Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study
15 p.
- Autores:
-
O’Donnell, Martin J.
Chin, Siu Lim
Rangarajan, Sumathy
Xavier, Denis
Liu, Lisheng
Zhang, Hongye
Rao Melacini, Purnima
Zhang, Xiaohe
Pais, Prem
Agapay, Steven
Lopez-Jaramillo, Patricio
Damasceno, Albertino
Langhorne, Peter
McQueen, Matthew J.
Rosengren, Annika
Dehghan, Mahshid
Hankey, Graeme J.
Dans, Antonio
ElSayed, Ahmed
Avezum, Alvaro
Mondo, Charles
Diener, Hans Christoph
Ryglewicz, Danuta
Czlonkowska, Anna
Pogosova, Nana
Weimar, Christian
Iqbal, Romaina
Diaz, Rafael
Yusoff, Khalid
Yusufali, Afzalhussein
Oguz, Aytekin
Wang, Xingyu
Penaherrera, Ernesto
Lanas, Fernando
Ogah, Okechukwu S.
Ogunniyi, Adesola
Iversen, Helle K.
Malaga, German
Rumboldt, Zvonko
Oveisgharan, Shahram
Hussain, Fawaz Al
Magazi, Daliwonga
Nilanont, Yongchai
Ferguson, John
Paré, Guillaume
Yusuf, Salim
INTERSTROKE investigators
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3452
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3452
- Palabra clave:
- Risk
Acute stroke
- Rights
- openAccess
- License
- Derechos Reservados - The Lancet, 2016
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Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study |
| title |
Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study |
| spellingShingle |
Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study Risk Acute stroke |
| title_short |
Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study |
| title_full |
Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study |
| title_fullStr |
Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study |
| title_full_unstemmed |
Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study |
| title_sort |
Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control study |
| dc.creator.fl_str_mv |
O’Donnell, Martin J. Chin, Siu Lim Rangarajan, Sumathy Xavier, Denis Liu, Lisheng Zhang, Hongye Rao Melacini, Purnima Zhang, Xiaohe Pais, Prem Agapay, Steven Lopez-Jaramillo, Patricio Damasceno, Albertino Langhorne, Peter McQueen, Matthew J. Rosengren, Annika Dehghan, Mahshid Hankey, Graeme J. Dans, Antonio ElSayed, Ahmed Avezum, Alvaro Mondo, Charles Diener, Hans Christoph Ryglewicz, Danuta Czlonkowska, Anna Pogosova, Nana Weimar, Christian Iqbal, Romaina Diaz, Rafael Yusoff, Khalid Yusufali, Afzalhussein Oguz, Aytekin Wang, Xingyu Penaherrera, Ernesto Lanas, Fernando Ogah, Okechukwu S. Ogunniyi, Adesola Iversen, Helle K. Malaga, German Rumboldt, Zvonko Oveisgharan, Shahram Hussain, Fawaz Al Magazi, Daliwonga Nilanont, Yongchai Ferguson, John Paré, Guillaume Yusuf, Salim INTERSTROKE investigators |
| dc.contributor.author.spa.fl_str_mv |
O’Donnell, Martin J. Chin, Siu Lim Rangarajan, Sumathy Xavier, Denis Liu, Lisheng Zhang, Hongye Rao Melacini, Purnima Zhang, Xiaohe Pais, Prem Agapay, Steven Lopez-Jaramillo, Patricio Damasceno, Albertino Langhorne, Peter McQueen, Matthew J. Rosengren, Annika Dehghan, Mahshid Hankey, Graeme J. Dans, Antonio ElSayed, Ahmed Avezum, Alvaro Mondo, Charles Diener, Hans Christoph Ryglewicz, Danuta Czlonkowska, Anna Pogosova, Nana Weimar, Christian Iqbal, Romaina Diaz, Rafael Yusoff, Khalid Yusufali, Afzalhussein Oguz, Aytekin Wang, Xingyu Penaherrera, Ernesto Lanas, Fernando Ogah, Okechukwu S. Ogunniyi, Adesola Iversen, Helle K. Malaga, German Rumboldt, Zvonko Oveisgharan, Shahram Hussain, Fawaz Al Magazi, Daliwonga Nilanont, Yongchai Ferguson, John Paré, Guillaume Yusuf, Salim INTERSTROKE investigators |
| dc.subject.proposal.eng.fl_str_mv |
Risk Acute stroke |
| topic |
Risk Acute stroke |
| description |
15 p. |
| publishDate |
2016 |
| dc.date.issued.spa.fl_str_mv |
2016-07-15 |
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2019-07-24T12:41:50Z |
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2019-07-24T12:41:50Z |
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Artículo de revista |
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10.1016/S0140-6736(16)30506-2 |
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0140-6736 |
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eng |
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eng |
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The Lancet |
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Derechos Reservados - The Lancet, 2016 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Derechos Reservados - The Lancet, 2016 Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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https://www.researchgate.net/publication/305384265_Global_and_regional_effects_of_potentially_modifiable_risk_factors_associated_with_acute_stroke_in_32_countries_INTERSTROKE_A_case-control_study/link/59f0cf6ea6fdcc1dc7b8ef9e/download |
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We sought to quantify the importance of potentially modifiable risk factors for stroke in different regions of the world, and in key populations and primary pathological subtypes of stroke. Methods We completed a standardised international case-control study in 32 countries in Asia, America, Europe, Australia, the Middle East, and Africa. Cases were patients with acute first stroke (within 5 days of symptom onset and 72 h of hospital admission). Controls were hospital-based or community-based individuals with no history of stroke, and were matched with cases, recruited in a 1:1 ratio, for age and sex. All participants completed a clinical assessment and were requested to provide blood and urine samples. Odds ratios (OR) and their population attributable risks (PARs) were calculated, with 99% confidence intervals. Findings Between Jan 11, 2007, and Aug 8, 2015, 26 919 participants were recruited from 32 countries (13 447 cases [10 388 with ischaemic stroke and 3059 intracerebral haemorrhage] and 13 472 controls). Previous history of hypertension or blood pressure of 140/90 mm Hg or higher (OR 2·98, 99% CI 2·72–3·28; PAR 47·9%, 99% CI 45·1–50·6), regular physical activity (0·60, 0·52–0·70; 35·8%, 27·7–44·7), apolipoprotein (Apo)B/ApoA1 ratio (1·84, 1·65–2·06 for highest vs lowest tertile; 26·8%, 22·2–31·9 for top two tertiles vs lowest tertile), diet (0·60, 0·53–0·67 for highest vs lowest tertile of modified Alternative Healthy Eating Index [mAHEI]; 23·2%, 18·2–28·9 for lowest two tertiles vs highest tertile of mAHEI), waist-to-hip ratio (1·44, 1·27–1·64 for highest vs lowest tertile; 18·6%, 13·3–25·3 for top two tertiles vs lowest), psychosocial factors (2·20, 1·78–2·72; 17·4%, 13·1–22·6), current smoking (1·67, 1·49–1·87; 12·4%, 10·2–14·9), cardiac causes (3·17, 2·68–3·75; 9·1%, 8·0–10·2), alcohol consumption (2·09, 1·64–2·67 for high or heavy episodic intake vs never or former drinker; 5·8%, 3·4–9·7 for current alcohol drinker vs never or former drinker), and diabetes mellitus (1·16, 1·05–1·30; 3·9%, 1·9–7·6) were associated with all stroke. Collectively, these risk factors accounted for 90·7% of the PAR for all stroke worldwide (91·5% for ischaemic stroke, 87·1% for intracerebral haemorrhage), and were consistent across regions (ranging from 82·7% in Africa to 97·4% in southeast Asia), sex (90·6% in men and in women), and age groups (92·2% in patients aged ≤55 years, 90·0% in patients aged >55 years). We observed regional variations in the importance of individual risk factors, which were related to variations in the magnitude of ORs (rather than direction, which we observed for diet) and differences in prevalence of risk factors among regions. Hypertension was more associated with intracerebral haemorrhage than with ischaemic stroke, whereas current smoking, diabetes, apolipoproteins, and cardiac causes were more associated with ischaemic stroke (p<0·0001). Interpretation Ten potentially modifiable risk factors are collectively associated with about 90% of the PAR of stroke in each major region of the world, among ethnic groups, in men and women, and in all ages. However, we found important regional variations in the relative importance of most individual risk factors for stroke, which could contribute to worldwide variations in frequency and case-mix of stroke. Our findings support developing both global and region-specific programmes to prevent stroke. Funding Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Canadian Stroke Network, Health Research Board Ireland, Swedish Research Council, Swedish Heart and Lung Foundation, The Health & Medical Care Committee of the Regional Executive Board, Region Västra Götaland (Sweden), AstraZeneca, Boehringer Ingelheim (Canada), Pfizer (Canada), MSD, Chest, Heart and Stroke Scotland, and The Stroke Association, with support from The UK Stroke Research Network.application/pdf10.1016/S0140-6736(16)30506-20140-6736https://repositorio.udes.edu.co/handle/001/3452engThe LancetDerechos Reservados - The Lancet, 2016info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.researchgate.net/publication/305384265_Global_and_regional_effects_of_potentially_modifiable_risk_factors_associated_with_acute_stroke_in_32_countries_INTERSTROKE_A_case-control_study/link/59f0cf6ea6fdcc1dc7b8ef9e/downloadRiskAcute strokeGlobal and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE) : A case-control studyArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILGlobal and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE). 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