Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor
20 páginas
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/34885
- Acceso en línea:
- https://hdl.handle.net/10818/34885
- Palabra clave:
- Adalimumab
Medicamentos -- Efectos fisiológicos
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensorAdalimumabMedicamentos -- Efectos fisiológicos20 páginasThis study describes the development of a immunosensory label-free quantification methodology based on surface plasmon resonance (SPR) and its applicability in measuring/evaluating therapeutic drug monitoring (TDM) of anti-TNF-alpha monoclonal antibody (adalimumab) in rheumatoid arthritis (RA) patients. The experimental parameters evaluated in this study were immobilising ligands by pre-concentration assays, sensor surface regeneration, ascertaining the method¿s sensitivity and correlating the results from quantifying plasma samples by ELISA immunoassay. The results showed that SPR immunosensory detection provided a precise, sensitive strategy, along with real-time determination, for quantifying adalimumab, having great potential for clinical routine regarding TDMUniversidad de La SabanaEspecialización en Farmacología ClínicaFacultad de Medicina2019-02-08T13:22:25Z2019-02-08T13:22:25Z2018-02-21Tesis/Trabajo de grado - Especializaciónhttp://purl.org/coar/resource_type/c_7a1fTextoinfo:eu-repo/semantics/otherhttp://purl.org/redcol/resource_type/COtherinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/10818/34885268174TE09520Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/restrictedAccesshttp://purl.org/coar/access_right/c_16ecBustos Cruz, Rosa HelenaZapata, CarlosEsteban Mancera, Efraín ArsenioGarcía Casallas, Julio CésarJáuregui, EdwinJaimes Fernández, Diego Alejandrooai:intellectum.unisabana.edu.co:10818/348852025-12-11T18:04:00Z |
| dc.title.none.fl_str_mv |
Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor |
| title |
Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor |
| spellingShingle |
Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor Adalimumab Medicamentos -- Efectos fisiológicos |
| title_short |
Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor |
| title_full |
Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor |
| title_fullStr |
Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor |
| title_full_unstemmed |
Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor |
| title_sort |
Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor |
| dc.subject.none.fl_str_mv |
Adalimumab Medicamentos -- Efectos fisiológicos |
| topic |
Adalimumab Medicamentos -- Efectos fisiológicos |
| description |
20 páginas |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-02-21 2019-02-08T13:22:25Z 2019-02-08T13:22:25Z |
| dc.type.none.fl_str_mv |
Tesis/Trabajo de grado - Especialización http://purl.org/coar/resource_type/c_7a1f Texto info:eu-repo/semantics/other http://purl.org/redcol/resource_type/COther info:eu-repo/semantics/acceptedVersion |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10818/34885 268174 TE09520 |
| url |
https://hdl.handle.net/10818/34885 |
| identifier_str_mv |
268174 TE09520 |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ restrictedAccess |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ restrictedAccess http://purl.org/coar/access_right/c_16ec |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad de La Sabana Especialización en Farmacología Clínica Facultad de Medicina |
| publisher.none.fl_str_mv |
Universidad de La Sabana Especialización en Farmacología Clínica Facultad de Medicina |
| dc.source.none.fl_str_mv |
Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana |
| institution |
Universidad de la Sabana |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1860891648365428736 |