Desarrollo de un sistema de microencapsulación de Baculovirus por atomización
256 páginas
- Autores:
-
Camacho Kurmen, Judith Elena
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- spa
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/17429
- Acceso en línea:
- http://hdl.handle.net/10818/17429
- Palabra clave:
- Investigaciones --- Colombia
Insectos perjudiciales -- Control biológico
Microorganismos patógenos
Investigaciones --- Colombia
Insectos perjudiciales -- Control biológico
Microorganismos patógenos
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
id |
REPOUSABA2_ea92c42843084fb6c3c9423a4a3fc8a3 |
---|---|
oai_identifier_str |
oai:intellectum.unisabana.edu.co:10818/17429 |
network_acronym_str |
REPOUSABA2 |
network_name_str |
Repositorio Universidad de la Sabana |
repository_id_str |
|
dc.title.es_CO.fl_str_mv |
Desarrollo de un sistema de microencapsulación de Baculovirus por atomización |
title |
Desarrollo de un sistema de microencapsulación de Baculovirus por atomización |
spellingShingle |
Desarrollo de un sistema de microencapsulación de Baculovirus por atomización Investigaciones --- Colombia Insectos perjudiciales -- Control biológico Microorganismos patógenos Investigaciones --- Colombia Insectos perjudiciales -- Control biológico Microorganismos patógenos |
title_short |
Desarrollo de un sistema de microencapsulación de Baculovirus por atomización |
title_full |
Desarrollo de un sistema de microencapsulación de Baculovirus por atomización |
title_fullStr |
Desarrollo de un sistema de microencapsulación de Baculovirus por atomización |
title_full_unstemmed |
Desarrollo de un sistema de microencapsulación de Baculovirus por atomización |
title_sort |
Desarrollo de un sistema de microencapsulación de Baculovirus por atomización |
dc.creator.fl_str_mv |
Camacho Kurmen, Judith Elena |
dc.contributor.advisor.none.fl_str_mv |
Gómez Álvarez, Martha Isabel Villamizar, Laura Fernanda |
dc.contributor.author.none.fl_str_mv |
Camacho Kurmen, Judith Elena |
dc.subject.es_CO.fl_str_mv |
Investigaciones --- Colombia Insectos perjudiciales -- Control biológico Microorganismos patógenos Investigaciones --- Colombia Insectos perjudiciales -- Control biológico Microorganismos patógenos |
topic |
Investigaciones --- Colombia Insectos perjudiciales -- Control biológico Microorganismos patógenos Investigaciones --- Colombia Insectos perjudiciales -- Control biológico Microorganismos patógenos |
description |
256 páginas |
publishDate |
2015 |
dc.date.issued.none.fl_str_mv |
2015-08-05 |
dc.date.accessioned.none.fl_str_mv |
8/5/2015 16:37 |
dc.date.available.none.fl_str_mv |
8/5/2015 16:37 |
dc.type.es_CO.fl_str_mv |
doctoralThesis |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_db06 |
dc.type.local.none.fl_str_mv |
Tesis de doctorado |
dc.type.hasVersion.es_CO.fl_str_mv |
publishedVersion |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10818/17429 |
dc.identifier.local.none.fl_str_mv |
260434 TE07312 |
url |
http://hdl.handle.net/10818/17429 |
identifier_str_mv |
260434 TE07312 |
dc.language.iso.es_CO.fl_str_mv |
spa |
language |
spa |
dc.rights.*.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
dc.format.es_CO.fl_str_mv |
application/pdf |
dc.publisher.es_CO.fl_str_mv |
Universidad de La Sabana |
dc.source.es_CO.fl_str_mv |
instname:Universidad de La Sabana reponame:Intellectum Repositorio Universidad de La Sabana |
instname_str |
Universidad de La Sabana |
institution |
Universidad de la Sabana |
reponame_str |
Intellectum Repositorio Universidad de La Sabana |
collection |
Intellectum Repositorio Universidad de La Sabana |
bitstream.url.fl_str_mv |
https://intellectum.unisabana.edu.co/bitstream/10818/17429/2/license_rdf https://intellectum.unisabana.edu.co/bitstream/10818/17429/1/Judith%20Elena%20Camacho%20Kurmen%20%28tesis%29.pdf https://intellectum.unisabana.edu.co/bitstream/10818/17429/3/license.txt https://intellectum.unisabana.edu.co/bitstream/10818/17429/4/Judith%20Elena%20Camacho%20Kurmen%20%28tesis%29.pdf.txt |
bitstream.checksum.fl_str_mv |
7c9ab7f006165862d8ce9ac5eac01552 23127ee1b52d0fab676a92e9d185597e f52a2cfd4df262e08e9b300d62c85cab 52d8ebc7ff4a82ccb755ff3c64419e4e |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Intellectum Universidad de la Sabana |
repository.mail.fl_str_mv |
contactointellectum@unisabana.edu.co |
_version_ |
1811952252123873280 |
spelling |
