Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia
8 p.
- Autores:
-
Morales Parra, Gloria Inés
Yaneth Giovanetti, María Cecilia
Zuleta Hernández, Andrés
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3478
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3478
- Palabra clave:
- Resistencia bacteriana
Meticilina
Macrólidos lincosamidas
MLSBc
MLSBi
Bacterial resistance
Methicillin
Lincosamides macrolides
Resistência bacteriana
Macrolídeos lincosamidas
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Santander, 2016
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Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia |
| dc.title.alternative.spa.fl_str_mv |
Fenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, Colombia |
| dc.title.alternative.por.fl_str_mv |
Fenótipos de resistência à meticilina, macrolídeos e lincosamidas em Staphylococcus aureus isolados de um hospital de Valledupar, Colombia |
| title |
Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia |
| spellingShingle |
Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia Resistencia bacteriana Meticilina Macrólidos lincosamidas MLSBc MLSBi Bacterial resistance Methicillin Lincosamides macrolides Resistência bacteriana Macrolídeos lincosamidas |
| title_short |
Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia |
| title_full |
Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia |
| title_fullStr |
Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia |
| title_full_unstemmed |
Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia |
| title_sort |
Phenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia |
| dc.creator.fl_str_mv |
Morales Parra, Gloria Inés Yaneth Giovanetti, María Cecilia Zuleta Hernández, Andrés |
| dc.contributor.author.spa.fl_str_mv |
Morales Parra, Gloria Inés Yaneth Giovanetti, María Cecilia Zuleta Hernández, Andrés |
| dc.subject.proposal.spa.fl_str_mv |
Resistencia bacteriana Meticilina Macrólidos lincosamidas |
| topic |
Resistencia bacteriana Meticilina Macrólidos lincosamidas MLSBc MLSBi Bacterial resistance Methicillin Lincosamides macrolides Resistência bacteriana Macrolídeos lincosamidas |
| dc.subject.proposal.eng.fl_str_mv |
MLSBc MLSBi Bacterial resistance Methicillin Lincosamides macrolides |
| dc.subject.proposal.por.fl_str_mv |
Resistência bacteriana Macrolídeos lincosamidas |
| description |
8 p. |
| publishDate |
2016 |
| dc.date.issued.spa.fl_str_mv |
2016-02-20 |
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2019-07-29T16:14:03Z |
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2019-07-29T16:14:03Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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https://repositorio.udes.edu.co/handle/001/3478 |
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spa |
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spa |
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Revista Ciencias de la Salud |
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Derechos Reservados - Universidad de Santander, 2016 |
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http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Morales Parra, Gloria Inés6f5581e6-83cf-4aac-9ed7-b20f06a4a296-1Yaneth Giovanetti, María Ceciliac5fe0c5c-bb0b-4431-a0f1-017672e1f348-1Zuleta Hernández, Andrésc3a19bcb-3838-4834-82ab-ac432207dfa2-12019-07-29T16:14:03Z2019-07-29T16:14:03Z2016-02-208 p.Introduction: Infections with methicillin-resistant S. aureus are a public health problem due to the multi-resistance profile presented by this pathogen. Objective: To determine resistance phenotypes to methicillin, macrolides and lincosamides in S. aureus. Materials and methods: 50 S. aureus strains, isolated from patients of the Hospital Rosario Lopez Pumarejo in the city of Valledupar, were analyzed. Susceptibility tests to methicillin, erythromycin and clindamycin were performed using microdilution and agar diffusion methods. Methicillin resistance was determined through agar dilution technique and inducible clindamycin resistance D-Test. Results: Methicillin resistance reached 50%, five phenotypes were established in the analyzed macrolides and lincosamides: phenotype sensitive to erythromycin and clindamycin (78%); phenotype resistant to erythromycin and clindamycin (16%) with constitutive resistance for both cMLSB antimicrobials, which lead the resistance phenotypes; phenotype with intermediate resistance to both antimicrobials (2%); the intermediate result phenotype resistant to erythromycin and clindamycin (2%); and the RS phenotype resistant to erythromycin and sensitive to clindamycin (2%) that show inducible iMLSB clindamycin resistance with positive D test. Conclusions: The inducible resistance to macrolides, lincosamides and streptogramines is not established through the standard antimicrobial susceptibility test. Not identifying the inducible resistance can lead to clindamycin treatment failure.Introdução: As infeções por S. aureus meticilino resistentes são um problema de saúde pública pelo perfil de multirresistência que apresenta este patógeno. Objetivo: Determinar o fenótipo de resistência à meticilina, macrolídeos e lincosamidad em cepas de S. aureus. Materiais e métodos: Analisaram-se 50 cepas de S. aureus isoladas de amostras clínicas de pacientes do Hospital Rosario Pumarejo de López na cidade de Valledupar, Colômbia. A susceptibilidade à meticilina, eritromicina e clindamicina se realizaram pelos métodos