Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano

30 Páginas.

Autores:

Tipo de recurso:

Fecha de publicación:: 2016

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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network_acronym_str	REPOUSABAN
network_name_str	Repositorio Universidad de la Sabana
repository_id_str
dc.title.none.fl_str_mv	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
spellingShingle	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano Ingeniería química Fusión nuclear Compatibilidad -- Pruebas
title_short	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title_full	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title_fullStr	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title_full_unstemmed	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title_sort	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
dc.contributor.none.fl_str_mv	Valero Valdivieso, Manuel Fernando
dc.subject.none.fl_str_mv	Ingeniería química Fusión nuclear Compatibilidad -- Pruebas
topic	Ingeniería química Fusión nuclear Compatibilidad -- Pruebas
description	30 Páginas.
publishDate	2016
dc.date.none.fl_str_mv	2016 2017-03-03T19:29:18Z 2017-03-03T19:29:18Z 2017-03-03
dc.type.none.fl_str_mv	Tesis/Trabajo de grado - Pregrado http://purl.org/coar/resource_type/c_7a1f http://purl.org/coar/version/c_970fb48d4fbd8a85 Texto info:eu-repo/semantics/bachelorThesis http://purl.org/redcol/resource_type/TP
dc.identifier.none.fl_str_mv	Adamczak, M. I., Hagesaether, E., Smistad, G., & Hiorth, M. (2016). An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells. International Journal of Pharmaceutics, 498(1¿2), 225¿33. https://doi.org/10.1016/j.ijpharm.2015.12.030 Aranaz, I., Mengibar, M., Harris, R., Panos, I., Miralles, B., Acosta, N., ¿ Heras, A. (2009). Functional Characterization of Chitin and Chitosan. Current Chemical Biology, 3(2), 203¿230. https://doi.org/10.2174/187231309788166415 Arévalo, S., & Ramirez, C. (2015). Síntesis, Caracterización y Degradabilidad in vitro de Polímeros Obtenidos de Aceite de Higuerilla y Quitosano. Bakhshi, H., Yeganeh, H., Mehdipour-Ataei, S., Shokrgozar, M. A., Yari, A., & Saeedi-Eslami, S. N. (2013). Synthesis and characterization of antibacterial polyurethane coatings from quaternary ammonium salts functionalized soybean oil based polyols. Materials Science and Engineering: C, 33(1), 153¿164. https://doi.org/10.1016/j.msec.2012.08.023 Bakhshi, H., Yeganeh, H., Yari, A., & Nezhad, S. K. (2014). Castor oil-based polyurethane coatings containing benzyl triethanol ammonium chloride: synthesis, characterization, and biological properties. Journal of Materials Science, 49(15), 5365¿5377. https://doi.org/10.1007/s10853-014- 8244-x Berridge, M. V, Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnology Annual Review, 11, 127¿52. https://doi.org/10.1016/S1387-2656(05)11004-7 Berridge, M. V, & Tan, A. S. (1993). Characterization of the Cellular Reduction of 3.pdf. Archives of Biochemestry and Biophisics, 474¿482. Retrieved from http://www.sciencedirect.com.ezproxy.unisabana.edu.co/science/article/pii/S0003986183713111 Brown, R. P., & Fustinoni, S. (2015). Chapter 5 ¿ Toxicity of Metals Released from Implanted Medical Devices. In Handbook on the Toxicology of Metals (pp. 113¿122). https://doi.org/10.1016/B978-0- 444-59453-2.00005-6 Caon, T., Zanetti-Ramos, B. G., Lemos-Senna, E., Cloutet, E., Cramail, H., Borsali, R., ¿ Simões, C. M. O. (2010). Evaluation of DNA damage and cytotoxicity of polyurethane-based nano- and microparticles as promising biomaterials for drug delivery systems. Journal of Nanoparticle Research, 12(5), 1655¿1665. https://doi.org/10.1007/s11051-009-9828-2 Castañeda Ramírez, C., De la Fuente Salcido, N. M., Pacheco