Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations
16 p.
- Autores:
-
Leal-Pinto, Sandra Milena
Roa Cordero, Martha Viviana
Nagles, Edgar
Muñoz Castro, Alvaro
Hurtado, John J.
Murcia, Ricardo A.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3167
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3167
- Palabra clave:
- Triazole ligands
Cobalt(II) and chromium(III) complexes
Antibacterial activity
Antifungal activity
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Santander, 2018
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Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations |
| title |
Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations |
| spellingShingle |
Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations Triazole ligands Cobalt(II) and chromium(III) complexes Antibacterial activity Antifungal activity |
| title_short |
Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations |
| title_full |
Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations |
| title_fullStr |
Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations |
| title_full_unstemmed |
Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations |
| title_sort |
Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations |
| dc.creator.fl_str_mv |
Leal-Pinto, Sandra Milena Roa Cordero, Martha Viviana Nagles, Edgar Muñoz Castro, Alvaro Hurtado, John J. Murcia, Ricardo A. |
| dc.contributor.author.spa.fl_str_mv |
Leal-Pinto, Sandra Milena Roa Cordero, Martha Viviana Nagles, Edgar Muñoz Castro, Alvaro Hurtado, John J. Murcia, Ricardo A. |
| dc.subject.proposal.spa.fl_str_mv |
Triazole ligands Cobalt(II) and chromium(III) complexes Antibacterial activity Antifungal activity |
| topic |
Triazole ligands Cobalt(II) and chromium(III) complexes Antibacterial activity Antifungal activity |
| description |
16 p. |
| publishDate |
2018 |
| dc.date.issued.spa.fl_str_mv |
2018-08-13 |
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2019-06-20T13:15:22Z |
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2019-06-20T13:15:22Z |
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10.3390/molecules23082013 |
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1420-3049 |
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https://repositorio.udes.edu.co/handle/001/3167 |
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10.3390/molecules23082013 1420-3049 |
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eng |
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eng |
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Molecules |
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Derechos Reservados - Universidad de Santander, 2018 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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openAccess |
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Leal-Pinto, Sandra Milenac1c80eb8-5914-40d9-9c7c-531b0b4b65a6-1Roa Cordero, Martha Viviana725277d6-8bc2-4458-968e-1ed6de3742e8-1Nagles, Edgarf6244031-ec54-4d81-af0b-53e140cd2885-1Muñoz Castro, Alvaro74b8e0c2-edea-4b05-ad10-187db7ac91fa-1Hurtado, John J.4eaad30c-8862-4ab3-bad0-3aa3d14b5b8b-1Murcia, Ricardo A.1a89b171-33e9-49e9-85c2-ab27ec1743fd-12019-06-20T13:15:22Z2019-06-20T13:15:22Z2018-08-1316 p.In this work, six complexes (2–7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3–7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL−1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.application/pdf10.3390/molecules230820131420-3049https://repositorio.udes.edu.co/handle/001/3167engMoleculesDerechos Reservados - Universidad de Santander, 2018info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.mdpi.com/1420-3049/23/8/2013Triazole ligandsCobalt(II) and chromium(III) complexesAntibacterial activityAntifungal activityDevelopment of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity EvaluationsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILDevelopment of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes. Synthesis and biological activity evaluations.pdf.jpgDevelopment of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes. Synthesis and biological activity evaluations.pdf.jpgGenerated Thumbnailimage/jpeg1632https://repositorio.udes.edu.co/bitstreams/0cf48441-613c-4b86-ae48-1aba4fbe8985/download659600e07c5ad6e277a504318648c747MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/afc9af22-aae8-4286-8907-ff18e81d6e96/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALDevelopment of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes. Synthesis and biological activity evaluations.pdfDevelopment of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes. Synthesis and biological activity evaluations.pdfDocumento Principalapplication/pdf2419215https://repositorio.udes.edu.co/bitstreams/20b85518-3e9f-4cb3-bf6d-10ae30a56a35/download89040bda8dfd5adaa3db374bfe4cbc2bMD51TEXTDevelopment of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes. Synthesis and biological activity evaluations.pdf.txtDevelopment of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes. Synthesis and biological activity evaluations.pdf.txtExtracted texttext/plain76076https://repositorio.udes.edu.co/bitstreams/f82386ab-9458-43ff-b605-9be54cebfdc7/downloadec38bfc0c26aac6416b215ef671c70dbMD53001/3167oai:repositorio.udes.edu.co:001/31672023-10-10 09:56:47.471https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Santander, 2018https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |