Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study
Digital
- Autores:
-
Farfán García, Ana Elvira
Imdad, Aamer
Zhang, Chengxian
Arias Guerrero, Monica Y.
Sánchez Álvarez, Nayibe T.
Iqbal, Junaid
Hernández-Gamboa, Adriana E.
Slaughter, James C.
Gómez Duarte, Oscar Gilberto
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/5666
- Acceso en línea:
- https://doi.org/10.1371/journal.pntd.0008375
https://repositorio.udes.edu.co/handle/001/5666
- Palabra clave:
- Rights
- openAccess
- License
- The Editor(s) and the Author(s), 2020
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Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study |
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Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study |
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Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study |
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Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study |
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Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study |
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Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study |
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Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study |
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Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study |
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Farfán García, Ana Elvira Imdad, Aamer Zhang, Chengxian Arias Guerrero, Monica Y. Sánchez Álvarez, Nayibe T. Iqbal, Junaid Hernández-Gamboa, Adriana E. Slaughter, James C. Gómez Duarte, Oscar Gilberto |
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Farfán García, Ana Elvira Imdad, Aamer Zhang, Chengxian Arias Guerrero, Monica Y. Sánchez Álvarez, Nayibe T. Iqbal, Junaid Hernández-Gamboa, Adriana E. Slaughter, James C. Gómez Duarte, Oscar Gilberto |
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CLINIUDES |
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2020-06-30 |
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2021-10-06T15:47:16Z |
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2021-10-06T15:47:16Z |
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https://repositorio.udes.edu.co/handle/001/5666 |
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https://doi.org/10.1371/journal.pntd.0008375 https://repositorio.udes.edu.co/handle/001/5666 |
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eng |
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eng |
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20 |
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30 de junio, 2020 |
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Farfán-García AE, Imdad A, Zhang C, Arias-Guerrero MY, Sánchez-Álvarez NT, Iqbal J, et al. (2020) Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. PLoS Negl Trop Dis 14(6): e0008375. https://doi.org/10.1371/journal.pntd.0008375 |
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PLoS Neglected Tropical Diseases, June 30, 2020 https://doi.org/10.1371/journal.pntd.0008375 |
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PLoS Neglected Tropical Diseases |
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The Editor(s) and the Author(s), 2020 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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PLOS Neglected Tropical Diseases |
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Estados Unidos |
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Farfán García, Ana Elvira74472815-bd1a-4bf4-932b-0264dd209268-1Imdad, Aamer46e95bf9-25a0-4af3-b643-50f85632a518-1Zhang, Chengxiana524736f-1323-48cb-bc34-f0769a860493-1Arias Guerrero, Monica Y.fbe9fbec-6d65-4d41-ab10-b70116adf78f-1Sánchez Álvarez, Nayibe T.4473292c-3c6c-44ba-80f5-25f619f2910f-1Iqbal, Junaidc7776124-d30d-4152-ac43-a935d08d9770-1Hernández-Gamboa, Adriana E.77980d2f-a402-4de0-a3db-022d5aface56-1Slaughter, James C.12bc3ebc-fd33-4eb4-8125-aac33dfdd58b-1Gómez Duarte, Oscar Gilberto9db9afe6-fc68-48aa-9961-f7fdf933be56-1CLINIUDES2021-10-06T15:47:16Z2021-10-06T15:47:16Z2020-06-30DigitalBackground Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low- and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. coli pathotypes. Methodology/Principal findings This was a prospective, matched for age, case-control study to assess the etiology of moderate to severe AGE in children less than 5 years of age in Bucaramanga, Colombia, South America. We tested for 24 pathogens using locally available diagnostic testing, including stool culture, polymerase chain reaction, microscopy and enzyme-linked immunoassay. Adjusted attributable fractions were calculated to assess the association between AGE and each pathogen in this study population. The study included 861 participants, 431 cases and 430 controls. Enteric pathogens were detected in 71% of cases and in 54% of controls (p = <0.001). Co-infection was identified in 28% of cases and in 14% of controls (p = <0.001). The adjusted attributable fraction showed that Norovirus GII explained 14% (95% CI: 10–18%) of AGE, followed by rotavirus 9.3% (6.4–12%), adenovirus 3% (1–4%), astrovirus 2.9% (0.6–5%), enterotoxigenic Escherichia coli (ETEC) 2.4% (0.4–4%), Cryptosporidium sp. 2% (0.5–4%), Campylobacter sp. 2% (0.2–4%), and Salmonella sp.1.9% (0.3 to 3.5%). Except for Cryptosporidium, all parasite infections were not associated with AGE. Three emergent diarrheagenic E. coli pathotypes were identified in cases (0.7%), including an enteroaggregative/enterotoxigenic E.coli (EAEC/ETEC), an enteroaggregative/enteropathogenic E.coli (EAEC/EPEC), and an emergent enteroinvasive E. coli with a rare O96:H19. No deaths were reported among cases or controls. Conclusions/Significance Norovirus and rotavirus explained the major proportion of moderate to severe AGE in this study. Higher proportion of infection in cases, in the form of single infections or co-infections, showed association with AGE. Three novel E. coli pathotypes were identified among cases in this geographic region.This study was supported, in part, by the NIH-NIAID R01-AI095346 to OGG and by the National Center for Advancing Translational Sciences of the National Institutes of Health under award number UL1TR001412 to the University at Buffalo. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ciencias básicas biomédicas, epidemiología, salud pública enfermedades infecciosas, enfermedades no transmisibles epidemiología, salud y desarrollo, discapacidad1 p.application/pdfhttps://doi.org/10.1371/journal.pntd.0008375https://repositorio.udes.edu.co/handle/001/5666engPLOS Neglected Tropical DiseasesEstados Unidos2030 de junio, 20201Farfán-García AE, Imdad A, Zhang C, Arias-Guerrero MY, Sánchez-Álvarez NT, Iqbal J, et al. (2020) Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. PLoS Negl Trop Dis 14(6): e0008375. https://doi.org/10.1371/journal.pntd.0008375PLoS Neglected Tropical Diseases, June 30, 2020 https://doi.org/10.1371/journal.pntd.0008375PLoS Neglected Tropical DiseasesThe Editor(s) and the Author(s), 2020info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008375Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control studyArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTCASOinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALEtiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia. 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