Cano, R. D., Ortiz-Rodriguez, T., & Barbosa Corona, J. E. (2011). Potencial de los quito-oligosacáridos generados de quitina y quitosana. Acta Universitaria, 21(3), 14¿23. Castro, C. (2006). Pruebas de tamizaje para determinar efectos citotóxicos en extractos, fracciones o sustancias, utilizando la prueba MTT. Universidad San Martín. Retrieved from http://old.iupac.org/publications/cd/medicinal_chemistry/Practica-IV-2.pdf Chapdelaine, J. M. (n.d.). MTT reduction -a tetrazolium-based colorimetric assay for cell survival and proliferation. Chen, Y., Tang¿, H., Liu¿, Y., & Tan, H. (2016). Preparation and study on the volume phase transition properties of novel carboxymethyl chitosan grafted polyampholyte superabsorbent polymers. Journal of the Taiwan Institute of Chemical Engineers, 59, 569¿577. https://doi.org/10.1016/j.jtice.2015.09.011 Chen, Y., Zhou, Y., Yang, S., Li, J. J., Li, X., Ma, Y., ¿ Yu, B. (2016). Novel bone substitute composed of chitosan and strontium-doped ¿-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility. Materials Science and Engineering: C, 66, 84¿91. https://doi.org/10.1016/j.msec.2016.04.070 Chien, R.-C., Yen, M.-T., & Mau, J.-L. (2015). Antimicrobial and antitumor activities of chitosan from shiitake stipes, compared to commercial chitosan from crab shells. Carbohydrate Polymers, 138, 259¿264. https://doi.org/10.1016/j.carbpol.2015.11.061 Crichton, M. L., Chen, X., Huang, H., & Kendall, M. A. F. (2013). Elastic modulus and viscoelastic properties of full thickness skin characterised at micro scales. Biomaterials, 34(8), 2087¿2097. https://doi.org/10.1016/j.biomaterials.2012.11.035 Croisier, F., & Jérôme, C. (2013). Chitosan-based biomaterials for tissue engineering. European Polymer Journal, 49(4), 780¿792. https://doi.org/10.1016/j.eurpolymj.2012.12.009 De Souza, J. F., Maia, K. N., De Oliveira Patrício, P. S., Fernandes-Cunha, G. M., Da Silva, M. G., De Matos Jensen, C. E., & Da Silva, G. R. (2016). Ocular inserts based on chitosan and brimonidine tartrate: Development, characterization and biocompatibility. Journal of Drug Delivery Science and Technology, 32, 21¿30. https://doi.org/10.1016/j.jddst.2016.01.008 Deng, M., Zhou, J., Chen, G., Burkley, D., Xu, Y., Jamiolkowski, D., & Barbolt, T. (2005). Effect of load and temperature on in vitro degradation of poly(glycolide-co-L-lactide) multifilament braids. Biomaterials, 26, 4327¿4336. https://doi.org/10.1016/j.biomaterials.2004.09.067 Dragostin, O. M., Samal, S. K., Dash, M., Lupascu, F., Pânzariu, A., Tuchilus, C., ¿ Profire, L. (2016). New antimicrobial chitosan derivatives for wound dressing applications. Carbohydrate Polymers, 141, 28¿40. https://doi.org/10.1016/j.carbpol.2015.12.078 Dutta, S., Karak, N., Saikia, J. P., & Konwar, B. K. (2009). Biocompatible epoxy modified bio-based polyurethane nanocomposites: Mechanical property, cytotoxicity and biodegradation. Bioresource Technology, 100(24), 6391¿6397. https://doi.org/10.1016/j.biortech.2009.06.029 ESCOBAR M, L., RIVERA, A., & ARISTIZÁBAL G, F. A. (2010). ESTUDIO COMPARATIVO DE LOS MÉTODOS DE RESAZURINA Y MTT EN ESTUDIOS DE CITOTOXICIDAD EN LÍNEAS CELULARES TUMORALES HUMANAS. Vitae, 17(1), 67¿74. Ghorbanian, L., Emadi, R., Razavi, S. M., Shin, H., & Teimouri, A. (2013). Fabrication and characterization of novel diopside/silk fibroin nanocomposite scaffolds for potential application in maxillofacial bone regeneration. International Journal of Biological Macromolecules, 58, 275¿80. https://doi.org/10.1016/j.ijbiomac.2013.04.004 Gómez, A. A. (n.d.). El fibroblasto: su origen, estructura, funciones y heterogeneidad dentro del periodonto Fibroblast: its origin, structure, functions and heterogeneity within the periodontium. Habiba, U., Islam, M. S., Siddique, T. A., Afifi, A. M., & Ang, B. C. (2016). Adsorption and photocatalytic degradation of anionic dyes on Chitosan/PVA/Na¿Titanate/TiO2 composites synthesized by solution casting method. Carbohydrate Polymers, 149, 317¿331. https://doi.org/10.1016/j.carbpol.2016.04.127 He, J., He, F.