Blood-pressure and cholesterol lowering in persons without cardiovascular disease
12 p.
- Autores:
-
Yusuf, Salim
Lonn, Eva
Pais, Prem
Bosch, Jackie
Lopez-Jaramillo, Patricio
Zhu, Jun
Xavier, Denis
Avezum, Alvaro
Leiter, Lawrence A.
Piegas, Leopoldo S.
Parkhomenko, Alexander
Keltai, Matyas
Keltai, Katalin
Sliwa, Karen
Chazova, Irina
Peters, Ron J.G.
Held, Claes
Yusoff, Khalid
Lewis, Basil S.
Jansky, Petr
Khunti, Kamlesh
Toff, William D.
Reid, Christopher M.
Varigos, John
Accini, Jose Luis
McKelvie, Robert
Pogue, Janice
Jung, Hyejung
Liu, Lisheng
Diaz, Rafael
Dans, Antonio
Dagenais, Gilles
HOPE-3 Investigators
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3458
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3458
- Palabra clave:
- Blood pressure
Cholesterol lowering
Cardiovascular disease
- Rights
- closedAccess
- License
- Derechos Reservados - New England Journal of Medicine, 2016
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Blood-pressure and cholesterol lowering in persons without cardiovascular disease |
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Blood-pressure and cholesterol lowering in persons without cardiovascular disease |
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Blood-pressure and cholesterol lowering in persons without cardiovascular disease Blood pressure Cholesterol lowering Cardiovascular disease |
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Blood-pressure and cholesterol lowering in persons without cardiovascular disease |
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Blood-pressure and cholesterol lowering in persons without cardiovascular disease |
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Blood-pressure and cholesterol lowering in persons without cardiovascular disease |
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Blood-pressure and cholesterol lowering in persons without cardiovascular disease |
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Blood-pressure and cholesterol lowering in persons without cardiovascular disease |
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Yusuf, Salim Lonn, Eva Pais, Prem Bosch, Jackie Lopez-Jaramillo, Patricio Zhu, Jun Xavier, Denis Avezum, Alvaro Leiter, Lawrence A. Piegas, Leopoldo S. Parkhomenko, Alexander Keltai, Matyas Keltai, Katalin Sliwa, Karen Chazova, Irina Peters, Ron J.G. Held, Claes Yusoff, Khalid Lewis, Basil S. Jansky, Petr Khunti, Kamlesh Toff, William D. Reid, Christopher M. Varigos, John Accini, Jose Luis McKelvie, Robert Pogue, Janice Jung, Hyejung Liu, Lisheng Diaz, Rafael Dans, Antonio Dagenais, Gilles HOPE-3 Investigators |
| dc.contributor.author.spa.fl_str_mv |
Yusuf, Salim Lonn, Eva Pais, Prem Bosch, Jackie Lopez-Jaramillo, Patricio Zhu, Jun Xavier, Denis Avezum, Alvaro Leiter, Lawrence A. Piegas, Leopoldo S. Parkhomenko, Alexander Keltai, Matyas Keltai, Katalin Sliwa, Karen Chazova, Irina Peters, Ron J.G. Held, Claes Yusoff, Khalid Lewis, Basil S. Jansky, Petr Khunti, Kamlesh Toff, William D. Reid, Christopher M. Varigos, John Accini, Jose Luis McKelvie, Robert Pogue, Janice Jung, Hyejung Liu, Lisheng Diaz, Rafael Dans, Antonio Dagenais, Gilles HOPE-3 Investigators |
| dc.subject.proposal.eng.fl_str_mv |
Blood pressure Cholesterol lowering Cardiovascular disease |
| topic |
Blood pressure Cholesterol lowering Cardiovascular disease |
| description |
12 p. |
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2016 |
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2016-04-02 |
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2019-07-24T16:33:32Z |
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eng |
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eng |
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New England Journal of Medicine |
