Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis

39 Páginas.

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2016
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Universidad de la Sabana
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https://hdl.handle.net/10818/28731
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Botánica médica
Farmacología experimental
Marihuana -- Uso terapéutico
Plantas alucinógenas
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oai_identifier_str oai:intellectum.unisabana.edu.co:10818/28731
network_acronym_str REPOUSABAN
network_name_str Repositorio Universidad de la Sabana
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dc.title.none.fl_str_mv Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis
title Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis
spellingShingle Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis
Botánica médica
Farmacología experimental
Marihuana -- Uso terapéutico
Plantas alucinógenas
title_short Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis
title_full Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis
title_fullStr Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis
title_full_unstemmed Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis
title_sort Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisis
dc.contributor.none.fl_str_mv Díaz Quijano, Diana Marcela
dc.subject.none.fl_str_mv Botánica médica
Farmacología experimental
Marihuana -- Uso terapéutico
Plantas alucinógenas
topic Botánica médica
Farmacología experimental
Marihuana -- Uso terapéutico
Plantas alucinógenas
description 39 Páginas.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-24T21:09:45Z
2016-11-24T21:09:45Z
2016-11-24
2016
dc.type.none.fl_str_mv Tesis/Trabajo de grado - Especialización
http://purl.org/coar/resource_type/c_7a1f
Texto
info:eu-repo/semantics/other
http://purl.org/redcol/resource_type/COther
info:eu-repo/semantics/acceptedVersion
status_str acceptedVersion
dc.identifier.none.fl_str_mv Cook J., Lloyd-Jones D., Ogden E. Medical use of cannabis: an addiction medicine perspective. Internal Medicine Journal. 2015; 45: 677-681.
Whiting P.F., Wolff R.F., Deshpande S, et al. Cannabinoids for medical Use: A Systematic Review and Meta-analysis. The Journal of the American Medical Association. 2015; 313(24): 2456-2473
Alpár A, Di Marzo V, Harkany T. At the tip of an iceberg: Prenatal marijuana and its possible relation to neuropsychiatric outcome in the offspring. Biological Psychiatry 2016; 79(7):e33-e45.
FDA.gov [Internet] Estados Unidos. FDA and Marijuana: Questions and Answers [Fecha de consulta 23 de octubre de 2016]. Disponible en: http://www.fda.gov/newsevents/publichealthfocus/ucm421168.htm
Ministerio de Salud y Protección Social. República de Colombia. Decreto 2467 de 2015. [Fecha de consulta 23 de octubre de 2016]. Disponible en: http://wp.presidencia.gov.co/sitios/normativa/decretos/2015/Decretos2015/DECRE TO%202467%20DEL%2022%20DE%20DICIEMBRE%20DE%202015.pdf
Pertwee R. Cannabinoid pharmacology: the first 66 years. British Journal of Pharmacology. 2006; 147: S163¿S171.
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151(4):264¿269
Shea BJ, Grimshaw JM, Wells GA, et al.: Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 2007, 7: 10.
. Scottish Intercollegiate Guidelines Network [Internet]. Search Filters. Scotland: SIGN 2001-2014. [actualizado 27 Ago 2015; citado 23 Dic 2015]. Disponible en: http://hiru.mcmaster.ca/hiru/HIRU_Hedges_home.aspx
Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;33(1):159¿174
Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al The NewcastleOttawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses. [Fecha de consulta 23 de diciembre de 2016]. Disponible en: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Hoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012; 65: 934¿939
Nguyen KA, Peer N, Mills EJ, Kengne AP. A Meta-Analysis of the Metabolic Syndrome Prevalence in the Global HIV-Infected Population. PLoS ONE 11(3): e0150970. doi:10.1371/journal. pone.0150970
Mills EJ, Jansen JP, Kanters S. Heterogeneity in meta-analysis of FDG-PET studies to diagnose lung cancer. JAMA. 2015; 313: 419.