-L., Li, D.-W., Liu, Y.-L., & Yin, D.-C. (2016). A novel porous Fe/Fe-W alloy scaffold with a double-layer structured skeleton: Preparation, in vitro degradability and biocompatibility. Colloids and Surfaces. B, Biointerfaces, 142, 325¿33. https://doi.org/10.1016/j.colsurfb.2016.03.002 ISO, 10993-5 DIN EN. (n.d.). Biological evaluation of medical devices ¿ Part 5: Tests for in vitro cytotoxicity. Retrieved April 28, 2016, from https://www.iso.org/obp/ui/#iso:std:iso:10993:-5:ed- 3:v1:en Janik, H., & Marzec, M. (2015). A review: Fabrication of porous polyurethane scaffolds. Materials Science and Engineering: C, 48, 586¿591. https://doi.org/10.1016/j.msec.2014.12.037 Kwan, S., & Mari¿, M. (2016). Thermoresponsive polymers with tunable cloud point temperatures grafted from chitosan via nitroxide mediated polymerization. Polymer, 86, 69¿82. https://doi.org/10.1016/j.polymer.2016.01.039 La Rosa, A. D. (2016). 4 ¿ Life cycle assessment of biopolymers. In Biopolymers and Biotech Admixtures for Eco-Efficient Construction Materials (pp. 57¿78). https://doi.org/10.1016/B978-0- 08-100214-8.00004-X López-Saucedo, F., Alvarez-Lorenzo, C., Concheiro, A., & Bucio, E. (2016). Radiation-grafting of vinyl monomers separately onto polypropylene monofilament sutures. https://doi.org/10.1016/j.radphyschem.2016.11.006 Macocinschi, D., Filip, D., Vlad, S., Butnaru, M., & Knieling, L. (2013). Evaluation of polyurethane based on cellulose derivative-ketoprofen biosystem for implant biomedical devices. International Journal of Biological Macromolecules, 52, 32¿7. https://doi.org/10.1016/j.ijbiomac.2012.09.026 https://hdl.handle.net/10818/29878 263585 TE08924
identifier_str_mv	Adamczak, M. I., Hagesaether, E., Smistad, G., & Hiorth, M. (2016). An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells. International Journal of Pharmaceutics, 498(1¿2), 225¿33. https://doi.org/10.1016/j.ijpharm.2015.12.030 Aranaz, I., Mengibar, M., Harris, R., Panos, I., Miralles, B., Acosta, N., ¿ Heras, A. (2009). Functional Characterization of Chitin and Chitosan. Current Chemical Biology, 3(2), 203¿230. https://doi.org/10.2174/187231309788166415 Arévalo, S., & Ramirez, C. (2015). Síntesis, Caracterización y Degradabilidad in vitro de Polímeros Obtenidos de Aceite de Higuerilla y Quitosano. Bakhshi, H., Yeganeh, H., Mehdipour-Ataei, S., Shokrgozar, M. A., Yari, A., & Saeedi-Eslami, S. N. (2013). Synthesis and characterization of antibacterial polyurethane coatings from quaternary ammonium salts functionalized soybean oil based polyols. Materials Science and Engineering: C, 33(1), 153¿164. https://doi.org/10.1016/j.msec.2012.08.023 Bakhshi, H., Yeganeh, H., Yari, A., & Nezhad, S. K. (2014). Castor oil-based polyurethane coatings containing benzyl triethanol ammonium chloride: synthesis, characterization, and biological properties. Journal of Materials Science, 49(15), 5365¿5377. https://doi.org/10.1007/s10853-014- 8244-x Berridge, M. V, Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnology Annual Review, 11, 127¿52. https://doi.org/10.1016/S1387-2656(05)11004-7 Berridge, M. V, & Tan, A. S. (1993). Characterization of the Cellular Reduction of 3.pdf. Archives of Biochemestry and Biophisics, 474¿482. Retrieved from http://www.sciencedirect.com.ezproxy.unisabana.edu.co/science/article/pii/S0003986183713111 Brown, R. P., & Fustinoni, S. (2015). Chapter 5 ¿ Toxicity of Metals Released from Implanted Medical Devices. In Handbook on the Toxicology of Metals (pp. 113¿122). https://doi.org/10.1016/B978-0- 444-59453-2.00005-6 Caon, T., Zanetti-Ramos, B. G., Lemos-Senna, E., Cloutet, E., Cramail, H., Borsali, R., ¿ Simões, C. M. O. (2010). Evaluation of DNA damage and cytotoxicity of polyurethane-based nano- and microparticles as promising biomaterials for drug delivery systems. Journal of Nanoparticle Research, 12(5), 1655¿1665. https://doi.org/10.1007/s11051-009-9828-2 Castañeda Ramírez, C., De la Fuente Salcido, N. M., Pacheco Cano, R. D., Ortiz-Rodriguez, T., & Barbosa Corona, J. E. (2011). Potencial de los quito-oligosacáridos generados de quitina y quitosana. Acta Universitaria, 21(3), 14¿23. Castro, C. (2006). Pruebas de tamizaje para determinar efectos citotóxicos en extractos, fracciones o sustancias, utilizando la prueba MTT. Universidad San Martín. Retrieved from http://old.iupac.org/publications/cd/medicinal_chemistry/Practica-IV-2.pdf Chapdelaine, J. M. (n.d.). MTT reduction -a tetrazolium-based colorimetric assay for cell survival and proliferation. Chen, Y., Tang¿, H., Liu¿, Y., & Tan, H. (2016). Preparation and study on the volume phase transition properties of novel carboxymethyl chitosan grafted polyampholyte superabsorbent polymers. Journal of the Taiwan Institute of Chemical Engineers, 59, 569¿577. https://doi.org/10.1016/j.jtice.2015.09.011 Chen, Y., Zhou, Y., Yang, S., Li, J. J., Li, X., Ma, Y., ¿ Yu, B. (2016). Novel bone substitute composed of chitosan and strontium-doped ¿-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility. Materials Science and Engineering: C, 66, 84¿91. https://doi.org/10.1016/j.msec.2016.04.070 Chien, R.-C., Yen, M.-T., & Mau, J.-L. (2015). Antimicrobial and antitumor activities of chitosan from shiitake stipes, compared to commercial chitosan from crab shells. Carbohydrate Polymers, 138, 259¿264. https://doi.org/10.1016/j.carbpol.2015.11.061 Crichton, M. L., Chen, X., Huang, H., & Kendall, M. A. F. (2013). Elastic modulus and viscoelastic properties of full thickness skin characterised at micro scales. Biomaterials, 34(8), 2087¿2097. https://doi.org/10.1016/j.biomaterials.2012.11.035 Croisier, F., & Jérôme, C. (2013). Chitosan-based biomaterials for tissue engineering. European Polymer Journal, 49(4), 780¿792. https://doi.org/10.1016/j.eurpolymj.2012.12.009 De Souza, J. F., Maia, K. N., De Oliveira Patrício, P. S., Fernandes-Cunha, G. M., Da Silva, M. G., De Matos Jensen, C. E., & Da Silva, G. R. (2016). Ocular inserts based on chitosan and brimonidine tartrate: Development, characterization and biocompatibility. Journal of Drug Delivery Science and Technology, 32, 21¿30. https://doi.org/10.1016/j.jddst.2016.01.008 Deng, M., Zhou, J., Chen, G., Burkley, D., Xu, Y., Jamiolkowski, D., & Barbolt, T. (2005). Effect of load and temperature on in vitro degradation of poly(glycolide-co-L-lactide) multifilament braids. Biomaterials, 26, 4327¿4336. https://doi.org/10.1016/j.biomaterials.2004.09.067 Dragostin, O. M., Samal, S. K., Dash, M., Lupascu, F., Pânzariu, A., Tuchilus, C., ¿ Profire, L. (2016). New antimicrobial chitosan derivatives for wound dressing applications. Carbohydrate Polymers, 141, 28¿40. https://doi.org/10.1016/j.carbpol.2015.12.078 Dutta, S., Karak, N., Saikia, J. P., & Konwar, B. K. (2009). Biocompatible epoxy modified bio-based polyurethane nanocomposites: Mechanical property, cytotoxicity and biodegradation. Bioresource Technology, 100(24), 6391¿6397. https://doi.org/10.1016/j.biortech.2009.06.029 ESCOBAR M, L., RIVERA, A., & ARISTIZÁBAL G, F. A. (2010). ESTUDIO COMPARATIVO DE LOS MÉTODOS DE RESAZURINA Y MTT EN ESTUDIOS DE CITOTOXICIDAD EN LÍNEAS CELULARES TUMORALES HUMANAS. Vitae, 17(1), 67¿74. Ghorbanian, L., Emadi, R., Razavi, S. M., Shin, H., & Teimouri, A. (2013). Fabrication and characterization of novel diopside/silk fibroin nanocomposite scaffolds