Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis
6 páginas
- Autores:
-
Santos, Ana M.
Peña, Paola
Avila, Mabel
Briceño Balcázar, Ignacio
Jaramillo, Carlos A.
Vargas Alarcon, Gilberto
Rueda, Juan C.
Saldarriaga, Eugenia Lucia
Angarita, Jose Ignacio
Martinez Rodriguez, Nancy
Londoño Patiño, John Darío
- Tipo de recurso:
- Fecha de publicación:
- 2016
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/41342
- Acceso en línea:
- https://pubmed.ncbi.nlm.nih.gov/28013432/
https://link.springer.com/content/pdf/10.1007/s10067-016-3516-2.pdf
http://hdl.handle.net/10818/41342
- Palabra clave:
- Allele frequency
Colombia
Genetics
HLA-B15
Humans
Spondyloarthritis
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Santos, Ana M.Peña, PaolaAvila, MabelBriceño Balcázar, IgnacioJaramillo, Carlos A.Vargas Alarcon, GilbertoRueda, Juan C.Saldarriaga, Eugenia LuciaAngarita, Jose IgnacioMartinez Rodriguez, NancyLondoño Patiño, John Darío5/30/2020 9:362020-05-30T14:36:05Z2016-12-24https://pubmed.ncbi.nlm.nih.gov/28013432/https://link.springer.com/content/pdf/10.1007/s10067-016-3516-2.pdfhttp://hdl.handle.net/10818/4134210.1007 / s10067-016-3516-26 páginasThere is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and Tunisian populations demonstrated the association of SpA and human leukocyte antigen (HLA) B15. The purpose of this study was to evaluate the association of HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of SpA. A total of 189 patients and 100 healthy subjects were included in the present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR. Of the 189 studied patients, 35 were reactive arthritis (ReA), 87 were ankylosing spondylitis (AS), and 67 undifferentiated SpA (uSpA). According to the Assessment of Spondyloarthritis International Society (ASAS) criteria, 167 were axial SpA (axSpA) and 171 were peripheral SpA (pSpA). 63.8% were men, with a mean age of 35.9 ± 12.7 years. 40.7% (77/189) of patients were HLA-B27 positive of which 52.9% had AS and 42.5% axSpA. 23.2% (44/189) of patients were HLA-B15 positive: 23.8% were uSpA, 12.57% were axSpA, and 11.7% were pSpA. In addition, HLA-DRB1*01 was associated with AS (58.6%) and axSpA (42.5%). Also, HLA-DRB1*04 was present in 62 patients with AS (71.2%) and in 26 with axSpA (15.5%). In this population, we found a strong association between the presence of HLA-B27 and the diagnosis of axSpA and AS, but the HLA-B15 is also significantly associated with all subtypes of the disease, predominantly with pSpA. Additionally, HLA-DR1 and DR4 were associated in a cohort of patients with SpA from Colombia.application/pdfengClinical RheumatologyClin Rheumatol . 2017 Abr;36 (4): 953-958Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaAllele frequencyColombiaGeneticsHLA-B15HumansSpondyloarthritisAssociation of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritisAsociación de antígenos leucocitarios humanos A, B y DR en pacientes colombianos con diagnóstico de espondiloartritisarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/41342/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/41342/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD5210818/41342oai:intellectum.unisabana.edu.co:10818/413422022-05-10 05:20:02.598Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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 |
| dc.title.es_CO.fl_str_mv |
Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis |
| dc.title.alternative.es_CO.fl_str_mv |
Asociación de antígenos leucocitarios humanos A, B y DR en pacientes colombianos con diagnóstico de espondiloartritis |
| title |
Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis |
| spellingShingle |
Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis Allele frequency Colombia Genetics HLA-B15 Humans Spondyloarthritis |
| title_short |
Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis |
| title_full |
Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis |
| title_fullStr |
Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis |
| title_full_unstemmed |
Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis |
| title_sort |
Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis |
| dc.creator.fl_str_mv |
Santos, Ana M. Peña, Paola Avila, Mabel Briceño Balcázar, Ignacio Jaramillo, Carlos A. Vargas Alarcon, Gilberto Rueda, Juan C. Saldarriaga, Eugenia Lucia Angarita, Jose Ignacio Martinez Rodriguez, Nancy Londoño Patiño, John Darío |
| dc.contributor.author.none.fl_str_mv |
Santos, Ana M. Peña, Paola Avila, Mabel Briceño Balcázar, Ignacio Jaramillo, Carlos A. Vargas Alarcon, Gilberto Rueda, Juan C. Saldarriaga, Eugenia Lucia Angarita, Jose Ignacio Martinez Rodriguez, Nancy Londoño Patiño, John Darío |
| dc.subject.es_CO.fl_str_mv |
Allele frequency Colombia Genetics HLA-B15 Humans Spondyloarthritis |
| topic |
Allele frequency Colombia Genetics HLA-B15 Humans Spondyloarthritis |
| description |
6 páginas |
| publishDate |
2016 |
| dc.date.issued.none.fl_str_mv |
2016-12-24 |
| dc.date.available.none.fl_str_mv |
2020-05-30T14:36:05Z |
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5/30/2020 9:36 |
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article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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https://pubmed.ncbi.nlm.nih.gov/28013432/ https://link.springer.com/content/pdf/10.1007/s10067-016-3516-2.pdf |
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http://hdl.handle.net/10818/41342 |
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10.1007 / s10067-016-3516-2 |
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https://pubmed.ncbi.nlm.nih.gov/28013432/ https://link.springer.com/content/pdf/10.1007/s10067-016-3516-2.pdf http://hdl.handle.net/10818/41342 |
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10.1007 / s10067-016-3516-2 |
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eng |
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eng |
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Clin Rheumatol . 2017 Abr;36 (4): 953-958 |
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Attribution-NonCommercial-NoDerivatives 4.0 International |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Clinical Rheumatology |
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