The somatosensory link in fibromyalgia
11 p.
- Autores:
-
Kim, Jieun
Loggia, Marco L.
Cahalan, Christine M.
Harris, Richard E.
Beissner, Florian
García, Ronald G.
Kim, Hyungjun
Barbieri, Riccardo
Wasan, Ajay D.
Edwards, Robert R.
Napadow, Vitaly
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3539
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3539
- Palabra clave:
- Somatosensory Link
Fibromyalgia
- Rights
- openAccess
- License
- Derechos Reservados - Arthritis & Rheumatology, 2015
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The somatosensory link in fibromyalgia |
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Functional connectivity of the primary somatosensory cortexis altered by sustained pain and is associated withclinical/autonomic dysfunction |
| title |
The somatosensory link in fibromyalgia |
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The somatosensory link in fibromyalgia Somatosensory Link Fibromyalgia |
| title_short |
The somatosensory link in fibromyalgia |
| title_full |
The somatosensory link in fibromyalgia |
| title_fullStr |
The somatosensory link in fibromyalgia |
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The somatosensory link in fibromyalgia |
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The somatosensory link in fibromyalgia |
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Kim, Jieun Loggia, Marco L. Cahalan, Christine M. Harris, Richard E. Beissner, Florian García, Ronald G. Kim, Hyungjun Barbieri, Riccardo Wasan, Ajay D. Edwards, Robert R. Napadow, Vitaly |
| dc.contributor.author.spa.fl_str_mv |
Kim, Jieun Loggia, Marco L. Cahalan, Christine M. Harris, Richard E. Beissner, Florian García, Ronald G. Kim, Hyungjun Barbieri, Riccardo Wasan, Ajay D. Edwards, Robert R. Napadow, Vitaly |
| dc.subject.proposal.eng.fl_str_mv |
Somatosensory Link Fibromyalgia |
| topic |
Somatosensory Link Fibromyalgia |
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11 p. |
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2015 |
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2015-05 |
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2019-08-06T17:06:20Z |
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10.1002/art.39043 |
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2326-5205 |
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https://repositorio.udes.edu.co/handle/001/3539 |
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eng |
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eng |
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Arthritis & Rheumatology |
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Derechos Reservados - Arthritis & Rheumatology, 2015 |
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https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.39043 |
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Kim, Jieun50116560-db3f-4ad0-9f98-e80b6e3116e9-1Loggia, Marco L.0dd849d1-5f7a-4e23-ae5d-898bc433e171-1Cahalan, Christine M.f66b748c-97ba-4ae2-9063-f345782a6e84-1Harris, Richard E.2ee407e3-8360-4510-ac5c-5be1293a8439-1Beissner, Floriane2897172-ba53-40cb-8ed4-19f70db97762-1García, Ronald G.41c4b822-ac96-4ffc-ac48-9d3227b75257-1Kim, Hyungjunb615cc24-de21-4b67-8873-7f23a43d32a7-1Barbieri, Riccardo55ed48ad-21cc-4907-831a-b87ac479a69c-1Wasan, Ajay D.121e368d-55c1-4776-beb2-5fc38235c935-1Edwards, Robert R.eb0345ff-5b93-4141-b41c-f75309362659-1Napadow, Vitalye2796f75-2336-48e3-94e5-3cab2fe51420-12019-08-06T17:06:20Z2019-08-06T17:06:20Z2015-0511 p.Objective.Fibromyalgia (FM) is a chronic func-tional pain syndrome characterized by widespread pain,significant pain catastrophizing, sympathovagal dysfunc-tion, and amplified temporal summation for evoked pain.While several studies have demonstrated altered restingbrain connectivity in FM, studies have not specificallyprobed the somatosensory system and its role in bothsomatic and nonsomatic FM symptoms. Our objective wasto evaluate resting primary somatosensory cortex (S1) con-nectivity and to explore how sustained, evoked deep tissuepain modulates this connectivity.Methods.We acquired functional magnetic reso-nance imaging and electrocardiography data on FMpatients and healthy controls during rest (the rest phase)and during sustained mechanical pressure–induced painover the lower leg (the pain phase). Functional connectiv-ity associated with different S1 subregions was calculated,while S1legconnectivity (representation of the leg in theprimary somatosensory cortex) was contrasted betweenthe rest phase and the pain phase and was correlated withclinically relevant measures in FM.Results.During the rest phase, FM patientsshowed decreased connectivity between multiple ipsilat-eral and cross-hemispheric S1 subregions, which wascorrelated with clinical pain severity. Compared to therest phase, the pain phase produced increased S1legconnectivity to the bilateral anterior insula in FMpatients, but not in healthy controls. Moreover, in FMpatients, sustained pain–altered S1legconnectivity tothe anterior insula was correlated with clinical/behavioral pain measures and autonomic responses.Conclusion.Our study demonstrates that bothsomatic and nonsomatic dysfunction in FM, includingclinical pain, pain catastrophizing, autonomic dysfunction,and amplified temporal summation, are closely linkedwith the degree to which evoked deep tissue pain alters S1 connectivity to salience/affective pain-processing regions. Additionally, diminished connectivity between S1 subregions during the rest phase in FM may result from ongoing widespread clinical pain.application/pdf10.1002/art.390432326-5205https://repositorio.udes.edu.co/handle/001/3539engArthritis & RheumatologyDerechos Reservados - Arthritis & Rheumatology, 2015info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.39043Somatosensory LinkFibromyalgiaThe somatosensory link in fibromyalgiaFunctional connectivity of the primary somatosensory cortexis altered by sustained pain and is associated withclinical/autonomic dysfunctionArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILThe Somatosensory Link in Fibromyalgia. Functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical autonomic dysfunction.pdf.jpgThe Somatosensory Link in Fibromyalgia. Functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical autonomic dysfunction.pdf.jpgGenerated Thumbnailimage/jpeg1787https://repositorio.udes.edu.co/bitstreams/b0b176a7-4f44-443e-a5f6-eb02153a92e5/download65319bb172584f29b229bbb2998918baMD54The somatosensory link in fibromyalgia.pdf.jpgThe somatosensory link in fibromyalgia.pdf.jpgGenerated Thumbnailimage/jpeg1499https://repositorio.udes.edu.co/bitstreams/2a1ac97e-8dcb-4560-9356-bdb2c6b8b4d5/downloadb005018ec201aeb8727002ecb04eaa0eMD57TEXTThe Somatosensory Link in Fibromyalgia. Functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical autonomic dysfunction.pdf.txtThe Somatosensory Link in Fibromyalgia. 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