for potential application in maxillofacial bone regeneration. International Journal of Biological Macromolecules, 58, 275¿80. https://doi.org/10.1016/j.ijbiomac.2013.04.004 Gómez, A. A. (n.d.). El fibroblasto: su origen, estructura, funciones y heterogeneidad dentro del periodonto Fibroblast: its origin, structure, functions and heterogeneity within the periodontium. Habiba, U., Islam, M. S., Siddique, T. A., Afifi, A. M., & Ang, B. C. (2016). Adsorption and photocatalytic degradation of anionic dyes on Chitosan/PVA/Na¿Titanate/TiO2 composites synthesized by solution casting method. Carbohydrate Polymers, 149, 317¿331. https://doi.org/10.1016/j.carbpol.2016.04.127 He, J., He, F.-L., Li, D.-W., Liu, Y.-L., & Yin, D.-C. (2016). A novel porous Fe/Fe-W alloy scaffold with a double-layer structured skeleton: Preparation, in vitro degradability and biocompatibility. Colloids and Surfaces. B, Biointerfaces, 142, 325¿33. https://doi.org/10.1016/j.colsurfb.2016.03.002 ISO, 10993-5 DIN EN. (n.d.). Biological evaluation of medical devices ¿ Part 5: Tests for in vitro cytotoxicity. Retrieved April 28, 2016, from https://www.iso.org/obp/ui/#iso:std:iso:10993:-5:ed- 3:v1:en Janik, H., & Marzec, M. (2015). A review: Fabrication of porous polyurethane scaffolds. Materials Science and Engineering: C, 48, 586¿591. https://doi.org/10.1016/j.msec.2014.12.037 Kwan, S., & Mari¿, M. (2016). Thermoresponsive polymers with tunable cloud point temperatures grafted from chitosan via nitroxide mediated polymerization. Polymer, 86, 69¿82. https://doi.org/10.1016/j.polymer.2016.01.039 La Rosa, A. D. (2016). 4 ¿ Life cycle assessment of biopolymers. In Biopolymers and Biotech Admixtures for Eco-Efficient Construction Materials (pp. 57¿78). https://doi.org/10.1016/B978-0- 08-100214-8.00004-X López-Saucedo, F., Alvarez-Lorenzo, C., Concheiro, A., & Bucio, E. (2016). Radiation-grafting of vinyl monomers separately onto polypropylene monofilament sutures. https://doi.org/10.1016/j.radphyschem.2016.11.006 Macocinschi, D., Filip, D., Vlad, S., Butnaru, M., & Knieling, L. (2013). Evaluation of polyurethane based on cellulose derivative-ketoprofen biosystem for implant biomedical devices. International Journal of Biological Macromolecules, 52, 32¿7. https://doi.org/10.1016/j.ijbiomac.2012.09.026 263585 TE08924
url	https://hdl.handle.net/10818/29878
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_16ec
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publisher.none.fl_str_mv	Universidad de La Sabana Ingeniería Química Facultad de Ingeniería
dc.source.none.fl_str_mv	Universidad de la Sabana Intellectum Repositorio Universidad de la Sabana
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spelling	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosanoIngeniería químicaFusión nuclearCompatibilidad -- Pruebas30 Páginas.En el presente trabajo se evaluaron materiales poliméricos a partir del aceite de higuerilla, por medio de transesterificación se obtuvieron tres variaciones de polioles (183, 196 y 236 mg KOH/g). Los cuales reaccionaron con diisocianato de isoforona para conformar una matriz de poliuretano, adicionalmente se incorporó quitosano en diferentes concentraciones (0, 2.5, 5 y 7.5 %p/p) con el fin de mejorar la viabilidad celular del polímero. El objetivo del estudio se centró en determinar el efecto de la adición de quitosano a la matriz de poliuretano sobre la viabilidad celular y así establecer si la mezcla tiene potencial para ser usada en aplicaciones biomédicas. Se evaluó la viabilidad celular in vitro de los polímeros y de sus extractos por medio del ensayo MTT sobre fibroblastos embrionarios de ratón L-929 (ATCC® CCL-1). Adicionalmente, se estudió una degradación acelerada de éstos en buffer fosfato a una temperatura