The role of the L-arginine-nitric oxide pathway in preeclampsia
15 p.
- Autores:
-
Lopez-Jaramillo, Patricio
Arenas, William D.
García, Ronald G.
Rincón, Melvin Y.
López Casillas, Marcos
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2008
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3691
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3691
- Palabra clave:
- Preeclampsia
Endothelium
Nitric oxide
Inflammation
Infection
- Rights
- openAccess
- License
- Derechos Reservados - Therapeutic Advances in Cardiovascular Disease, 2008
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The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title |
The role of the L-arginine-nitric oxide pathway in preeclampsia |
| spellingShingle |
The role of the L-arginine-nitric oxide pathway in preeclampsia Preeclampsia Endothelium Nitric oxide Inflammation Infection |
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The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_full |
The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_fullStr |
The role of the L-arginine-nitric oxide pathway in preeclampsia |
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The role of the L-arginine-nitric oxide pathway in preeclampsia |
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The role of the L-arginine-nitric oxide pathway in preeclampsia |
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Lopez-Jaramillo, Patricio Arenas, William D. García, Ronald G. Rincón, Melvin Y. López Casillas, Marcos |
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Lopez-Jaramillo, Patricio Arenas, William D. García, Ronald G. Rincón, Melvin Y. López Casillas, Marcos |
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Preeclampsia Endothelium Nitric oxide Inflammation Infection |
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Preeclampsia Endothelium Nitric oxide Inflammation Infection |
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15 p. |
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2008 |
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2019-08-29T16:56:05Z |
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eng |
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eng |
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Therapeutic Advances in Cardiovascular Disease |
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Therapeutic Advances in Cardiovascular Disease;Vol. 2 (4), pp. 261-275. 2008 |
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Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Arenas, William D.a776bc8f-583d-45a0-b958-c4982c17557b-1García, Ronald G.41c4b822-ac96-4ffc-ac48-9d3227b75257-1Rincón, Melvin Y.7a43a890-d706-4c22-895c-54683fec12bc-1López Casillas, Marcosd77850e1-b3f1-4c4b-95bd-26c376e92c62-12019-08-29T16:56:05Z2019-08-29T16:56:05Z2008-08-0115 p.: Preeclampsia (PE) is a major cause of maternal and perinatal mortality, especially in developing countries. Its etiology involves multiple factors, but no specific cause has been identified. Evidence suggests that clinical manifestations are caused by endothelial dysfunction. Nitric oxide (NO), which is synthesized from L-arginine in endothelial cells by the endothelial nitric oxide synthase (eNOS), provides a tonic dilator tone and regulates the adhesion of white blood cells and platelet aggregation. Alterations in the L-arginine-NO pathway have been associated with the development of PE. Various studies, reporting decreased, elevated or unchanged levels of nitrite (NO2) and nitrate (NO3), two end products of NO metabolism, have been published. Our group contributed to those contradictory reports describing cases of PE with both elevated and decreased levels of NO2 and NO3. Apparently, diminished levels of NO could be related to deficiencies in the ingestion of dietary calcium associated to low levels of plasma ionic calcium, which is crucial to the eNOS’ activity. Also, low levels of NO could be associated with the presence of eNOS polymorphisms or the presence of increased levels of ADMA, the endogenous inhibitor of NO. High levels of NO associated to low levels of cGMP suggest a decreased bioactivity of NO, which is probably related to an increased degradation of NO caused by a high production of superoxide in states of infection and inflammation. The present article analyses and reviews the reported paradoxical roles of the L-arginine-NO pathway in PE and gives a possible explanation for these results.application/pdf10.1177/17539447080922771753-94551753-9447https://repositorio.udes.edu.co/handle/001/3691engTherapeutic Advances in Cardiovascular DiseaseTherapeutic Advances in Cardiovascular Disease;Vol. 2 (4), pp. 261-275. 2008Derechos Reservados - Therapeutic Advances in Cardiovascular Disease, 2008info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://journals.sagepub.com/doi/pdf/10.1177/1753944708092277PreeclampsiaEndotheliumNitric oxideInflammationInfectionThe role of the L-arginine-nitric oxide pathway in preeclampsiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationORIGINALThe role of the L-arginine-nitric oxide pathway in preeclampsia.pdfThe role of the L-arginine-nitric oxide pathway in preeclampsia.pdfapplication/pdf296478https://repositorio.udes.edu.co/bitstreams/b514ae40-8c67-494f-85da-9cfab2c3631b/download1360aa8ba4672002ad1e9ec7c13c893cMD56LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/f697a9c3-6722-4b9f-b248-70b45fee9941/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTThe role of the L-arginine-nitric oxide pathway in preeclampsia.pdf.txtThe role of the L-arginine-nitric oxide pathway in preeclampsia.pdf.txtExtracted texttext/plain58224https://repositorio.udes.edu.co/bitstreams/f2aab1c9-5db3-4ee5-b6b1-4ed8f9232c1c/download6ec20b9679f5c477aedbc2933fde092bMD53THUMBNAILThe role of the L-arginine-nitric oxide pathway in preeclampsia.pdf.jpgThe role of the L-arginine-nitric oxide pathway in preeclampsia.pdf.jpgGenerated Thumbnailimage/jpeg1813https://repositorio.udes.edu.co/bitstreams/701e9587-d600-4fcf-8f9b-5b1d652cd86d/downloada9edc3d872770a023f5076acd7a196faMD54001/3691oai:repositorio.udes.edu.co:001/36912023-10-10 08:31:03.898https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Therapeutic Advances in Cardiovascular Disease, 2008https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |