Immunological Memory to Zika Virus in a University Community in Colombia, South America
Digital
- Autores:
-
Cárdenas Sierra, Denny-Miley
Jaimes, Miguel A.
Vega, Leidy D.
Oliveros, Nicolas L.
Soto, Javier-Andrés
Chía, Claudia R.
Osorio, Jorge E.
Ciuoderis, Karl A.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/5628
- Acceso en línea:
- http://dx.doi.org/10.1590/0001-3765202020190883
https://repositorio.udes.edu.co/handle/001/5628
- Palabra clave:
- Cytokines
Flavivirus infection
Immunological memory
Seroepidemiologic studies
Zika virus
- Rights
- openAccess
- License
- The Editor(s) and the Author(s), 2020
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Immunological Memory to Zika Virus in a University Community in Colombia, South America |
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Immunological Memory to Zika Virus in a University Community in Colombia, South America |
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Immunological Memory to Zika Virus in a University Community in Colombia, South America Cytokines Flavivirus infection Immunological memory Seroepidemiologic studies Zika virus |
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Immunological Memory to Zika Virus in a University Community in Colombia, South America |
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Immunological Memory to Zika Virus in a University Community in Colombia, South America |
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Immunological Memory to Zika Virus in a University Community in Colombia, South America |
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Immunological Memory to Zika Virus in a University Community in Colombia, South America |
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Immunological Memory to Zika Virus in a University Community in Colombia, South America |
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Cárdenas Sierra, Denny-Miley Jaimes, Miguel A. Vega, Leidy D. Oliveros, Nicolas L. Soto, Javier-Andrés Chía, Claudia R. Osorio, Jorge E. Ciuoderis, Karl A. |
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Cárdenas Sierra, Denny-Miley Jaimes, Miguel A. Vega, Leidy D. Oliveros, Nicolas L. Soto, Javier-Andrés Chía, Claudia R. Osorio, Jorge E. Ciuoderis, Karl A. |
| dc.subject.proposal.eng.fl_str_mv |
Cytokines Flavivirus infection Immunological memory Seroepidemiologic studies Zika virus |
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Cytokines Flavivirus infection Immunological memory Seroepidemiologic studies Zika virus |
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Digital |
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2020 |
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2020-05-29 |
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eng |
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01. 2020 |
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CÁRDENAS, DENNY M. et al. Immunological Memory to Zika Virus in a University Community in Colombia, South America. Anais da Academia Brasileira de Ciências [online]. 2020, v. 92, n. 01 [Accessed 20 September 2021] , e20190883. Available from: <https://doi.org/10.1590/0001-3765202020190883>. Epub 29 May 2020. ISSN 1678-2690. https://doi.org/10.1590/0001-3765202020190883. |
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Cárdenas Sierra, Denny-Mileyc14329ed-4165-45da-8d6e-5e302f2caef2-1Jaimes, Miguel A.4bb5e549-698e-4dc9-aee9-2c7ceedb53f5-1Vega, Leidy D.1170268f-9a92-4c8a-a7cc-29a30eb71789-1Oliveros, Nicolas L.542554e0-df84-4186-b3a8-5d779d158f46-1Soto, Javier-Andrésd924ce22-9555-4607-bfd1-cb5724e4183e-1Chía, Claudia R.b979beed-f5da-418b-9cb1-8a66587513a4-1Osorio, Jorge E.cdbe3dbb-b139-4b9e-bda5-d41d834ea75a-1Ciuoderis, Karl A.21bd78b5-32b8-4080-8df4-8af4e815d47b-12021-09-20T13:02:19Z2021-09-20T13:02:19Z2020-05-29DigitalZika virus appeared in South America in 2015, generating alarm worldwide as it causes microcephaly and autoimmunity. This study aims to determine the serological footprint of the incoming epidemic in a student community and to characterize the memory functional cell response during post convalescence. In a cross-sectional study, Zika-specific IgG using LIA immunoassay was found in 328 university students (CI=95%), while in the second phase, the functional cellular memory response for IFN-γ and IL-2 was quantified using post-stimulus ELISpot with inactivated virus, starting with individuals seropositive for Zika and control individuals (seropositive only for Dengue and seronegative for Zika-Dengue). Depending on the antigen used, memory humoral response (IgG) against Zika Virus was observed in >60% of the population; seropositivity for NS1 was 21.1% higher than E antigen with high intensity. The analysis of cell functionality in 22 individuals seropositive for Zika virus revealed either IFN-γ+ or IL-2+ cells in 86.3% of cases (Th1 profile), presenting multifunctionality in 50% (11 individuals), 64% of which presented> 6 SFC/104 PBMCs (>600 SFC/106 PBMC), reflecting memory circulating cells. A good agreement (Kappa= 0.754) was observed between the coexistence of both cellular and humoral responses but not in their intensity.1 ed.1 p.application/pdfhttp://dx.doi.org/10.1590/0001-3765202020190883https://repositorio.udes.edu.co/handle/001/5628engRio de Janeiro, Brasil2101. 2020192CÁRDENAS, DENNY M. et al. Immunological Memory to Zika Virus in a University Community in Colombia, South America. Anais da Academia Brasileira de Ciências [online]. 2020, v. 92, n. 01 [Accessed 20 September 2021] , e20190883. Available from: <https://doi.org/10.1590/0001-3765202020190883>. Epub 29 May 2020. ISSN 1678-2690. https://doi.org/10.1590/0001-3765202020190883.Anais da Academia Brasileira de CiênciasThe Editor(s) and the Author(s), 2020info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100917&tlng=enCytokinesFlavivirus infectionImmunological memorySeroepidemiologic studiesZika virusImmunological Memory to Zika Virus in a University Community in Colombia, South AmericaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationORIGINALImmunological_Memory_to_Zika_Virus_in_a_University_Community_in_Colombia_South_America.pdfImmunological_Memory_to_Zika_Virus_in_a_University_Community_in_Colombia_South_America.pdfapplication/pdf221841https://repositorio.udes.edu.co/bitstreams/3d760980-42dd-407c-9fc1-9dc0f076a57c/downloadc56bbda1b34946cd0f820e1ca0db34d3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/7a277906-956c-4d4a-abdb-1400a441c55f/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTImmunological_Memory_to_Zika_Virus_in_a_University_Community_in_Colombia_South_America.pdf.txtImmunological_Memory_to_Zika_Virus_in_a_University_Community_in_Colombia_South_America.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/7887d510-407e-4f14-8934-9f4a9fd54844/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILImmunological_Memory_to_Zika_Virus_in_a_University_Community_in_Colombia_South_America.pdf.jpgImmunological_Memory_to_Zika_Virus_in_a_University_Community_in_Colombia_South_America.pdf.jpgGenerated Thumbnailimage/jpeg8243https://repositorio.udes.edu.co/bitstreams/9ce9fe19-90c2-45e5-af81-63c147a2706b/download1935b2276afb18d0f60c0e9521e8e91bMD54001/5628oai:repositorio.udes.edu.co:001/56282023-10-09 10:14:40.166https://creativecommons.org/licenses/by-nc/4.0/The Editor(s) and the Author(s), 2020https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |