chagas disease Trypanosoma cruzi Immunomodulation Antioxidant Lippia alba, Essential oil fractions |
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Digital |
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2021 |
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2021-07-02 |
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2022-03-01T21:37:07Z |
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2022-03-01T21:37:07Z |
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https://doi.org/10.1186/s12906-021-03347-6 |
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https://repositorio.udes.edu.co/handle/001/6209 |
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https://doi.org/10.1186/s12906-021-03347-6 https://repositorio.udes.edu.co/handle/001/6209 |
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eng |
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eng |
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16 |
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1 |
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21 |
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Quintero, W.L., Moreno, E.M., Pinto, S.M.L. et al. Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae). BMC Complement Med Ther 21, 187 (2021). https://doi.org/10.1186/s12906-021-03347-6 |
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Scopus |
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BMC Complementary Medicine and Therapies |
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© The Author(s). 2021 |
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http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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© The Author(s). 2021 Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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16 p |
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application/pdf |
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Reino Unido |
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https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-021-03347-6 |
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Universidad de Santander |
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Quintero, Wendy Lorena4869bf53-22f3-4e46-a2c2-2030d3545beb-1Moreno, Erika Marcela95cdc261-244c-46f5-b327-15ce8e565388-1Leal Pinto, Sandra Milena595a83be-311e-4b69-9ecd-ead999adb5af-1Sanabria, Sandra Milena1c223aa3-be5f-4342-8abd-6d5bf118ac9d-1Stashenko, Elenaaffc219c-860b-47be-a71f-0e14a734eaf4-1García, Liliana Torcoromafe133513-613e-481a-9ec7-4a9aeaa0f414-1CliniUDES2022-03-01T21:37:07Z2022-03-01T21:37:07Z2021-07-02DigitalBackground: Parasite persistence, exacerbated and sustained immune response, and continuous oxidative stress have been described to contribute to the development of the cardiac manifestations in Chronic Chagas Disease. Nevertheless, there are no efficient therapies to resolve the Trypanosoma cruzi infection and prevent the disease progression. Interestingly, trypanocide, antioxidant, and immunodulatory properties have been reported separately for some major terpenes, as citral (neral plus geranial), limonene, and caryophyllene oxide, presents in essential oils (EO) extracted from two chemotypes (Citral and Carvone) of Lippia alba. The aim of this study was to obtain L. alba essential oil fractions enriched with the aforementioned bioactive terpenes and to evaluate the impact of these therapies on trypanocide, oxidative stress, mitochondrial bioenergetics, genotoxicity, and inflammatory markers on T. cruzi-infected macrophages. Methods: T. cruzi-infected J774A.1 macrophage were treated with limonene-enriched (ACT1) and citral/caryophyllene oxide-enriched (ACT2) essential oils fractions derived from Carvone and Citral-L. alba chemotypes, respectively. Results: ACT1 (IC50 = 45 ± 1.7 μg/mL) and ACT2 (IC50 = 80 ± 1.9 μg/mL) exhibit similar trypanocidal effects to Benznidazole (BZN) (IC50 = 48 ± 2.5 μg/mL), against amastigotes. Synergistic antiparasitic activity was observed when ACT1 was combined with BZN (∑FIC = 0.52 ± 0.13 μg/mL) or ACT2 (∑FIC = 0.46 ± 1.7 μg/mL). ACT1 also decreased the oxidative stress, mitochondrial metabolism, and genotoxicity of the therapies. The ACT1 + ACT2 and ACT1 + BZN experimental treatments reduced the pro-inflammatory cytokines (IFN-γ, IL-2, and TNF-α) and increased the antiinflammatory cytokines (IL-4 and IL-10). Conclusion: Due to its highly trypanocidal and immunomodulatory properties, ACT1 (whether alone or in combination with BZN or ACT2) represents a promising L. alba essential oil fraction for further studies in drug development towards the Chagas disease control.Ciencias Médicas y de la Salud16 papplication/pdfhttps://doi.org/10.1186/s12906-021-03347-6https://repositorio.udes.edu.co/handle/001/6209engReino Unido16121Quintero, W.L., Moreno, E.M., Pinto, S.M.L. et al. Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae). BMC Complement Med Ther 21, 187 (2021). https://doi.org/10.1186/s12906-021-03347-6ScopusBMC Complementary Medicine and Therapies© The Author(s). 2021info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-021-03347-6Chagas diseaseTrypanosoma cruziImmunomodulationAntioxidantLippia alba, Essential oil fractionsImmunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALImmunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae).pdfImmunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae).pdfapplication/pdf248398https://repositorio.udes.edu.co/bitstreams/4cdd50fe-832d-4973-8747-d47634e5be68/download570ab465f2056b37d5cf828b8f7097deMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/939aee12-f0ef-44e5-aae1-91c63f8e1c72/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTImmunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae).pdf.txtImmunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae).pdf.txtExtracted texttext/plain8https://repositorio.udes.edu.co/bitstreams/a7d7c43a-2030-45fa-ac49-75be124835e4/download34a9d760095bb0c290f35e73faa3ef88MD53THUMBNAILImmunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae).pdf.jpgImmunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae).pdf.jpgGenerated Thumbnailimage/jpeg11100https://repositorio.udes.edu.co/bitstreams/9d27bc50-b15e-4798-95d4-56fbe75f8765/download7e714515bbab74631e11adade5a55568MD54001/6209oai:repositorio.udes.edu.co:001/62092023-10-10 09:34:45.172https://creativecommons.org/licenses/by-nc/4.0/© The Author(s). 2021https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |