Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development
This study focuses on the complex relationship between positive pressure mechanical ventilation, the pulmonary microbiome, cytokine dynamics, and metabolomic profiles in patients with ventilator-associated pneumonia (VAP). Our research emphasizes how alterations in microbial dynamics are associated...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/63003
- Acceso en línea:
- https://hdl.handle.net/10818/63003
- Palabra clave:
- Microbioma pulmonar
Enfermedades respiratorias virales -- Estudios clínicos
COVID-19
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) developmentMicrobioma pulmonarEnfermedades respiratorias virales -- Estudios clínicosCOVID-19This study focuses on the complex relationship between positive pressure mechanical ventilation, the pulmonary microbiome, cytokine dynamics, and metabolomic profiles in patients with ventilator-associated pneumonia (VAP). Our research emphasizes how alterations in microbial dynamics are associated with the onset of VAP, underscoring the pivotal role of microbiomes in maintaining respiratory health, particularly in the context of viral respiratory diseases such as COVID-19. We observed significant variations in microbial abundances, which have implications for the development and progression of VAP. Furthermore, our analysis of cytokine dynamics revealed a distinctive immunological modulation in VAP patients, characterized by an enhanced response of neutralizing antibodies coupled with reduced levels of proinflammatory cytokines.El presente estudio se enfoca en la compleja relación entre la ventilación mecánica con presión positiva, el microbioma pulmonar, la dinámica de citoquinas y los perfiles metabolómicos en pacientes con neumonía asociada a ventilación (VAP). Nuestra investigación destaca cómo las alteraciones en la dinámica microbiana están asociadas con el inicio de VAP, subrayando el papel crucial de los microbiomas en el mantenimiento de la salud respiratoria, especialmente en el contexto de enfermedades respiratorias virales como COVID-19. Observamos variaciones significativas en las abundancias microbianas, lo que tiene implicaciones en el desarrollo y progresión de VAP. Además, el análisis de la dinámica de citoquinas reveló una modulación inmunológica distintiva en pacientes con VAP, caracterizada por una respuesta aumentada de anticuerpos neutralizantes junto con niveles reducidos de citoquinas proinflamatorias.Doctor en BiocienciasDoctoradoUniversidad de La SabanaDoctorado en BiocienciasFacultad de Ingeniería2024-11-28T14:38:54Z2024-11-28T14:38:54Z2024-10-23Tesis/Trabajo de grado - Doctoradohttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/doctoralThesishttp://purl.org/redcol/resource_type/TD154 páginasapplication/pdfapplication/pdfhttps://hdl.handle.net/10818/63003engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Bustos Moya, Ingrid GisellReyes Velasco, Luis Felipeoai:intellectum.unisabana.edu.co:10818/630032026-02-13T16:28:28Z |
| dc.title.none.fl_str_mv |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| spellingShingle |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development Microbioma pulmonar Enfermedades respiratorias virales -- Estudios clínicos COVID-19 |
| title_short |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title_full |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title_fullStr |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title_full_unstemmed |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title_sort |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| dc.subject.none.fl_str_mv |
Microbioma pulmonar Enfermedades respiratorias virales -- Estudios clínicos COVID-19 |
| topic |
Microbioma pulmonar Enfermedades respiratorias virales -- Estudios clínicos COVID-19 |
| description |
This study focuses on the complex relationship between positive pressure mechanical ventilation, the pulmonary microbiome, cytokine dynamics, and metabolomic profiles in patients with ventilator-associated pneumonia (VAP). Our research emphasizes how alterations in microbial dynamics are associated with the onset of VAP, underscoring the pivotal role of microbiomes in maintaining respiratory health, particularly in the context of viral respiratory diseases such as COVID-19. We observed significant variations in microbial abundances, which have implications for the development and progression of VAP. Furthermore, our analysis of cytokine dynamics revealed a distinctive immunological modulation in VAP patients, characterized by an enhanced response of neutralizing antibodies coupled with reduced levels of proinflammatory cytokines. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-11-28T14:38:54Z 2024-11-28T14:38:54Z 2024-10-23 |
| dc.type.none.fl_str_mv |
Tesis/Trabajo de grado - Doctorado http://purl.org/coar/resource_type/c_db06 http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/doctoralThesis http://purl.org/redcol/resource_type/TD |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10818/63003 |
| url |
https://hdl.handle.net/10818/63003 |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
| dc.format.none.fl_str_mv |
154 páginas application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad de La Sabana Doctorado en Biociencias Facultad de Ingeniería |
| publisher.none.fl_str_mv |
Universidad de La Sabana Doctorado en Biociencias Facultad de Ingeniería |
| institution |
Universidad de la Sabana |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1860891580397780992 |