microdiluição em caldo e difusão em ágar. Determinou-se a resistência à meticilina mediante a técnica ágar diluição e a resistência induzível a clindamicina, com a prova D-Test. Resultados: A resistência a meticilina foi de 50%, se evidenciaram cinco fenótipos nos macrolídeos e lincosamidas analisados: o fenótipo com sensibilidade à eritromicina e clindamicina (78%), fenótipo com resistência à eritromicina e clindamicina (16%), que apresentam resistência constitutiva para ambos os antimicrobianos MLSBc, liderando os fenótipos de resistência; o fenótipo com sensibilidade intermedia a ambos os antimicrobianos (2%), o fenótipo com resultado intermédio para a eritromicina e sensibilidade à clindamicina (2%) e o fenótipo com resistência a eritromicina e sensibilidade à clindamicina (2%), que apresentam resistência induzível à clindamicina MLSBi, com prova test D positiva. Conclusões: A resistência induzível para macrolídeos, lincosamidas e streptograminas não se detecta usando os testes de susceptibilidade antimicrobiana standard. A não identificação desta resistência induzível pode conduzir à falha do tratamento com clindamicina.Introducción: las infecciones por S. aureus meticilino resistentes son un problema de salud pública por el perfil de multirresistencia que presenta este patógeno. Objetivo: determinar el fenotipo de resistencia a meticilina, macrólidos y lincosamidas en cepas de S. aureus. Materiales y métodos: se analizaron 50 cepas de S. aureus aisladas de muestras clínicas de pacientes del Hospital Rosario Pumarejo de López en la ciudad de Valledupar. Las pruebas de susceptibilidad a meticilina, eritromicina y clindamicina se realizaron por los métodos microdilución en caldo y difusión en agar. Se determinó la resistencia a meticilina mediante la técnica agar dilución y la resistencia inducible a clindamicina, con la prueba del D-Test. Resultados: la resistencia a meticilina fue del 50%, se evidenciaron cinco fenotipos en los macrólidos y lincosamidas analizados: el fenotipo con sensibilidad a eritromicina y clindamicina (78%), fenotipo con resistencia a eritromicina y clindamicina (16%), que presentan resistencia constitutiva para ambos antimicrobianos MLSBc, liderando los fenotipos de resistencia; el fenotipo con sensibilidad intermedia a ambos antimicrobianos (2%), el fenotipo con resultado intermedio para eritromicina y sensibilidad a clindamicina (2%) y el fenotipo con resistencia a eritromicina y sensibilidad a clindamicina (2%), que presentan resistencia inducible a clindamicina MLSBi, con prueba test D positiva. Conclusiones: la resistencia inducible para macrólidos, lincosamidas y streptograminas no se detecta usando los test de susceptibilidad antimicrobiana estándar. La no identificación de esta resistencia inducible puede conducir a falla del tratamiento con clindamicina.application/pdf2145-45071692-7273https://repositorio.udes.edu.co/handle/001/3478spaRevista Ciencias de la SaludDerechos Reservados - Universidad de Santander, 2016info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2http://www.scielo.org.co/pdf/recis/v14n2/v14n2a08.pdfResistencia bacterianaMeticilinaMacrólidos lincosamidasMLSBcMLSBiBacterial resistanceMethicillinLincosamides macrolidesResistência bacterianaMacrolídeos lincosamidasPhenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, ColombiaFenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, ColombiaFenótipos de resistência à meticilina, macrolídeos e lincosamidas em Staphylococcus aureus isolados de um hospital de Valledupar, ColombiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILPhenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia.pdf.jpgPhenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia.pdf.jpgGenerated Thumbnailimage/jpeg1692https://repositorio.udes.edu.co/bitstreams/e5d1d2a0-9f71-4ea9-8f43-a8f929e91ce0/download3f6739c42d90457a2b0ced288e7ac396MD54Fenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, Colombia.pdf.jpgFenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, Colombia.pdf.jpgGenerated Thumbnailimage/jpeg10282https://repositorio.udes.edu.co/bitstreams/b0773913-b45c-4074-a7be-9d539f228cb9/downloadc76e979aa6b116038a13785cbe8de0d8MD57TEXTPhenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia.pdf.txtPhenotype resistance to methicillin, macrolides and lincosamides in staphylococcus aureus, isolated in a hospital in Valledupar, Colombia.pdf.txtExtracted texttext/plain27728https://repositorio.udes.edu.co/bitstreams/ca07e375-799d-461d-8218-03971e4c5aed/download78b33fbc832f062cfe7851c10f704270MD53Fenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, Colombia.pdf.txtFenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, Colombia.pdf.txtExtracted texttext/plain8https://repositorio.udes.edu.co/bitstreams/c032d162-d0d8-4407-9d46-bff4adf324ce/download34a9d760095bb0c290f35e73faa3ef88MD56LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/00e2a0b0-154e-4bcf-82da-fefb724d2c69/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALFenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, Colombia.pdfFenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, Colombia.pdfapplication/pdf298686https://repositorio.udes.edu.co/bitstreams/e7727ce6-2075-426e-ba1c-3b3609fcb4bf/download8be04cd1a1bf07c097a77aae026a83d1MD55001/3478oai:repositorio.udes.edu.co:001/34782023-10-10 17:14:52.851https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Santander, 2016https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |