The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis
10 páginas
- Autores:
-
Fernández Sarmiento, Jaime
Salazar Peláez, Lina María
Carcillo, Joseph, A.
- Tipo de recurso:
- Fecha de publicación:
- 2020
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/48055
- Acceso en línea:
- https://journals.lww.com/pccmjournal/Fulltext/2020/05000/The_Endothelial_Glycocalyx__A_Fundamental.32.aspx
http://hdl.handle.net/10818/48055
- Palabra clave:
- Edema
Endothelium
Fluids
Septic shock
Vascular tone
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis |
| title |
The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis |
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The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis Edema Endothelium Fluids Septic shock Vascular tone |
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The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis |
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The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis |
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The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis |
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The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis |
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The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis |
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Fernández Sarmiento, Jaime Salazar Peláez, Lina María Carcillo, Joseph, A. |
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Fernández Sarmiento, Jaime Salazar Peláez, Lina María Carcillo, Joseph, A. |
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Edema Endothelium Fluids Septic shock Vascular tone |
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Edema Endothelium Fluids Septic shock Vascular tone |
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10 páginas |
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2020 |
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2020-05 |
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2021-07-30T15:00:25Z |
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Fernández-Sarmiento, J., Salazar-Peláez, L.& Carcillo, J. (2020)- MD3 The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis, Pediatric Critical Care Medicine,21(5),291-300 doi: 10.1097/PCC.0000000000002266 |
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1947-3893 |
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https://journals.lww.com/pccmjournal/Fulltext/2020/05000/The_Endothelial_Glycocalyx__A_Fundamental.32.aspx |
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http://hdl.handle.net/10818/48055 |
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10.1097/PCC.0000000000002266 |
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Fernández-Sarmiento, J., Salazar-Peláez, L.& Carcillo, J. (2020)- MD3 The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis, Pediatric Critical Care Medicine,21(5),291-300 doi: 10.1097/PCC.0000000000002266 1947-3893 10.1097/PCC.0000000000002266 |
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eng |
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eng |
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Pediatric Critical Care Medicine,21(5) |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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Pediatric Critical Care Medicine |
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Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana |
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Fernández Sarmiento, JaimeSalazar Peláez, Lina MaríaCarcillo, Joseph, A.7/30/2021 10:002021-07-30T15:00:25Z2020-05Fernández-Sarmiento, J., Salazar-Peláez, L.& Carcillo, J. (2020)- MD3 The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis, Pediatric Critical Care Medicine,21(5),291-300 doi: 10.1097/PCC.00000000000022661947-3893https://journals.lww.com/pccmjournal/Fulltext/2020/05000/The_Endothelial_Glycocalyx__A_Fundamental.32.aspxhttp://hdl.handle.net/10818/4805510.1097/PCC.000000000000226610 páginasObjectives: Sepsis is a significant cause of morbidity and mortality. Children with sepsis often have alterations in microcirculation and vascular permeability. Our objective is current evidence regarding the role of the endothelial glycocalyx as a determinant of capillary leakage in these patients. Data Sources: We reviewed PubMed, EMBASE, and Google scholar using MeSH terms “glycocalyx”, “fluids”, “syndecan”, “endothelium”, “vascular permeability”, “edema”, “sepsis”, “septic shock”, “children”. Study Selection: Articles in all languages were included. We include all studies in animals and humans related to glycocalyx and vascular permeability. Data Extraction: Studies in children and adults, as well as animal studies, were included. Data Synthesis: One of the fundamental components of the endothelial barrier structure is the glycocalyx. It is a variable thickness layer distributed throughout the whole body, which fulfills a very important function for life: the regulation of blood vessel permeability to water and solutes, favoring vascular protection, modulation, and hemostasis. In the last few years, there has been a special interest in glycocalyx disorders and their relationship to increased vascular permeability, especially in patients with sepsis in whom the alterations that occur in the glycocalyx are unknown when they are subjected to different water resuscitation strategies, vasopressors, etc. This review describes the structural and functional characteristics of the glycocalyx, alterations in patients with sepsis, with regard to its importance in vascular permeability conservation and the possible impact of strategies to prevent and/or treat the injury of this fundamental structure. Conclusions: The endothelial glycocalyx is a fundamental component of the endothelium and an important determinant of the mechanotransduction and vascular permeability in patients with sepsis. Studies are needed to evaluate the role of the different types of solutions used in fluid bolus, vasoactive support, and other interventions described in pediatric sepsis on microcirculation, particularly on endothelial integrity and the glycocalyx.application/pdfengPediatric Critical Care MedicinePediatric Critical Care Medicine,21(5)Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaEdemaEndotheliumFluidsSeptic shockVascular toneThe Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in SepsisarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/48055/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/48055/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD5310818/48055oai:intellectum.unisabana.edu.co:10818/480552022-05-10 05:21:36.106Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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 |