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Derechos Reservados - New England Journal of Medicine, 2016 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Yusuf, Salim06a836b5-f5e3-41d9-a516-9cc46e5d7948-1Lonn, Eva7a977a4b-14e3-44cc-8057-933d424aaa9b-1Pais, Prem5abdbf77-3c3f-4396-8634-83723aa215b9-1Bosch, Jackie503f2202-0dda-463c-acc9-f5888e895278-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Zhu, Jund97cdbd2-6a82-430c-abfe-c978f085997e-1Xavier, Denis88c9cf48-fa3b-45c6-be03-2cc79e59289d-1Avezum, Alvaro8b920360-abb2-4ec8-b5ee-4e3f4e0b11eb-1Leiter, Lawrence A.bcdd3211-40b7-474d-9f6c-8a1051ceb9bf-1Piegas, Leopoldo S.0f1da4dd-76bd-4381-87fa-1e01066eee6f-1Parkhomenko, Alexander11fab1ea-f0f6-47e0-97e9-36e372b7e2f9-1Keltai, Matyas65c5da4f-dca6-4e4f-aa9e-6c2ff81f2df9-1Keltai, Kataline6748cb0-125e-4199-9d27-8f14335aec02-1Sliwa, Karen7ff2b80f-9412-4d65-99cd-7d01d5578687-1Chazova, Irinace6fc484-15aa-401c-a370-8afcad931907-1Peters, Ron J.G.43007a97-9e31-41a5-a7fc-ce7357bd484f-1Held, Claes76b69ce8-c468-49c5-8d48-95a823d8b565-1Yusoff, Khalid933db13d-f5bb-4ea6-91a5-68eea1ca9ffc-1Lewis, Basil S.a8106b8e-2b4b-412e-90c7-4012b1272405-1Jansky, Petrbf8ec62a-6edc-439c-a698-2e4fa4172f04-1Khunti, Kamleshe9aff03a-6f97-433d-a56e-8d7f703caa03-1Toff, William D.97acb6df-c33b-45ad-b772-c52ac4aa7281-1Reid, Christopher M.7d8a8211-12ad-464c-948d-16952b66144d-1Varigos, Johnedec3b03-87c5-454c-aec5-b2c04c91a9d9-1Accini, Jose Luis0a64fd59-b75f-432f-8268-d96da4646e86-1McKelvie, Robertb7cfc72e-3a56-4797-8848-d0db71a3ef50-1Pogue, Janiceda5c963c-440a-4bf6-981a-f2217b50fc1d-1Jung, Hyejung50f4ceae-59e5-4f12-9788-b713f56de3be-1Liu, Lishenga14adafe-ef37-42b0-8f5b-0de4ea71b0fc-1Diaz, Rafaelf2be4a74-501a-4e63-8bbd-965cbcf8c57b-1Dans, Antoniof365ef5a-7610-4022-8485-31d6d3879cd6-1Dagenais, Gillesc865f015-4dc7-483d-9dae-132288d901f8-1HOPE-3 Investigatorsad5cd98d-86e0-4739-a226-91ef50ed152c-12019-07-24T16:33:32Z2019-07-24T16:33:32Z2016-04-0212 p.BACKGROUND Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of cardiovascular events substantially. METHODS In a trial with 2-by-2 factorial design, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to rosuvastatin (10 mg perday) or placebo and to candesartan (16 mg per day) plus hydrochlorothiazide (12.5 mg per day) or placebo. In the analyses reported here, we compared the 3180 participants assigned to combined therapy (with rosuvastatin and the two antihypertensive agents) with the 3168 participants assigned to dual placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included heart failure, cardiac arrest, or revascularization. The median follow-up was 5.6 years. RESULTS The decrease in the LDL cholesterol level was 33.7 mg per deciliter (0.87 mmol per liter) greater in the combined-therapy group than in the dual-placebo group, and the decrease in systolic blood pressure was 6.2 mm Hg greater with combined therapy than with dual placebo. The first coprimary outcome occurred in 113 participants (3.6%) in the combined-therapy group and in 157 (5.0%) in the dual-placebo group (hazard ratio, 0.71; 95% confidence interval [CI], 0.56 to 0.90; P=0.005). The second coprimary outcome occurred in 136 participants (4.3%) and 187 participants (5.9%), respectively (hazard ratio, 0.72; 95% CI, 0.57 to 0.89; P=0.003). Muscle weakness and dizziness were more common in the combined-therapy group than in the dual-placebo group, but the overall rate of discontinuation of the trial regimen was similar in the two groups. CONCLUSIONS The combination of rosuvastatin (10 mg per day), candesartan (16 mg per day), and hydrochlorothiazide (12.5 mg per day) was associated with a significantly lower rate of cardiovascular events than dual placebo among persons at intermediate risk who did not have cardiovascular disease. 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