Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE)
Digital
- Autores:
-
Dagenais, Gilles R.
Leong, Darryl P.
Rangarajan, Sumathy
Lanas, Fernando
Lopez-Jaramillo, Patricio
Gupta, Rajeev
Diaz, Rafael
Avezum, Alvaro
Alhabib, Khalid F.
Temizhan, Ahmet
Ismail, Noorhassim
Chifamba, Jephat
Yeates, Karen
Khatib, Rasha
Rahman, Omar
Zatonska, Katarzyna
Kazmi, Khawar
Wei, Li
Zhu, Jun
Rosengren, Annika
Vijayakumar, K.
Kaur, Manmeet
Mohan, Viswanathan
Yusufali, AfzalHussein
Kelishadi, Roya
Teo, Koon K.
Joseph, Philip
Yusuf, Salim
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/5725
- Acceso en línea:
- https://doi.org/10.1016/S0140-6736(19)32007-0
https://repositorio.udes.edu.co/handle/001/5725
- Palabra clave:
- Rights
- closedAccess
- License
- Copyright © 2019 Elsevier Inc.
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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE) |
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A prospective cohort study |
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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE) |
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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE) |
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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE) |
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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE) |
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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE) |
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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE) |
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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE) |
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Dagenais, Gilles R. Leong, Darryl P. Rangarajan, Sumathy Lanas, Fernando Lopez-Jaramillo, Patricio Gupta, Rajeev Diaz, Rafael Avezum, Alvaro Alhabib, Khalid F. Temizhan, Ahmet Ismail, Noorhassim Chifamba, Jephat Yeates, Karen Khatib, Rasha Rahman, Omar Zatonska, Katarzyna Kazmi, Khawar Wei, Li Zhu, Jun Rosengren, Annika Vijayakumar, K. Kaur, Manmeet Mohan, Viswanathan Yusufali, AfzalHussein Kelishadi, Roya Teo, Koon K. Joseph, Philip Yusuf, Salim |
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Dagenais, Gilles R. Leong, Darryl P. Rangarajan, Sumathy Lanas, Fernando Lopez-Jaramillo, Patricio Gupta, Rajeev Diaz, Rafael Avezum, Alvaro Alhabib, Khalid F. Temizhan, Ahmet Ismail, Noorhassim Chifamba, Jephat Yeates, Karen Khatib, Rasha Rahman, Omar Zatonska, Katarzyna Kazmi, Khawar Wei, Li Zhu, Jun Rosengren, Annika Vijayakumar, K. Kaur, Manmeet Mohan, Viswanathan Yusufali, AfzalHussein Kelishadi, Roya Teo, Koon K. Joseph, Philip Yusuf, Salim |
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Elsevier |
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2019 |
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2019-09-03 |
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2021-11-23T21:43:56Z |
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2021-11-23T21:43:56Z |
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Artículo de revista |
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eng |
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395 |
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Scopus |
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The Lancet |
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Copyright © 2019 Elsevier Inc. |
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14 p |
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Elsevier Inc. |
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Dagenais, Gilles R.f72492d7-dc96-43b0-9237-b00656585504-1Leong, Darryl P.707b53c2-976c-44c2-a420-3de6a35f35e8-1Rangarajan, Sumathy5466c363-e515-4bd2-8537-eb839320f385-1Lanas, Fernandod22b7fe4-9f1f-4028-a22b-be782ef03d3c-1Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Gupta, Rajeevde1826df-aac8-4d9f-9b84-f21ba704686c-1Diaz, Rafaelf2be4a74-501a-4e63-8bbd-965cbcf8c57b-1Avezum, Alvaro8b920360-abb2-4ec8-b5ee-4e3f4e0b11eb-1Alhabib, Khalid F.84dc113a-dcf3-43f0-adec-af4dabb61538-1Temizhan, Ahmet626c731f-6484-4126-b211-2d9f81423b38-1Ismail, Noorhassim1101b3a5-610e-458d-87ec-bde747adae7c-1Chifamba, Jephatf2496279-e934-40b8-8f61-0039a09f03f8-1Yeates, Karen79418492-ec06-4cc6-831a-4bf5b245b584-1Khatib, Rasha7beae0a6-cfd5-4272-bf8c-1b5896fed8e5-1Rahman, Omar2fdf224c-97c9-4fb0-b7a9-ea79427bc631-1Zatonska, Katarzyna6d84170f-b69c-462b-9d93-3f363491580a-1Kazmi, Khawar69af1dac-e1e0-45dd-91e9-6add426eb64e-1Wei, Li9ce9792c-a35b-44fd-9eff-3b6b86002adb-1Zhu, Jund97cdbd2-6a82-430c-abfe-c978f085997e-1Rosengren, Annika923779f9-3a92-4086-b3d9-9d78974926d9-1Vijayakumar, K.d97df464-6693-4241-a590-1b34260afcf0-1Kaur, Manmeet857257e4-cebb-4bea-8d9b-e134b46dc72b-1Mohan, Viswanathane7246d73-7de3-4d86-9c7b-b9ca011e618b-1Yusufali, AfzalHussein87a3a6f4-8d24-4d8d-817c-56878de667b9-1Kelishadi, Roya4cdb25d6-6e41-4905-a399-c9d53f250b42-1Teo, Koon K.10190d66-4f2e-4a41-8a15-bc2d4ba9d1f8-1Joseph, Philip35ddb523-bb0e-4c55-9a59-b24968824fbf-1Yusuf, Salim06a836b5-f5e3-41d9-a516-9cc46e5d7948-1ElsevierEverest2021-11-23T21:43:56Z2021-11-23T21:43:56Z2019-09-03DigitalBackground To our knowledge, no previous study has prospectively documented the incidence of common diseases and related mortality in high-income countries (HICs), middle-income countries (MICs), and low-income countries (LICs) with standardised approaches. Such information is key to developing global and context-specific health strategies. In our analysis of the Prospective Urban Rural Epidemiology (PURE) study, we aimed to evaluate differences in the incidence of common diseases, related hospital admissions, and related mortality in a large contemporary cohort of adults from 21 HICs, MICs, and LICs across five continents by use of standardised approaches. Methods The PURE study is a prospective, population-based cohort study of individuals aged 35–70 years who have been enrolled from 21 countries across five continents. The key outcomes were the incidence of fatal and non-fatal cardiovascular diseases, cancers, injuries, respiratory diseases, and hospital admissions, and we calculated the age-standardised and sex-standardised incidence of these events per 1000 person-years. Findings This analysis assesses the incidence of events in 162 534 participants who were enrolled in the first two phases of the PURE core study, between Jan 6, 2005, and Dec 4, 2016, and who were assessed for a median of 9·5 years (IQR 8·5–10·9). During follow-up, 11 307 (7·0%) participants died, 9329 (5·7%) participants had cardiovascular disease, 5151 (3·2%) participants had a cancer, 4386 (2·7%) participants had injuries requiring hospital admission, 2911 (1·8%) participants had pneumonia, and 1830 (1·1%) participants had chronic obstructive pulmonary disease (COPD). Cardiovascular disease occurred more often in LICs (7·1 cases per 1000 person-years) and in MICs (6·8 cases per 1000 person-years) than in HICs (4·3 cases per 1000 person-years). However, incident cancers, injuries, COPD, and pneumonia were most common in HICs and least common in LICs. Overall mortality rates in LICs (13·3 deaths per 1000 person-years) were double those in MICs (6·9 deaths per 1000 person-years) and four times higher than in HICs (3·4 deaths per 1000 person-years). This pattern of the highest mortality in LICs and the lowest in HICs was observed for all causes of death except cancer, where mortality was similar across country income levels. Cardiovascular disease was the most common cause of deaths overall (40%) but accounted for only 23% of deaths in HICs (vs 41% in MICs and 43% in LICs), despite more cardiovascular disease risk factors (as judged by INTERHEART risk scores) in HICs and the fewest such risk factors in LICs. The ratio of deaths from cardiovascular disease to those from cancer was 0·4 in HICs, 1·3 in MICs, and 3·0 in LICs, and four upper-MICs (Argentina, Chile, Turkey, and Poland) showed ratios similar to the HICs. Rates of first hospital admission and cardiovascular disease medication use were lowest in LICs and highest in HICs. Interpretation Among adults aged 35–70 years, cardiovascular disease is the major cause of mortality globally. However, in HICs and some upper-MICs, deaths from cancer are now more common than those from cardiovascular disease, indicating a transition in the predominant causes of deaths in middle-age. As cardiovascular disease decreases in many countries, mortality from cancer will probably become the leading cause of death. The high mortality in poorer countries is not related to risk factors, but it might be related to poorer access to health care. Funding Full funding sources are listed at the end of the paper (see Acknowledgments).Ciencias Médicas y de la Salud14 papplication/pdfhttps://doi.org/10.1016/S0140-6736(19)32007-0https://repositorio.udes.edu.co/handle/001/5725engElsevier Inc.Reino Unido79410226785395ScopusThe LancetCopyright © 2019 Elsevier Inc.info:eu-repo/semantics/closedAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_14cbhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32007-0/fulltext#%20Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE)A prospective cohort studyArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Todas las AudienciasPublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/84133608-e3f4-4907-b37a-e9922e4d2ad8/download38d94cf55aa1bf2dac1a736ac45c881cMD53ORIGINALVariations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE). A prospective cohort study.pdfVariations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE). A prospective cohort study.pdfapplication/pdf199551https://repositorio.udes.edu.co/bitstreams/47545fbd-93f3-4f04-9a25-fdfaa3252fcc/downloadfcb89252d1e5a9f57afff03b2f449652MD54TEXTVariations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE). A prospective cohort study.pdf.txtVariations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE). A prospective cohort study.pdf.txtExtracted texttext/plain5https://repositorio.udes.edu.co/bitstreams/fe5d5f1c-c32c-4cde-a839-d6e103ff9f0d/download5dbe86c1111d64f45ba435df98fdc825MD55THUMBNAILVariations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE). 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