Babson K., Boden M., Bonn-Miller M. Sleep Quality Moderates the Relation between Depression Symptoms and Problematic Cannabis Use among Medical Cannabis Users. The American Journal of Drug and Alcohol Abuse. 2013; 39 (3): 211-216.
. Belendiuk K., Babson K., Vandrey R., Bonn-Miller M. Cannabis species and cannabinoid concentration preference among sleep-disturbed medicinal cannabis users. Addictve Behaviors. 2015; 50: 178-181
. Harris D., Jones R., Rank R., Nath R., Hernandez E., Goldstein K., Meldenson J. Self-Reported Marijuana Effects and Characteristics of 100 San Francisco Medical Marijuana Club Members. Journal of Addictive Diseases. 2000; 19 (3): 89- 103.
Harris G., Dupuis L., Mugford G., Johnston L., Haase D., Page G., Haldane H., Harris N., Midodzi W., Dow G. Patterns and correlates of cannabis use among individuals with HIV/AIDS in Maritime Canada. Can J Infect Dis Med Microbiol. 2014; 25 (1): e1-e7.
Ilgen M., Bohnert K., Kleinberg F., Jannausch M., Bohner A., Walton M., Blow F. Characteristics of adults seeking medical marijuana certification. Drug and Alcohol Dependence. 2013; 132: 654-659.
Swartz R. Medical marijuana users in substance abuse treatment. Harm Reduction Journal. 2010; 7: 1-9.
Ware MA, Doyle CR, Woods R, Lynch ME, Clark AJ. Cannabis use for chronic noncancer pain: Results of a prospective survey. Pain. 2003; 102: 211-216.
Bonn-Miller M., Trafton J. Prevalence of Cannabis Use Disorder Diagnoses Among Veterans in 2002, 2008, and 2009. Psychological Services. 2012; 9 (4): 404-416.
Cerdá M., Wall M., Keyes K., Galea S., Hasin D. Medical marijuana laws in 50 states: Investigating the relationship between state legalization of medical marijuana and marijuana use, abuse and dependence. Drug and Alcohol Dependence. 2012; 120: 22-27.
D¿Amico E., Miles J., Tucker J. Gateway to Curiosity: Medical Marijuana Ads and Intention and Use During Middle School. Psychology of Addictive Behaviors. 2015; 29 (3): 613-619.
. Degenhardt L., Lintzeris N., Campbell G., Bruno R., Cohen., Farrell M., Hall W. Experience of adjunctive cannabis use for chronic non-cancer pain:Findings from the Pain and Opioids IN Treatment (POINT) study. Drug and Alcohol Dependence. 2015; 147: 144-150.
. Ghandour L., El Sayed D., Martins S., Martins S. Prevalence and patterns of commonly abused psychoactive prescription drugs in a sample of university students from Lebanon: An opportunity for cross-cultural comparisons. Drug and Alcohol Dependence. 2012; 121: 110-117.
Gunderson E., Haughey H., Ait-Daoud N., Joshi A., Hart C. A Survey of Synthetic Cannabinoid Consumption by Current Cannabis Users. Substance Abuse. 2014; 35: 184-189.
Kim H., Anderson J., Saghafi O., Heard K., Monte A. Cyclic Vomiting Presentations Following Marijuana Liberalization in Colorado. Academic Emergency Medicine. 2015; 22 (6): 694-699.
Pacula RL, Powell D, Heaton P, Sevigny EL. Assessing the effects of medical marijuana laws on marijuana use: the devil is in the details. Journal of Policy Analysis & Management. 2015; 34 (1): 7-31.
Schuermeyer J, Salomonsen-Sautel S, Price RK, Balan S, Thurstone C, Min S-J, Sakai JT. Temporal trends in marijuana attitudes, availability and use in Colorado compared to non-medical marijuana states: 2003¿11. Drug and Alcohol Dependence. 2014; 140: 145-155.
https://hdl.handle.net/10818/28731
263029
TE08800
identifier_str_mv Cook J., Lloyd-Jones D., Ogden E. Medical use of cannabis: an addiction medicine perspective. Internal Medicine Journal. 2015; 45: 677-681.
Whiting P.F., Wolff R.F., Deshpande S, et al. Cannabinoids for medical Use: A Systematic Review and Meta-analysis. The Journal of the American Medical Association. 2015; 313(24): 2456-2473
Alpár A, Di Marzo V, Harkany T. At the tip of an iceberg: Prenatal marijuana and its possible relation to neuropsychiatric outcome in the offspring. Biological Psychiatry 2016; 79(7):e33-e45.
FDA.gov [Internet] Estados Unidos. FDA and Marijuana: Questions and Answers [Fecha de consulta 23 de octubre de 2016]. Disponible en: http://www.fda.gov/newsevents/publichealthfocus/ucm421168.htm
Ministerio de Salud y Protección Social. República de Colombia. Decreto 2467 de 2015. [Fecha de consulta 23 de octubre de 2016]. Disponible en: http://wp.presidencia.gov.co/sitios/normativa/decretos/2015/Decretos2015/DECRE TO%202467%20DEL%2022%20DE%20DICIEMBRE%20DE%202015.pdf
Pertwee R. Cannabinoid pharmacology: the first 66 years. British Journal of Pharmacology. 2006; 147: S163¿S171.
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151(4):264¿269
Shea BJ, Grimshaw JM, Wells GA, et al.: Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 2007, 7: 10.
. Scottish Intercollegiate Guidelines Network [Internet]. Search Filters. Scotland: SIGN 2001-2014. [actualizado 27 Ago 2015; citado 23 Dic 2015]. Disponible en: http://hiru.mcmaster.ca/hiru/HIRU_Hedges_home.aspx
Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;33(1):159¿174
Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al The NewcastleOttawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses. [Fecha de consulta 23 de diciembre de 2016]. Disponible en: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Hoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012; 65: 934¿939
Nguyen KA, Peer N, Mills EJ, Kengne AP. A Meta-Analysis of the Metabolic Syndrome Prevalence in the Global HIV-Infected Population. PLoS ONE 11(3): e0150970. doi:10.1371/journal. pone.0150970
Mills EJ, Jansen JP, Kanters S. Heterogeneity in meta-analysis of FDG-PET studies to diagnose lung cancer. JAMA. 2015; 313: 419.
Babson K., Boden M., Bonn-Miller M. Sleep Quality Moderates the Relation between Depression Symptoms and Problematic Cannabis Use among Medical Cannabis Users. The American Journal of Drug and Alcohol Abuse. 2013; 39 (3): 211-216.
. Belendiuk K., Babson K., Vandrey R., Bonn-Miller M. Cannabis species and cannabinoid concentration preference among sleep-disturbed medicinal cannabis users. Addictve Behaviors. 2015; 50: 178-181
. Harris D., Jones R., Rank R., Nath R., Hernandez E., Goldstein K., Meldenson J. Self-Reported Marijuana Effects and Characteristics of 100 San Francisco Medical Marijuana Club Members. Journal of Addictive Diseases. 2000; 19 (3): 89- 103.
Harris G., Dupuis L., Mugford G., Johnston L., Haase D., Page G., Haldane H., Harris N., Midodzi W., Dow G. Patterns and correlates of cannabis use among individuals with HIV/AIDS in Maritime Canada. Can J Infect Dis Med Microbiol. 2014; 25 (1): e1-e7.
Ilgen M., Bohnert K., Kleinberg F., Jannausch M., Bohner A., Walton M., Blow F. Characteristics of adults seeking medical marijuana certification. Drug and Alcohol Dependence. 2013; 132: 654-659.
Swartz R. Medical marijuana users in substance abuse treatment. Harm Reduction Journal. 2010; 7: 1-9.
Ware MA, Doyle CR, Woods R, Lynch ME, Clark AJ. Cannabis use for chronic noncancer pain: Results of a prospective survey. Pain. 2003; 102: 211-216.
Bonn-Miller M., Trafton J. Prevalence of Cannabis Use Disorder Diagnoses Among Veterans in 2002, 2008, and 2009. Psychological Services. 2012; 9 (4): 404-416.
Cerdá M., Wall M., Keyes K., Galea S., Hasin D. Medical marijuana laws in 50 states: Investigating the relationship between state legalization of medical marijuana and marijuana use, abuse and dependence. Drug and Alcohol Dependence. 2012; 120: 22-27.
D¿Amico E., Miles J., Tucker J. Gateway to Curiosity: Medical Marijuana Ads and Intention and Use During Middle School. Psychology of Addictive Behaviors. 2015; 29 (3): 613-619.
. Degenhardt L., Lintzeris N., Campbell G., Bruno R., Cohen., Farrell M., Hall W. Experience of adjunctive cannabis use for chronic non-cancer pain:Findings from the Pain and Opioids IN Treatment (POINT) study. Drug and Alcohol Dependence. 2015; 147: 144-150.
. Ghandour L., El Sayed D., Martins S., Martins S. Prevalence and patterns of commonly abused psychoactive prescription drugs in a sample of university students from Lebanon: An opportunity for cross-cultural comparisons. Drug and Alcohol Dependence. 2012; 121: 110-117.
Gunderson E., Haughey H., Ait-Daoud N., Joshi A., Hart C. A Survey of Synthetic Cannabinoid Consumption by Current Cannabis Users. Substance Abuse. 2014; 35: 184-189.
Kim H., Anderson J., Saghafi O., Heard K., Monte A. Cyclic Vomiting Presentations Following Marijuana Liberalization in Colorado. Academic Emergency Medicine. 2015; 22 (6): 694-699.
Pacula RL, Powell D, Heaton P, Sevigny EL. Assessing the effects of medical marijuana laws on marijuana use: the devil is in the details. Journal of Policy Analysis & Management. 2015; 34 (1): 7-31.
Schuermeyer J, Salomonsen-Sautel S, Price RK, Balan S, Thurstone C, Min S-J, Sakai JT. Temporal trends in marijuana attitudes, availability and use in Colorado compared to non-medical marijuana states: 2003¿11. Drug and Alcohol Dependence. 2014; 140: 145-155.
263029
TE08800
url https://hdl.handle.net/10818/28731
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language spa
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rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.publisher.none.fl_str_mv Universidad de La Sabana
Universidad de La Sabana.
Especialización en Farmacología Clínica
Facultad de Medicina
publisher.none.fl_str_mv Universidad de La Sabana
Universidad de La Sabana.
Especialización en Farmacología Clínica
Facultad de Medicina
dc.source.none.fl_str_mv Universidad de La Sabana
Intellectum Repositorio Universidad de la Sabana
institution Universidad de la Sabana
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Cannabinoides medicinales y su desvío para uso recreativo: Revisión sistemática de la literatura y meta análisisBotánica médicaFarmacología experimentalMarihuana -- Uso terapéuticoPlantas alucinógenas39 Páginas.Introducción: El uso de cannabis para fines medicinales ha crecido progresivamente en diversas regiones del mundo, llevando a la búsqueda de aprobación por parte de las autoridades regulatorias. En este contexto, resulta importante evaluar la seguridad de esta alternativa en términos de su desvío hacia uso recreacional. Métodos: Se realizó un búsqueda sistematica en las bases de datos de MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE Daily Update, Embase, PsycINFO, Lilacs y Cinahl Plus desde el origen hasta enero de 2016. Se incluyeron estudios de diseño observacional que reportaran información de desvío hacia uso recreativo de cannabinoides utilizados con fines terapéuticos y se siguieron las