In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils
Digital
- Autores:
-
Quimbaya-Ramírez, John Jaime
Gonzalez, Clara Isabel
Stashenko, Elena
Mantilla-Hernández, Julio Cesar
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/6343
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/6343
- Palabra clave:
- Chagas disease
Chronic chagasic cardiomyopathy
Trypanosoma cruzi
In vivo model
Lippia alba
Terpenes
- Rights
- closedAccess
- License
- © 2021 Elsevier B.V. All rights reserved.
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In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils |
| title |
In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils |
| spellingShingle |
In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils Chagas disease Chronic chagasic cardiomyopathy Trypanosoma cruzi In vivo model Lippia alba Terpenes |
| title_short |
In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils |
| title_full |
In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils |
| title_fullStr |
In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils |
| title_full_unstemmed |
In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils |
| title_sort |
In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils |
| dc.creator.fl_str_mv |
Quimbaya-Ramírez, John Jaime Gonzalez, Clara Isabel Stashenko, Elena Mantilla-Hernández, Julio Cesar |
| dc.contributor.author.none.fl_str_mv |
Quimbaya-Ramírez, John Jaime Gonzalez, Clara Isabel Stashenko, Elena Mantilla-Hernández, Julio Cesar |
| dc.contributor.researchgroup.spa.fl_str_mv |
GICA |
| dc.subject.proposal.eng.fl_str_mv |
Chagas disease Chronic chagasic cardiomyopathy Trypanosoma cruzi In vivo model Lippia alba Terpenes |
| topic |
Chagas disease Chronic chagasic cardiomyopathy Trypanosoma cruzi In vivo model Lippia alba Terpenes |
| description |
Digital |
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2021 |
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2021-09-05 |
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2022-03-16T15:21:41Z |
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2022-03-16T15:21:41Z |
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10.1016/j.indcrop.2021.113553 |
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https://repositorio.udes.edu.co/handle/001/6343 |
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eng |
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eng |
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Quimbaya Ramírez, John AU - González, Clara - Stashenko, Elena - Hernández, Julio - Galvis, Martha - García, Liliana - 2021/09/01 - 113553 - In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils - 10.1016/j.indcrop.2021.113553 Industrial Crops and Products |
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Scopus |
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Industrial Crops and Products |
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© 2021 Elsevier B.V. All rights reserved. |
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Atribución 4.0 Internacional (CC BY 4.0) |
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41 p |
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Paises Bajos |
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Quimbaya-Ramírez, John Jaime34382098-950d-4c81-a7ba-86a75fd37412Gonzalez, Clara Isabel678fc7f6-546f-4717-9922-858c5c6a0030Stashenko, Elenaaffc219c-860b-47be-a71f-0e14a734eaf4-1Mantilla-Hernández, Julio Cesar9a6c962a-5701-4bb5-89b5-42029020a19aGICA2022-03-16T15:21:41Z2022-03-16T15:21:41Z2021-09-05DigitalThe present study reports the trypanocidal and cardioprotective properties of fractions derived from Lippia alba (Verbenaceae family) essential oils (EOs), in a murine model of chronic Chagas disease (ChD). This infection represents one of the most serious public health problems in Latin American countries, without an effective therapy for chronic infection and its eventual cardiac complications. In the model established herein, the therapeutic scheme which involved 30 oral and daily doses of OxiLim (a mix composed by fractions enriched in citral, caryophyllene oxide, and limonene) was not toxic and exhibited trypanocidal activity comparable to benznidazole (assessed by parasitic DNA quantification-qPCR); but with an additional protective effects against cardiomyopathy progression. This last finding was confirmed by both echocardiography (reduction in the maximum diameter of the cardiac silhouette), and heart histopathology (tissue recovery, abundant fibroblasts, and mild separation of cardiac fibers). Conversely, rats treated only with benznidazole showed a significant increase in cardiac diameter with severe fiber dilation, angiogenesis, and high diversity of immune infiltrate. This research reports a highly trypanocidal (similar to benznidazole) therapeutic scheme based on L. alba essential oil fractions (OxiLim), which also exhibits a positive cardioprotective effect in the course of chronic chagasic car-diomyopathy, in rats.Medicina Veterinaria41 papplication/pdf10.1016/j.indcrop.2021.113553https://repositorio.udes.edu.co/handle/001/6343engPaises Bajos41231167Quimbaya Ramírez, John AU - González, Clara - Stashenko, Elena - Hernández, Julio - Galvis, Martha - García, Liliana - 2021/09/01 - 113553 - In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils - 10.1016/j.indcrop.2021.113553 Industrial Crops and ProductsScopusIndustrial Crops and Products© 2021 Elsevier B.V. All rights reserved.info:eu-repo/semantics/closedAccessAtribución 4.0 Internacional (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_14cbhttps://www.sciencedirect.com/science/article/abs/pii/S0926669021003174?via%3DihubChagas diseaseChronic chagasic cardiomyopathyTrypanosoma cruziIn vivo modelLippia albaTerpenesIn vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oilsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/6bac1abf-7ab1-4955-abd6-4e2af55859d7/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALIn vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils.pdfIn vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils.pdfapplication/pdf245093https://repositorio.udes.edu.co/bitstreams/81cbd40e-6caa-4e40-9205-572de2ba614f/download360d36ede77ac62eaeee11918a65756fMD51TEXTIn vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils.pdf.txtIn vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/0213445e-9686-44f5-b5c3-0bc25e558e02/download5dbe86c1111d64f45ba435df98fdc825MD53THUMBNAILIn vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils.pdf.jpgIn vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils.pdf.jpgGenerated Thumbnailimage/jpeg5813https://repositorio.udes.edu.co/bitstreams/077c2a71-976b-4b22-af28-23471cd0c7ce/downloadc4ecc51c23b6bb50d676b538243926d5MD54001/6343oai:repositorio.udes.edu.co:001/63432022-10-25 09:55:49.621https://creativecommons.org/licenses/by/4.0/© 2021 Elsevier B.V. All rights reserved.https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |