Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017

57 páginas

Autores:

Tipo de recurso:

Fecha de publicación:: 2019

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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repository_id_str
dc.title.none.fl_str_mv	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
spellingShingle	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017 Metapneumovirus Enfermedades respiratorias pediátricas Insuficiencia respiratoria en niños -- Prevención y control
title_short	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title_full	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title_fullStr	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title_full_unstemmed	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
title_sort	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017
dc.contributor.none.fl_str_mv	Fernández Sarmiento, Jaime Gamboa Garay, Oscar Andrés Acevedo, Lorena
dc.subject.none.fl_str_mv	Metapneumovirus Enfermedades respiratorias pediátricas Insuficiencia respiratoria en niños -- Prevención y control
topic	Metapneumovirus Enfermedades respiratorias pediátricas Insuficiencia respiratoria en niños -- Prevención y control
description	57 páginas
publishDate	2019
dc.date.none.fl_str_mv	2019-04-30T19:28:59Z 2019-04-30T19:28:59Z 2019-01-25
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status_str	acceptedVersion
dc.identifier.none.fl_str_mv	Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human metapneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719¿24. Betty E. Owor, Geoffrey N. Masankwa, et al. Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya,2007-11, BMC Infectious Diseases (2016) 16:301 Skiadopoulos MH, Biacchesi et al. Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity. Virology. 2006;345(2):492¿501. Jennifer E. Schuster and John V. Williams. BMC Infectious Diseases (2016) 16:301Pediatrics in Review 2013;34;558 Williams JV, Edwards KM, Weinberg GA et al. Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis. 2010;201:1890¿8 Barbosa Ramirez J, Pulido Dominguez P, Rey Benito G, et al. Human respiratory syncytial virus and metapneumovirus in patients with acute respiratory infection in Colombia, 2000-2011. Rev Panam Salud Publica. 2014;36(2):101¿109. Panda S, Mohakud N, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. International Journal of Infectious Diseases (2014) 25 e45¿e52 Erickson JJ, Gilchuk P, Hastings AK, et al. Viral acute lower respiratory infections impair CD8þ T cells through PD-1. J Clin Invest. 2012;122(8):2967¿2982 Spaulding, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5): 443¿450 Williams JV, Tollefson SJ, Nair S, Chonmaitree T. Association of human metapneumovirus with acute otitis media. Int J Pediatr Otorhinolaryngol 2006;70(7):1189¿1193 Madhi SA, Ludewick H, Kuwanda L, et al. Pneumococcal coinfection with human metapneumovirus. J Infect Dis. 2006;193 (9):1236¿1243 García-García ML, Calvo C, Casas I, et al. Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr Pulmonol 2007 Widmer K, Zhu Y, Williams JV, Griffin MR, Edwards KM, Talbot HK. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis. 2012;206(1):56¿62 Estrada B, Carter M, Barik S, Vidal R, Herbert D, Ramsey KM. Severe human metapneumovirus infection in hospitalized children. Clin Pediatr (Phila) 2007;46(3):258¿262 Van den Hoogen BG, Osterhaus DM, Fouchier RA. Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 2004;23(1, Suppl):S25¿S32 Paget SP, Andresen DN, Kesson AM, Egan JR. Comparison of human metapneumovirus and respiratory syncytial virus in children admitted to a paediatric intensive care unit. J Paediatr Child Health 2011;47(10):737¿741 Hahn A, Wang W, Jaggi P, et al. Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages. Epidemiol Infect 2013;141(10): 2213¿2223 Maertzdorf J, Wang CK, Brown JB, et al. Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages. J Clin Microbiol 2004; 42(3):981¿986 Principi N, Bosis S, Esposito S. Human metapneumovirus in paediatric patients. Clin Microbiol Infect 2006;12(4):301¿308 Piralla A, Lunghi G, Percivalle E et al. FilmArray respiratory panel performance in respiratory samples from neonatal care units. Diagn Microbiol Infect Dis [Internet]. Elsevier Inc.; 2014;79(2):183¿6. Pardo J, Klinker KP, Borgert SJ, Butler BM, Giglio PG, Rand KH. Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2016 Feb;84(2):159- 64 Marcone, D. N., Carballal, G., Ricarte, C., & Echavarria, M. (2015). Diagnóstico de virus respiratorios utilizando un sistema automatizado de PCR múltiples (FilmArray) y su comparación con métodos convencionales. Revista Argentina de Microbiologia, 47(1), 29¿35 Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 2006;16(1):37¿48 Leévy C, Aerts L, Hamelin ME, et al. Virus-like particle vaccine induces crossprotection against human metapneumovirus infections in mice. Vaccine 2013;31(25):2778¿2785 Ren, J., Phan, T., & Bao, X. (2015). Recent vaccine development for human metapneumovirus. Journal of General Virology, 96(7), 1515¿1520 McCracken JP, Arvelo W, Orti¿z J, et al. Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala. Influenza Other Respir Viruses 2014;8:414¿21. United nations children´s fund (UNICEF). Levels and trends in child mortality. Report 2018. Disponible en: https://data.unicef.org/wpcontent/uploads/2018/10/Child-Mortality-Report-2018.pdf Avila Adarme, Leidy Viviana. Identificación de la presencia de dos paramixovirus (virus sincitial respiratorio y metapneumovirus humano) en muestras de secreciones respiratorias recolectadas durante la vigilancia centinela en Colombia del 2000 al 2009. Maestría thesis, Universidad Nacional de Colombia. (2014) Liu P, Xu M. Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015. Jpn J Infect Dis. 2018 Jan 23;71(1):39-44. Appak, Duman et al. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2018 Dec 20 Jain S, Williams DJ, Arnold SR, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Children. N Engl J Med. 2015; 372:835-45. Nor'e SS, Sam IC, Mohamad Fakri EF, et al. Phylogenetic analysisof hu man metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia. Trop Biomed 2014;31:562¿6. García-García ML1,2,3, Calvo C. Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study. PLoS One. 2017 Mar 16;12(3):e0173504 Broor S, Bharaj P, Chahar HS. Human metapneumovirus: a new respiratory pathogen. J Biosci 2008;33:483¿93. Loo LH, Tan BH, Ng LM, Tee NW, Lin RT, Sugrue RJ. Human metapneumovirus in children, Singapore. Emerging infectious diseases. 2007;13(9):1396. Schuster JE, Khuri-Bulos N, Faouri S, Shehabi A, Johnson M, Wang L, et al. Human Metapneumovirus Infection in Jordanian Children. Epidemiology and Risk Factors for Severe Disease. Pediatr Infect Dis J 2015;34:1335¿1341 McAdam AJ, Hasenbein ME, Feldman HA, et al. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis 2004;190:20¿6. Samransamruajkit R, Thanasugarn W, Prapphal N, Theamboonlers A, Poovorawan Y. Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations. Journal of Infection. 2006;52(4):254-263. Lim FJ, de Klerk N et al Systematic review and meta-analysis of respiratory viral coinfections in children. 2016 Respirology.May;21(4):648-55. Rodriguez PE, Adamo MP, Paglini MG, et al. [Monoinfection of human metapneumovirus in Cordoba: first clinical and epidemiological research in children with respiratory infection in 2011]. Rev Fac Cien Med Univ Nac Cordoba 2016;73:170¿5. Zhang L, Liu W et al. Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016. BMJ Open. 2018 Feb 6;8(2):e019308. https://hdl.handle.net/10818/35437 271090 TE10077
identifier_str_mv	Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human metapneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719¿24. Betty E. Owor, Geoffrey N. Masankwa, et al. Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya,2007-11, BMC Infectious Diseases (2016) 16:301 Skiadopoulos MH, Biacchesi et al. Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity. Virology. 2006;345(2):492¿501. Jennifer E. Schuster and John V. Williams. BMC Infectious Diseases (2016) 16:301Pediatrics in Review 2013;34;558 Williams JV, Edwards KM, Weinberg GA et al. Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis. 2010;201:1890¿8 Barbosa Ramirez J, Pulido Dominguez P, Rey Benito G, et al. Human respiratory syncytial virus and metapneumovirus in patients with acute respiratory infection in Colombia, 2000-2011. Rev Panam Salud Publica. 2014;36(2):101¿109. Panda S, Mohakud N, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. International Journal of Infectious Diseases (2014) 25 e45¿e52 Erickson JJ, Gilchuk P, Hastings AK, et al. Viral acute lower respiratory infections impair CD8þ T cells through PD-1. J Clin Invest. 2012;122(8):2967¿2982 Spaulding, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5): 443¿450 Williams JV, Tollefson SJ, Nair S, Chonmaitree T. Association of human metapneumovirus with acute otitis media. Int J Pediatr Otorhinolaryngol 2006;70(7):1189¿1193 Madhi SA, Ludewick H, Kuwanda L, et al. Pneumococcal coinfection with human metapneumovirus. J Infect Dis. 2006;193 (9):1236¿1243 García-García ML, Calvo C, Casas I, et al. Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr Pulmonol 2007 Widmer K, Zhu Y, Williams JV, Griffin MR, Edwards KM, Talbot HK. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis. 2012;206(1):56¿62 Estrada B, Carter M, Barik S, Vidal R, Herbert D, Ramsey KM. Severe human metapneumovirus infection in hospitalized children. Clin Pediatr (Phila) 2007;46(3):258¿262 Van den Hoogen BG, Osterhaus DM, Fouchier RA. Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 2004;23(1, Suppl):S25¿S32 Paget SP, Andresen DN, Kesson AM, Egan JR. Comparison of human metapneumovirus and respiratory syncytial virus in children admitted to a paediatric intensive care unit. J Paediatr Child Health 2011;47(10):737¿741 Hahn A, Wang W, Jaggi P, et al. Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages. Epidemiol Infect 2013;141(10): 2213¿2223 Maertzdorf J, Wang CK, Brown JB, et al. Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages. J Clin Microbiol 2004; 42(3):981¿986 Principi N, Bosis S, Esposito S. Human metapneumovirus in paediatric patients. Clin Microbiol Infect 2006;12(4):301¿308 Piralla A, Lunghi G, Percivalle E et al. FilmArray respiratory panel performance in respiratory samples from neonatal care units. Diagn Microbiol Infect Dis [Internet]. Elsevier Inc.; 2014;79(2):183¿6. Pardo J, Klinker KP, Borgert SJ, Butler BM, Giglio PG, Rand KH. Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2016 Feb;84(2):159- 64 Marcone, D. N., Carballal, G., Ricarte, C., & Echavarria, M. (2015). Diagnóstico de virus respiratorios utilizando un sistema automatizado de PCR múltiples (FilmArray) y su comparación con métodos convencionales. Revista Argentina de Microbiologia, 47(1), 29¿35 Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 2006;16(1):37¿48 Leévy C, Aerts L, Hamelin ME, et al. Virus-like particle vaccine induces crossprotection against human metapneumovirus infections in mice. Vaccine 2013;31(25):2778¿2785 Ren, J., Phan, T., & Bao, X. (2015). Recent vaccine development for human metapneumovirus. Journal of General Virology, 96(7), 1515¿1520 McCracken JP, Arvelo W, Orti¿z J, et al. Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala. Influenza Other Respir Viruses 2014;8:414¿21. United nations children´s fund (UNICEF). Levels and trends in child mortality. Report 2018. Disponible en: https://data.unicef.org/wpcontent/uploads/2018/10/Child-Mortality-Report-2018.pdf Avila Adarme, Leidy Viviana. Identificación de la presencia de dos paramixovirus (virus sincitial respiratorio y metapneumovirus humano) en muestras de secreciones respiratorias recolectadas durante la vigilancia centinela en Colombia del 2000 al 2009. Maestría thesis, Universidad Nacional de Colombia. (2014) Liu P, Xu M. Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015. Jpn J Infect Dis. 2018 Jan 23;71(1):39-44. Appak, Duman et al. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2018 Dec 20 Jain S, Williams DJ, Arnold SR, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Children. N Engl J Med. 2015; 372:835-45. Nor'e SS, Sam IC, Mohamad Fakri EF, et al. Phylogenetic analysisof hu man metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia. Trop Biomed 2014;31:562¿6. García-García ML1,2,3, Calvo C. Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study. PLoS One. 2017 Mar 16;12(3):e0173504 Broor S, Bharaj P, Chahar HS. Human metapneumovirus: a new respiratory pathogen. J Biosci 2008;33:483¿93. Loo LH, Tan BH, Ng LM, Tee NW, Lin RT, Sugrue RJ. Human metapneumovirus in children, Singapore. Emerging infectious diseases. 2007;13(9):1396. Schuster JE, Khuri-Bulos N, Faouri S, Shehabi A, Johnson M, Wang L, et al. Human Metapneumovirus Infection in Jordanian Children. Epidemiology and Risk Factors for Severe Disease. Pediatr Infect Dis J 2015;34:1335¿1341 McAdam AJ, Hasenbein ME, Feldman HA, et al. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis 2004;190:20¿6. Samransamruajkit R, Thanasugarn W, Prapphal N, Theamboonlers A, Poovorawan Y. Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations. Journal of Infection. 2006;52(4):254-263. Lim FJ, de Klerk N et al Systematic review and meta-analysis of respiratory viral coinfections in children. 2016 Respirology.May;21(4):648-55. Rodriguez PE, Adamo MP, Paglini MG, et al. [Monoinfection of human metapneumovirus in Cordoba: first clinical and epidemiological research in children with respiratory infection in 2011]. Rev Fac Cien Med Univ Nac Cordoba 2016;73:170¿5. Zhang L, Liu W et al. Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016. BMJ Open. 2018 Feb 6;8(2):e019308. 271090 TE10077
url	https://hdl.handle.net/10818/35437
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
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dc.publisher.none.fl_str_mv	Universidad de La Sabana
publisher.none.fl_str_mv	Universidad de La Sabana
dc.source.none.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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spelling	Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017MetapneumovirusEnfermedades respiratorias pediátricasInsuficiencia respiratoria en niños -- Prevención y control57 páginasDe forma global, la infección respiratoria aguda es la enfermedad más frecuente independiente de la edad y el género, siendo los virus los patógenos más comunes. En la población pediátrica el virus sincitial respiratorio (VSR), el virus de parainfluenza e influenza han sido considerados durante muchos años los principales agentes etiológicos en infección respiratoria aguda baja. En el 2001 el doctor Van Den Hoogen y colaboradores, describieron en los Países Bajos un nuevo virus conocido como metapneumovirus humano (HMPV) perteneciente a la familia Paramyxoviridae que presenta una alta similitud filogenética al VSR, compartiendo una organización genómica similar, 1,2 . En los últimos años y gracias a la posibilidad diagnóstica de nuevos agentes etiológicos, la infección por HMPV ha cobrado mayor impacto atribuyéndole como agente causal de infecciones respiratorias agudas altas y bajas como croup, bronquiolitis, exacerbación de asma y neumonía en el escenario de hospitalización, con el potencial desarrollo de enfermedad severa y requerimiento de manejo en unidad de cuidado intensivo.Universidad de La SabanaFernández Sarmiento, JaimeGamboa Garay, Oscar AndrésAcevedo, LorenaObando Belalcázar, Evelyn PaolaMontoya Jiménez, David Leonardo2019-04-30T19:28:59Z2019-04-30T19:28:59Z2019-01-25Tesis/Trabajo de grado - Especializaciónhttp://purl.org/coar/resource_type/c_7a1fTextoinfo:eu-repo/semantics/otherhttp://purl.org/redcol/resource_type/COtherinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfVan den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human metapneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719¿24.Betty E. Owor, Geoffrey N. Masankwa, et al. Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya,2007-11, BMC Infectious Diseases (2016) 16:301Skiadopoulos MH, Biacchesi et al. Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity. Virology. 2006;345(2):492¿501.Jennifer E. Schuster and John V. Williams. BMC Infectious Diseases (2016) 16:301Pediatrics in Review 2013;34;558Williams JV, Edwards KM, Weinberg GA et al. Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis. 2010;201:1890¿8Barbosa Ramirez J, Pulido Dominguez P, Rey Benito G, et al. Human respiratory syncytial virus and metapneumovirus in patients with acute respiratory infection in Colombia, 2000-2011. Rev Panam Salud Publica. 2014;36(2):101¿109.Panda S, Mohakud N, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. International Journal of Infectious Diseases (2014) 25 e45¿e52Erickson JJ, Gilchuk P, Hastings AK, et al. Viral acute lower respiratory infections impair CD8þ T cells through PD-1. J Clin Invest. 2012;122(8):2967¿2982Spaulding, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5): 443¿450Williams JV, Tollefson SJ, Nair S, Chonmaitree T. Association of human metapneumovirus with acute otitis media. Int J Pediatr Otorhinolaryngol 2006;70(7):1189¿1193Madhi SA, Ludewick H, Kuwanda L, et al. Pneumococcal coinfection with human metapneumovirus. J Infect Dis. 2006;193 (9):1236¿1243García-García ML, Calvo C, Casas I, et al. Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr Pulmonol 2007Widmer K, Zhu Y, Williams JV, Griffin MR, Edwards KM, Talbot HK. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis. 2012;206(1):56¿62Estrada B, Carter M, Barik S, Vidal R, Herbert D, Ramsey KM. Severe human metapneumovirus infection in hospitalized children. Clin Pediatr (Phila) 2007;46(3):258¿262Van den Hoogen BG, Osterhaus DM, Fouchier RA. Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 2004;23(1, Suppl):S25¿S32Paget SP, Andresen DN, Kesson AM, Egan JR. Comparison of human metapneumovirus and respiratory syncytial virus in children admitted to a paediatric intensive care unit. J Paediatr Child Health 2011;47(10):737¿741Hahn A, Wang W, Jaggi P, et al. Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages. Epidemiol Infect 2013;141(10): 2213¿2223Maertzdorf J, Wang CK, Brown JB, et al. Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages. J Clin Microbiol 2004; 42(3):981¿986Principi N, Bosis S, Esposito S. Human metapneumovirus in paediatric patients. Clin Microbiol Infect 2006;12(4):301¿308Piralla A, Lunghi G, Percivalle E et al. FilmArray respiratory panel performance in respiratory samples from neonatal care units. Diagn Microbiol Infect Dis [Internet]. Elsevier Inc.; 2014;79(2):183¿6.Pardo J, Klinker KP, Borgert SJ, Butler BM, Giglio PG, Rand KH. Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2016 Feb;84(2):159- 64Marcone, D. N., Carballal, G., Ricarte, C., & Echavarria, M. (2015). Diagnóstico de virus respiratorios utilizando un sistema automatizado de PCR múltiples (FilmArray) y su comparación con métodos convencionales. Revista Argentina de Microbiologia, 47(1), 29¿35Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 2006;16(1):37¿48Leévy C, Aerts L, Hamelin ME, et al. Virus-like particle vaccine induces crossprotection against human metapneumovirus infections in mice. Vaccine 2013;31(25):2778¿2785Ren, J., Phan, T., & Bao, X. (2015). Recent vaccine development for human metapneumovirus. Journal of General Virology, 96(7), 1515¿1520McCracken JP, Arvelo W, Orti¿z J, et al. Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala. Influenza Other Respir Viruses 2014;8:414¿21.United nations children´s fund (UNICEF). Levels and trends in child mortality. Report 2018. Disponible en: https://data.unicef.org/wpcontent/uploads/2018/10/Child-Mortality-Report-2018.pdfAvila Adarme, Leidy Viviana. Identificación de la presencia de dos paramixovirus (virus sincitial respiratorio y metapneumovirus humano) en muestras de secreciones respiratorias recolectadas durante la vigilancia centinela en Colombia del 2000 al 2009. Maestría thesis, Universidad Nacional de Colombia. (2014)Liu P, Xu M. Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015. Jpn J Infect Dis. 2018 Jan 23;71(1):39-44.Appak, Duman et al. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2018 Dec 20Jain S, Williams DJ, Arnold SR, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Children. N Engl J Med. 2015; 372:835-45.Nor'e SS, Sam IC, Mohamad Fakri EF, et al. Phylogenetic analysisof hu man metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia. Trop Biomed 2014;31:562¿6.García-García ML1,2,3, Calvo C. Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study. PLoS One. 2017 Mar 16;12(3):e0173504Broor S, Bharaj P, Chahar HS. Human metapneumovirus: a new respiratory pathogen. J Biosci 2008;33:483¿93.Loo LH, Tan BH, Ng LM, Tee NW, Lin RT, Sugrue RJ. Human metapneumovirus in children, Singapore. Emerging infectious diseases. 2007;13(9):1396.Schuster JE, Khuri-Bulos N, Faouri S, Shehabi A, Johnson M, Wang L, et al. Human Metapneumovirus Infection in Jordanian Children. Epidemiology and Risk Factors for Severe Disease. Pediatr Infect Dis J 2015;34:1335¿1341McAdam AJ, Hasenbein ME, Feldman HA, et al. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis 2004;190:20¿6.Samransamruajkit R, Thanasugarn W, Prapphal N, Theamboonlers A, Poovorawan Y. 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BMJ Open. 2018 Feb 6;8(2):e019308.https://hdl.handle.net/10818/35437271090TE10077Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaspaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2oai:intellectum.unisabana.edu.co:10818/354372025-12-11T18:17:07Z

Prevalencia y comportamiento clínico de la infección por metapneumovirus humano en pacientes pediátricos con infección respiratoria aguda en la Fundación Cardioinfantil de Bogotá del 2015-2017

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