procedimientos metodológicos estándar esperados por el grupo Cochrane. Resultados: Trece estudios cumplieron con los criterios de inclusión. Doce de ellos tuvieron un diseño transversal y uno prospectivo. El porcentaje de pacientes con condiciones físicas o mentales con reporte de desvío de cannabis medicinal varía entre un 0% a un 94.4%. Así mismo, se tuvo un porcentaje de 24% y 73.7% de personas que desvían el uso de cannabis medicinal de pacientes con indicación. No hubo desvío cuando se utilizaron cannabinoides con presentación farmacológica definida. La mayoría de estudios analizados tuvieron un riesgo de sesgo moderado. Conclusiones: La evidencia encontrada es heterogenea y no puede establecerse causalidad ante el diseño de los estudios evaluados. Es posible que el riesgo de desvio sea mínimo con presentaciones farmacológicas definidas. ¿¿¿Universidad de La SabanaUniversidad de La Sabana.Especialización en Farmacología ClínicaFacultad de MedicinaDíaz Quijano, Diana MarcelaFeliciano Alfonso, John EdwinVargas Bautista, Marie Fernanda2016-11-24T21:09:45Z2016-11-24T21:09:45Z2016-11-242016Tesis/Trabajo de grado - Especializaciónhttp://purl.org/coar/resource_type/c_7a1fTextoinfo:eu-repo/semantics/otherhttp://purl.org/redcol/resource_type/COtherinfo:eu-repo/semantics/acceptedVersionapplication/pdfCook J., Lloyd-Jones D., Ogden E. Medical use of cannabis: an addiction medicine perspective. Internal Medicine Journal. 2015; 45: 677-681.Whiting P.F., Wolff R.F., Deshpande S, et al. Cannabinoids for medical Use: A Systematic Review and Meta-analysis. The Journal of the American Medical Association. 2015; 313(24): 2456-2473Alpár A, Di Marzo V, Harkany T. At the tip of an iceberg: Prenatal marijuana and its possible relation to neuropsychiatric outcome in the offspring. Biological Psychiatry 2016; 79(7):e33-e45.FDA.gov [Internet] Estados Unidos. FDA and Marijuana: Questions and Answers [Fecha de consulta 23 de octubre de 2016]. Disponible en: http://www.fda.gov/newsevents/publichealthfocus/ucm421168.htmMinisterio de Salud y Protección Social. República de Colombia. Decreto 2467 de 2015. [Fecha de consulta 23 de octubre de 2016]. Disponible en: http://wp.presidencia.gov.co/sitios/normativa/decretos/2015/Decretos2015/DECRE TO%202467%20DEL%2022%20DE%20DICIEMBRE%20DE%202015.pdfPertwee R. Cannabinoid pharmacology: the first 66 years. British Journal of Pharmacology. 2006; 147: S163¿S171.Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151(4):264¿269Shea BJ, Grimshaw JM, Wells GA, et al.: Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 2007, 7: 10.. Scottish Intercollegiate Guidelines Network [Internet]. Search Filters. Scotland: SIGN 2001-2014. [actualizado 27 Ago 2015; citado 23 Dic 2015]. Disponible en: http://hiru.mcmaster.ca/hiru/HIRU_Hedges_home.aspxLandis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;33(1):159¿174Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al The NewcastleOttawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses. [Fecha de consulta 23 de diciembre de 2016]. Disponible en: http://www.ohri.ca/programs/clinical_epidemiology/oxford.aspHoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012; 65: 934¿939Nguyen KA, Peer N, Mills EJ, Kengne AP. A Meta-Analysis of the Metabolic Syndrome Prevalence in the Global HIV-Infected Population. PLoS ONE 11(3): e0150970. doi:10.1371/journal. pone.0150970Mills EJ, Jansen JP, Kanters S. Heterogeneity in meta-analysis of FDG-PET studies to diagnose lung cancer. JAMA. 2015; 313: 419.Babson K., Boden M., Bonn-Miller M. Sleep Quality Moderates the Relation between Depression Symptoms and Problematic Cannabis Use among Medical Cannabis Users. The American Journal of Drug and Alcohol Abuse. 