Polyurethanes for vascular applications : Effect of polyol blend composition on biomechanics

Cardiovascular diseases are the lead cause of death around the world. Ischemic heart attacks and stroke are the top pathologies related to the narrowing and occluding of blood vessels. Despite governmental and non-governmental organizations' considerable efforts to improve lifestyle and prevention, surgical interventions are widely performed to repair the damaged vessel. The vascular bypass is a surgical alternative where the broken vein or artery is replaced with another blood vessel (autologous) or prosthesis. Like the saphenous vein, an autologous graft is a gold standard; however, there is a lack of suitable blood vessels in patients due to other blood vessel diseases. On the other hand, the revascularization and compliance mismatch between the native vessel and the graft persist. In the past, polyurethanes were used for vascular grafts because of high compliance and similar mechanical properties to native tissue. The polyurethanes segment made it a special group of heterochain polymers that can be tailored from monomers selection. This thesis proposes studying the polyol composition on the physic properties and biomechanics of polyurethane-based vascular graft. Here, we studied a novel group of polyurethanes synthesized from polycaprolactone diol, polyethylene glycol and, a novel crosslinker, the pentaerythritol, using isophorone diisocyanate. The first section of this dissertation provides a comprehensive description of the physic-chemical properties and the cell-material interaction. Four compositions were selected for further numerical and computational analysis. The four compositions: 5- 90-5, 45-45-10, 46.3-46.3-7.5, 47.5.47.5-5, provide a homogenous phase distribution between segments and the best damping behavior in the experimental space.

• Fecha de publicación: 2021
• Institución: Universidad de la Sabana
• Repositorio: Repositorio Universidad de la Sabana
• Idioma: eng
• OAI Identifier: oai:intellectum.unisabana.edu.co:10818/47647
• Acceso en línea: https://hdl.handle.net/10818/47647
• Palabra clave: Polímeros; Sistema cardiovascular -- Enfermedades; Patología; Innovaciones en medicina; Injerto vascular
• License: Attribution-NonCommercial-NoDerivatives 4.0 Internacional