de 105ºC por 72 horas. Se encontró que el incremento en la funcionalidad del poliol favorece la viabilidad celular y la adición de quitosano no afecta la proliferación celular. Además, se evidenció la resistencia a la degradación con valores menores a 1%. Con base en los resultados obtenidos, se concluyó que los polímeros pueden tener un alto potencial en aplicaciones biomédicas.Universidad de La SabanaIngeniería QuímicaFacultad de IngenieríaValero Valdivieso, Manuel FernandoAndrade Becerra, Laura Patricia2017-03-03T19:29:18Z2017-03-03T19:29:18Z20162017-03-03Tesis/Trabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85Textoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/redcol/resource_type/TPapplication/pdfAdamczak, M. I., Hagesaether, E., Smistad, G., & Hiorth, M. (2016). An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells. International Journal of Pharmaceutics, 498(1¿2), 225¿33. https://doi.org/10.1016/j.ijpharm.2015.12.030Aranaz, I., Mengibar, M., Harris, R., Panos, I., Miralles, B., Acosta, N., ¿ Heras, A. (2009). Functional Characterization of Chitin and Chitosan. Current Chemical Biology, 3(2), 203¿230. https://doi.org/10.2174/187231309788166415Arévalo, S., & Ramirez, C. (2015). Síntesis, Caracterización y Degradabilidad in vitro de Polímeros Obtenidos de Aceite de Higuerilla y Quitosano.Bakhshi, H., Yeganeh, H., Mehdipour-Ataei, S., Shokrgozar, M. A., Yari, A., & Saeedi-Eslami, S. N. (2013). Synthesis and characterization of antibacterial polyurethane coatings from quaternary ammonium salts functionalized soybean oil based polyols. Materials Science and Engineering: C, 33(1), 153¿164. https://doi.org/10.1016/j.msec.2012.08.023Bakhshi, H., Yeganeh, H., Yari, A., & Nezhad, S. K. (2014). Castor oil-based polyurethane coatings containing benzyl triethanol ammonium chloride: synthesis, characterization, and biological properties. Journal of Materials Science, 49(15), 5365¿5377. https://doi.org/10.1007/s10853-014- 8244-xBerridge, M. V, Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnology Annual Review, 11, 127¿52. https://doi.org/10.1016/S1387-2656(05)11004-7Berridge, M. V, & Tan, A. S. (1993). Characterization of the Cellular Reduction of 3.pdf. Archives of Biochemestry and Biophisics, 474¿482. Retrieved from http://www.sciencedirect.com.ezproxy.unisabana.edu.co/science/article/pii/S0003986183713111Brown, R. P., & Fustinoni, S. (2015). Chapter 5 ¿ Toxicity of Metals Released from Implanted Medical Devices. In Handbook on the Toxicology of Metals (pp. 113¿122). https://doi.org/10.1016/B978-0- 444-59453-2.00005-6Caon, T., Zanetti-Ramos, B. G., Lemos-Senna, E., Cloutet, E., Cramail, H., Borsali, R., ¿ Simões, C. M. O. (2010). Evaluation of DNA damage and cytotoxicity of polyurethane-based nano- and microparticles as promising biomaterials for drug delivery systems. Journal of Nanoparticle Research, 12(5), 1655¿1665. https://doi.org/10.1007/s11051-009-9828-2Castañeda Ramírez, C., De la Fuente Salcido, N. M., Pacheco Cano, R. D., Ortiz-Rodriguez, T., & Barbosa Corona, J. E. (2011). Potencial de los quito-oligosacáridos generados de quitina y quitosana. Acta Universitaria, 21(3), 14¿23.Castro, C. (2006). Pruebas de tamizaje para determinar efectos citotóxicos en extractos, fracciones o sustancias, utilizando la prueba MTT. Universidad San Martín. Retrieved from http://old.iupac.org/publications/cd/medicinal_chemistry/Practica-IV-2.pdfChapdelaine, J. M. (n.d.). MTT reduction -a tetrazolium-based colorimetric assay for cell survival and proliferation.Chen, Y., Tang¿, H., Liu¿, Y., & Tan, H. (2016). Preparation and study on the volume phase transition properties of novel carboxymethyl chitosan grafted polyampholyte superabsorbent polymers. 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