Gómez Álvarez, Martha IsabelVillamizar, Laura FernandaCamacho Kurmen, Judith Elena8/5/2015 16:378/5/2015 16:372015-08-05http://hdl.handle.net/10818/17429260434TE07312256 páginasLos aspectos negativos del control de plagas agrícolas con plaguicidas químicos ha motivado el desarrollo de productos amigables con el medio ambiente, como es la utilización de agentes de control biológico, dentro de los cuales los Baculovirus, han sido muy estudiados debido a su alta patogenicidad para un gran número de especies de insectos considerados como plagas. Sin embargo, una de sus limitantes es su pérdida de actividad bajo condiciones de campo, debido a la inactivación causada principalmente por la luz ultra violeta, por lo que se hace necesario el desarrollo de formulaciones que reduzcan dicha inactivación, siendo la microencapsulación, una técnica promisoria para la obtención de formulaciones fotoestables. Teniendo en cuenta el potencial del aislamiento colombiano de nucleopoliedrovirus NPV003 de Spodoptera frugiperda para el desarrollo de un bioplaguicida y los resultados promisorios de fotoestabilización obtenidos previamente mediante un proceso de microencapsulación utilizando la técnica de evaporación de solventes, el objetivo del presente estudio fue desarrollar un sistema de microencapsulación del virus por el método de atomización utilizando el polímero Eudragit® S100. Se determinó el efecto de la temperatura sobre el virus, se seleccionó el sistema de atomización y las condiciones óptimas del proceso, se validó el proceso de microencapsulación, se determinaron las propiedades físicas de las micropartículas obtenidas, su fotoestabilidad y actividad insecticida.application/pdfspaUniversidad de La SabanaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2instname:Universidad de La Sabanareponame:Intellectum Repositorio Universidad de La SabanaInvestigaciones --- ColombiaInsectos perjudiciales -- Control biológicoMicroorganismos patógenosInvestigaciones --- ColombiaInsectos perjudiciales -- Control biológicoMicroorganismos patógenosDesarrollo de un sistema de microencapsulación de Baculovirus por atomizacióndoctoralThesisTesis de doctoradopublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_db06Alhnan M, Kidia E, Basit A. 2011. Spray-drying enteric polymers from aqueous solutions: A novel, economic,and environmentally friendly approach to produce pH-responsive microparticles.European Journal of Pharmaceutics and Biopharmaceutics 79: 432–439.Año G, Esquisabel A, Pastor M, Talavera A, Cedréa B, Fernández S, Sifontesa S, Aranguren Y, Falero G, García L, Solís RL, Pedraz JL.2011. A new oral vaccine candidate based on the microencapsulation by spray-drying of inactivated Vibrio cholera.Vaccine 29:5758–5764.Armenta R, Martínez A, Chapman J, Magallanes R, Goulson D, Caballero P, Cave R, Cisneros J, Valle J, Castillejos V, Penagos D, Garcia L, Williams T. 2003. Impact of a nucleopolyhedrovirus bioinsecticide and selected synthetic insecticides on the abundance of insect natural enemies on maize in southern Mexico. Journal of Economic Entomology 96: 649-661.Arthurs S, Lacey L, Behle R. 2006. Evaluation of spray dried lignin-based formulations and adjuvants as solar protectans for the granulovirus of the codling moth, Cydia pomonella (L). Journal Invertebrate Pathology 93: 88-95.Association of Official Analytical Chemists – AOAC. 2007. Official methods of analysis. 18 th ed. Maryland,USA: AOAC.2590 p.Batista A, Alves S, Augusto N, Pereira R, Alves L.2001. Stability and persistence of two formulations Lepidoptera Anticarsia gemmatalis Nuclear polyhedrovirus (AgMNPV). Neotropical Entomology 30: 411–416.Beck R, Pohlmann R, Guterres S. 2004. Nanoparticle-coated microparticles: preparation and characterization. Journal of Microencapsulation 21: 499–512.Behle R, y Popham H. 2012. Laboratory and field evaluations of the efficacy of a fast-killing baculovirus isolate from Spodoptera frugiperda. Journal of Invertebrate Pathology 109:194–200Behle R, Tamez-Guerra P, Mcguire M. 2006. Evaluating conditions for producing spray-dried formulations of Anagrapha falcifera nucleopolyhedroviruses (AfMNPV). Biocontrol Science and Technology 16:941- 952.Behle R, Tamez-Guerra P, McGuire M, 2003. Field activity and storage stability of Anagrapha falcifera nucleopolyhedrovirus (AfMNPV) in spray-dried ligninbased formulations. Journal of Economic Entomology 96: 1066–1075.Behle R, Tamez-Guerra P, Mcguire M. 2000.Effect of Light Energy on AlkaliReleased Virions from Anagrapha falcifera Nucleopolyhedrovirus. Journal of Invertebrate Pathology 76: 120-126.Beltrán L, Chanona-Pérez J, Jiménez-Aparicio A, Gutiérrez-López G. 2005.Description of morphological changes of particles along spray drying.Journal of Food Engineering 67: 179–184.Bianchi F, Snoeijing I, Van Der Werf W, Mans R, Smits P, Vlak J. 2000. Biological activity of SeMNPV, AcMNPV, and three AcMNPV deletion mutants against Spodoptera exigua larvae (105epidoptera: noctuidae). Journal of invertebrate pathology 75: 28-35.Boschetti N, Wyss K, Mischler A, Hostettler T, Kempf C. 2003. Stability of minute virus of mice against temperature and sodium hydroxide.Biologicals 31: 181–185.Bregni C, Degrossi J, García R, Lamas M, Firenstein R, D`Aquino M. 2000. Alginate microspheres of Bacillus subtillis. Ars Pharmaceutica 41:245-248.Burges H. 1998. Formulation of microbial biopesticides: Beneficial microorganisms, nematodes and seed treatments. Kluwer Academic Publishers. Holanda. pp 7-21.Bürki K, Jeon I, Arpagaus C, Betz G. 2011. New insights into respirable protein powder preparation using a nano spray dryer. International Journal of Pharmaceutics 408: 248–256Caballero P, Murillo R, Muñoz D, Williams T. 2009. El nucleopoliedrovirus de Spodoptera exigua (Lepidoptera: Noctuidae) como bioplaguicida: análisis de avances recientes en España. Revista Colombiana de Entomología 35: 105 – 115.Caballero P, Lopez Ferber M, Williams T. 2001. Los baculovirus y sus aplicaciones como bioinsecticidas en el control biológico de plagas. Universidad pública de Navarra. Editorial Phytoma. España. 517 p.Camacho J, Gómez M,Villamizar L. 2013.Effect of temperature and two drying processes on the insecticidal activity of a nucleopolyhedrovirus of Spodoptera frugiperda. Revista Mexicana de Ingeniería Química12:437-450.Chaparro M, Espinel C, Cotes A, Villamizar L. 2010. Fotoestabilidad y actividad insecticida de dos formulaciones de granulovirus sobre larvas de Tecia solanivora. Revista Colombiana de Entomología 36:25-30.Chan W.A., Boswell C.D., Zhang Z. 2001. Comparison of the release profiles of a water soluble drug carried by Eudragit-coated capsules in different in-vitro dissolution liquids.Powder Technology 119: 26–32.Charpentier A, Gadielle P, Benoit P. 1999. Rhizobacteria microencapsulation : properties of microparticles obtained by spray-drying. Journal of Microencapsulation 16: 215-229.Cheng X, Liu R, He Y. 2010. A simple method for the preparation of monodisperse protein-loaded microspheres with high encapsulation efficiencies. European Journal of Pharmaceutics and Biopharmaceutics 76:336–341.Cheow W, Li S, Hadinoto K. 2010.Spray drying formulation of hollow spherical aggregates of silica nanoparticles by experimental design. Chemical engineering research and design 88: 673–685.Chia SM, Wan A, Quek C, Mao HQ, Xu X, Shen L, Ng N, Leong KW, Yu H. 2002. Multi layered microcapsules for cell encapsulation. Biomaterials 23: 849- 856Clem R. 2005. The role of apoptosisin defense against baculovirus infection in insects. Current Topics in Microbiology and Inmunology. 289:113-130.Cruz L, Assumpção E, Stanisçuaski S. 2009. High encapsulation efficiency of sodium alendronate in Eudragit®S100/HPMC blend microparticles.Quimica Nova. 32:1170-1174.Claro de Souza M y Maldonado J. 2011.Development of albendazole sulfoxideloaded Eudragit microparticles: A potential strategy to improve the drug bioavailability Advanced. Powder Technology 23:801-807.Daigle D y Cotty P. 1997. The effect of sterilization, pH, filler and spore 106epidopte concentration on the preparation of alginate pellets. Biocontrol Science and Technology 7: 3- 10Della Porta G, Castaldoa F, Scognamiglioa M, Paciello L, Parascandolaa P, Reverchona E. 2012. Bacteria microencapsulation in PLGA microdevices by supercritical emulsion extraction. Journal of Supercritical Fluids 63: 1–7.Devotto L y Gerding M. 2003. Respuesta de dos ailamientos Chilenos de Metarhizium anisopliae (Metschnikoff) Sorokin a la adición de un protector solar. Agricultura técnica (Chile). 63: 339-346.Dobry D, Settell D, Baumann J, Ray R, Graham L, Beyerinck R. 2009.A Model Based Methodology for Spray-Drying Process Development. Journal of Pharmaceutical Innovation 4: 133-142.EPA, 2013. Pesticides: Regulating Pesticides. Biopesticide Ingredient & Product List. Disponible en: www.epa.gov/pesticides/biopesticides/product_lists.Consultada en Abril de 2014Esposito E, Roncarati R, Cortesi R, Cervellati F, Nastruzzi C. 2000. Production of Eudragit microparticles by spray-drying technique: influence of experimental parameters on morphological and dimensional characteristics. Pharmaceutical Development Technology 5:267–78.Evonik Röhm GmbH. 2011.Eudragit® Polímeros acrílicos para formas farmacéuticas sólidas orales. 15 p.FAO. 2012. Agronoticias America Latina y El Caribe. Disponible en: www.fao.org/agronoticias/agr_noticias/detalle/es/c/143943/. Consultada en Abril de 2014Fondo Nacional Cerealista Fenalce. 2009. Informe de Gestión Consolidado. FENALCE.194 p.Fernandes L, Turatti I, Lopes N, Ferreira J, Candido R, Oliveira W. 2008. Volatile Retention and Antifungal Properties of Spray-Dried Microparticles of Lippia sidoides Essential Oil. Drying Technology 26:1534–1542Filho A, Alves S, Augusto N, Pereira R, Alves E. 2001. Stability and persistence of Two Formulations Containing Anticarsia gemmatalis Nuclear Polyhedrovirus (AgMNPV). Neotropical Entomology 30: 411-416Fini A, Cavallari C, Ospitali F. 2008. Raman and thermal analysis of indomethacin/PVP solid dispersion enteric microparticles. European Journal of Pharmaceutics and Biopharmaceutics 70: 409–420.Finney D. 1952. Probit Analysis. Cambridge University Press. London. 151 p.Fisher TW, L.A. A. 1999. Quarantine. In T.S Bellows and T.W. Fisher (ed.) Handbook of Biological Control. Academic Press, San Diego, California, USA. Pp.103-124Fitzpatrick S, Ding Y, Seiler Ch, Lovegrove C, Booth S, Forster R, Parker R, Jonathan S. 2003. Positron Emission Particle Tracking Studies of a Wurster Process for Coating Applications.Pharmaceutical Technology 70-78Friesen P., Miller L. 2001. General Virology. Capítulo 20: insect virases, Cuarta edición. Lippincot Williams y Wilkins. pp. 599-621Fritzen-Freire C, Prudencio E, Amboni R, Pinto S, Negrao-Murakami A, Murakami F. 2012. Microencapsulation of bifidobacteria by spray drying in the presence of prebiotics. Food Research International 45: 306-312.Gander B, Johansen P, Nam Tran H, Merkle H. 1996.Thermodynamic approach to protein microencapsulation into poly(D,L-Lactide) by Spray Drying. International Journal of Pharmaceutics 129: 51-61.García F, Mosquera M, Vargas C, Rojas L. 2002. Control biológico, microbiológico y físico de Spodoptera frugiperda (Lepidoptera: Noctuidae) plaga de maíz y otros cultivos en Colombia. Revista Colombiana de Entomología 28: 53-60.Gennaro A. 2003. Remington Farmacia. 20ª edición. Editorial Panamericana. Buenos Aires. Argentina. 2506 p.Glatt. Disponible en: http://www.glatt.com/e/01_tecnologien/01_04_09.htm Consultada en febrero del 2014Gómez J, Guevara J, Cuartas P, Espinel C, Villamizar L. 2013. Microencapsulated Spodoptera frugiperda nucleopolyhedrovirus: insecticidal activity and effect on arthropod populations in maize. Biocontrol Science and Technology 23: 829-846Gómez J, Guevara EJ, Barrera GP, Cotes AM, Villamizar LF. 2010. Aislamiento, Identificación y Caracterización de Nucleopoliedrovirus Nativos de Spodoptera frugiperda en Colombia. Revista Facultad Nacional de Agronomía de Medellín 63: 5511-5520.Guimarães F, Becerra E, Santiago Alvarez C, Vargas Osuna E. 2005. Patogenicidade do nucleopolyhedrovirus (NPV) (Baculoviridae) isolados em larvas de Spodoptera exigua e S. littoralis sobre larvas de S. frugiperda. Manejo integrado de plagas y agroecología (Costa Rica) 70:74-77Gutiérrez S y López Ferber M. 2004. Les estratégies des baculovirus pour frainchir l´intestin des insects. Virology 8: 311- 321.Harrison R y Hoover K. 2012. Viruses Insect Pathology. United States Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA. Pennsylvania State University, Pennsylvania, USA pp.73-131Hede P, Bach P, Jensen A. 2008. Top-spray fluid bed coating: Scale-up in terms of relative droplet size and drying force. Powder Technology 184: 318– 332.Herniu E, Olszewski J, O´reilly D, Cory J. 2004.Ancient coevolution of Baculoviruses and their insect host. Journal of Virology 78: 3244-3251.Holdeman LV, Cato EP, More W E C. 1977. Chromatographic procedures for analysis of acid and alcohol products. Anaerobic Laboratory Manual, VPI Press, pp 134-178.Horaczek A, Viernstein H. 2004a. Beauveria brongniartii subjected to spraydrying in a composite carrier matrix system. Journal of Microencapsulation 21: 317–330Horaczek A, Viernstein H. 2004b. Comparison of three commonly used drying technologies with respect to activity and longevity of aerial conidia of Beauveria brongniartii and Metarhizium anisopliae. Biological Control 31: 65–71.Hughes P y Wood H. 1981. A synchronous per oral technique for the bioassay of insect viruses. Journal of Invertebrate Pathology 37:154-159Hynes R y Boyetchko S. 2006. Research initiatives in the art and science of biopesticide formulations. Soil Biology and Biochemistry 38: 845 – 849.Ibargutxi M, Muñoz D, Bernal A, Ruiz de Escudero I, Caballero P. 2008. Effects of stilbene optical brighteners on the insecticidal activity of Bacillus thuringiensis and a single nucleopolyhedrovirus on Helicoverpa armigera. Biological Control 47: 322–327Jarafi S, Assadpoor E, He Y, Bhandari B.2008. Encapsulation Efficiency of Food Flavours and Oils during Spray Drying.Drying Technology 26: 816–835.Jehle J, Blissard G, Bonning B, Cory J, Herniou E, Rohrmann G,Theilmann D, Thiem S, Vlak J. 2006. On the classification and nomenclature of baculoviruses: a proposal for revision. Archives of Virology 151:1257–1266.Jenkins N y Grzywacz D. 2003. Towards the standardization of Quality Control of fungal and viral Biocontrol Agents. En: Quality Control and Production of Biological Control Agents. Theory and Testing Procedures. (ed. J.C. Van Lenteren). Wageningen University, Netherlands. pp. 247 – 263Jin X y Custis D. 2011. Microencapsulating aerial conidia of T. harzianum through spray drying at elevated temperatures. Biological Control 56: 202–208.Johansen P, Merkle H, Gander B. 2000. Technological considerations related to the up-scaling of protein microencapsulation by spray-drying. European Journal of Pharmaceutics and Biopharmaceutics 50:413-417Jones K.y Burges H.1998. Technology of formulation and application. In H. D. Burges (Ed.), Formulation of microbial biopesticides. Beneficial microorganisms, nematodes and seed treatments. Netherlands: Kluwer Academic. pp. 7-27Jyothi N, Prasanna P, Sakarkar S, Prabha K, Ramaiah P, Srawan