2013; 39 (3): 211-216.. Belendiuk K., Babson K., Vandrey R., Bonn-Miller M. Cannabis species and cannabinoid concentration preference among sleep-disturbed medicinal cannabis users. Addictve Behaviors. 2015; 50: 178-181. Harris D., Jones R., Rank R., Nath R., Hernandez E., Goldstein K., Meldenson J. Self-Reported Marijuana Effects and Characteristics of 100 San Francisco Medical Marijuana Club Members. Journal of Addictive Diseases. 2000; 19 (3): 89- 103.Harris G., Dupuis L., Mugford G., Johnston L., Haase D., Page G., Haldane H., Harris N., Midodzi W., Dow G. Patterns and correlates of cannabis use among individuals with HIV/AIDS in Maritime Canada. Can J Infect Dis Med Microbiol. 2014; 25 (1): e1-e7.Ilgen M., Bohnert K., Kleinberg F., Jannausch M., Bohner A., Walton M., Blow F. Characteristics of adults seeking medical marijuana certification. Drug and Alcohol Dependence. 2013; 132: 654-659.Swartz R. Medical marijuana users in substance abuse treatment. Harm Reduction Journal. 2010; 7: 1-9.Ware MA, Doyle CR, Woods R, Lynch ME, Clark AJ. Cannabis use for chronic noncancer pain: Results of a prospective survey. Pain. 2003; 102: 211-216.Bonn-Miller M., Trafton J. Prevalence of Cannabis Use Disorder Diagnoses Among Veterans in 2002, 2008, and 2009. Psychological Services. 2012; 9 (4): 404-416.Cerdá M., Wall M., Keyes K., Galea S., Hasin D. Medical marijuana laws in 50 states: Investigating the relationship between state legalization of medical marijuana and marijuana use, abuse and dependence. Drug and Alcohol Dependence. 2012; 120: 22-27.D¿Amico E., Miles J., Tucker J. Gateway to Curiosity: Medical Marijuana Ads and Intention and Use During Middle School. Psychology of Addictive Behaviors. 2015; 29 (3): 613-619.. Degenhardt L., Lintzeris N., Campbell G., Bruno R., Cohen., Farrell M., Hall W. Experience of adjunctive cannabis use for chronic non-cancer pain:Findings from the Pain and Opioids IN Treatment (POINT) study. Drug and Alcohol Dependence. 2015; 147: 144-150.. Ghandour L., El Sayed D., Martins S., Martins S. Prevalence and patterns of commonly abused psychoactive prescription drugs in a sample of university students from Lebanon: An opportunity for cross-cultural comparisons. Drug and Alcohol Dependence. 2012; 121: 110-117.Gunderson E., Haughey H., Ait-Daoud N., Joshi A., Hart C. A Survey of Synthetic Cannabinoid Consumption by Current Cannabis Users. Substance Abuse. 2014; 35: 184-189.Kim H., Anderson J., Saghafi O., Heard K., Monte A. Cyclic Vomiting Presentations Following Marijuana Liberalization in Colorado. Academic Emergency Medicine. 2015; 22 (6): 694-699.Pacula RL, Powell D, Heaton P, Sevigny EL. Assessing the effects of medical marijuana laws on marijuana use: the devil is in the details. Journal of Policy Analysis & Management. 2015; 34 (1): 7-31.Schuermeyer J, Salomonsen-Sautel S, Price RK, Balan S, Thurstone C, Min S-J, Sakai JT. Temporal trends in marijuana attitudes, availability and use in Colorado compared to non-medical marijuana states: 2003¿11. Drug and Alcohol Dependence. 2014; 140: 145-155.https://hdl.handle.net/10818/28731263029TE08800Universidad de La SabanaIntellectum Repositorio Universidad de la SabanaspaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/restrictedAccesshttp://purl.org/coar/access_right/c_16ecoai:intellectum.unisabana.edu.co:10818/287312025-12-11T18:04:08Z