Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases
10 páginas
- Autores:
-
Martínez Lozano, Julio Cesar
Gómez, Rosa Margarita
Zarate Sanabria, Andrés Gabriel
Jubiz, Giovanny
Otalora Valderrama, Sonia del Pilar
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/48110
- Acceso en línea:
- https://www.eurekaselect.com/155206
http://hdl.handle.net/10818/48110
- Palabra clave:
- Glial cell
Genetics
Neurodegenerative disease
Molecular mechanism
Neuroglia
Synapses
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases |
| title |
Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases |
| spellingShingle |
Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases Glial cell Genetics Neurodegenerative disease Molecular mechanism Neuroglia Synapses |
| title_short |
Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases |
| title_full |
Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases |
| title_fullStr |
Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases |
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Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases |
| title_sort |
Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases |
| dc.creator.fl_str_mv |
Martínez Lozano, Julio Cesar Gómez, Rosa Margarita Zarate Sanabria, Andrés Gabriel Jubiz, Giovanny Otalora Valderrama, Sonia del Pilar |
| dc.contributor.author.none.fl_str_mv |
Martínez Lozano, Julio Cesar Gómez, Rosa Margarita Zarate Sanabria, Andrés Gabriel Jubiz, Giovanny Otalora Valderrama, Sonia del Pilar |
| dc.subject.other.en.fl_str_mv |
Glial cell Genetics Neurodegenerative disease Molecular mechanism Neuroglia Synapses |
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Glial cell Genetics Neurodegenerative disease Molecular mechanism Neuroglia Synapses |
| description |
10 páginas |
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2018 |
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2018-07-30 |
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2021-08-04T19:12:37Z |
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8/4/2021 14:12 |
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"Martínez J, Julio Cesar., Gómez, R., Zarate, A., Jubiz, G. y Otalora, S.(2018). Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases. Current Pharmaceutical Design, 24(15), 1727-1735 ISSN (Print): 1381-6128. ISSN (Online): 1873-4286." |
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1381-6128 |
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http://hdl.handle.net/10818/48110 |
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10.2174/1381612823666170828134055 |
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"Martínez J, Julio Cesar., Gómez, R., Zarate, A., Jubiz, G. y Otalora, S.(2018). Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases. Current Pharmaceutical Design, 24(15), 1727-1735 ISSN (Print): 1381-6128. ISSN (Online): 1873-4286." 1381-6128 10.2174/1381612823666170828134055 |
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https://www.eurekaselect.com/155206 http://hdl.handle.net/10818/48110 |
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eng |
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Current Pharmaceutical Design, 24(15), 1727-1735 |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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Current Pharmaceutical Design |
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Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana |
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Universidad de la Sabana |
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Martínez Lozano, Julio CesarGómez, Rosa MargaritaZarate Sanabria, Andrés GabrielJubiz, GiovannyOtalora Valderrama, Sonia del Pilar8/4/2021 14:122021-08-04T19:12:37Z2018-07-30"Martínez J, Julio Cesar., Gómez, R., Zarate, A., Jubiz, G. y Otalora, S.(2018). Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases. Current Pharmaceutical Design, 24(15), 1727-1735 ISSN (Print): 1381-6128. ISSN (Online): 1873-4286."1381-6128https://www.eurekaselect.com/155206http://hdl.handle.net/10818/4811010.2174/138161282366617082813405510 páginasGlial cells (also known as glia or neuroglia) are structures which are found in large numbers throughout the nervous system, fulfilling multiple functions, such as regulating the synapses, providing structure, support and nutrition, contributing towards the immune response and tissue oxygenation. Knowledge regarding glial cells has increased during the last few years, since Virchow defined them as supporting connective tissue, followed by Ramón y Cajal who described them as tissue in themselves, until today when a first order physiological role has been recognised for them and a leading role in the appearance and progression of various pathological processes, primarily in the group of Neurodegenerative Diseases (ND). The ND represents a group of pathologies which gradually cause the degeneration of nervous tissue, have a broad spectrum regarding their appearance and, in some cases, are the direct consequence of genetic alterations leading to physiological changes in the nervous system. The present article has thus been aimed at describing glial cells’ genetic interaction with ND through a systemic review of the pertinent literature. The mechanisms through which the different classes of glial cells become involved in the appearance of ND are poorly understood; however, evidence indicates that their role could be a critical factor in these pathologies’ appearance, regulation and chronicity, these being largely determined by different types of cellular interactions and interaction with the microenvironment. This review shows that ND genetics regarding glial cells’ cellular, molecular and genetic functioning represents a complex and understudied process; studying these factors could be a key step for ascertaining the origin of these pathologies, thereby leading to more effective therapies being developed.application/pdfengCurrent Pharmaceutical DesignCurrent Pharmaceutical Design, 24(15), 1727-1735Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_16ecUniversidad de La SabanaIntellectum Repositorio Universidad de La SabanaGlial cellGeneticsNeurodegenerative diseaseMolecular mechanismNeurogliaSynapsesGenetic Aspects of Glial Cells Regarding Neurodegenerative DiseasesarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstream/10818/48110/3/license.txtf52a2cfd4df262e08e9b300d62c85cabMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://intellectum.unisabana.edu.co/bitstream/10818/48110/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD5210818/48110oai:intellectum.unisabana.edu.co:10818/481102022-05-10 05:21:28.563Intellectum Universidad de la Sabanacontactointellectum@unisabana.edu.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 |