G. 2010. Microencapsulation techniques, factors influencing encapsulation efficiency. Journal of Microencapsulation 27:187–197.Khandare J y Haag R. 2010. Pharmaceutically Used Polymers: Principles, Structures, and Applications of Pharmaceutical Delivery Systems en Drug Delivery. M. Schafer-Korting (ed.) Handbook of Experimental Pharmacology 197, Springer-Verlag Berlin Heidelberg. pp. 221-250Kaplan B. 1958. The Heat Inactivation of Vaccinia Virus. Journal of general Microbiology 18:58-63.Kho K y Hadinoto K. 2010a. Effects of excipient formulation on the morphology and aqueous re-dispersibility of dry-powder silica nano-aggregates Colloids and Surfaces A: Physicochemical and Engineering Aspects 359: 71–81.Kho K y Hadinoto K. 2010b. Aqueous re-dispersibility characterization of spraydried hollow spherical silica nano-aggregates. Powder Technology 198: 354– 363.Kılıcarslan y Baykara, 2003 The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres. International Journal of Pharmaceutics 252: 99–109.Kim B, Hwang S, Park H. 2002. Preparation and characterization of drug-loaded polymetracrylate microspheres by an emulsion solvent evaporation method. Journal of Microencapsulation 19:811-822.Krishnan S, Kshirsagar A, Singhal R.2005. The use of gum Arabic and modified starch in the microencapsulation of a food flavoring agent. Carbohydrate polymers 62: 309 – 315.Lacey L y Kaya HK.2007. Field Manual of Techniques in Invertebrate Pathology. Application and Evaluation of Pathogens for Control of Insects and other Invertebrate Pest. 2a. Edición.Springer. Holanda. 867 p.Lacey L y Arthurs S. 2005. New method for testing solar sensitivity of commercial formulations of the granulovirus of codling moth (Cydia pomonella, Tortricidae: Lepidoptera). Journal of Invertebrate Pathology 90: 85–90.Lasa R,Williams T,Caballero P. 2008.Insecticidal Properties and Microbial Contaminants in a Spodoptera exigua Multiple Nucleopolyhedrovirus (Baculoviridae) Formulation Stored at Different Temperatures. Journal of Economic Entomology 101: 42-49Lasa R, Ruiz C, Alcazar M, Belda J, Caballero P,Williams T. 2007.Efficacy of optical brightener formulations of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) as a biological insecticide in greenhouses in southern Spain.Biological Control 40: 89–96.Li X, Anton N, Arpagaus C, Belleteix F, Vandamme Th. 2010. Nanoparticles by Spray drying using innovate new technology: The Büchi Nano Spray Dryer B90. Journal of Controlled Release 147:304-310.Li X, Guang Chen X, Wu Suna Z, Park HJ, Cha D-S. 2011.Preparation of alginate/chitosan/carboxymethyl chitosan complex microcapsules and application in Lactobacillus casei ATCC 393.Carbohydrate Polymers 83: 1479–1485Liu X, Atarashi T, Furuta T, Yoshii H, Aishima S, Ohkawara M, Linko P. 2001. Microencapsulation of emulsified hydrophobic flavors by spray drying. Drying Technology19: 1361-1374.Liu Ch y Liu S-D. 2009. Low-Temperature Spray Drying for the Microencapsulation of the Fungus Beauveria bassiana. Drying Technology 27:747-753.Madene A, Jacquot M, Scher J, Desobry S. 2006.Flavor encapsulation and controlled release – a review. International. Journal of Food Science and Technology 41: 1-21.Manzano O. y Morales M. 2000. Formas Farmaceúticas sólidas. Microcápsulas. Grupo Gylsa S. A. de C. V. México.17 pMafadi S, Hayert M, Poncelet D. 2003. Fluidization Control in the Wurster Coating Process. Hemijska Industrija 57: 641-644.Marina FC,Williams T,Valle J.2000. Effect of Temperature, pH, Ion Concentration, and Chloroform Treatment on the Stability of Invertebrate Iridescent Virus 6. Journal of Invertebrate Pathology 75:91-94Martínez A, Williams T, López MF, Caballero P. 2005. Optical Brighteners Do Not Influence Covert Baculovirus Infection of Spodoptera frugiperda. Applied and Environmental Microbiology 71:1668-1670.Martínez G, Christian P, Marina C, Williams T.2003. Sensitivity of Invertebrate iridescent virus 6 to organic solvents, detergents, enzymes and temperature treatment. Virus Research 91: 249-254.Martoni C, Bhathena J, Malgorzata A, Prakash S. 2008. Microencapsulated bile salt hydrolase producing Lactobacillus reuteri for oral targeted delivery in the gastrointestinal tract. Biotechnological Products and Process Engineering 81: 225 – 233.Mauguet M, Legrand J, Brujes L, Carnelle G, Larre C, Popineau Y. 2007. Gliadin matrices for microencapsulation processes by simple coacervation method. Journal of Microencapsulation 19: 377-384.McGuireM, Tamez-Guerra P, Behle R, Streett D. 2001.Comparative Weld stability of selected entomopathogenic virus formulations.Journal of Economic Entomology 94: 1037-1044.Michalsky R, Pfromm P, Czermak P, Sorensen C, Passarelli AL.2008. Effects of temperature and shear force on infectivity of the baculovirus Autographa californica M nucleopolyhedrovirus.Journal of Virological Methods. 153: 90-96.Miller LK. The Baculoviruses.1997. U. of Georgia. PLENUM PRESS. New York and London. 