Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia

4 páginas

Autores:: Romero Sánchez, C.
Londoño Patiño, John Darío
Delgado, G.
Jaimes Fernández, Diego Alejandro
Mora Saboyá, Eduardo Alfonso
Ávila Portillo, Luz Mabel
Castellanos, J.
Valle Oñate, R.
Briceño Balcázar, Ignacio

Tipo de recurso:

Fecha de publicación:: 2011

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Romero Sánchez, C.Londoño Patiño, John DaríoDelgado, G.Jaimes Fernández, Diego AlejandroMora Saboyá, Eduardo AlfonsoÁvila Portillo, Luz MabelCastellanos, J.Valle Oñate, R.Briceño Balcázar, Ignacio7/16/2018 14:472018-07-16T19:47:22Z2011https://link.springer.com/article/10.1007%2Fs00296-011-1883-1https://link.springer.com/content/pdf/10.1007/s00296-011-1883-1.pdfhttp://hdl.handle.net/10818/3335310.1007/s00296-011-1883-14 páginasThe pathogenesis of SpA is considered to be a complex and multi-factorial process and, similar to other autoimmune diseases, includes the activity of proinflammatory cytokines such as TNF alpha. Our study compared the -308 promoter polymorphism of TNF alpha with TNF alpha levels, HLA-B27 status, age at the onset of symptoms, SpA subtype and the clinical degree of activity in Colombian SpA patients and healthy subjects (HS). Comparisons of the TNF alpha-308A genotype among HS and SpA patients (P = 0.004), uSpA patients (P = 0.040), ReA patients (P = 0.001), were significantly different and AS patients (P = 0.110), as were alleles for SpAs (P = 0.007) between patients with SpAs and controls. Initial exploratory analyses demonstrated that the TNF alpha-308 SNP genotype frequencies were different among SpA patients and HS in the Colombian population studied. Furthermore, there was no significant correlation with activity and functional clinical index, serum TNF alpha level or HLA B27 status. Allele frequencies, on the other hand, were correlated with the activity clinical index.application/pdfengJCR Journal of Clinical RheumatologyJCR Journal of Clinical Rheumatology 16(3):S3-S3Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaTNF AlphaPolymorphismSpondyloarthritidesAssociation of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in ColombiaarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/33353/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/33353/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/33353oai:intellectum.unisabana.edu.co:10818/333532022-05-10 05:16:42.636Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.es_CO.fl_str_mv	Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title	Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
spellingShingle	Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia TNF Alpha Polymorphism Spondyloarthritides
title_short	Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title_full	Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title_fullStr	Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title_full_unstemmed	Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title_sort	Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
dc.creator.fl_str_mv	Romero Sánchez, C. Londoño Patiño, John Darío Delgado, G. Jaimes Fernández, Diego Alejandro Mora Saboyá, Eduardo Alfonso Ávila Portillo, Luz Mabel Castellanos, J. Valle Oñate, R. Briceño Balcázar, Ignacio
dc.contributor.author.none.fl_str_mv	Romero Sánchez, C. Londoño Patiño, John Darío Delgado, G. Jaimes Fernández, Diego Alejandro Mora Saboyá, Eduardo Alfonso Ávila Portillo, Luz Mabel Castellanos, J. Valle Oñate, R. Briceño Balcázar, Ignacio
dc.subject.es_CO.fl_str_mv	TNF Alpha Polymorphism Spondyloarthritides
topic	TNF Alpha Polymorphism Spondyloarthritides
description	4 páginas
publishDate	2011
dc.date.issued.none.fl_str_mv	2011
dc.date.available.none.fl_str_mv	2018-07-16T19:47:22Z
dc.date.accessioned.none.fl_str_mv	7/16/2018 14:47
dc.type.en.fl_str_mv	article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.type.hasVersion.es_CO.fl_str_mv	publishedVersion
dc.identifier.other.none.fl_str_mv	https://link.springer.com/article/10.1007%2Fs00296-011-1883-1 https://link.springer.com/content/pdf/10.1007/s00296-011-1883-1.pdf
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/33353
dc.identifier.doi.none.fl_str_mv	10.1007/s00296-011-1883-1
url	https://link.springer.com/article/10.1007%2Fs00296-011-1883-1 https://link.springer.com/content/pdf/10.1007/s00296-011-1883-1.pdf http://hdl.handle.net/10818/33353
identifier_str_mv	10.1007/s00296-011-1883-1
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	JCR Journal of Clinical Rheumatology 16(3):S3-S3
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.es_CO.fl_str_mv	application/pdf
dc.publisher.es_CO.fl_str_mv	JCR Journal of Clinical Rheumatology
dc.source.es_CO.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
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Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia

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