Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi
9 p.
- Autores:
-
Rueda Clausen, Christian F.
Córdoba Porras, A.
Bedoya, G.
Silva Sieger, Federico Arturo
Zarruk, Juan G.
Lopez-Jaramillo, Patricio
Villa, L.A.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2012
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3654
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3654
- Palabra clave:
- Association
Asymmetric Dimethylarginine
Hispanic hyperhomocysteinemia
Stroke
- Rights
- openAccess
- License
- Derechos Reservados - The Authors, European Journal of Neurology, 2012
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Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi |
| title |
Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi |
| spellingShingle |
Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi Association Asymmetric Dimethylarginine Hispanic hyperhomocysteinemia Stroke |
| title_short |
Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi |
| title_full |
Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi |
| title_fullStr |
Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi |
| title_full_unstemmed |
Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi |
| title_sort |
Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi |
| dc.creator.fl_str_mv |
Rueda Clausen, Christian F. Córdoba Porras, A. Bedoya, G. Silva Sieger, Federico Arturo Zarruk, Juan G. Lopez-Jaramillo, Patricio Villa, L.A. |
| dc.contributor.author.spa.fl_str_mv |
Rueda Clausen, Christian F. Córdoba Porras, A. Bedoya, G. Silva Sieger, Federico Arturo Zarruk, Juan G. Lopez-Jaramillo, Patricio Villa, L.A. |
| dc.subject.proposal.eng.fl_str_mv |
Association Asymmetric Dimethylarginine Hispanic hyperhomocysteinemia Stroke |
| topic |
Association Asymmetric Dimethylarginine Hispanic hyperhomocysteinemia Stroke |
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9 p. |
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2012 |
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2012-03 |
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2019-08-27T16:07:40Z |
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2019-08-27T16:07:40Z |
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Artículo de revista |
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10.1111/j.1468-1331.2011.03534.x |
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https://repositorio.udes.edu.co/handle/001/3654 |
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10.1111/j.1468-1331.2011.03534.x |
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https://repositorio.udes.edu.co/handle/001/3654 |
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eng |
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eng |
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European Journal of Neurology |
| dc.relation.ispartofseries.eng.fl_str_mv |
European Journal of Neurology;Volume19, Issue3 March 2012 Pages 417-425 |
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Derechos Reservados - The Authors, European Journal of Neurology, 2012 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Rueda Clausen, Christian F.bb29e148-b8c5-43f2-9fc0-4eeebb36706b-1Córdoba Porras, A.3fb82bd2-d774-464e-a201-8190069ddcf0-1Bedoya, G.6a989d56-cbec-407e-8a61-cbe3d404bddd-1Silva Sieger, Federico Arturo9cced475-6773-4f4f-b4e7-bbebe82a3e16-1Zarruk, Juan G.d274699c-e1ac-43b5-a287-26ee11182046-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Villa, L.A.890b7571-69e0-4d5d-8fe7-8c5427e74016-12019-08-27T16:07:40Z2019-08-27T16:07:40Z2012-039 p.BACKGROUND AND PURPOSE:Despite sharing some metabolic and pathological mechanisms, the reported association between total homocysteine (tHcy), asymmetric dimethylarginine (ADMA) and stroke remains controversial, particularly in Hispanic populations from developing countries in which genetic, socioeconomic, and nutritional factors are different to those described in developed countries. Our objectives were to determine the relationships of these factors to stroke and to each other independent of other cardiovascular risk factors, and to explore potential sex differences. METHODS: This national (Colombia) multicenter case-control study included 238 cases and 238 controls to evaluate traditional and emerging risk factors for ischemic stroke including tHcy and ADMA plasma levels. RESULTS: The median plasma levels of tHcy were 8.48 μM for controls and 10.01 μM for cases (P<0.0001). Plasma levels of tHcy between 12 and 50μM were considered moderate hyperhomocysteinemia (HtHcy). There were no differences in plasma ADMA concentration between groups (P=0.40). Plasma levels of ADMA and creatinine were not correlated (P=0.47). After adjusting for confounding factors, the presence of HtHcy was strongly associated with stroke (OR 8.97; P<0.0001). The adjusted association between HtHcy and stroke in men (OR 9.98) was comparable to that in women (OR 8.98) (P=0.41). CONCLUSIONS: In this Hispanic population, with relatively normal renal function, plasma levels of tHcy but not ADMA were associated with stroke independent of other cardiovascular risk factors.application/pdf10.1111/j.1468-1331.2011.03534.xhttps://repositorio.udes.edu.co/handle/001/3654engEuropean Journal of NeurologyEuropean Journal of Neurology;Volume19, Issue3 March 2012 Pages 417-425Derechos Reservados - The Authors, European Journal of Neurology, 2012info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-1331.2011.03534.xAssociationAsymmetric DimethylarginineHispanic hyperhomocysteinemiaStrokeIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecviArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi.PNG.jpgIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi.PNG.jpgGenerated Thumbnailimage/jpeg1451https://repositorio.udes.edu.co/bitstreams/9664a28b-a0f6-4d56-9a90-cbf8cc4e03bd/download555d8f738671c4a21973474af111ccf7MD53Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi.pdf.jpgIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi.pdf.jpgGenerated Thumbnailimage/jpeg1613https://repositorio.udes.edu.co/bitstreams/d2bc2254-e967-4128-abdc-1ba43e0f30a4/download2555b16e032d5e710e0a3d049ccc9598MD56ORIGINALIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi.pdfIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi.pdfapplication/pdf118581https://repositorio.udes.edu.co/bitstreams/92346f88-1f92-4bd0-a720-849d0cb5271a/download7d08e4e0cd8e8116eed0fd852fa058c9MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/ece97cc1-569f-44e4-99bd-1907ec117603/download38d94cf55aa1bf2dac1a736ac45c881cMD52TEXTIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi.pdf.txtIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi.pdf.txtExtracted texttext/plain2https://repositorio.udes.edu.co/bitstreams/6400895b-f238-4e86-9798-9e8fde063c0c/downloadd784fa8b6d98d27699781bd9a7cf19f0MD55001/3654oai:repositorio.udes.edu.co:001/36542023-10-10 10:23:54.981https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - The Authors, European Journal of Neurology, 2012https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |