Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular

Introducción: El consumo de cereales, frutos secos, especias y leche de vaca es elevado a nivel global. Estos alimentos son susceptibles a la contaminación biológica, incluyendo la causada por hongos del género Aspergillus, que producen metabolitos tóxicos llamados aflatoxinas, los cuales ocasionan...

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Autores:
Londoño-Cifuentes, Erika Melissa
Martínez-Miranda, María Marcela
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad de Caldas
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Repositorio Institucional U. Caldas
Idioma:
spa
OAI Identifier:
oai:repositorio.ucaldas.edu.co:ucaldas/16014
Acceso en línea:
https://doi.org/10.17151/biosa.2017.16.1.7
https://repositorio.ucaldas.edu.co/handle/ucaldas/16014
Palabra clave:
aflatoxins
prevalence
risk assessment
carcinoma
hepatocellular
aflatoxinas
prevalencia
medición de riesgo
carcinoma hepatocelular
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openAccess
License
Derechos de autor 2017 Biosalud
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dc.title.spa.fl_str_mv Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular
dc.title.translated.eng.fl_str_mv Aflatoxins in food and dietary exposure as a risk factor for hepatocellular carcinoma
title Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular
spellingShingle Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular
aflatoxins
prevalence
risk assessment
carcinoma
hepatocellular
aflatoxinas
prevalencia
medición de riesgo
carcinoma hepatocelular
title_short Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular
title_full Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular
title_fullStr Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular
title_full_unstemmed Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular
title_sort Aflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelular
dc.creator.fl_str_mv Londoño-Cifuentes, Erika Melissa
Martínez-Miranda, María Marcela
dc.contributor.author.spa.fl_str_mv Londoño-Cifuentes, Erika Melissa
Martínez-Miranda, María Marcela
dc.subject.eng.fl_str_mv aflatoxins
prevalence
risk assessment
carcinoma
hepatocellular
topic aflatoxins
prevalence
risk assessment
carcinoma
hepatocellular
aflatoxinas
prevalencia
medición de riesgo
carcinoma hepatocelular
dc.subject.spa.fl_str_mv aflatoxinas
prevalencia
medición de riesgo
carcinoma hepatocelular
description Introducción: El consumo de cereales, frutos secos, especias y leche de vaca es elevado a nivel global. Estos alimentos son susceptibles a la contaminación biológica, incluyendo la causada por hongos del género Aspergillus, que producen metabolitos tóxicos llamados aflatoxinas, los cuales ocasionan efectos adversos en la salud. Las aflatoxinas B1 y M1 han sido clasificadas por la Agencia Internacional de Investigación del Cáncer (IARC) en el Grupo I como carcinógenos para humanos. El presente artículo muestra la ocurrencia de aflatoxinas en algunos alimentos de consumo humano y su relación con el desarrollo de carcinoma hepatocelular. Métodos: Se llevó a cabo una búsqueda bibliográfica en las bases de datos: Science Direct, Scopus, Pubmed y Web of Science. Se utilizaron palabras como “risk assessment and aflatoxin”, “ocurrence and aflatoxins”, “aflatoxins and hepatocellular carcinoma”, “aflatoxins and foodstuffs”. Resultados: Con base en los estudios consultados se demuestra que la ocurrencia de aflatoxinas es alta, principalmente en cereales como arroz, maíz y trigo. Además, las investigaciones relacionadas con la evaluación de la exposición destacan el vínculo existente entre el consumo frecuente de estas micotoxinas y el riesgo de desarrollar carcinoma hepatocelular, especialmente en personas que han contraído el virus de la hepatitis B. Conclusión: La presencia de aflatoxinas en alimentos ha generado alarmas de seguridad alimentaria a nivel mundial. Aunque se han creado algunas regulaciones, en países donde hay mayor exposición a estas micotoxinas, existe poco o ningún control de calidad. Por ello, es importante generar mecanismos de vigilancia pertinentes para disminuir el riesgo de contaminación fúngica y alimentos con aflatoxinas.
publishDate 2016
dc.date.issued.none.fl_str_mv 2016-01-01
dc.date.accessioned.none.fl_str_mv 2017-01-01 00:00:00
2021-02-14T10:01:16Z
dc.date.available.none.fl_str_mv 2017-01-01 00:00:00
2021-02-14T10:01:16Z
dc.type.spa.fl_str_mv Artículo de revista
Sección Artículos de Revisión
dc.type.eng.fl_str_mv Journal Article
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https://repositorio.ucaldas.edu.co/handle/ucaldas/16014
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dc.relation.ispartofjournal.spa.fl_str_mv Biosalud
dc.relation.references.spa.fl_str_mv Harrison P. Agricultura mundial: hacia los años 2015/2030. Dirección de Información de la FAO. 2002.
Cano-Sancho G, Ramos AJ, Marín S, Sanchis V. Presence and co-occurrence of aflatoxins, deoxynivalenol, fumonisins and zearalenone in gluten-free and ethnic foods. Food Control. 2012; 26(2):282-6.
Zhao X, Schaffner DW, Yue T. Quantification of aflatoxin risk associated with Chinese spices: point and probability risk assessments for aflatoxin B 1. Food control. 2013; 33(2):366-77.
Wogan GN, Kensler TW, Groopman JD. Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review. Food additives & contaminants: part A. 2012; 29(2):249-57.
Ossa DEH, Hincapié DA, Peñuela GA. Determination of aflatoxin M 1 in ice cream samples using immunoaffinity columns and ultra-high performance liquid chromatography coupled to tandem mass spectrometry. Food Control. 2015; 56:34-40.
Majeed S, Iqbal M, Asi MR, Iqbal SZ. Aflatoxins and ochratoxin A contamination in rice, corn and corn products from Punjab, Pakistan. Journal of Cereal Science. 2013; 58(3):446-50.
IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs 2012; 100.
Wang J-S, Groopman JD. DNA damage by mycotoxins. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 1999; 424(1):167-81.
FAO. Seguimiento del mercado del arroz de la FAO. Organización de las Naciones Unidas para la Alimentación y la Agricultura FAO. 2015; XVIII(4).
Diaz G, Perilla N, Rojas Y. Occurrence of aflatoxins in selected Colombian foods. Mycotoxin research. 2001; 17(1):15-20.
Nguyen MT, Tozlovanu M, Tran TL, Pfohl-Leszkowicz A. Occurrence of aflatoxin B1, citrinin and ochratoxin A in rice in five provinces of the central region of Vietnam. Food chemistry. 2007; 105(1):42- 7.
Reiter EV, Vouk F, Böhm J, Razzazi-Fazeli E. Aflatoxins in rice–a limited survey of products marketed in Austria. Food Control. 2010; 21(7):988-91.
Lai X, Liu R, Ruan C, Zhang H, Liu C. Occurrence of aflatoxins and ochratoxin A in rice samples from six provinces in China. Food Control. 2015; 50:401-4.
Commission E. Commission Regulation (EC) No. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union. 2006; 364:5-24.
Lutfullah G, Hussain A. Studies on contamination level of aflatoxins in some cereals and beans of Pakistan. Food Control. 2012; 23(1):32-6.
Aflatoxins I. IARC monographs on the evaluation of carcinogenic risks to humans. Lyon: International Agency for Research on Cancer. 1993:245-395.
Park J, Kim E, Kim Y. Estimation of the daily exposure of Koreans to aflatoxin B1 through food consumption. Food additives and contaminants. 2004; 21(1):70-5.
Sugita-Konishi Y, Sato T, Saito S, Nakajima M, Tabata S, Tanaka T, et al. Exposure to aflatoxins in Japan: risk assessment for aflatoxin B1. Food Additives and Contaminants. 2010; 27(3):365-72.
Las Aflatoxinas DdDSlC. Programa Conjunto FAO/OMS Sobre Normas Alimentarias Comité del Codex sobre Contaminantes de los Alimentos Séptima reunión Moscú, Federación Rusa, 8-12 de abril de 2013. 2013.
Hussain A, Luttfullah G. Reduction of Aflatoxin-B-1 and Ochratoxin-A levels in Polished Basmati Rice (Oryza sativa Linn.) by Different Cooking Methods. Journal of the Chemical Society of Pakistan. 2009; 31(6):911-5.
Paliwal RL, Granados G, Lafitte HR, Violic AD, Marathée J-P. El maíz en los trópicos: Mejoramiento y producción: Food & Agriculture Org.; 2001.
Karami-Osboo R, Mirabolfathy M, Kamran R, Shetab-Boushehri M, Sarkari S. Aflatoxin B1 in maize harvested over 3 years in Iran. Food Control. 2012; 23(1):271-4.
Rojas V, Martin M, Quinzada M. Aflatoxinas en maíz recién cosechado en Panamá. Rev méd Panamá. 2000; 25:4-7.
NOM NOM. 188-SSAI-2002. Control de aflatoxinas en cereales para consumo humano y animal. 2002.
Martínez R, Melgarejo J, García G. Inspección de aflatoxinas en maíz cultivado, almacenado y transportado en Tamaulipas, México, en 1998. Anales del Instituto de Biología serie Botánica. 74(002).
Speijers GJA, Speijers MHM. Combined toxic effects of mycotoxins. Toxicology letters. 2004; 153(1):91- 8.
Villa P, Markaki P. Aflatoxin B 1 and ochratoxin A in breakfast cereals from Athens market: occurrence and risk assessment. Food Control. 2009; 20(5):455-61.
Blankson G, Mill-Robertson F. Aflatoxin contamination and exposure in processed cereal-based complementary foods for infants and young children in greater Accra, Ghana. Food Control. 2016; 64:212-7.
Agency FS. Survey of baby foods for mycotoxins. Food Survey Information Sheet No 68/04. 2004.
Ibáñez-Vea M, Martínez R, González-Peñas E, Lizarraga E, de Cerain AL. Co-occurrence of aflatoxins, ochratoxin A and zearalenone in breakfast cereals from spanish market. Food Control. 2011; 22(12):1949-55.
Sun G, Wang S, Hu X, Su J, Zhang Y, Xie Y, et al. Co-contamination of aflatoxin B1 and fumonisin B1 in food and human dietary exposure in three areas of China. Food additives and contaminants. 2011; 28(4):461-70.
Kilonzo RM, Imungi JK, Muiru WM, Lamuka PO, Njage PMK. Household dietary exposure to aflatoxins from maize and maize products in Kenya. Food Additives & Contaminants: Part A. 2014; 31(12):2055- 62.
Aguilera-Luiz M, Plaza-Bolaños P, Romero-González R, Vidal JM, Frenich AG. Comparison of the efficiency of different extraction methods for the simultaneous determination of mycotoxins and pesticides in milk samples by ultra high-performance liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry. 2011; 399(8):2863-75.
Pérez JGR, Vega S, Díaz G, Urbán G, Coronado M, Escobar A. Ocurrencia de aflatoxina M1 en leches cruda, ultrapasteurizada y orgánica, producidas y comercializadas en el altiplano mexicano. Revista de Salud Animal. 2008; 30(2):53-60
Hernández JC, Abadía B, Moreno JdJ. Determinación de aflatoxina M1 en leche proveniente del Caribe colombiano, empleando cromatografía líquida de ultra resolución. Revista Colombiana de Ciencias Pecuarias. 2009; 22(3).
Signorini ML GM, Molineri A., Chiericatti CA, Zapata de Basílico ML, Basílico JC, Pisani M. Exposure assessment of mycotoxins in cow’s milk in Argentina. Food and Chemical Toxicology. 2012; 50:250-7.
Veronezi Silva M JV, Bando E, Machinski M. Occurrence and estimative of aflatoxin M1 intake in UHT cow milk in Paraná a State, Brazil. Food Control. 2015; 53:222-5.
Rama A, Montesissa C, Lucatello L, Galina G, Benetti C, Bajraktari D. A study on the occurrence of aflatoxin M1 in milk consumed in Kosovo during 2009–2010. Food Control. 2016; 62:52-5.
Bilandžić N, Varenina I, Solomun B. Aflatoxin M 1 in raw milk in Croatia. Food Control. 2010; 21(9):1279-81.
Kaniou-Grigoriadou I, Eleftheriadou A, Mouratidou T, Katikou P. Determination of aflatoxin M 1 in ewe’s milk samples and the produced curd and Feta cheese. Food control. 2005; 16(3):257-61.
Elgerbi A, Aidoo K, Candlish A, Tester R. Occurrence of aflatoxin M1 in randomly selected North African milk and cheese samples. Food additives and contaminants. 2004; 21(6):592-7.
Chavarría G, Granados-Chinchilla F, Alfaro-Cascante M, Molina A. Detection of aflatoxin M1 in milk, cheese and sour cream samples from Costa Rica using enzyme-assisted extraction and HPLC. Food Additives & Contaminants: Part B. 2015; 8(2):128-35.
Redouane-Salah S, Morgavi D, Arhab R, Messaï A, Boudra H. Presence of aflatoxin M1 in raw, reconstituted, and powdered milk samples collected in Algeria. Environmental monitoring and assessment. 2015; 187(6):1-4.
Shundo L, de Almeida AP, Alaburda J, Lamardo LC, Navas SA, Ruvieri V, et al. Aflatoxins and ochratoxin A in Brazilian paprika. Food Control. 2009; 20(12):1099-102.
Hernández-Hierro JM, Garcia-Villanova RJ, Rodríguez P, Toruño IM. Aflatoxins and ochratoxin A in red paprika for retail sale in Spain: occurrence and evaluation of a simultaneous analytical method. Journal of agricultural and food chemistry. 2008; 56(3):751-6.
Cho S-H, Lee C-H, Jang M-R, Son Y-W, Lee S-M, Choi I-S, et al. Aflatoxins contamination in spices and processed spice products commercialized in Korea. Food Chemistry. 2008; 107(3):1283-8.
Colak H, Bingol EB, Hampikyan H, Nazli B. Determination of aflatoxin contamination in red-scaled, red and black pepper by ELISA and HPLC. Journal of Food and Drug Analysis. 2006; 14(3):292-6.
Waheed S, Siddique N. Evaluation of dietary status with respect to trace element intake from dry fruits consumed in Pakistan: a study using instrumental neutron activation analysis. International journal of food sciences and nutrition. 2009; 60(4):333-43.
Iqbal SZ, Asi MR, Zuber M, Akram N, Batool N. Aflatoxins contamination in peanut and peanut products commercially available in retail markets of Punjab, Pakistan. Food control. 2013; 32(1):83-6.
Leong Y-H, Ismail N, Latif AA, Ahmad R. Aflatoxin occurrence in nuts and commercial nutty products in Malaysia. Food Control. 2010; 21(3):334-8.
Chun HS, Kim HJ, Ok HE, Hwang J-B, Chung D-H. Determination of aflatoxin levels in nuts and their products consumed in South Korea. Food Chemistry. 2007; 102(1):385-91.
Neamatallah A, Serdar SA. Incidence of aflatoxins in commercial nuts in the holy city of Mekkah. Food Control. 2013; 29(1):121-4.
Council EEC. Commission regulation (EC). No. 1525/98. Official Journal of the European Communities. 1998; 201:43-6.
Masood M, Iqbal SZ, Asi MR, Malik N. Natural occurrence of aflatoxins in dry fruits and edible nuts. Food Control. 2015; 55:62-5.
Van de Perre E, Jacxsens L, Lachat C, El Tahan F, De Meulenaer B. Impact of maximum levels in European legislation on exposure of mycotoxins in dried products: Case of aflatoxin B1 and ochratoxin A in nuts and dried fruits. Food and Chemical Toxicology. 2015; 75:112-7.
Mupunga I, Lebelo S, Mngqawa P, Rheeder J, Katerere D. Natural occurrence of aflatoxins in peanuts and peanut butter from Bulawayo, Zimbabwe. Journal of Food Protection®. 2014; 77(10):1814-8.
Qian G-S, Ross RK, Yu MC, Yuan J-M, Gao Y-T, Henderson BE, et al. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epidemiology Biomarkers & Prevention. 1994; 3(1):3-10.
Soriano del Castillo JM. Micotoxinas en alimentos: Ediciones Díaz de Santos; 2007.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer. 2015; 136(5):E359-E86.
Liu Y, Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental health perspectives. 2010; 118(6):818-24.
McGlynn KA, London WT. The global epidemiology of hepatocellular carcinoma: present and future. Clinics in liver disease. 2011; 15(2):223-43.
Ding X, Li P, Bai Y, Zhou H. Aflatoxin B 1 in post-harvest peanuts and dietary risk in China. Food Control. 2012; 23(1):143-8.
Pottenger LH, Andrews LS, Bachman AN, Boogaard PJ, Cadet J, Embry MR, et al. An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride. Critical reviews in toxicology. 2014; 44(4):348-91.
Salud INd. Evaluación de riesgo de carcinoma hepatocelular en poblacion colombiana por consumo en arepa de maíz contaminada con aflatoxina B1 (AFB1). In: Social MdSyP, editor. 2015.
Alimentarius FOCdC. Documento de debate sobre directrices para las opciones de gestión de riesgos sobre cómo abordar los resultados de nuevas metodologías de evaluación de riesgos. La Haya (Países Bajos), 2011.
(EFSA) EFSA. Opinion of the Scientific Committee on a request from EFSA related to a harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA Journal. 2005; 3(10):1-31.
Thuvander A, Möller T, Enghardt Barbieri H, Jansson A, Salomonsson A-C, Olsen M. Dietary intake of some important mycotoxins by the Swedish population. Food Additives & Contaminants. 2001; 18(8):696-706.
Leblanc J-C, Tard A, Volatier J-L, Verger P. Estimated dietary exposure to principal food mycotoxins from The First French Total Diet Study. Food Additives and Contaminants. 2005; 22(7):652-72.
Azziz-Baumgartner E, Lindblade K, Gieseker K, Rogers HS, Kieszak S, Njapau H, et al. Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environmental Health Perspectives. 2005:1779- 83.
Yard EE, Daniel JH, Lewis LS, Rybak ME, Paliakov EM, Kim AA, et al. Human aflatoxin exposure in Kenya, 2007: a cross-sectional study. Food Additives & Contaminants: Part A. 2013; 30(7):1322-31.
Shephard GS. Risk assessment of aflatoxins in food in Africa. Food Additives and Contaminants. 2008; 25(10):1246-56.
Lee HM, Hwang JH, Ryuem TK, Jang DD, Yang J-H. Risk assessment of aflatoxin B1 from food consumption in the Korean general population. Human and Ecological Risk Assessment. 2009; 15(6):1273-85.
Chin C, Abdullah A, Sugita-Konishi Y. Dietary intake of aflatoxins in the adult Malaysian population–an assessment of risk. Food Additives and Contaminants: Part B. 2012; 5(4):286-94.
Andrade P, de Mello MH, França J, Caldas E. Aflatoxins in food products consumed in Brazil: a preliminary dietary risk assessment. Food Additives & Contaminants: Part A. 2013; 30(1):127-36.
Andrade P, Caldas E. Aflatoxins in cereals: worldwide occurrence and dietary risk assessment. World Mycotoxin Journal. 2015; 8(4):415-31.
Bhat Ramesh V, Vasanthi S. Mycotoxin food safety risk in developing countries. International Food Policy Research Institute (IFPRI), 2003.
Wild CP MJ, Groopman JD. Mycotoxin Control in Low- and Middle-Income Countries. Lyon, France: International Agency for Research on Cancer (IARC Working Group Report No 9). 2015.
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spelling Londoño-Cifuentes, Erika Melissac5b233c6663e5fb2fc44ef76eeac754b300Martínez-Miranda, María Marcelad9df25cc883e962267fa308dfa8e7aea3002017-01-01 00:00:002021-02-14T10:01:16Z2017-01-01 00:00:002021-02-14T10:01:16Z2016-01-011657-9550https://doi.org/10.17151/biosa.2017.16.1.7https://repositorio.ucaldas.edu.co/handle/ucaldas/1601410.17151/biosa.2017.16.1.72462-960XIntroducción: El consumo de cereales, frutos secos, especias y leche de vaca es elevado a nivel global. Estos alimentos son susceptibles a la contaminación biológica, incluyendo la causada por hongos del género Aspergillus, que producen metabolitos tóxicos llamados aflatoxinas, los cuales ocasionan efectos adversos en la salud. Las aflatoxinas B1 y M1 han sido clasificadas por la Agencia Internacional de Investigación del Cáncer (IARC) en el Grupo I como carcinógenos para humanos. El presente artículo muestra la ocurrencia de aflatoxinas en algunos alimentos de consumo humano y su relación con el desarrollo de carcinoma hepatocelular. Métodos: Se llevó a cabo una búsqueda bibliográfica en las bases de datos: Science Direct, Scopus, Pubmed y Web of Science. Se utilizaron palabras como “risk assessment and aflatoxin”, “ocurrence and aflatoxins”, “aflatoxins and hepatocellular carcinoma”, “aflatoxins and foodstuffs”. Resultados: Con base en los estudios consultados se demuestra que la ocurrencia de aflatoxinas es alta, principalmente en cereales como arroz, maíz y trigo. Además, las investigaciones relacionadas con la evaluación de la exposición destacan el vínculo existente entre el consumo frecuente de estas micotoxinas y el riesgo de desarrollar carcinoma hepatocelular, especialmente en personas que han contraído el virus de la hepatitis B. Conclusión: La presencia de aflatoxinas en alimentos ha generado alarmas de seguridad alimentaria a nivel mundial. Aunque se han creado algunas regulaciones, en países donde hay mayor exposición a estas micotoxinas, existe poco o ningún control de calidad. Por ello, es importante generar mecanismos de vigilancia pertinentes para disminuir el riesgo de contaminación fúngica y alimentos con aflatoxinas.Introduction: Consumption of grains, nuts dried fruits, spices and cow’s milk is high globally elevated. These foods are susceptible sensitive to biological contamination, including that caused by fungi of the genus Aspergillus, which produce secondary toxic metabolites called aflatoxins, which cause adverse health effects. The aflatoxin B1 and M1 have been classified by the International Agency for Research on Cancer (IARC) in Group I as carcinogenic to humans. This article shows the occurrence of aflatoxins in some foods for human consumption and its relationship to the development of hepatocellular carcinoma. Methods: A bibliographic search was carried out in the databases: Science Direct, Scopus, Pubmed and Web of Science. Words like “risk assessment and aflatoxin”, “occurrence and aflatoxins”, “aflatoxins and hepatocellular carcinoma”, “aflatoxins and foodstuffs” were used. Results: Based on the studies conducted it was demonstrated that the occurrence of aflatoxins is high, especially in cereals grains such as rice, corn, and wheat. In addition, research related to exposure assessment highlighted the link between frequent consumption of these mycotoxins and the risk of developing hepatocellular carcinoma, especially in people who have contracted hepatitis B virus. Conclusion: The high prevalence of aflatoxins in food has generated food security safety alarms worldwide. Although some regulations have been created, in countries where there is greater more exposure to these mycotoxins there is little or no quality control. It is Therefore, it is important to create relevant monitoring mechanisms so that the to reduce the risk of fungal contamination and food with aflatoxins. possible cases of liver cancer may be lower.application/pdfspaUniversidad de CaldasDerechos de autor 2017 Biosaludhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/3736aflatoxinsprevalencerisk assessmentcarcinomahepatocellularaflatoxinasprevalenciamedición de riesgocarcinoma hepatocelularAflatoxinas en alimentos y exposición dietaria como factor de riesgo para el carcinoma hepatocelularAflatoxins in food and dietary exposure as a risk factor for hepatocellular carcinomaArtículo de revistaSección Artículos de RevisiónJournal Articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a856615316BiosaludHarrison P. Agricultura mundial: hacia los años 2015/2030. Dirección de Información de la FAO. 2002.Cano-Sancho G, Ramos AJ, Marín S, Sanchis V. Presence and co-occurrence of aflatoxins, deoxynivalenol, fumonisins and zearalenone in gluten-free and ethnic foods. Food Control. 2012; 26(2):282-6.Zhao X, Schaffner DW, Yue T. Quantification of aflatoxin risk associated with Chinese spices: point and probability risk assessments for aflatoxin B 1. Food control. 2013; 33(2):366-77.Wogan GN, Kensler TW, Groopman JD. Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review. Food additives & contaminants: part A. 2012; 29(2):249-57.Ossa DEH, Hincapié DA, Peñuela GA. Determination of aflatoxin M 1 in ice cream samples using immunoaffinity columns and ultra-high performance liquid chromatography coupled to tandem mass spectrometry. Food Control. 2015; 56:34-40.Majeed S, Iqbal M, Asi MR, Iqbal SZ. Aflatoxins and ochratoxin A contamination in rice, corn and corn products from Punjab, Pakistan. Journal of Cereal Science. 2013; 58(3):446-50.IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs 2012; 100.Wang J-S, Groopman JD. DNA damage by mycotoxins. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 1999; 424(1):167-81.FAO. Seguimiento del mercado del arroz de la FAO. Organización de las Naciones Unidas para la Alimentación y la Agricultura FAO. 2015; XVIII(4).Diaz G, Perilla N, Rojas Y. Occurrence of aflatoxins in selected Colombian foods. Mycotoxin research. 2001; 17(1):15-20.Nguyen MT, Tozlovanu M, Tran TL, Pfohl-Leszkowicz A. Occurrence of aflatoxin B1, citrinin and ochratoxin A in rice in five provinces of the central region of Vietnam. Food chemistry. 2007; 105(1):42- 7.Reiter EV, Vouk F, Böhm J, Razzazi-Fazeli E. Aflatoxins in rice–a limited survey of products marketed in Austria. Food Control. 2010; 21(7):988-91.Lai X, Liu R, Ruan C, Zhang H, Liu C. Occurrence of aflatoxins and ochratoxin A in rice samples from six provinces in China. Food Control. 2015; 50:401-4.Commission E. Commission Regulation (EC) No. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union. 2006; 364:5-24.Lutfullah G, Hussain A. Studies on contamination level of aflatoxins in some cereals and beans of Pakistan. Food Control. 2012; 23(1):32-6.Aflatoxins I. IARC monographs on the evaluation of carcinogenic risks to humans. Lyon: International Agency for Research on Cancer. 1993:245-395.Park J, Kim E, Kim Y. Estimation of the daily exposure of Koreans to aflatoxin B1 through food consumption. Food additives and contaminants. 2004; 21(1):70-5.Sugita-Konishi Y, Sato T, Saito S, Nakajima M, Tabata S, Tanaka T, et al. Exposure to aflatoxins in Japan: risk assessment for aflatoxin B1. Food Additives and Contaminants. 2010; 27(3):365-72.Las Aflatoxinas DdDSlC. Programa Conjunto FAO/OMS Sobre Normas Alimentarias Comité del Codex sobre Contaminantes de los Alimentos Séptima reunión Moscú, Federación Rusa, 8-12 de abril de 2013. 2013.Hussain A, Luttfullah G. Reduction of Aflatoxin-B-1 and Ochratoxin-A levels in Polished Basmati Rice (Oryza sativa Linn.) by Different Cooking Methods. Journal of the Chemical Society of Pakistan. 2009; 31(6):911-5.Paliwal RL, Granados G, Lafitte HR, Violic AD, Marathée J-P. El maíz en los trópicos: Mejoramiento y producción: Food & Agriculture Org.; 2001.Karami-Osboo R, Mirabolfathy M, Kamran R, Shetab-Boushehri M, Sarkari S. Aflatoxin B1 in maize harvested over 3 years in Iran. Food Control. 2012; 23(1):271-4.Rojas V, Martin M, Quinzada M. Aflatoxinas en maíz recién cosechado en Panamá. Rev méd Panamá. 2000; 25:4-7.NOM NOM. 188-SSAI-2002. Control de aflatoxinas en cereales para consumo humano y animal. 2002.Martínez R, Melgarejo J, García G. Inspección de aflatoxinas en maíz cultivado, almacenado y transportado en Tamaulipas, México, en 1998. Anales del Instituto de Biología serie Botánica. 74(002).Speijers GJA, Speijers MHM. Combined toxic effects of mycotoxins. Toxicology letters. 2004; 153(1):91- 8.Villa P, Markaki P. Aflatoxin B 1 and ochratoxin A in breakfast cereals from Athens market: occurrence and risk assessment. Food Control. 2009; 20(5):455-61.Blankson G, Mill-Robertson F. Aflatoxin contamination and exposure in processed cereal-based complementary foods for infants and young children in greater Accra, Ghana. Food Control. 2016; 64:212-7.Agency FS. Survey of baby foods for mycotoxins. Food Survey Information Sheet No 68/04. 2004.Ibáñez-Vea M, Martínez R, González-Peñas E, Lizarraga E, de Cerain AL. Co-occurrence of aflatoxins, ochratoxin A and zearalenone in breakfast cereals from spanish market. Food Control. 2011; 22(12):1949-55.Sun G, Wang S, Hu X, Su J, Zhang Y, Xie Y, et al. Co-contamination of aflatoxin B1 and fumonisin B1 in food and human dietary exposure in three areas of China. Food additives and contaminants. 2011; 28(4):461-70.Kilonzo RM, Imungi JK, Muiru WM, Lamuka PO, Njage PMK. Household dietary exposure to aflatoxins from maize and maize products in Kenya. Food Additives & Contaminants: Part A. 2014; 31(12):2055- 62.Aguilera-Luiz M, Plaza-Bolaños P, Romero-González R, Vidal JM, Frenich AG. Comparison of the efficiency of different extraction methods for the simultaneous determination of mycotoxins and pesticides in milk samples by ultra high-performance liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry. 2011; 399(8):2863-75.Pérez JGR, Vega S, Díaz G, Urbán G, Coronado M, Escobar A. Ocurrencia de aflatoxina M1 en leches cruda, ultrapasteurizada y orgánica, producidas y comercializadas en el altiplano mexicano. Revista de Salud Animal. 2008; 30(2):53-60Hernández JC, Abadía B, Moreno JdJ. Determinación de aflatoxina M1 en leche proveniente del Caribe colombiano, empleando cromatografía líquida de ultra resolución. Revista Colombiana de Ciencias Pecuarias. 2009; 22(3).Signorini ML GM, Molineri A., Chiericatti CA, Zapata de Basílico ML, Basílico JC, Pisani M. Exposure assessment of mycotoxins in cow’s milk in Argentina. Food and Chemical Toxicology. 2012; 50:250-7.Veronezi Silva M JV, Bando E, Machinski M. Occurrence and estimative of aflatoxin M1 intake in UHT cow milk in Paraná a State, Brazil. Food Control. 2015; 53:222-5.Rama A, Montesissa C, Lucatello L, Galina G, Benetti C, Bajraktari D. A study on the occurrence of aflatoxin M1 in milk consumed in Kosovo during 2009–2010. Food Control. 2016; 62:52-5.Bilandžić N, Varenina I, Solomun B. Aflatoxin M 1 in raw milk in Croatia. Food Control. 2010; 21(9):1279-81.Kaniou-Grigoriadou I, Eleftheriadou A, Mouratidou T, Katikou P. Determination of aflatoxin M 1 in ewe’s milk samples and the produced curd and Feta cheese. Food control. 2005; 16(3):257-61.Elgerbi A, Aidoo K, Candlish A, Tester R. Occurrence of aflatoxin M1 in randomly selected North African milk and cheese samples. Food additives and contaminants. 2004; 21(6):592-7.Chavarría G, Granados-Chinchilla F, Alfaro-Cascante M, Molina A. Detection of aflatoxin M1 in milk, cheese and sour cream samples from Costa Rica using enzyme-assisted extraction and HPLC. Food Additives & Contaminants: Part B. 2015; 8(2):128-35.Redouane-Salah S, Morgavi D, Arhab R, Messaï A, Boudra H. Presence of aflatoxin M1 in raw, reconstituted, and powdered milk samples collected in Algeria. Environmental monitoring and assessment. 2015; 187(6):1-4.Shundo L, de Almeida AP, Alaburda J, Lamardo LC, Navas SA, Ruvieri V, et al. Aflatoxins and ochratoxin A in Brazilian paprika. Food Control. 2009; 20(12):1099-102.Hernández-Hierro JM, Garcia-Villanova RJ, Rodríguez P, Toruño IM. Aflatoxins and ochratoxin A in red paprika for retail sale in Spain: occurrence and evaluation of a simultaneous analytical method. Journal of agricultural and food chemistry. 2008; 56(3):751-6.Cho S-H, Lee C-H, Jang M-R, Son Y-W, Lee S-M, Choi I-S, et al. Aflatoxins contamination in spices and processed spice products commercialized in Korea. Food Chemistry. 2008; 107(3):1283-8.Colak H, Bingol EB, Hampikyan H, Nazli B. Determination of aflatoxin contamination in red-scaled, red and black pepper by ELISA and HPLC. Journal of Food and Drug Analysis. 2006; 14(3):292-6.Waheed S, Siddique N. Evaluation of dietary status with respect to trace element intake from dry fruits consumed in Pakistan: a study using instrumental neutron activation analysis. International journal of food sciences and nutrition. 2009; 60(4):333-43.Iqbal SZ, Asi MR, Zuber M, Akram N, Batool N. Aflatoxins contamination in peanut and peanut products commercially available in retail markets of Punjab, Pakistan. Food control. 2013; 32(1):83-6.Leong Y-H, Ismail N, Latif AA, Ahmad R. Aflatoxin occurrence in nuts and commercial nutty products in Malaysia. Food Control. 2010; 21(3):334-8.Chun HS, Kim HJ, Ok HE, Hwang J-B, Chung D-H. Determination of aflatoxin levels in nuts and their products consumed in South Korea. Food Chemistry. 2007; 102(1):385-91.Neamatallah A, Serdar SA. Incidence of aflatoxins in commercial nuts in the holy city of Mekkah. Food Control. 2013; 29(1):121-4.Council EEC. Commission regulation (EC). No. 1525/98. Official Journal of the European Communities. 1998; 201:43-6.Masood M, Iqbal SZ, Asi MR, Malik N. Natural occurrence of aflatoxins in dry fruits and edible nuts. Food Control. 2015; 55:62-5.Van de Perre E, Jacxsens L, Lachat C, El Tahan F, De Meulenaer B. Impact of maximum levels in European legislation on exposure of mycotoxins in dried products: Case of aflatoxin B1 and ochratoxin A in nuts and dried fruits. Food and Chemical Toxicology. 2015; 75:112-7.Mupunga I, Lebelo S, Mngqawa P, Rheeder J, Katerere D. Natural occurrence of aflatoxins in peanuts and peanut butter from Bulawayo, Zimbabwe. Journal of Food Protection®. 2014; 77(10):1814-8.Qian G-S, Ross RK, Yu MC, Yuan J-M, Gao Y-T, Henderson BE, et al. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epidemiology Biomarkers & Prevention. 1994; 3(1):3-10.Soriano del Castillo JM. Micotoxinas en alimentos: Ediciones Díaz de Santos; 2007.Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer. 2015; 136(5):E359-E86.Liu Y, Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental health perspectives. 2010; 118(6):818-24.McGlynn KA, London WT. The global epidemiology of hepatocellular carcinoma: present and future. Clinics in liver disease. 2011; 15(2):223-43.Ding X, Li P, Bai Y, Zhou H. Aflatoxin B 1 in post-harvest peanuts and dietary risk in China. Food Control. 2012; 23(1):143-8.Pottenger LH, Andrews LS, Bachman AN, Boogaard PJ, Cadet J, Embry MR, et al. An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride. Critical reviews in toxicology. 2014; 44(4):348-91.Salud INd. Evaluación de riesgo de carcinoma hepatocelular en poblacion colombiana por consumo en arepa de maíz contaminada con aflatoxina B1 (AFB1). In: Social MdSyP, editor. 2015.Alimentarius FOCdC. Documento de debate sobre directrices para las opciones de gestión de riesgos sobre cómo abordar los resultados de nuevas metodologías de evaluación de riesgos. La Haya (Países Bajos), 2011.(EFSA) EFSA. Opinion of the Scientific Committee on a request from EFSA related to a harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA Journal. 2005; 3(10):1-31.Thuvander A, Möller T, Enghardt Barbieri H, Jansson A, Salomonsson A-C, Olsen M. Dietary intake of some important mycotoxins by the Swedish population. Food Additives & Contaminants. 2001; 18(8):696-706.Leblanc J-C, Tard A, Volatier J-L, Verger P. Estimated dietary exposure to principal food mycotoxins from The First French Total Diet Study. Food Additives and Contaminants. 2005; 22(7):652-72.Azziz-Baumgartner E, Lindblade K, Gieseker K, Rogers HS, Kieszak S, Njapau H, et al. Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environmental Health Perspectives. 2005:1779- 83.Yard EE, Daniel JH, Lewis LS, Rybak ME, Paliakov EM, Kim AA, et al. Human aflatoxin exposure in Kenya, 2007: a cross-sectional study. Food Additives & Contaminants: Part A. 2013; 30(7):1322-31.Shephard GS. Risk assessment of aflatoxins in food in Africa. Food Additives and Contaminants. 2008; 25(10):1246-56.Lee HM, Hwang JH, Ryuem TK, Jang DD, Yang J-H. Risk assessment of aflatoxin B1 from food consumption in the Korean general population. Human and Ecological Risk Assessment. 2009; 15(6):1273-85.Chin C, Abdullah A, Sugita-Konishi Y. Dietary intake of aflatoxins in the adult Malaysian population–an assessment of risk. Food Additives and Contaminants: Part B. 2012; 5(4):286-94.Andrade P, de Mello MH, França J, Caldas E. Aflatoxins in food products consumed in Brazil: a preliminary dietary risk assessment. Food Additives & Contaminants: Part A. 2013; 30(1):127-36.Andrade P, Caldas E. Aflatoxins in cereals: worldwide occurrence and dietary risk assessment. World Mycotoxin Journal. 2015; 8(4):415-31.Bhat Ramesh V, Vasanthi S. Mycotoxin food safety risk in developing countries. International Food Policy Research Institute (IFPRI), 2003.Wild CP MJ, Groopman JD. Mycotoxin Control in Low- and Middle-Income Countries. Lyon, France: International Agency for Research on Cancer (IARC Working Group Report No 9). 2015.Núm. 1 , Año 2017 : Enero - Juniohttps://revistasojs.ucaldas.edu.co/index.php/biosalud/article/download/3736/3450OREORE.xmltext/xml2617https://repositorio.ucaldas.edu.co/bitstream/ucaldas/16014/1/ORE.xml1cc405911efbc3e5dfdfc19e571cff03MD51ucaldas/16014oai:repositorio.ucaldas.edu.co:ucaldas/160142021-02-14 10:01:16.317Repositorio Digital de la Universidad de Caldasbdigital@metabiblioteca.com

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