Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus

8 páginas

Autores:: Rabinowitz, Yaron S.
Galvis, Virgilio
Rueda, Daniela
García, Juan Daniel

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Rabinowitz, Yaron S.Galvis, VirgilioRueda, DanielaGarcía, Juan Daniel8/1/2021 22:172021-08-02T03:17:05Z2020-10-24"Rabinowitz, Y.S., Galvis, V., Tello, A., Rueda, D., García, J.D. (2020) Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus. Experimental Eye Research. In press. 10.1016/j.exer.2020.108328 Nota. Se pasa a registro este producto el 22 de febrero de 2021, debido a que a la fecha de consulta el producto en mención ya cuenta con DOI. Sin embargo, es responsabilidad de la Facultad, actualizar Olis con la información de volumen, número y páginas, una vez la revista haya asignado esta información para la presente publicación. SB"0014-4835https://pubmed.ncbi.nlm.nih.gov/33172608/http://hdl.handle.net/10818/4808710.1016/j.exer.2020.1083288 páginasBoth genetic and environmental factors have been considered to play a role in the etiology keratoconus. Eye rubbing, and more recently eye compression due to sleeping position, have been identified to be highly related to the condition, and are present in a high percentage of patients. Today, the predominant model is that these factors can provide the "second hit" necessary to generate the condition in a genetically susceptible individual. In addition, the extremely high prevalence in Arab populations, where endogamy could play a role, the high concordance rate in monozygotic twins, and the presence of family history of the condition between 5 and 23% of cases, support a genetic influence. Segregation analysis studies suggest that keratoconus is a complex non-Mendelian disease. Results from linkage analysis, next generation sequencing studies and genome-wide association studies also have suggested that genetic factors are involved in the condition. Recently, it has been proposed that mechanical trauma (i.e. eye rubbing or eye compression at night), is a sine quanon condition for the onset of keratoconus, and quite possibly its only cause. There are various arguments for and against this hypothesis. Indeed, it is possible, as initially suggested around 55 years ago, that the term "keratoconus" include diverse phenotypically similar conditions, which are actually of different etiology.application/pdfengExp Eye Res . 2021 Jan;202:108328Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_16ecUniversidad de La SabanaIntellectum Repositorio Universidad de La SabanaCorneaCorneal diseasesCorneal pachymetryCorneal topographyKeratoconusGenetics vs chronic corneal mechanical trauma in the etiology of keratoconusarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/48087/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/48087/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/48087oai:intellectum.unisabana.edu.co:10818/480872022-05-10 05:21:25.356Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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
dc.title.en.fl_str_mv	Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus
title	Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus
spellingShingle	Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus Cornea Corneal diseases Corneal pachymetry Corneal topography Keratoconus
title_short	Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus
title_full	Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus
title_fullStr	Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus
title_full_unstemmed	Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus
title_sort	Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus
dc.creator.fl_str_mv	Rabinowitz, Yaron S. Galvis, Virgilio Rueda, Daniela García, Juan Daniel
dc.contributor.author.none.fl_str_mv	Rabinowitz, Yaron S. Galvis, Virgilio Rueda, Daniela García, Juan Daniel
dc.subject.other.en.fl_str_mv	Cornea Corneal diseases Corneal pachymetry Corneal topography Keratoconus
topic	Cornea Corneal diseases Corneal pachymetry Corneal topography Keratoconus
description	8 páginas
publishDate	2020
dc.date.issued.none.fl_str_mv	2020-10-24
dc.date.available.none.fl_str_mv	2021-08-02T03:17:05Z
dc.date.accessioned.none.fl_str_mv	8/1/2021 22:17
dc.type.en.fl_str_mv	article
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dc.identifier.citation.es_CO.fl_str_mv	"Rabinowitz, Y.S., Galvis, V., Tello, A., Rueda, D., García, J.D. (2020) Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus. Experimental Eye Research. In press. 10.1016/j.exer.2020.108328 Nota. Se pasa a registro este producto el 22 de febrero de 2021, debido a que a la fecha de consulta el producto en mención ya cuenta con DOI. Sin embargo, es responsabilidad de la Facultad, actualizar Olis con la información de volumen, número y páginas, una vez la revista haya asignado esta información para la presente publicación. SB"
dc.identifier.issn.none.fl_str_mv	0014-4835
dc.identifier.other.none.fl_str_mv	https://pubmed.ncbi.nlm.nih.gov/33172608/
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10818/48087
dc.identifier.doi.none.fl_str_mv	10.1016/j.exer.2020.108328
identifier_str_mv	"Rabinowitz, Y.S., Galvis, V., Tello, A., Rueda, D., García, J.D. (2020) Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus. Experimental Eye Research. In press. 10.1016/j.exer.2020.108328 Nota. Se pasa a registro este producto el 22 de febrero de 2021, debido a que a la fecha de consulta el producto en mención ya cuenta con DOI. Sin embargo, es responsabilidad de la Facultad, actualizar Olis con la información de volumen, número y páginas, una vez la revista haya asignado esta información para la presente publicación. SB" 0014-4835 10.1016/j.exer.2020.108328
url	https://pubmed.ncbi.nlm.nih.gov/33172608/ http://hdl.handle.net/10818/48087
dc.language.iso.es_CO.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.none.fl_str_mv	Exp Eye Res . 2021 Jan;202:108328
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Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus

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