397 p.Miller D y Gil M. 2012. Spray-Drying Technology. En:Formulating Poorly Water Soluble Drugs.Springer. New York. pp. 363-442Mirzaei H, Pourjafar H, Homayouni A. 2012. Effect of calcium alginate and resistant starch microencapsulation on the survival rate of Lactobacillus acidophilus La5 and sensory properties in Iranian white brined cheese Food Chemistry 132: 1966-1970.Mor S y Matthews G. 2003. Recent Developments in Sprayers for Application of Biopesticides an Overview. Biosystems Engineering 84:119–125Moscardi F, Lobo de Souza M, Batista de Castro M,Lara Moscardi M, Szewczyk B. 2011.Baculovirus Pesticides: Present Stateand Future Perspectives Chapter 16 I. Ahmad et al. (eds.), Microbes and Microbial Technology: Agricultural and Environmental Applications. Springer. pp. 415-445Moscardi F. 1999. Assessment of the application of baculoviruses for control of Lepidoptera. Annual Review Entomology 44:257-289.Motlekar N y Youan B. 2008.Optimization of experimental parameters for the production of LMWH-loaded polymeric microspheres. Drug Design Development and Therapy 2:39-47.Muñoz-Celaya A, Ortiz-García M,Vernon-Carter E, Jauregui-Rincón J, Galindo E, Serrano-Carreón L. 2012. Spray-drying microencapsulation of T. harzianum conidias in carbohydrate polymers matrices. Carbohydrate Polymers 88:1141- 1148.Mustafin R. 2011. Drug synthesis methods and manufacturing technology. Interpolymer combinations of chemically complementarygrades of eudragit copolymers: a new direction in thedesign of peroral solid dosage forms of drug deliverysystems with controlled release (review). Pharmaceutical chemistry journal 45: 285-295.Nikam V, Kotade K, Gaware V, Dolas R, Dhamak K, Somwanshi S, Khadse A, Kashid A. 2011.Eudragit a versatile polymer : A Review. Pharmacologyonline 1:152-164.Negrete F y Morales JG. 2003. El gusano cogollero del maíz (S. frugiperda.Smith). CORPOICA. Colombia. 26 pNiegel D. y Dylan G. 2003. Ecological Roles of solar UV radiation: Towards and Integrated approach (Review): TRENDS in Ecology and Evolution. Elservier 18: 48– 54Oers M. 2011.Opportunities and challenges for the Baculovirus expression system. Journal of Invertebrate Pathology 107: S3-S15.Okuno S, Takatsuka J, Nakai M, Ototake S, Masui A, Kunimi Y. 2003. Viralenhancing activity of various stilbene-derived brighteners for a Spodoptera litura (Lepidoptera: Noctuidae) nucleopolyhedrovirus. Biological Control 26:146-152.Oliveira B, Santana M, Ré M. 2005.Spray-dried chitosan microspheres crosslinked with d, l-glyceraldehyde as a potential drug delivery system: preparation and characterization. Brazilian Journal of Chemical Engineering 22, (consultada en Redylac on line Abril 2014)Organización Mundial de la Salud. 2003. Indice UV Solar mundial. OMS. Guía práctica. 28 pPantone, 2011. Escala de colores para litografía. Pantone. Fórmula Guide.Color pardo oscuro: código 7588u, página 26, Disponible: www.Pantone.com. Consultada en Octubre de 2014Peng F, Fuxa JR, Richter A, Johnson S. 1999.Effects of Heat-Sensitive Agents, Soil Type, Moisture, and Leaf Surface on Persistence of Anticarsia gemmatalis (Lepidoptera: Noctuidae) Nucleopolyhedrovirus. Environmental Entomology 28: 330-338.Pemsel M, Schwabb S, Scheurerb A, Freitagc D, Schatza R, Schluckera E. 2010. Advanced PGSS process for the encapsulation of the biopesticide Cydia pomonella granulovirus Journal of Supercritical Fluids 53:174-178.Poncelet D. 2006. Microencapsulation: fundamentals, methods and applications. Surface Chemistry. Biomedical and Environmental Science.228:23– 34.Raffin R, Colome L, Shapoval E, Polhman A, Guterres S. 2008.Increasing sodium pantoprazole photostability by microencapsulation: Effect of the polymer and the preparation technique. European Journal of Pharmaceutics and Biopharmaceutics 69:1014–1018.Raffin R, Colome L, Haas S, Jornada D, Pohlmann A, Guterres S. 2007. Development of HPMC and Eudragit® S100 blended microparticles containing sodium pantoprazole.Pharmazie 62: 361-364Raffin R, Jornada D, Ré MI, Pohlmann A, Guterres S.2006. Sodium pantoprazole-loaded enteric microparticles prepared by spray drying: Effect of the scale of production and process validation.International Journal of Pharmaceutics 324:10-18Rattes A y Oliveira W. 2007.Spray drying conditions and encapsulating composition effects on formation and properties of sodium diclofenac microparticles. Powder Technology 171:7-14Raula J, Eerikäinena H, Kauppinen E. 2004.Influence of the solvent composition on the aerosol synthesis of pharmaceutical polymer nanoparticles. International Journal of Pharmaceutics 284:13-21Rohrmann G.F. 2008. Baculovirus Molecular Biology. Bethesda (MD): National Library of Medicine (US), NCBI;Disponible en:http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=bacvir. Consultada en Abril 2014Ronsse F, Pieters J, Dewettinck K. 2008. Modelling side-effect spray drying in top-spray fluidized bed coating processes. Journal of Food Engineering 86: 529-541.Ronsse F, Pieters J. G, Dewettinck K. 2009. Modelling heat and mass transfer in batch, top-spray fluidised bed coating processes. Powder Technology 190: 170-175Rujivipat S y Bodmeier R. 2012. Moisture plasticization for enteric Eudragit_ L30D-55-coated pellets prior to compression into tablets. European Journal of Pharmaceutics and Biopharmaceutics 81:223-9Salazar R. 2003. Tecnología Farmacéutica Industrial. Fabricación y control de medicamentos sólidos de administración por vía oral. Labortecnic, Barcelona.34p.Schaffazick S, Pohlmann A, Mezzalira G, Guterres S.2006.Development of Nanocapsule Suspensions and Nanocapsule Spray-Dried Powders Containing Melatonin.Journalof the Brazilian Chemical Society 17:562-569.Scragg A. 2001. Biotecnología ambiental. Editorial ACRIBIA, S.A. Zaragoza. 307 pShah V, Shinde M, Patil S, Nikam M, Ghodke D, Shah R. 2011.Impact of Selected Variables on the Preparation of Aceclofenac Microspheres by Spray Drying using Full Factorial Design.International Journal of Pharmaceutical Technology Research 3: 1066-1072.Shapiro M. 1989. Congo red as an ultraviolet protectant for the gypsy moth (Lepidoptera: Limantriidae) nuclear polyhedrosis virus. Journal of Economical Entomology 82:548-550.Shimadzu.2007. News 3: Avoiding engine damage determination of methanol in biodiesel. pp 2-3. Disponible en: http://www.ssi.shimadzu.com/enews/pdf/Shimadzu_DeterminationMethanolCon tentGC.pdf Consultada en Noviembre de 2014Shukla R y Tiwari A. 2012. Carbohydrate polymers: Applications and recent advances in delivering drugs to the colon. Carbohydrate Polymers 88: 399– 416.Simón O, Williams T, López M, Caballero P. 2004. Genetic Structure of a Spodoptera frugiperda Nucleopolyhedrovirus Population: High Prevalence of Deletion Genotypes. Applied and Environmental Microbiology 70: 5579 – 5588.Skalsky B y Stegemann S. 2011. Coated Multiparticulates for Controlling Drug Release. En: Controlled Release in Oral Drug Delivery, Advances in Delivery Science and Technology, Controlled Release Society. Wilson C. G. and Crowley P.(eds.), USA.pp. 257-276Srivastava S, Mishra G. 2010. Fluid Bed Technology: Overview and Parameters for Process Selection. International Journal of Pharmaceutical Sciences and Drug Research 2: 236-246.Sporleder M, Zegarra O, Rodriguez EM, Kroschel J. 2008. Effects of temperature on the activity and kinetics of the granulovirus infecting the potato tuber moth Phthorimaea operculella Zeller (Lepidoptera: Gelechiidae). Biological Control 44: 286-295.Suryan A, Sun Kim D, Dong Kim H. 2010. Experimental Study on the Inlet Fogging System Using Two-Fluid Nozzles. Journal of Thermal Science 19:132- 135Tajber L, Corrigan O, Healy A. 2009. Spray drying of budesonide, formoterol fumarate and their Composites—II. Statistical factorial design and in vitro deposition properties. International Journal of Pharmaceutics 367: 86-96Tamez P, Zamudio V, Carrillo JL, Rodríguez C, Gómez R. 2006. Formulaciones granulares de Baculovirus en combinación con abrillantadores ópticos para su empleo como Bioinsecticida. Ciencia UANL 9:149-156.Tamez P, McGuire M, Behle R, Shasha B, Pingel R. 2002. Storage Stability of Anagrapha falcifera nucleopolyehedrovirus in spray dried formulations. Journal of Invertebrate Pathology 79: 7-16.Tamez-Guerra P, McGuireM, Behle R, Hamm J, Sumner H, Shasha B. 2000. Sunlight persistence and rainfastness of spray-dried formulations of baculovirus isolated from Anagrapha falcifera (Lepidoptera: Noctuidae). Journal of Economic Entomology 93: 210-218Turchiuli C, Gianfrancesco A, Palzer S, Dumoulin E. 2011. Evolution of particle properties during spray drying in relation with stickiness and agglomeration control. Powder Technology 208: 433-440.Vaydya S, Bhosale R, Singhal R. 2006. Microencapsulation of Cinnamon Oleoresin by Spray Drying Using Different Wall Materials. Drying Technology 24: 983-992.Valicente F y Da costa E. 1995. Controle da lagarta do cartucho, S. frugiperda (J.E. Smith), como Baculovirus spodoptera, aplicado via água de irrigação.Annual Society Entomology Brasil 24: 61-67.Vila J.L. 2006. Nanotecnología Farmacéutica: Una Galénica Emergente. Instituto de España. Real Academia Nacional de Farmacia. Madrid. 91 pVillamizar L, Guevara J, Espinel C, Gómez M, Gómez J, Cuartas P, Barrera G, Cruz M, Santos A, Uribe L, Ruiz C, Castro O, Lopez-ferber M, Valicente F, Caballero P, Simon O, López Avila A, Martínez F, Cotes A.M. 2012. Desarrollo de un bioplaguicida a base de nucleopoliedrovirus para el control de gusano cogollero del maíz, Spodoptera frugiperda. Bogotá: Corpoica.100pVillamizar L. 2011. Virus entomopatógenos y cambio climático. En: Ed: Sociedad Colombiana De Entomologia Socolen. Memorias Cambio Climático: Retos Y Oportunidades Para La Entomología. 38 Congreso Socolen.Colombia. pp.127-143.Villamizar L, Barrera G, Cotes A, Martínez F.2010. Eudragit S100 microparticles containing Spodoptera frugiperda nucleopolyehedrovirus: Physicochemical, characterization, photostability and invitro virus release. Journal of Microencapsulation 27:314-324.Villamizar L, Espinel C, Cotes A. 2009. Efecto de la radiación ultravioleta sobre la actividad insecticida de un nucleopoliedrovirus de Spodoptera frugiperda (Lepidoptera: Noctuidae).Revista Colombiana de Entomología 35:116-121Villamizar L, Martinez F. 2008.Determination of the basic conditions for microencapsulation of an enthomopathogenic Baculovirus by means of coacervation using Eudragit S100®. VITAE 15: 123-131.Wandrey C, Bartkowiak A, Harding S. 2010. Materials for Encapsulation. En:Encapsulation Technologies for Active Food Ingredients and Food Processing. Zuidam N. J. and Nedović V.(eds.). Springer Verlag. USA. pp.31- 100Wang X y Zhang Q. 2012. pH-sensitive polymeric nanoparticles to improve oral bioavailability 4 of peptide/protein drugs and poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics 82:219-229Williams T. 2010. Insecticidas basados en los Baculovirus.Disponible en: http:// www.trevorwilliams.info/Virus_insecticidas_es.htm. Consultada en Abril 2014Williams T, Cisneros J, Penagos D, Valle J, Tamez-Guerra P. 2004.Ultralow rates of spinosad in phagostimulant granules provide control of Spodoptera frugiperda (Lepidoptera: noctuidae) in maize.Journal of Economic Entomology 97: 422-428.Williams T. 2002. Diseño y aplicación de los bioinsecticidas.Basados en baculovirus.PHYTOMA 144:1-4Williams T, Goulson D, Caballero P, Cisneros J, Martínez A, Chapman J, Roman D, Cave R. 1999. Evaluation of a baculovirus bioinsecticide for smallscale maize growers in Latin America. Biological Control 14: 67-75.Winder R, Wheeler J, Conder N, Otvos I, Nevill R, Duan L. 2003. Microencapsulation: A Strategy for Formulation of Inoculum Biocontrol. Science and Technology 13:155-169.Wiggenhorn M.2007.Scale-Up of Liposome Manufacturing: Combining High Pressure Liposome Extrusion with Drying Technologies. Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München.München, Germany. 238 p.Winstaley Dy Reilly`O D. 1999. Baculoviruses (Baculoviridae). Granuloviruses in: Encyclopedy of Virology. pp.140-146Yañez J, Salazar J, Chaires Martínez L, Jiménez Hernández J,Márquez Robles M, Ramos Ramírez E.2002. Aplicaciones Biotecnológicas de la Microencapsulación. Avance y Perspectiva 21: 313-319Yeo Y y Kinam P. 2004. A New Microencapsulation Method using and ultrasonic atomizer based and interfacial solvent exchange. Journal of Controlled Release 100: 379-388Yeo Y y Park K.2004. Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Archives of Pharmacal Research 27:1-12Yin Hsu F, Syuan Yu D, Chiang Huang Ch. 2013.Development of pH-sensitive pectinate/alginate microspheresfor colon drug delivery. Journal of Materials Science 24:317–323Yoo J, Giri N,Lee Ch. 2011. pH-sensitive Eudragit nanoparticles for mucosal drug delivery. International Journal of Pharmaceutics 403:262-267.Young S. 2000. Persistence of viruses in environment.Disponible en: http: www.Agctr.isu.edu/s265/young.htm. Consultada en Abril del 2014Yu C, Wang W, Yao H, Liu H. 2007. Preparation of Phospholipid Microcapsule by Spray Drying. Drying Technology 25:695-702.Zar J. 1999. Biostatical analysis. 4th ed. New Jersey: Prentice Hall.523 pZhang Y, Wu X, Meng L., Zhang Y., Ai R., Qi N., He H., Xu H., Tang X. 2012. Thiolated Eudragit nanoparticles for oral insulin delivery: Preparation, characterization and in vivo evaluation. International Journal of Pharmaceutics 436: 341-350Zhang W, Guang C, Li P, Liu Cheng S, Zhi He Q. 2008.Preparation and Characterization of Carboxymethyl Chitosan and β-Cyclodextrin Microspheres by Spray Drying. Drying Technology 26:108-115.Zebron. 2014. GC Selection Guide. Disponible en: www.phenomenex.com/zebron. Consultada en Noviembre de 2014Facultad de IngenieríaUniversidad de La SabanaDoctorado en BiocienciasDoctor en BiocienciasCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstream/10818/17429/2/license_rdf7c9ab7f006165862d8ce9ac5eac01552MD52ORIGINALJudith Elena Camacho Kurmen (tesis).pdfJudith Elena Camacho Kurmen (tesis).pdfVer documento en PDFapplication/pdf8535757https://intellectum.unisabana.edu.co/bitstream/10818/17429/1/Judith%20Elena%20Camacho%20Kurmen%20%28tesis%29.pdf23127ee1b52d0fab676a92e9d185597eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/17429/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53TEXTJudith Elena Camacho Kurmen (tesis).pdf.txtJudith Elena Camacho Kurmen (tesis).pdf.txtExtracted Texttext/plain257https://intellectum.unisabana.edu.co/bitstream/10818/17429/4/Judith%20Elena%20Camacho%20Kurmen%20%28tesis%29.pdf.txt52d8ebc7ff4a82ccb755ff3c64419e4eMD5410818/17429oai:intellectum.unisabana.edu.co:10818/174292022-02-18 12:08:47.582Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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 |